Detailed information for compound 1140960

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.39 | Formula: C22H18N2O3
  • H donors: 1 H acceptors: 2 LogP: 4.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(N)c1c(n2)ccc(c1)COC(=O)c1ccccc1
  • InChi: 1S/C22H18N2O3/c1-26-16-8-10-20-18(12-16)21(23)17-11-14(7-9-19(17)24-20)13-27-22(25)15-5-3-2-4-6-15/h2-12H,13H2,1H3,(H2,23,24)
  • InChiKey: RPKMXDFRSYJPDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0028 0.0028
Echinococcus multilocularis RUN 0.0064 0.0283 0.0283
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0011 0.0137
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0159 0.0458
Schistosoma mansoni hypothetical protein 0.0037 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0084
Echinococcus multilocularis PHD finger protein rhinoceros 0.0114 0.0793 0.0793
Echinococcus multilocularis lysine specific demethylase 5A 0.0138 0.104 0.104
Onchocerca volvulus 0.0064 0.0283 0.097
Schistosoma mansoni hypothetical protein 0.0066 0.0295 0.0864
Echinococcus multilocularis peregrin 0.0124 0.0891 0.0891
Loa Loa (eye worm) hypothetical protein 0.0179 0.1463 0.4368
Mycobacterium ulcerans beta-lactamase 0.004 0.0028 0.000000000000018399
Loa Loa (eye worm) MH2 domain-containing protein 0.0363 0.3348 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0327 0.0327
Plasmodium falciparum LCCL domain-containing protein 0.0064 0.0283 0.3568
Schistosoma mansoni jumonji domain containing protein 0.0297 0.267 0.781
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.2216 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0283 0.0845
Brugia malayi hypoxia-induced factor 1 0.0166 0.132 0.3817
Toxoplasma gondii ABC1 family protein 0.004 0.0028 0.0353
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0091 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0172 0.1386 0.4139
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0793 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0033 0.129
Brugia malayi TAR-binding protein 0.0191 0.1587 0.4588
Leishmania major hypothetical protein, conserved 0.0062 0.0255 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0084 0.025
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0028 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0028 0.0082
Schistosoma mansoni hypothetical protein 0.0039 0.0022 0.0065
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0374 0.3458 0.3458
Loa Loa (eye worm) hypothetical protein 0.0256 0.2253 0.6728
Toxoplasma gondii PHD-finger domain-containing protein 0.0114 0.0793 1
Mycobacterium leprae conserved hypothetical protein 0.004 0.0028 0.5
Loa Loa (eye worm) beta-lactamase 0.004 0.0028 0.0084
Mycobacterium leprae Probable lipase LipE 0.004 0.0028 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0028 0.0082
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0033 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0138 0.0138
Schistosoma mansoni inositol monophosphatase 0.004 0.0033 0.0096
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0011 0.0137
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0028 0.0081
Loa Loa (eye worm) hypothetical protein 0.0049 0.0124 0.0369
Schistosoma mansoni inositol monophosphatase 0.004 0.0033 0.0096
Loa Loa (eye worm) hypothetical protein 0.0114 0.0793 0.2369
Brugia malayi follicle stimulating hormone receptor 0.0256 0.2252 0.6512
Echinococcus multilocularis transcription factor btf3 0.0038 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0064 0.0283 0.0845
Echinococcus granulosus GPCR family 2 0.0066 0.0295 0.0295
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0187 0.7329
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.5142
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.175 0.5061
Loa Loa (eye worm) hypothetical protein 0.0142 0.1077 0.3216
Echinococcus granulosus neuropeptide receptor A26 0.1012 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0327 0.0957
Schistosoma mansoni zinc finger protein 0.0062 0.0255 0.0745
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.0283 0.0283
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0241 0.2091 0.2091
Brugia malayi beta-lactamase family protein 0.004 0.0028 0.0081
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0011 0.0033
Mycobacterium ulcerans hypothetical protein 0.004 0.0028 0.000000000000018399
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0033 0.0414
Brugia malayi MH2 domain containing protein 0.0363 0.3348 0.9682
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0069 0.0327 0.0977
Brugia malayi PAS domain containing protein 0.0053 0.0171 0.0493
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0033 0.129
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.5142
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0028 0.7796
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0028 0.7796
Loa Loa (eye worm) hypothetical protein 0.0155 0.1209 0.361
Loa Loa (eye worm) PHD-finger family protein 0.0083 0.0475 0.1419
Schistosoma mansoni tar DNA-binding protein 0.0191 0.1587 0.4641
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0187 0.2353
Schistosoma mansoni polycystin 1-related 0.0064 0.0283 0.0828
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0028 0.11
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0138 0.0399
