Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma brucei | unspecified product | 0.0019 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 1 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 21 ug ml-1 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | ChEMBL. | 20304535 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.