Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0788 | 0.0788 |
Onchocerca volvulus | 0.0037 | 0.0788 | 0.1542 | |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.004 | 0.0978 | 0.0978 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0978 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0037 | 0.0788 | 0.1542 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Onchocerca volvulus | 0.0104 | 0.5111 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.014 | 0.7421 | 0.7421 |
Echinococcus granulosus | cathepsin l1 | 0.0037 | 0.0788 | 0.0788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Loa Loa (eye worm) | cysteine protease | 0.0037 | 0.0788 | 0.0788 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0.0978 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0788 | 0.0788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0037 | 0.0788 | 0.0788 |
Onchocerca volvulus | 0.0037 | 0.0788 | 0.1542 | |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7421 | 0.885 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Leishmania major | cathepsin L-like protease | 0.0141 | 0.7485 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0037 | 0.0788 | 0.0788 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0.0978 | 1 |
Onchocerca volvulus | 0.0037 | 0.0788 | 0.1542 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0181 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0.0978 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 0.7485 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.083 | 0.099 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | fibroinase | 0.0037 | 0.0788 | 0.0788 |
Onchocerca volvulus | Cathepsin F homolog | 0.0037 | 0.0788 | 0.1542 |
Plasmodium vivax | vivapain-2 | 0.0037 | 0.0788 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.083 | 0.083 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1953 | 0.1953 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0037 | 0.0788 | 0.094 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0788 | 0.0788 |
Schistosoma mansoni | alpha glucosidase | 0.004 | 0.0978 | 0.1166 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0129 | 0.6697 | 0.8824 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 0.7485 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0788 | 0.0788 |
Loa Loa (eye worm) | ctsf protein | 0.0037 | 0.0788 | 0.0788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Leishmania major | cathepsin L-like protease | 0.0141 | 0.7485 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.004 | 0.0978 | 0.0978 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0978 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 0.7421 | 0.7421 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Onchocerca volvulus | 0.0037 | 0.0788 | 0.1542 | |
Entamoeba histolytica | cysteine protease, putative | 0.0037 | 0.0788 | 0.806 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.083 | 0.083 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0978 | 0.0283 |
Plasmodium vivax | vivapain-2 | 0.0037 | 0.0788 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.004 | 0.0978 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0181 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0978 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0978 | 0.0283 |
Leishmania major | cathepsin L-like protease | 0.0141 | 0.7485 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0181 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Brugia malayi | RNA binding protein | 0.014 | 0.7421 | 0.7421 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0037 | 0.0788 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0978 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0111 | 0.5542 | 0.7098 |
Echinococcus multilocularis | tar DNA binding protein | 0.014 | 0.7421 | 0.7201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0037 | 0.0788 | 0.806 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.004 | 0.0978 | 0.0978 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.004 | 0.0978 | 0.0206 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 0.7421 | 0.7421 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0037 | 0.0788 | 0.0788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7421 | 0.885 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0788 | 0.0788 |
Leishmania major | alpha glucosidase II subunit, putative | 0.004 | 0.0978 | 0.0283 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0788 | 0.0788 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0037 | 0.0788 | 0.0788 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0181 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.0788 | 0.1542 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1953 | 0.1953 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Onchocerca volvulus | 0.0037 | 0.0788 | 0.1542 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0037 | 0.0788 | 0.1542 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.004 | 0.0978 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0.0978 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0037 | 0.0788 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7421 | 0.885 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0037 | 0.0788 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 0.7485 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 0.7421 | 0.7421 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1953 | 0.1953 |
Brugia malayi | TAR-binding protein | 0.014 | 0.7421 | 0.7421 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0155 | 0.8385 | 1 |
Onchocerca volvulus | 0.0037 | 0.0788 | 0.1542 | |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7421 | 0.885 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0037 | 0.0788 | 0.806 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0037 | 0.0788 | 0.094 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0978 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.004 | 0.0978 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0037 | 0.0788 | 0.0788 |
Schistosoma mansoni | alpha-glucosidase | 0.0155 | 0.8385 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 0.7421 | 0.7421 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 0.7485 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0141 | 0.7485 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.7421 | 0.885 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0788 | 0.806 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0788 | 0.0788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.