Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | trypanothione reductase | Starlite/ChEMBL | References |
Trypanosoma brucei gambiense | trypanothione reductase, putative | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0152 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0152 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0053 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0152 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0053 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0152 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0152 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0053 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0152 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0152 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0053 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0152 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0053 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0053 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0152 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0152 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0152 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0053 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0053 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0152 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0053 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0152 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0152 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0053 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0053 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 5.6 uM | Antitrypanosomal activity against blood stream form Trypanosoma brucei brucei by resazurin fluorescence-based viability assay | ChEMBL. | 21851087 |
EC50 (ADMET) | = 6 uM | Cytotoxicity against human MRC5 cells by resazurin fluorescence-based viability assay | ChEMBL. | 21851087 |
IC50 (binding) | = 0.37 uM | Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assay | ChEMBL. | 21851087 |
Ki (binding) | = 0.27 uM | Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk method | ChEMBL. | 21851087 |
Ki (binding) | = 1.78 uM | Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk method | ChEMBL. | 21851087 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 21851087 | ||
Homo sapiens | ChEMBL23 | 21851087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.