Detailed information for compound 113908

Basic information

Technical information
  • TDR Targets ID: 113908
  • Name: 2-(1,3-benzoxazol-2-ylsulfanylmethyl)-4,5-dib enzyl-1,1-dioxo-1,2,5-thiadiazolidin-3-one
  • MW: 479.571 | Formula: C24H21N3O4S2
  • H donors: 0 H acceptors: 4 LogP: 4.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(Cc2ccccc2)N(S(=O)(=O)N1CSc1nc2c(o1)cccc2)Cc1ccccc1
  • InChi: 1S/C24H21N3O4S2/c28-23-21(15-18-9-3-1-4-10-18)26(16-19-11-5-2-6-12-19)33(29,30)27(23)17-32-24-25-20-13-7-8-14-22(20)31-24/h1-14,21H,15-17H2
  • InChiKey: DRSMPZCIYBFYPF-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(1,3-benzoxazol-2-ylthio)methyl]-4,5-dibenzyl-1,1-dioxo-1,2,5-thiadiazolidin-3-one
  • 2-(1,3-benzoxazol-2-ylsulfanylmethyl)-1,1-dioxo-4,5-bis(phenylmethyl)-1,2,5-thiadiazolidin-3-one
  • 2-[(1,3-benzoxazol-2-ylthio)methyl]-4,5-dibenzyl-1,1-diketo-1,2,5-thiadiazolidin-3-one
  • 2-[(1,3-benzoxazol-2-ylthio)methyl]-1,1-dioxo-4,5-bis(phenylmethyl)-1,2,5-thiadiazolidin-3-one
  • 2-[(1,3-benzoxazol-2-ylthio)methyl]-4,5-bis(benzyl)-1,1-diketo-1,2,5-thiadiazolidin-3-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0051 0.0302 0.1344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0389 0.0753
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0169 0.0703
Brugia malayi Hsp90 protein 0.0013 0.0025 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0563
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0116 0.0155
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0302 0.0503
Schistosoma mansoni smad 0.0016 0.0047 0.0082
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0664 0.3261
Echinococcus multilocularis neurogenic locus protein delta 0.0025 0.0113 0.0187
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0163 0.5298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0119 0.0234
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Schistosoma mansoni hypothetical protein 0.0032 0.0163 0.0308
Brugia malayi Smad1 0.0016 0.0047 0.0188
Brugia malayi Muscle positioning protein 4 0.0025 0.0113 0.0484
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0163 0.0271
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0006 0.0001
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0067 0.0086
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0163 0.0737
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0438 0.1959
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0163 0.0735
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0664 0.2981
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0089 0.0073
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0104 0.0094
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0303 0.1349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Echinococcus multilocularis fat cadherin tumor suppressor 0.0025 0.0113 0.0187
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.5101 0.8492
Onchocerca volvulus Dual oxidase homolog 0.0078 0.0505 0.2261
Loa Loa (eye worm) hypothetical protein 0.0043 0.0242 0.1094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0153 0.029
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0006 0.0011
Brugia malayi CXXC zinc finger family protein 0.0029 0.014 0.0609
Brugia malayi steroid hormone receptor 0.0051 0.0302 0.1344
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Brugia malayi EGF-like domain containing protein 0.0025 0.0113 0.0484
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0025 0.0042
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0103 0.0442
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0505 0.2261
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Leishmania major hypothetical protein, conserved 0.0051 0.0303 0.1349
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0047 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0302 0.1344
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0302 0.0582
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0664 0.1301
Echinococcus multilocularis heat shock protein 0.0033 0.0169 0.0282
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.023 0.1
Schistosoma mansoni coup transcription factor 0.0051 0.0302 0.0582
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0505 0.2261
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0302 0.1344
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Echinococcus granulosus protein jagged 2 0.0025 0.0113 0.0221
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0302 0.0593
Schistosoma mansoni endoplasmin 0.0033 0.0169 0.0321
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0643 0.0891
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0242 0.0403
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0212 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0302 0.1344
Onchocerca volvulus 0.005 0.0299 0.1328
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0103 0.0442
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0011 0.0005 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.014 0.0633
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0103 0.0442
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0116 0.0155
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0302 0.0582
Onchocerca volvulus 0.024 0.1701 0.7682
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0153 0.029
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0116 0.0111
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0163 0.0674
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0302 0.1344
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.021
Schistosoma mansoni notch 0.0025 0.0113 0.021
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0383 0.2766 0.2761
Brugia malayi hypothetical protein 0.0124 0.0844 0.3798
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0119 0.0567
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0302 0.0582
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0153 0.0536
Brugia malayi nuclear hormone receptor 0.0024 0.0103 0.0442
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0951 0.1323
