Detailed information for compound 1138831

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.324 | Formula: C17H15FN4O3
  • H donors: 2 H acceptors: 3 LogP: 2.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CNc1c(NCc2ccc(cc2)OC)nc(nc1c1ccco1)F
  • InChi: 1S/C17H15FN4O3/c1-24-12-6-4-11(5-7-12)9-19-16-15(20-10-23)14(21-17(18)22-16)13-3-2-8-25-13/h2-8,10H,9H2,1H3,(H,20,23)(H,19,21,22)
  • InChiKey: MXZIWIAAVBUXPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1177 0.6035
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0487 0.0579
Loa Loa (eye worm) inositol-1 0.0041 0.0326 0.0389
Schistosoma mansoni cpg binding protein 0.0064 0.0596 0.0596
Echinococcus granulosus ferritin 0.0036 0.0268 0.0268
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0326 0.0971
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0062 0.0908
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0487 0.0487
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0036 0.0268 0.028
Echinococcus multilocularis dnaJ subfamily B 0.0868 1 1
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0487 0.0487
Mycobacterium tuberculosis Conserved protein 0.0114 0.1177 0.137
Schistosoma mansoni ferritin 0.0036 0.0268 0.0268
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0085 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0487 0.0579
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0218
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0326 0.1674
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.002 0.002
Leishmania major hypothetical protein, conserved 0.0114 0.1177 0.6035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1177 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0146 0.0146
Brugia malayi hypothetical protein 0.0027 0.0154 0.0184
Brugia malayi latrophilin 2 splice variant baaae 0.05 0.5693 0.6777
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0036 0.0268 0.8001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0035 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0487 0.0579
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0154 0.1311
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.1177 0.3653
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0062 0.008
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0227 0.1164
Schistosoma mansoni hypothetical protein 0.0231 0.255 0.255
Plasmodium vivax endoplasmin, putative 0.0033 0.0227 0.193
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.1177 0.6035
Trypanosoma brucei unspecified product 0.0014 0.001 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0632 0.0632
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0487 0.0579
Echinococcus granulosus neuropeptide receptor A26 0.0514 0.5856 0.5856
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0149 0.0342
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0146 0.0174
Trypanosoma brucei trypanothione reductase 0.0048 0.0398 0.2043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0487 0.0579
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0632 0.1911
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.1177 0.137
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0085 0.0101
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0085 0.0085
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0632 0.3243
Schistosoma mansoni inositol monophosphatase 0.0041 0.0326 0.0326
Echinococcus granulosus heat shock protein 0.0033 0.0227 0.0227
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.0661 0.0661
Brugia malayi nuclear receptor NHR-67 0.0026 0.0146 0.0174
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0146 0.0174
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.9184 0.9184
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0632 0.0632
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0146 0.0146
Trichomonas vaginalis ferritin, putative 0.0036 0.0268 0.0798
Schistosoma mansoni heat shock protein 0.0033 0.0227 0.0227
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1562 0.1832
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0035 0.018
Leishmania major DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Schistosoma mansoni lamin 0.0029 0.0183 0.0183
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0487 0.0487
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.1177 0.137
Brugia malayi Protein kinase domain containing protein 0.018 0.195 0.2321
Entamoeba histolytica protein kinase, putative 0.018 0.195 0.58
Echinococcus multilocularis dna polymerase eta 0.0048 0.0405 0.0405
Echinococcus multilocularis GPCR, family 2 0.0231 0.255 0.255
Echinococcus granulosus lamin dm0 0.0029 0.0183 0.0183
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1252 0.7809
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.002 0.002
Schistosoma mansoni transient receptor potential channel 4 0.0106 0.108 0.108
Onchocerca volvulus 0.0026 0.0146 0.0887
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.018 0.195 0.195
Loa Loa (eye worm) hypothetical protein 0.0106 0.108 0.1285
Schistosoma mansoni hypothetical protein 0.0707 0.812 0.812
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1111 0.1291
Schistosoma mansoni tar DNA-binding protein 0.0538 0.6133 0.6133
Schistosoma mansoni zinc finger protein 0.0026 0.0146 0.0146
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0146 0.0174
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0487 0.0487
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0731 0.8401 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0231 0.255 0.3036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.3204 0.3204
Echinococcus granulosus tar DNA binding protein 0.0538 0.6133 0.6133
Schistosoma mansoni cpg binding protein 0.0061 0.0556 0.0556
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1355 0.1355
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0326 1
Schistosoma mansoni nuclear receptor 0.0026 0.0146 0.0146
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0487 0.0487
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0183 0.0183
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0146 0.0146
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0035 0.0035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0487 0.0487
