Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2546 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.2546 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0824 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0824 | 0.0824 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.103 | 0.103 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0148 | 0.0148 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.2888 | 0.2888 |
Echinococcus multilocularis | lamin | 0.0027 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0824 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0445 | 0.0445 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0453 | 0.0453 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.2236 | 0.266 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2546 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0453 | 0.0538 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.103 | 0.1225 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2888 | 0.2888 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0445 | 0.0445 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0011 | 0.0029 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.2546 | 0.2546 |
Schistosoma mansoni | DNA ligase IV | 0.0011 | 0.0029 | 0.0034 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2546 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.2345 | 0.2345 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0117 | 0.0117 |
Onchocerca volvulus | 0.0011 | 0.0029 | 0.0281 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0453 | 0.0453 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.2236 | 0.266 |
Brugia malayi | topoisomerase | 0.0011 | 0.0029 | 0.0029 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0111 | 0.6361 | 0.6361 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0824 | 0.0824 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0445 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.2888 | 0.2888 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.2236 | 0.266 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.2345 | 0.2345 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.2546 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.2546 | 1 |
Brugia malayi | DKFZp564C0469 protein | 0.0011 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.2345 | 0.2345 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0824 | 0.1255 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0824 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0453 | 0.0538 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0824 | 1 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0011 | 0.0029 | 0.0029 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0453 | 0.0453 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2546 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.2345 | 0.9201 |
Schistosoma mansoni | thyroid hormone receptor | 0.0144 | 0.8404 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0445 | 0.139 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0238 | 0.0238 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.2546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0453 | 0.0453 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0445 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0824 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0824 | 0.1255 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0824 | 1 |
Onchocerca volvulus | 0.0024 | 0.0824 | 0.8 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0824 | 0.1255 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0453 | 0.0453 |
Echinococcus multilocularis | nibrin | 0.0011 | 0.0029 | 0.0029 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.2546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0148 | 0.0148 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0011 | 0.0029 | 0.0034 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.2546 | 0.2546 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0238 | 0.0238 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0824 | 0.0824 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0169 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.103 | 1 | |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0111 | 0.6361 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.103 | 0.1225 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.6361 | 0.6361 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0824 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.2236 | 0.266 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2546 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0144 | 0.8404 | 0.8404 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.2546 | 0.3029 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0824 | 1 |
Echinococcus granulosus | nibrin | 0.0011 | 0.0029 | 0.0029 |
Echinococcus granulosus | muscleblind protein | 0.0169 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0133 | 0.7729 | 0.7729 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0445 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0453 | 0.0453 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0113 | 0.647 | 0.7699 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.103 | 0.103 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0453 | 0.0453 |
Schistosoma mansoni | topbp1 | 0.0011 | 0.0029 | 0.0034 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0111 | 0.6361 | 0.6361 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.2345 | 0.2345 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.2546 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2345 | 0.2345 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.2345 | 0.2345 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0445 | 0.0445 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.2546 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.2345 | 0.2345 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0011 | 0.0029 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.7729 | 0.9197 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0117 | 0.0117 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0824 | 0.0824 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0011 | 0.0029 | 0.0029 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.2546 | 0.2546 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.2771 | 0.2771 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.2546 | 0.2546 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0011 | 0.0029 | 0.0029 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1761 | 0.1761 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.2546 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.103 | 0.103 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.103 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0824 | 0.0824 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.2546 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0111 | 0.6361 | 0.6361 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.2345 | 0.279 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0453 | 0.0453 |
Echinococcus multilocularis | musashi | 0.0027 | 0.103 | 0.103 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0133 | 0.7729 | 0.7729 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1761 | 0.1761 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0824 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.103 | 0.103 |
Echinococcus granulosus | lamin | 0.0027 | 0.103 | 0.103 |
Schistosoma mansoni | lamin | 0.0027 | 0.103 | 0.1225 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0824 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0159 | 0.938 | 0.938 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0159 | 0.938 | 0.938 |
Echinococcus multilocularis | muscleblind protein | 0.0169 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0144 | 0.8404 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0105 | 0.5934 | 0.5934 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0453 | 0.0538 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0445 | 0.0445 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.103 | 0.103 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.0445 | 0.5234 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0453 | 0.0538 |
Treponema pallidum | DNA ligase (lig) | 0.0011 | 0.0029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0998 | 0.0998 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.2888 | 0.2888 |
Onchocerca volvulus | 0.0027 | 0.103 | 1 | |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0453 | 0.0453 |
Echinococcus multilocularis | expressed conserved protein | 0.0105 | 0.5934 | 0.5934 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.2546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0445 | 0.0445 |
Schistosoma mansoni | topbp1 | 0.0011 | 0.0029 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0029 | 0.0029 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0453 | 0.0453 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1761 | 0.2095 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3024 | 0.3024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.