Schistosoma mansoni notch 0.0025 0.0113 0.021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.2025 1
Schistosoma mansoni hypothetical protein 0.0032 0.0163 0.0308
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0119 0.0464
Loa Loa (eye worm) hypothetical protein 0.0124 0.0844 0.3814
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0302 0.1366
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Schistosoma mansoni hypothetical protein 0.0032 0.0163 0.0308
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0103 0.0442
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.028 0.1243
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0976 0.716 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0302 0.1344
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0163 0.0712
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0302 0.0503
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Echinococcus multilocularis GPCR, family 2 0.0032 0.0163 0.0271
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0023 0.0597
Brugia malayi hypothetical protein 0.0027 0.0125 0.0539
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0643 0.085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Brugia malayi hypothetical protein 0.0024 0.0103 0.0442
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1068 0.1486
Brugia malayi ecdysteroid receptor 0.0051 0.0302 0.1344
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0025 0.0072
Echinococcus multilocularis heat shock protein 90 0.0033 0.0169 0.0282
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Loa Loa (eye worm) brahma associated protein 0.0011 0.0006 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0505 0.228
Brugia malayi nuclear receptor RXR 0.0027 0.0125 0.0539
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0025 0.0113 0.0484
Echinococcus multilocularis neurogenic locus notch protein 4 0.0025 0.0113 0.0187
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.2095 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.007 0.0292
Schistosoma mansoni cpg binding protein 0.0031 0.0152 0.0288
Schistosoma mansoni cpg binding protein 0.0029 0.014 0.0264
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0081
Brugia malayi MH2 domain containing protein 0.0241 0.1714 0.7738
Onchocerca volvulus Slit protein homolog 0.0025 0.0113 0.0484
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0297 0.1322
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Leishmania major heat shock protein, putative 0.0013 0.0025 0.0009
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0383 0.2766 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0169 0.0703
Brugia malayi notch-like transmembrane receptor 0.0025 0.0113 0.0484
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.007 0.0317
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0125 0.0539
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.007 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus granulosus smad 0.0016 0.0047 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Onchocerca volvulus Neurogenic locus notch homolog 0.0025 0.0113 0.0484
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0242 0.0475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0302 0.1366
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0095 0.0186
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0119 0.0096
Loa Loa (eye worm) hypothetical protein 0.0124 0.0844 0.3814
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0103 0.0191
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0104 0.0138
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0303 0.1349
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0011 0.0005 0.0002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0047 0.0093
Mycobacterium ulcerans DNA polymerase IV 0.002 0.007 0.0047
Echinococcus granulosus tumor protein p63 0.0344 0.2476 0.4854
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0302 0.1344
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0103 0.0466
Schistosoma mansoni hypothetical protein 0.0041 0.0231 0.0442
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0571 0.0791
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0103 0.0172
Brugia malayi Delta serrate ligand family protein 0.0025 0.0113 0.0484
Brugia malayi hypothetical protein 0.0309 0.2213 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0302 0.0593
Onchocerca volvulus 0.0025 0.0113 0.0484
Onchocerca volvulus 0.0025 0.0113 0.0484
Schistosoma mansoni hypothetical protein 0.0345 0.2483 0.4861
Trypanosoma brucei trypanothione reductase 0.0038 0.0208 0.0892
Echinococcus multilocularis protein patched 0.0043 0.0242 0.0403
Schistosoma mansoni septate junction protein 0.0025 0.0113 0.021
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0169 0.0813
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0951 0.1283
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0208 0.0284
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0302 0.0582
Echinococcus granulosus geminin 0.0345 0.2483 0.4867
Echinococcus granulosus peroxidasin 0.0078 0.0505 0.0989
Echinococcus multilocularis Smad4 0.0016 0.0047 0.0079
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0116 0.0111
Plasmodium vivax SET domain protein, putative 0.0031 0.0153 0.4967
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.007 0.0225
Echinococcus multilocularis protein jagged 1 0.0025 0.0113 0.0187
Echinococcus multilocularis expressed conserved protein 0.0094 0.0619 0.103
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.1714 0.7743
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0103 0.0202
Plasmodium vivax endoplasmin, putative 0.0033 0.0169 0.55
Giardia lamblia Grp94/Hsp90 0.0026 0.0119 0.0565
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0023 0.0091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0302 0.0582
Schistosoma mansoni peroxidasin 0.0078 0.0505 0.098
Brugia malayi Cadherin domain containing protein 0.0025 0.0113 0.0484
Giardia lamblia DINP protein human, muc B family 0.002 0.007 0.0321