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.1177 0.137
Echinococcus granulosus dual specificity 0.018 0.195 0.195
Echinococcus granulosus dna polymerase kappa 0.0021 0.0085 0.0085
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Entamoeba histolytica hypothetical protein 0.018 0.195 0.58
Schistosoma mansoni hypothetical protein 0.0231 0.255 0.255
Echinococcus multilocularis ferritin 0.0036 0.0268 0.0268
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0146 0.0146
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0029 0.0177 0.0211
Schistosoma mansoni ferritin light chain 0.0036 0.0268 0.0268
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Echinococcus multilocularis expressed protein 0.0036 0.0268 0.0268
Plasmodium falciparum glutathione reductase 0.0016 0.0035 0.088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Loa Loa (eye worm) hypothetical protein 0.0114 0.1177 0.1401
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0146 0.0174
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.0315
Onchocerca volvulus 0.0055 0.0487 0.295
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0154 0.1293
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0405 0.2075
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1252 0.1461
Loa Loa (eye worm) hypothetical protein 0.0231 0.255 0.3036
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.3363 1
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.018 0.195 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0487 0.0579
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0487 0.0487
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0276 0.0899
Onchocerca volvulus 0.0154 0.165 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0487 0.0579
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0035 0.0042
Echinococcus multilocularis musashi 0.0029 0.0183 0.0183
Onchocerca volvulus 0.0029 0.0183 0.1112
Mycobacterium tuberculosis Probable reductase 0.0108 0.1111 0.1291
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0085 0.0252
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.018 0.195 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Schistosoma mansoni ferritin 0.0036 0.0268 0.0268
Schistosoma mansoni cpg binding protein 0.0064 0.0596 0.0596
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.018 0.195 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0085 0.0435
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0227 0.193
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0062 0.0523
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0487 0.0487
Echinococcus granulosus neuropeptide s receptor 0.0514 0.5856 0.5856
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Leishmania major DNA polymerase eta, putative 0.0034 0.0238 0.1218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.3204 0.3204
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.1177 0.137
Brugia malayi nuclear receptor NHR-88 0.0055 0.0487 0.0579
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0146 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0063 0.0063
Brugia malayi RNA binding protein 0.0538 0.6133 0.7301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1252 0.1461
Onchocerca volvulus 0.0114 0.1177 0.7132
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.002 0.002
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0035 0.5
Brugia malayi nuclear hormone receptor 0.0026 0.0146 0.0174
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0227 0.1164
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0154 0.3873
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0398 0.2043
Loa Loa (eye worm) hypothetical protein 0.0154 0.165 0.1964
Schistosoma mansoni intermediate filament proteins 0.0029 0.0183 0.0183
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0487 0.295
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0731 0.8401 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0154 0.0791
Plasmodium falciparum thioredoxin reductase 0.0048 0.0398 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0025 0.003
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0025 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1177 0.1177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0287 0.3204 0.3814
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0405 0.2075
Echinococcus multilocularis transient receptor potential gamma protein 0.0106 0.108 0.108
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0487 0.0487
Brugia malayi hypothetical protein 0.0036 0.026 0.031
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0085 0.0085
Loa Loa (eye worm) beta-lactamase 0.0114 0.1177 0.1401
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0146 0.0146
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0227 0.0675
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0303 0.036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0062 0.0085
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3363 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0632 0.0632
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0035 0.018
Echinococcus granulosus heat shock protein 90 0.0026 0.0149 0.0149
Brugia malayi tailless protein 0.0026 0.0146 0.0174
Mycobacterium ulcerans bacterioferritin BfrB 0.0036 0.0268 0.0746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0487 0.0579
Brugia malayi beta-lactamase family protein 0.0114 0.1177 0.1401
Brugia malayi beta-lactamase family protein 0.0114 0.1177 0.1401
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0149 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0487 0.0487
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.006 0.0072
Schistosoma mansoni hypothetical protein 0.0231 0.255 0.255
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0487 0.0579
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0227 0.027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Onchocerca volvulus 0.0026 0.0146 0.0887
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0179 0.1939 0.2308
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0094 0.0484
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0231 0.255 0.255
Schistosoma mansoni inositol monophosphatase 0.0041 0.0326 0.0326
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0227 0.0577
