Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0044 | 0.0332 | 0.5 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0044 | 0.0332 | 0.0368 |
Schistosoma mansoni | gliotactin | 0.0044 | 0.0332 | 0.0368 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2179 | 0.2416 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0044 | 0.0332 | 0.0368 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0288 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0263 | 0.9019 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.2179 | 0.2416 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.3325 | 0.3445 |
Brugia malayi | Carboxylesterase family protein | 0.0263 | 0.9019 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0044 | 0.0332 | 0.0368 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.2179 | 0.2416 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.9019 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2179 | 0.2416 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0288 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0263 | 0.9019 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0044 | 0.0332 | 0.0368 |
Echinococcus multilocularis | acetylcholinesterase | 0.0263 | 0.9019 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0263 | 0.9019 | 1 |
Onchocerca volvulus | 0.0044 | 0.0332 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0044 | 0.0332 | 0.0368 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0332 | 0.0368 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.2179 | 0.2126 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.3325 | 0.3445 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0263 | 0.9019 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0263 | 0.9019 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0141 | 0.4152 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0263 | 0.9019 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0044 | 0.0332 | 0.0368 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0044 | 0.0332 | 0.0368 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0332 | 0.0368 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2179 | 0.2416 |
Echinococcus granulosus | neuroligin | 0.0044 | 0.0332 | 0.0368 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0332 | 0.0368 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0332 | 0.0368 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Onchocerca volvulus | 0.0044 | 0.0332 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0263 | 0.9019 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2179 | 0.2416 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.9019 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.2179 | 0.2416 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0332 | 0.0368 |
Brugia malayi | Carboxylesterase family protein | 0.0044 | 0.0332 | 0.0368 |
Schistosoma mansoni | acetylcholinesterase | 0.0044 | 0.0332 | 0.0368 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0141 | 0.4152 | 1 |
Onchocerca volvulus | 0.0044 | 0.0332 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0263 | 0.9019 | 1 |
Onchocerca volvulus | 0.0044 | 0.0332 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0044 | 0.0332 | 0.0368 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0141 | 0.4152 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0332 | 0.0368 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.3325 | 0.3686 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.2179 | 0.2416 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0044 | 0.0332 | 0.0368 |
Echinococcus multilocularis | acetylcholinesterase | 0.0263 | 0.9019 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0044 | 0.0332 | 0.0368 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.353 uM | Antimalarial activity Plasmodium falciparum 3D7 | ChEMBL. | 20610151 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20610151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.