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0981 0.1922
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0505 0.2261
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0103 0.0202
Echinococcus granulosus heat shock protein 90 0.0033 0.0169 0.0332
Schistosoma mansoni heat shock protein 0.0033 0.0169 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0505 0.2261
Onchocerca volvulus 0.0025 0.0113 0.0484
Echinococcus multilocularis fibropellin Ia 0.0025 0.0113 0.0187
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Loa Loa (eye worm) notch protein 0.0025 0.0113 0.0508
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.136 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus granulosus endoplasmin 0.0026 0.0119 0.0234
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0113 0.0484
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.028 0.1243
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0169 0.0703
Toxoplasma gondii EGF family domain-containing protein 0.0025 0.0113 0.0389
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0023 0.0091
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0047 0.0079
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0025 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0302 0.1344
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.2025 0.2007
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0125 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0302 0.1344
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0006 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0163 0.0272
Echinococcus granulosus dna polymerase kappa 0.002 0.007 0.0137
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0201 0.023
Loa Loa (eye worm) Notch2 0.0025 0.0113 0.0508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0103 0.0172
Brugia malayi Pre-SET motif family protein 0.0031 0.0153 0.0669
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0201 0.0274
Plasmodium falciparum thioredoxin reductase 0.0013 0.0023 0.0597
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Loa Loa (eye worm) endoplasmin 0.0033 0.0169 0.0764
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0113 0.0484
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0025 0.0101
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0302 0.0593
Trichomonas vaginalis MYB, putative 0.0011 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Brugia malayi EGF-like domain containing protein 0.0025 0.0113 0.0484
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0302 0.1366
Loa Loa (eye worm) hypothetical protein 0.0069 0.0438 0.198
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.007 0.0323
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0299 0.0575
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0981 0.1632
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0208 0.0892
Trypanosoma brucei unspecified product 0.002 0.007 0.0225
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0025 0.066
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.1714 0.7743
Echinococcus granulosus delta-like protein 1 0.0025 0.0113 0.0221
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0163 0.0674
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0081
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0169 0.0813
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0302 0.1366
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0103 0.0466
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Mycobacterium ulcerans thioesterase 0.0022 0.0089 0.0066
Onchocerca volvulus Putative cubilin 0.0025 0.0113 0.0484
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0571 0.0791
Echinococcus multilocularis geminin 0.0345 0.2483 0.4133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0103 0.0202
Onchocerca volvulus 0.0309 0.2213 1
Echinococcus granulosus dna polymerase eta 0.002 0.007 0.0137
Onchocerca volvulus Huntingtin homolog 0.0124 0.0844 0.3798
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0302 0.0582
Mycobacterium ulcerans DNA polymerase IV 0.002 0.007 0.0047
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0163 0.5298
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0119 0.054
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0113 0.0221
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0104 0.0138
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0119 0.0567
Echinococcus multilocularis peroxidasin 0.0078 0.0505 0.084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0302 0.1366
Echinococcus granulosus microtubule associated protein 2 0.0699 0.5101 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0163 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0242 0.1175
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0505 0.2261
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0023 0.0597
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0116 0.0155
Onchocerca volvulus Peroxidase homolog 0.0078 0.0505 0.2261
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0212 0.0416
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0302 0.1344
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0571 0.0791
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0153 0.03
Schistosoma mansoni notch 0.0025 0.0113 0.021
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0169 0.0703
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0116 0.0401
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Schistosoma mansoni hypothetical protein 0.0292 0.2086 0.4083
Brugia malayi isocitrate dehydrogenase 0.0032 0.0163 0.0713
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0163 0.0572
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.2095 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0103 0.0172
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.1486 0.6716
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0303 1
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0113 0.0187
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Plasmodium falciparum glutathione reductase 0.0038 0.0208 0.6816
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0163 0.0319