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.002 0.002
Schistosoma mansoni transient receptor potential channel 0.007 0.0661 0.0661
Schistosoma mansoni tar DNA-binding protein 0.0538 0.6133 0.6133
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0218
Plasmodium falciparum endoplasmin, putative 0.002 0.0078 0.1966
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0035 0.088
Brugia malayi steroid hormone receptor 0.0055 0.0487 0.0579
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1111 0.6808
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0231 0.255 0.3036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0004 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0146 0.0146
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0035 0.0294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0218
Toxoplasma gondii ABC1 family protein 0.0114 0.1177 0.986
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Loa Loa (eye worm) hypothetical protein 0.0027 0.0154 0.0184
Schistosoma mansoni hypothetical protein 0.0707 0.812 0.812
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0085 0.0085
Brugia malayi TAR-binding protein 0.0538 0.6133 0.7301
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0487 0.0579
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.1177 0.137
Trypanosoma brucei unspecified product 0.0014 0.001 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0487 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0487 0.0579
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0085 0.0252
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0094 0.0484
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0311
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0487 0.0487
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0035 0.018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0004 0.0012
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0183 0.0183
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.018 0.195 1
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0487 0.0579
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0227 0.1164
Brugia malayi Transient-receptor-potential like protein 0.0039 0.0303 0.036
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0149 0.0763
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1177 0.6035
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0154 0.0791
Entamoeba histolytica protein kinase, putative 0.018 0.195 0.58
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0326 0.0971
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0149 0.0763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.3204 0.3204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0632 0.1911
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0069 0.0356
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0487 0.0487
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0035 0.018
Brugia malayi beta-lactamase 0.0114 0.1177 0.1401
Trichomonas vaginalis heat shock protein, putative 0.002 0.0078 0.0233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.1194 1
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0487 0.0487
Brugia malayi hypothetical protein 0.0029 0.0183 0.0218
Loa Loa (eye worm) glutathione reductase 0.0048 0.0398 0.0474
Loa Loa (eye worm) hypothetical protein 0.0179 0.1939 0.2308
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.1177 0.1177
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0487 0.0487
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0146 0.0887
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0004 0.0012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0398 0.0436
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0556 0.0661
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0154 0.3873
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0004 0.0012
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0326 0.0971
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Giardia lamblia DINP protein human, muc B family 0.0021 0.0085 0.0149
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Echinococcus granulosus GPCR family 2 0.0231 0.255 0.255
Echinococcus granulosus geminin 0.0707 0.812 0.812
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0218
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0487 0.295
Mycobacterium tuberculosis Conserved protein 0.0114 0.1177 0.137
Loa Loa (eye worm) RNA binding protein 0.0538 0.6133 0.7301
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0094 0.0484
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0326 0.1674
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0183 0.0183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0231 0.255 0.255
Loa Loa (eye worm) endoplasmin 0.0033 0.0227 0.027
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0094 0.019
Trypanosoma brucei unspecified product 0.0021 0.0085 0.0435
Echinococcus multilocularis heat shock protein 0.0033 0.0227 0.0227
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0085 0.0159
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0062 0.008
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.0303 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0487 0.0579
Onchocerca volvulus 0.0029 0.0183 0.1112
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0183 0.0218
Brugia malayi Cytochrome P450 family protein 0.0022 0.0094 0.0112
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0183
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Brugia malayi Latrophilin receptor protein 2 0.0231 0.255 0.3036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0287 0.3204 0.3814
Entamoeba histolytica protein kinase domain containing protein 0.018 0.195 0.58
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0004 0.0012
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0227 0.0675
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0227 0.1164
Schistosoma mansoni tar DNA-binding protein 0.0538 0.6133 0.6133
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0183 0.0218
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0183 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0094 0.0112
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0146 0.0146
