Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.1214 | 0.151 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.5099 | 0.6345 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.8037 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.5099 | 0.6727 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.5099 | 0.6727 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.5099 | 0.6345 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.5099 | 0.6345 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.7437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4581 | 0.4769 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0717 | 0.0592 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.5099 | 0.6727 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3864 | 0.3972 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0294 | 0.0366 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.5099 | 0.6727 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0397 | 0.0114 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.7437 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.5099 | 0.4159 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0717 | 0.0592 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.3853 | 0.2673 |
Leishmania major | hypothetical protein, conserved | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.1214 | 0.1287 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.3456 | 0.4427 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.3456 | 0.4427 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0294 | 0.0366 |
Trypanosoma brucei | ISWI complex protein | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0717 | 0.0891 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.1214 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.9283 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4261 | 0.4413 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.5099 | 0.5346 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0894 | 0.0667 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0294 | 0.0366 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0294 | 0.0366 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0894 | 0.1112 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 41.72 uM | Antimalarial activity against Plasmodium falciparum infected in human O+ erythrocytes after 48 hrs by HRP2-ELISA method | ChEMBL. | 20621497 |
IZ (functional) | = 10 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 50 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 15 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 100 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 18 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 200 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 22 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 300 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 32 mm | Antibacterial activity against Escherichia coli ATCC 8739 at 500 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 10 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.