Brugia malayi EGF-like domain containing protein 0.0025 0.0113 0.0484
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0163 0.0272
Brugia malayi nuclear receptor NHR-88 0.0024 0.0103 0.0442
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.007 0.0127
Brugia malayi conserved hypotetical protein 0.0024 0.0103 0.0442
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0023 0.0597
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0676 0.3035
Schistosoma mansoni nuclear receptor 0.0024 0.0103 0.0191
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0302 0.0503
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.007 0.0225
Schistosoma mansoni notch 0.0025 0.0113 0.021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Schistosoma mansoni cpg binding protein 0.0031 0.0152 0.0288
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0104 0.0094
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0025 0.0113 0.0484
Echinococcus granulosus Smad4 0.0016 0.0047 0.0093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0078
Loa Loa (eye worm) hypothetical protein 0.0052 0.0314 0.1417
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0125 0.0207
Schistosoma mansoni hypothetical protein 0.0032 0.0163 0.0308
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0025 0.0089
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0163 0.0712
Brugia malayi MH2 domain containing protein 0.0016 0.0047 0.0188
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.2025 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0019 0.0068 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.007 0.0225
Schistosoma mansoni smad1 5 8 and 0.0016 0.0047 0.0082
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0169 0.0703
Loa Loa (eye worm) hypothetical protein 0.005 0.0299 0.135
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0303 1
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Echinococcus granulosus slit 2 protein 0.0025 0.0113 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0153 0.029
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.007 0.0292
Echinococcus granulosus neural cadherin 0.0025 0.0113 0.0221
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0006 0.0001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0125 0.0233
Schistosoma mansoni hypothetical protein 0.0041 0.0231 0.0442
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus multilocularis endoplasmin 0.0026 0.0119 0.0199
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0169 0.0764
Echinococcus multilocularis slit 2 protein 0.0025 0.0113 0.0187
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0109 0.0493
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0163 0.0221
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0119 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0025 0.0009
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0113 0.0484
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0103 0.0191
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Brugia malayi Pax transcription factor protein 2 0.0245 0.1742 0.7867
Schistosoma mansoni Smad4 0.0016 0.0047 0.0082
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0302 0.0593
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0006 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.014 0.0275
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0006 0.0009
Schistosoma mansoni DNA polymerase eta 0.002 0.007 0.0127
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0006 0.0025
Plasmodium vivax heat shock protein, putative 0.0013 0.0025 0.066
Schistosoma mansoni cell polarity protein 0.0025 0.0113 0.021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0302 0.0593
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0103 0.0442
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0119 0.0116
Schistosoma mansoni heat shock protein 0.0013 0.0025 0.0038
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0103 0.0442
Brugia malayi heat shock protein 90 0.0033 0.0169 0.0741
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0104 0.0445
Leishmania major DNA polymerase kappa, putative 0.002 0.007 0.0225
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.007 0.0225
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.021
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.021
Onchocerca volvulus 0.0024 0.0103 0.0442
Onchocerca volvulus Peroxidase homolog 0.0078 0.0505 0.2261
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Loa Loa (eye worm) DR-78 0.0024 0.0103 0.0466
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0104 0.0081
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.007 0.0225
Loa Loa (eye worm) Smad1 0.0016 0.0047 0.0213
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0693
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0037 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0302 0.0593
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0201 0.0178
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0302 0.0503
Brugia malayi EGF-like domain containing protein 0.0025 0.0113 0.0484
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0125 0.0539
Schistosoma mansoni slit 0.0025 0.0113 0.021
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.007 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0317
Brugia malayi hypothetical protein 0.0027 0.0125 0.0539
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0383 0.2766 0.383
Echinococcus multilocularis X box binding protein 1 0.0292 0.2086 0.3473
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0153 0.0255
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0025 0.0101
Loa Loa (eye worm) hypothetical protein 0.0051 0.0303 0.1369
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0505 0.228
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0023 0.008
Brugia malayi Cadherin domain containing protein 0.0025 0.0113 0.0484
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0047 0.0079
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0103 0.0191