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0035 0.018
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0227 0.1903
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0146 0.0174
Brugia malayi hypothetical protein 0.0154 0.165 0.1964
Brugia malayi ecdysteroid receptor 0.0055 0.0487 0.0579
Schistosoma mansoni hypothetical protein 0.0868 1 1
Brugia malayi ecdysone receptor 0.0026 0.0146 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0146 0.0146
Trichomonas vaginalis esterase, putative 0.0114 0.1177 0.35
Onchocerca volvulus 0.0114 0.1177 0.7132
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0149 0.0364
Echinococcus multilocularis tar DNA binding protein 0.0538 0.6133 0.6133
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0035 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0085 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0487 0.0579
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0227 0.1164
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0183 0.0218
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Schistosoma mansoni tar DNA-binding protein 0.0538 0.6133 0.6133
Plasmodium falciparum thioredoxin reductase 0.0016 0.0035 0.088
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0146 0.0146
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0085 0.0085
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1177 0.35
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0326 0.1674
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0149 0.3901
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.0661 0.0661
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0146 0.0174
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0487 0.0579
Schistosoma mansoni hypothetical protein 0.0231 0.255 0.255
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0326 0.1674
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0146 0.0146
Loa Loa (eye worm) DR-78 0.0026 0.0146 0.0174
Echinococcus granulosus cpg binding protein 0.0064 0.0596 0.0596
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0146 0.0146
Schistosoma mansoni ferritin 0.0036 0.0268 0.0268
Echinococcus multilocularis transient receptor potential ion channel A 0.0102 0.1038 0.1038
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0632 0.0632
Onchocerca volvulus 0.0061 0.0556 0.3367
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0227 0.1164
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0632 0.1911
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0231 0.255 0.255
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.1177 0.3653
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0146 0.0174
Leishmania major hypothetical protein, conserved 0.0027 0.0154 0.0791
Echinococcus multilocularis dual specificity 0.018 0.195 0.195
Schistosoma mansoni apoferritin-2 0.0036 0.0268 0.0268
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0227 0.1164
Schistosoma mansoni DNA polymerase eta 0.0048 0.0405 0.0405
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1177 0.35
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0487 0.0487
Mycobacterium ulcerans lipase LipD 0.0114 0.1177 0.3653
Echinococcus multilocularis neuropeptide receptor A26 0.0514 0.5856 0.5856
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0326 0.0326
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0238 0.1218
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0062 0.0062
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0007 0.0007
Mycobacterium ulcerans beta-lactamase 0.0114 0.1177 0.3653
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1177 0.35
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0398 0.3386
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Leishmania major DNA polymerase eta, putative 0.0048 0.0405 0.2075
Brugia malayi nuclear receptor RXR 0.0029 0.0183 0.0218
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1562 0.4885
Mycobacterium tuberculosis Conserved protein 0.0114 0.1177 0.137
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0036 0.0268 0.0846
Brugia malayi nuclear hormone receptor 0.0055 0.0487 0.0579
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.1177 0.137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0487 0.0487
Schistosoma mansoni ap endonuclease 0.0019 0.0062 0.0062
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0035 0.0104
Echinococcus multilocularis neuropeptide s receptor 0.0514 0.5856 0.5856
Echinococcus multilocularis lamin dm0 0.0029 0.0183 0.0183
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0487 0.0487
Schistosoma mansoni endoplasmin 0.0033 0.0227 0.0227
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.1177 0.1401
Schistosoma mansoni coup transcription factor 0.0055 0.0487 0.0487
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0487 0.0487
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0773
Toxoplasma gondii exonuclease III APE 0.0019 0.0062 0.0515
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0773
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0487 0.0579
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.1177 0.1401
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.3363 1
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0227 0.1164
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0183 0.0183
Brugia malayi nuclear receptor RXR 0.0026 0.0146 0.0174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0218
Echinococcus granulosus endoplasmin 0.0026 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1234 0.1468
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0773
Loa Loa (eye worm) hypothetical protein 0.0114 0.1177 0.1401
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0146 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.001 0.0049
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0632 0.0717
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.0661 0.0661
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0146 0.0887
Echinococcus multilocularis endoplasmin 0.0026 0.0149 0.0149
Echinococcus multilocularis heat shock protein 90 0.0033 0.0227 0.0227
Schistosoma mansoni transient receptor potential channel 0.0106 0.108 0.108
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.001 0.0049
