Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.009 | 0.403 | 0.3506 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.3355 | 0.3161 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.1638 | 0.0904 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.3611 | 0.3424 |
Loa Loa (eye worm) | GMP reductase | 0.0079 | 0.3355 | 0.3355 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.1638 | 0.1393 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0178 | 0.9325 | 0.9266 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.019 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1638 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.1638 | 0.0904 |
Trypanosoma cruzi | GMP reductase | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1335 | 0.1335 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.46 | 0.4268 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.4368 | 0.4296 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.8633 | 0.8633 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.1638 | 0.153 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.019 | 1 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0079 | 0.3355 | 0.5 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0178 | 0.9325 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.01 | 0.46 | 0.4268 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.1638 | 0.0904 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0178 | 0.9325 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.1638 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1638 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0806 | 0.0806 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0806 | 0.0806 |
Brugia malayi | GMP reductase | 0.0079 | 0.3355 | 0.3161 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.4368 | 0.4296 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.4368 | 0.4368 |
Echinococcus multilocularis | geminin | 0.0167 | 0.8633 | 0.8616 |
Trypanosoma brucei | GMP reductase | 0.019 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.4368 | 0.4203 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.1638 | 0.153 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.4368 | 0.4368 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.1638 | 0.0904 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.1638 | 0.0904 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.1638 | 0.153 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.2595 | 0.25 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.1638 | 0.1638 |
Toxoplasma gondii | IMP dehydrogenas | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3327 | 0.3327 |
Leishmania major | guanosine monophosphate reductase | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1462 | 0.1462 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.1638 | 0.0904 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.1016 | 0.0901 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.1016 | 0.0901 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0806 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.1638 | 0.0904 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1178 | 0.1178 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0806 | 0.0806 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.009 | 0.403 | 0.3664 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0806 | 0.0688 |
Echinococcus granulosus | geminin | 0.0167 | 0.8633 | 0.8616 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1173 | 0.0915 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.4368 | 0.4296 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1638 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0806 | 0.0688 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.4368 | 0.4296 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.1638 | 0.0904 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.4368 | 0.4368 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.019 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0079 | 0.3355 | 0.3161 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0127 | 0.0127 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.2595 | 0.25 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.4368 | 0.4368 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.1638 | 0.1638 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0806 | 0.0538 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.8633 | 0.8633 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.019 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1638 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.1638 | 0.0904 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.1638 | 0.153 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.2832 | 0.2832 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.