Brugia malayi MH2 domain containing protein 0.0016 0.0047 0.0188
Echinococcus multilocularis protein dispatched 1 0.0049 0.0287 0.0478
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0103 0.0191
Brugia malayi MH1 domain containing protein 0.0016 0.0047 0.0188
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.007 0.0323
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0103 0.0172
Trichomonas vaginalis set domain proteins, putative 0.024 0.1701 0.8397
Loa Loa (eye worm) pax transcription factor protein 2 0.0245 0.1742 0.7872
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0163 0.0272
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0119 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0302 0.1366
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0302 0.0593
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0119 0.0567
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0125 0.0244
Echinococcus granulosus X box binding protein 1 0.0292 0.2086 0.409
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0563
Leishmania major DNA polymerase eta, putative 0.002 0.007 0.0225
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0242 0.1094
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0103 0.0191
Echinococcus granulosus fibropellin Ia 0.0025 0.0113 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0563
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0952 0.4483
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0065 0.0218
Echinococcus multilocularis dna polymerase eta 0.002 0.007 0.0117
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0664 0.1105
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0103 0.0202
Brugia malayi CHE-14 protein 0.0043 0.0242 0.1072
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0505 0.2261
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Brugia malayi hypothetical protein 0.0024 0.0103 0.0442
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.007 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0302 0.1344
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.007 0.0225
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0169 0.0703
Echinococcus multilocularis neural cadherin 0.0025 0.0113 0.0187
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0047 0.0213
Schistosoma mansoni hypothetical protein 0.0041 0.0231 0.0442
Onchocerca volvulus 0.0025 0.0113 0.0484
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0095 0.0158
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0113 0.0221
Brugia malayi glutathione reductase 0.0038 0.0208 0.0918
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Echinococcus multilocularis protein jagged 2 0.0025 0.0113 0.0187
Echinococcus granulosus heat shock protein 0.0033 0.0169 0.0332
Brugia malayi Blistered cuticle protein 3 0.0078 0.0505 0.2261
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0109 0.0146
Leishmania major trypanothione reductase 0.0038 0.0208 0.0892
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.5101 1
Trichomonas vaginalis endoplasmin, putative 0.002 0.0075 0.0346
Brugia malayi nuclear receptor NHR-67 0.0024 0.0103 0.0442
Onchocerca volvulus 0.0245 0.1742 0.7867
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Echinococcus multilocularis dna polymerase kappa 0.002 0.007 0.0117
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0303 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0571 0.0791
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.021
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0119 0.0096
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0302 0.0593
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0025 0.066
Trichomonas vaginalis heat shock protein, putative 0.002 0.0075 0.0346
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0643 0.0891
Brugia malayi nuclear hormone receptor 0.0051 0.0302 0.1344
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.023 0.1
Schistosoma mansoni nuclear receptor 0.0024 0.0103 0.0191
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0505 0.228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0125 0.0233
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0016 0.0071
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.136 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0163 0.0674
Schistosoma mansoni heat shock protein 0.0033 0.0169 0.0321
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0006 0.0009
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0025 0.0113 0.021
Giardia lamblia High cysteine protein 0.0025 0.0113 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0302 0.1344
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0302 0.0582
Brugia malayi tailless protein 0.0024 0.0103 0.0442
Loa Loa (eye worm) hypothetical protein 0.01 0.0664 0.2999
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0025 0.0072
Echinococcus granulosus cpg binding protein 0.0031 0.0152 0.0299
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Loa Loa (eye worm) hypothetical protein 0.0032 0.0163 0.0735
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0643 0.0891
Brugia malayi MH1 domain containing protein 0.0016 0.0047 0.0188
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Treponema pallidum heat shock protein 90 0.0026 0.0119 0.0096
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0025 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0302 0.1344
Brugia malayi ecdysone receptor 0.0024 0.0103 0.0442
Schistosoma mansoni notch 0.0025 0.0113 0.021
Onchocerca volvulus 0.0078 0.0505 0.2261
Echinococcus granulosus notch 0.0025 0.0113 0.0221
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0302 0.0582
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0302 0.0503
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0163 0.0272
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0302 0.1344
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.023 0.1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0053 0.0173
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0563
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0821 0.6007 1