Treponema pallidum heat shock protein 90 0.0026 0.0149 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0487 0.0579
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0405 0.0482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.3204 0.3204
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.05 0.5693 0.5693
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0227 0.1903
Leishmania major cytochrome p450-like protein 0.0022 0.0094 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.001 0.0049
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0731 0.8401 1
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0227 0.0675
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0094 0.0112
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0035 0.0104
Schistosoma mansoni heat shock protein 0.0033 0.0227 0.0227
Schistosoma mansoni nuclear receptor 0.0026 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Echinococcus multilocularis geminin 0.0707 0.812 0.812
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0231 0.255 0.255
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0183 0.0218
Plasmodium falciparum heat shock protein 90 0.0033 0.0227 0.5699
Echinococcus granulosus dna polymerase eta 0.0048 0.0405 0.0405
Echinococcus granulosus transient receptor potential ion channel A 0.0102 0.1038 0.1038
Brugia malayi Cytochrome P450 family protein 0.0022 0.0094 0.0112
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0094 0.0112
Brugia malayi Endoplasmin precursor 0.0033 0.0227 0.027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0062 0.0315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.3204 0.3204
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0062 0.0062
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0035 0.0294
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0632 0.5299
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0035 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0114 0.1177 0.1401
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0487 0.0487
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0149 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0062 0.1544
Schistosoma mansoni transient receptor potential channel 0.007 0.0661 0.0661
Echinococcus granulosus heat shock protein 90 0.0033 0.0227 0.0227
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0149 0.0442
Schistosoma mansoni tar DNA-binding protein 0.0538 0.6133 0.6133
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0146 0.0146
Brugia malayi nuclear receptor NHR-88 0.0026 0.0146 0.0174
Brugia malayi conserved hypotetical protein 0.0026 0.0146 0.0174
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0085 0.0085
Loa Loa (eye worm) glutaminase 2 0.0284 0.3161 0.3762
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0036 0.0268 0.028
Schistosoma mansoni lamin 0.0029 0.0183 0.0183
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.1177 0.137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0487 0.0487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.3204 0.3204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0487 0.0487
Mycobacterium leprae Probable lipase LipE 0.0114 0.1177 0.7275
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0062 0.0315
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0062 0.0315
Schistosoma mansoni ferritin 0.0036 0.0268 0.0268
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1111 0.1291
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0035 0.0298
Plasmodium vivax glutathione reductase, putative 0.0048 0.0398 0.3386
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0085 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0062 0.0073
Schistosoma mansoni apoferritin-2 0.0036 0.0268 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0487 0.0579
Brugia malayi Cytochrome P450 family protein 0.0033 0.0229 0.0272
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0154 0.0791
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1177 0.35
Onchocerca volvulus 0.0114 0.1177 0.7132
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0035 0.018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0487 0.0579
Brugia malayi MH2 domain containing protein 0.0119 0.1234 0.1468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0004 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0326 0.0971
Entamoeba histolytica hypothetical protein 0.0036 0.026 0.0773
Mycobacterium ulcerans bacterioferritin BfrA 0.0036 0.0268 0.0746
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Toxoplasma gondii thioredoxin reductase 0.0048 0.0398 0.3338
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0063 0.0075
Brugia malayi Thioredoxin reductase 0.0048 0.0398 0.0474
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0035 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0062 0.0183
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0326 0.2735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0004 0.0012
Trichomonas vaginalis glutaminase, putative 0.0284 0.3161 0.94
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Brugia malayi Inositol-1 0.0041 0.0326 0.0389
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0487 0.0487
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Echinococcus granulosus transient receptor potential gamma protein 0.0106 0.108 0.108
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0035 0.088
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0487 0.0487
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0731 0.8401 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0146 0.0174
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0146 0.0146
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0062 0.0073
Loa Loa (eye worm) hypothetical protein 0.0114 0.1177 0.1401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0405 0.0482
Mycobacterium ulcerans glutaminase 0.0284 0.3161 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.0661 0.0661
Brugia malayi glutathione reductase 0.0048 0.0398 0.0474
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0238 0.199
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0035 0.0298
Loa Loa (eye worm) hypothetical protein 0.05 0.5693 0.6777
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0487 0.0579
