Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0038 | 0.1653 | 1 |
Onchocerca volvulus | 0.0016 | 0.0027 | 0.5 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0027 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5337 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.5337 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.0027 | 0.0075 |
Onchocerca volvulus | 0.0016 | 0.0027 | 0.5 | |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.6806 | 0.8837 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0016 | 0.0027 | 0.0116 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.7701 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.3527 | 0.9942 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0038 | 0.1653 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.6806 | 0.8837 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.0027 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.2299 | 0.648 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0057 | 0.3115 | 0.8781 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.2299 | 0.648 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.2299 | 0.4279 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.0027 | 0.0075 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0027 | 0.0075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.2511 | 0.7079 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Echinococcus granulosus | cathepsin l1 | 0.0016 | 0.0027 | 0.0075 |
Schistosoma mansoni | eyes absent homolog | 0.0086 | 0.5337 | 0.5337 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.2299 | 0.648 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0062 | 0.3548 | 0.6647 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.2299 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.3527 | 0.9942 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0038 | 0.1653 | 0.2146 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Echinococcus granulosus | dna polymerase kappa | 0.0038 | 0.1653 | 0.4658 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.2299 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0038 | 0.1653 | 0.3062 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0062 | 0.3548 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.1653 | 0.4658 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1458 | 0.4109 |
Leishmania major | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma brucei | unspecified product | 0.0038 | 0.1653 | 0.4658 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5337 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0038 | 0.1653 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0016 | 0.0027 | 0.0075 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0036 | 0.1567 | 0.6818 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0761 | 0.2146 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0038 | 0.1653 | 0.1653 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Onchocerca volvulus | 0.0016 | 0.0027 | 0.5 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0016 | 0.0027 | 0.0116 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.3527 | 0.9942 |
Trypanosoma brucei | unspecified product | 0.0026 | 0.0761 | 0.2146 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.7701 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.6806 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.6806 | 0.8837 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Echinococcus multilocularis | dna polymerase eta | 0.0062 | 0.3548 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0027 | 0.005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0761 | 0.2146 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0027 | 0.0075 |
Echinococcus granulosus | dna polymerase eta | 0.0062 | 0.3548 | 1 |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.0027 | 0.0116 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0027 | 0.0075 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0038 | 0.1653 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.0027 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0062 | 0.3548 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Onchocerca volvulus | 0.0016 | 0.0027 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Schistosoma mansoni | DNA polymerase eta | 0.0062 | 0.3548 | 0.3548 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0027 | 0.005 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1458 | 0.8801 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.2299 | 0.2985 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1458 | 0.2731 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.2299 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0038 | 0.1653 | 0.4658 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma brucei | unspecified product | 0.0026 | 0.0761 | 0.2146 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1458 | 0.8801 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.7701 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.2299 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0038 | 0.1653 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.0027 | 0.0075 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1458 | 0.1458 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.2299 | 1 |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.0027 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3548 | 0.6631 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0027 | 0.005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.0027 | 0.0075 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.3527 | 0.9942 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.2299 | 0.648 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.3527 | 0.9942 |
Onchocerca volvulus | 0.0016 | 0.0027 | 0.5 | |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0036 | 0.1567 | 0.4418 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.3527 | 0.9942 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0027 | 0.0027 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.0027 | 0.0075 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0027 | 0.005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0038 | 0.1653 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0016 | 0.0027 | 0.005 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0027 | 0.005 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0016 | 0.0027 | 0.0075 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0026 | 0.0761 | 0.2146 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.0016 | 0.0027 | 0.0116 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0038 | 0.1653 | 0.2146 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.1653 | 0.4658 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1458 | 0.8801 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.2299 | 0.4307 |
Leishmania major | trypanothione reductase | 0.0046 | 0.2299 | 0.648 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.0027 | 0.005 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0016 | 0.0027 | 0.0075 |
Leishmania major | cathepsin L-like protease | 0.0016 | 0.0027 | 0.0075 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.0027 | 0.0075 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Onchocerca volvulus | Cathepsin F homolog | 0.0016 | 0.0027 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.6806 | 0.8837 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.2299 | 0.4279 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1458 | 0.1458 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0016 | 0.0027 | 0.0075 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.0027 | 0.0027 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1458 | 0.8801 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1458 | 0.4109 |
Onchocerca volvulus | 0.0016 | 0.0027 | 0.5 | |
Leishmania major | DNA polymerase eta, putative | 0.0036 | 0.1567 | 0.4418 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Echinococcus multilocularis | dna polymerase kappa | 0.0038 | 0.1653 | 0.4658 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0038 | 0.1653 | 0.3096 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0062 | 0.3548 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0038 | 0.1653 | 0.1653 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0062 | 0.3527 | 0.9942 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0038 | 0.1653 | 0.4658 |
Onchocerca volvulus | 0.0016 | 0.0027 | 0.5 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.7701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.0027 | 0.0161 |
Brugia malayi | glutathione reductase | 0.0046 | 0.2299 | 0.4307 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.3527 | 0.9942 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0016 | 0.0027 | 0.0116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.