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0113 0.021
Echinococcus granulosus neurogenic locus protein delta 0.0025 0.0113 0.0221
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0047 0.0082
Brugia malayi Thioredoxin reductase 0.0038 0.0208 0.0918
Onchocerca volvulus 0.0078 0.0505 0.2261
Brugia malayi hypothetical protein 0.0078 0.0505 0.2261
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0163 0.0272
Onchocerca volvulus 0.0024 0.0103 0.0442
Mycobacterium ulcerans hypothetical protein 0.0154 0.1068 0.1047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0302 0.0503
Plasmodium falciparum thioredoxin reductase 0.0038 0.0208 0.6816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0302 0.1366
Echinococcus multilocularis notch 0.0025 0.0113 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2095 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0302 0.0582
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.007 0.0323
Toxoplasma gondii hypothetical protein 0.0047 0.0275 0.0978
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0952 0.4483
Onchocerca volvulus 0.0025 0.0113 0.0484
Brugia malayi hypothetical protein 0.0051 0.0303 0.1347
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0242 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0302 0.1344
Schistosoma mansoni notch 0.0025 0.0113 0.021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0023 0.009
Echinococcus granulosus GPCR family 2 0.0032 0.0163 0.0319
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.023 0.1
Plasmodium vivax glutathione reductase, putative 0.0038 0.0208 0.6816
Mycobacterium tuberculosis Probable reductase 0.0087 0.0571 0.0791
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0169 0.0703
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.007 0.0225
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.034 0.1214
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0116 0.0155
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0081
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0065 0.0042
Onchocerca volvulus Huntingtin homolog 0.0124 0.0844 0.3798
Echinococcus multilocularis heat shock protein 90 0.0026 0.0119 0.0199
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0201 0.0274
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0069 0.0221
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0302 0.0582
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0116 0.0093
Brugia malayi Peroxidasin 0.0078 0.0505 0.2261
Schistosoma mansoni hypothetical protein 0.0069 0.0438 0.0849
Schistosoma mansoni zinc finger protein 0.0024 0.0103 0.0191
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.021
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0089 0.0118
Brugia malayi EGF-like domain containing protein 0.0025 0.0113 0.0484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Trypanosoma brucei unspecified product 0.0013 0.0025 0.0009
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0116 0.0111
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0163 0.0572
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0952 0.4483
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0303 0.1349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0163 0.0319
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0023 0.0066
Echinococcus multilocularis neurogenic locus protein delta 0.0025 0.0113 0.0187
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0119 0.016
Echinococcus granulosus protein jagged 1 0.0025 0.0113 0.0221
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0113 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0103 0.0172
Loa Loa (eye worm) glutathione reductase 0.0038 0.0208 0.0941
Echinococcus granulosus heat shock protein 90 0.0026 0.0119 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.007 0.0225
Schistosoma mansoni hypothetical protein 0.0345 0.2483 0.4861
Trypanosoma brucei unspecified product 0.0013 0.0025 0.0009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0153 0.0255
Echinococcus granulosus expressed conserved protein 0.0094 0.0619 0.1213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.136 1 1
Plasmodium falciparum endoplasmin, putative 0.002 0.0075 0.233
Brugia malayi nuclear receptor RXR 0.0024 0.0103 0.0442
Brugia malayi EGF-like domain containing protein 0.0025 0.0113 0.0484
Loa Loa (eye worm) hypothetical protein 0.0101 0.0676 0.3052
Echinococcus granulosus protein jagged 2 0.0025 0.0113 0.0221
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2095 1
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0302 0.0503
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Echinococcus granulosus protein jagged 1 0.0025 0.0113 0.0221
Schistosoma mansoni patched 1 0.0043 0.0242 0.0464
Loa Loa (eye worm) hypothetical protein 0.0078 0.0505 0.228
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0116 0.0093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.007 0.0137
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0103 0.0442
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0169 0.0811
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0037 0.0045
Echinococcus multilocularis cpg binding protein 0.0031 0.0152 0.0254
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0302 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0951 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Schistosoma mansoni peroxidasin 0.0078 0.0505 0.098
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0302 0.1344
Schistosoma mansoni hypothetical protein 0.0041 0.0231 0.0442
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0025 0.066
Brugia malayi EGF-like domain containing protein 0.0025 0.0113 0.0484
Schistosoma mansoni endoplasmin 0.0033 0.0169 0.0321
Onchocerca volvulus 0.0078 0.0505 0.2261
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.007 0.0127
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0302 0.1344
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0023 0.0597
Onchocerca volvulus 0.0025 0.0109 0.0469
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0119 0.0464
