Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1279 | 0.4052 | 0.4052 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1279 | 0.4052 | 0.4052 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3107 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | patched 1 | 0.1279 | 0.4052 | 0.4052 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3107 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1457 | 0.4633 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1457 | 0.4633 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1279 | 0.4052 | 0.4052 |
Echinococcus multilocularis | protein dispatched 1 | 0.1279 | 0.4052 | 0.4052 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.1279 | 0.4052 | 0.4052 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1279 | 0.4052 | 0.4052 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3107 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1457 | 0.4633 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0034 | 0 | 0.5 |
Brugia malayi | CHE-14 protein | 0.1279 | 0.4052 | 0.4052 |
Echinococcus multilocularis | protein patched | 0.1279 | 0.4052 | 0.4052 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1279 | 0.4052 | 0.4052 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3107 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1457 | 0.4633 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1279 | 0.4052 | 0.4052 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3107 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1279 | 0.4052 | 0.4052 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3107 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3107 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3107 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3107 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.32 uM | Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 | ChEMBL. | 8667363 |
IC50 (binding) | = 0.32 uM | Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 | ChEMBL. | 8667363 |
Inhibition (functional) | = 69.2 % | In vivo inhibitory percentage of pressor response induced by exogenous submaxilmal dose of angiotensin-II (3 ug/kg) administered iv to pithed rats | ChEMBL. | 8667363 |
Inhibition (functional) | = 69.2 % | In vivo inhibitory percentage of pressor response induced by exogenous submaxilmal dose of angiotensin-II (3 ug/kg) administered iv to pithed rats | ChEMBL. | 8667363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.