Brugia malayi CXXC zinc finger family protein 0.0061 0.0556 0.0661
Loa Loa (eye worm) hypothetical protein 0.0114 0.1177 0.1401
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0085 0.0435
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0229 0.0272
Brugia malayi intermediate filament protein 0.0029 0.0183 0.0218
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0487 0.0579
Brugia malayi RNA recognition motif domain containing protein 0.0538 0.6133 0.7301
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Schistosoma mansoni glutaminase 0.0284 0.3161 0.3161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0487 0.0487
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0085 0.0252
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0085 0.0435
Mycobacterium ulcerans hypothetical protein 0.0114 0.1177 0.3653
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0029 0.0183 0.0183
Brugia malayi hypothetical protein 0.0029 0.0183 0.0218
Loa Loa (eye worm) glutaminase 0.0284 0.3161 0.3762
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0149 0.0442
Brugia malayi hypothetical protein 0.0026 0.0146 0.0174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.002 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1177 0.35
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1234 0.1468
Echinococcus granulosus expressed protein 0.0036 0.0268 0.0268
Schistosoma mansoni endoplasmin 0.0033 0.0227 0.0227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0085 0.0101
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Brugia malayi hypothetical protein 0.0017 0.0044 0.0052
Echinococcus granulosus lamin 0.0029 0.0183 0.0183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0487 0.0579
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0149 0.0763
Echinococcus multilocularis heat shock protein 90 0.0026 0.0149 0.0149
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.026 0.026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0085 0.006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0729 0.8368 1
Brugia malayi heat shock protein 90 0.0033 0.0227 0.027
Trichomonas vaginalis helicase, putative 0.0014 0.0004 0.0012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1562 1
Treponema pallidum bacterioferrin (TpF1) 0.0036 0.0268 0.0701
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1111 0.1291
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1111 0.1291
Mycobacterium leprae conserved hypothetical protein 0.0114 0.1177 0.7275
Echinococcus multilocularis lamin 0.0029 0.0183 0.0183
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0276 0.0289
Loa Loa (eye worm) hypothetical protein 0.0066 0.0619 0.0737
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0487 0.295
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0487 0.0487
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.018 0.195 0.2321
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1252 0.1461
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0487 0.0579
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.3363 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.3204 0.3204
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0008
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0398 0.0474
Leishmania major trypanothione reductase 0.0048 0.0398 0.2043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1177 0.1177
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0183 0.0218
Loa Loa (eye worm) TAR-binding protein 0.0538 0.6133 0.7301
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.0012
Trichomonas vaginalis endoplasmin, putative 0.002 0.0078 0.0233
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0035 0.018
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0326 0.0326
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0146 0.0146
Giardia lamblia Grp94/Hsp90 0.0026 0.0149 0.0342
Loa Loa (eye worm) hypothetical protein 0.0114 0.1177 0.1401
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0326 0.0932
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0062 0.0183
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0174
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.3363 1
Schistosoma mansoni hypothetical protein 0.0036 0.026 0.026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0149 0.0149
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0538 0.6133 0.7301
Trypanosoma brucei heat shock protein, putative 0.0033 0.0227 0.1164
Schistosoma mansoni ferritin light chain 0.0036 0.0268 0.0268
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0487 0.0487
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0055 0.0487 0.0579
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1111 0.1291
Plasmodium falciparum glutathione reductase 0.0048 0.0398 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0487 0.0487
Brugia malayi hypothetical protein 0.0026 0.0146 0.0174
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.1177 0.1177
Echinococcus multilocularis cpg binding protein 0.0064 0.0596 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.0435
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.0303 0.0303
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0487 0.0579
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0146 0.0146
Leishmania major heat shock protein 83-1 0.0033 0.0227 0.1164
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0062 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0487 0.0487
Brugia malayi glutaminase DH11.1 0.0284 0.3161 0.3762

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) < 0.2 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by twofold dilution method ChEMBL. 20488716
IC50 (functional) < 0.2 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay ChEMBL. 19427200
IC90 (functional) < 0.2 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by twofold dilution method ChEMBL. 20488716
IC90 (functional) < 0.2 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay ChEMBL. 19427200
MIC (functional) > 64 ug ml-1 Antibacterial activity against Escherichia coli ChEMBL. 19427200

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mycobacterium tuberculosis 19427200

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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