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0675 0.1314
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0006 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0003
Loa Loa (eye worm) blistered cuticle protein 3 0.0078 0.0505 0.228
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0976 0.716 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Onchocerca volvulus 0.0029 0.014 0.0609
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0208 0.6816
Brugia malayi hypothetical protein 0.0033 0.0169 0.074
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0103 0.0442
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0065 0.004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0163 0.0309
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0208 0.0941
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0302 0.0582
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0025 0.0049
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0383 0.2766 0.2749
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0505 0.228
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0163 0.032
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0466
Onchocerca volvulus Chorion peroxidase homolog 0.0078 0.0505 0.2261
Echinococcus multilocularis tumor protein p63 0.0344 0.2476 0.4122
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0037 0.0014
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Brugia malayi nuclear receptor NHR-88 0.0051 0.0302 0.1344
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0047 0.0213
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0302 0.1344
Echinococcus multilocularis protein jagged 1 0.0025 0.0113 0.0187
Leishmania major heat shock protein 83-1 0.0033 0.0169 0.0703
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0103 0.0202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0153 0.029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0676 0.3052
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.007 0.0091
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0104 0.0138
Mycobacterium ulcerans polyketide synthase 0.0024 0.0104 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0302 0.0582
Trypanosoma brucei heat shock protein, putative 0.0033 0.0169 0.0703
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0169 0.0703
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0047 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2025 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0163 0.0674
Plasmodium falciparum heat shock protein 90 0.0033 0.0169 0.55
Mycobacterium ulcerans polyketide synthase 0.0026 0.0116 0.0093
Plasmodium falciparum glutathione reductase 0.0013 0.0023 0.0597
Schistosoma mansoni hypothetical protein 0.0023 0.0095 0.0175
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0169 0.0813
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0563
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0116 0.0155
Brugia malayi GCC2 and GCC3 family protein 0.0025 0.0113 0.0484
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0103 0.0202
Echinococcus multilocularis smad 0.0016 0.0047 0.0079
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0065 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0109 0.0469
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0023 0.0066
Schistosoma mansoni hypothetical protein 0.0025 0.0113 0.021
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0303 0.1078
Echinococcus granulosus neurogenic locus notch protein 4 0.0025 0.0113 0.0221
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0169 0.0594
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0089 0.0066
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0676 0.3035
Onchocerca volvulus 0.0031 0.0153 0.0669
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0169 0.0594
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0302 0.0593
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0169 0.55
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0505 0.2261
Brugia malayi Endoplasmin precursor 0.0033 0.0169 0.0741
Brugia malayi Pre-SET motif family protein 0.0211 0.1486 0.6708
Loa Loa (eye worm) hypothetical protein 0.0309 0.2213 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0571 0.0749
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0103 0.0466
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.2025 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0571 0.0791
Onchocerca volvulus 0.0046 0.0268 0.1188
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0103 0.0172
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0302 0.0503
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0508
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0023 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.007 0.0225
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0163 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0302 0.1344
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.007 0.0225
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0163 0.0713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0302 0.1366
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.1074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0302 0.1344
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.1366
Toxoplasma gondii thioredoxin reductase 0.0038 0.0208 0.0735
Schistosoma mansoni smad1 5 8 and 0.0016 0.0047 0.0082

Activities

Activity type Activity value Assay description Source Reference
K inact/Ki (binding) = 5430 M-1 s-1 Second order rate constant for the inhibition of human skin chymase. ChEMBL. 10465545
K inact/Ki (binding) = 5430 M-1 s-1 Second order rate constant for the inhibition of human skin chymase. ChEMBL. 10465545
K inact/Ki (binding) = 17130 M-1 s-1 Second order rate constant for the inhibition of leukocyte Cathepsin G (Cat G). ChEMBL. 10465545
K inact/Ki (binding) = 17130 M-1 s-1 Second order rate constant for the inhibition of leukocyte Cathepsin G (Cat G). ChEMBL. 10465545

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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