Schistosoma mansoni jumonji/arid domain-containing protein 0.0146 0.1119 0.3273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0138 0.0403
Leishmania major basic transcription factor 3a, putative 0.0038 0.0011 0.0428
Schistosoma mansoni hypothetical protein 0.0142 0.1077 0.315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0327 0.0957
Plasmodium vivax multidomain scavenger receptor, putative 0.0064 0.0283 0.3568
Brugia malayi PHD-finger family protein 0.01 0.0652 0.1886
Loa Loa (eye worm) doublecortin family protein 0.0064 0.0283 0.0845
Brugia malayi Bromodomain containing protein 0.0302 0.2724 0.7876
Echinococcus multilocularis tumor protein p63 0.0334 0.305 0.305
Schistosoma mansoni hypothetical protein 0.037 0.3418 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0037 0.0005 0.0187
Schistosoma mansoni jumonji/arid domain-containing protein 0.0146 0.1119 0.3273
Brugia malayi RNA recognition motif domain containing protein 0.0191 0.1587 0.4588
Brugia malayi hypothetical protein 0.0064 0.0283 0.0818
Echinococcus granulosus jumonji domain containing protein 0.0159 0.1252 0.1252
Toxoplasma gondii PHD-finger domain-containing protein 0.0037 0.0005 0.006
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0187 0.2353
Loa Loa (eye worm) hypothetical protein 0.0285 0.2547 0.7606
Schistosoma mansoni lipoxygenase 0.0317 0.2879 0.8421
Schistosoma mansoni transcription factor btf3 0.0038 0.0011 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0295 0.0854
Schistosoma mansoni survival motor neuron protein 0.0052 0.0159 0.0464
Schistosoma mansoni tar DNA-binding protein 0.0191 0.1587 0.4641
Echinococcus granulosus tumor protein p63 0.0334 0.305 0.305
Loa Loa (eye worm) TAR-binding protein 0.0191 0.1587 0.4738
Schistosoma mansoni lipoxygenase 0.0201 0.1689 0.494
Brugia malayi AF-10 protein 0.0037 0.0005 0.0014
Brugia malayi F/Y-rich N-terminus family protein 0.0045 0.0084 0.0242
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0011 0.0428
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0022 0.0065
Loa Loa (eye worm) hypothetical protein 0.0164 0.1307 0.3903
Echinococcus granulosus lysine specific demethylase 5A 0.0146 0.1119 0.1119
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0091 0.0554 0.1622
Onchocerca volvulus 0.004 0.0028 3.3843e-17
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0028 0.000000000000018399
Brugia malayi Bromodomain containing protein 0.0154 0.1206 0.3487
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.5142
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0187 0.2353
Onchocerca volvulus 0.004 0.0028 3.3843e-17
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.2252 0.6725
Schistosoma mansoni hypothetical protein 0.0114 0.0793 0.2321
Brugia malayi hypothetical protein 0.0039 0.0022 0.0064
Schistosoma mansoni methyl-cpg binding protein mbd 0.0069 0.0327 0.0957
Brugia malayi hypothetical protein 0.0179 0.1463 0.4229
Schistosoma mansoni methyl-cpg binding protein mbd 0.0069 0.0327 0.0957
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0005 0.006
Schistosoma mansoni single-minded 0.0053 0.0171 0.0499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0138 0.0403
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0045 0.0079 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0138 0.0138
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0124 0.0362
Onchocerca volvulus 0.0052 0.0159 0.0496
Loa Loa (eye worm) RNA binding protein 0.0191 0.1587 0.4738
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0879 0.8644 0.8644
Loa Loa (eye worm) jmjC domain-containing protein 0.0146 0.1119 0.3341
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.2253 0.2253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0138 0.0138
Schistosoma mansoni rab6-interacting 0.0064 0.0283 0.0828
Toxoplasma gondii PHD-finger domain-containing protein 0.0114 0.0793 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0145 0.1108 0.1108
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0187 0.7329
Loa Loa (eye worm) hypothetical protein 0.0196 0.163 0.4868
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.2253 0.2253
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0033 1
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0011 0.0428
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0295 0.0295
Loa Loa (eye worm) jmjC domain-containing protein 0.0236 0.2041 0.6094
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0745
Echinococcus granulosus RUN 0.0064 0.0283 0.0283
Brugia malayi RNA binding protein 0.0191 0.1587 0.4588
Schistosoma mansoni hypothetical protein 0.0083 0.0475 0.139
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0033 0.5
Echinococcus multilocularis jumonji domain containing protein 0.0159 0.1252 0.1252
Plasmodium vivax hypothetical protein, conserved 0.004 0.0028 0.0353
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0295 0.0295
Loa Loa (eye worm) bromodomain containing protein 0.0071 0.0353 0.1053
Echinococcus granulosus peregrin 0.0124 0.0891 0.0891
Brugia malayi bHLH-PAS transcription factor 0.004 0.0028 0.0081
Brugia malayi jmjC domain containing protein 0.0146 0.1119 0.3235
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0069 0.0327 0.0327
Schistosoma mansoni rab6-interacting 0.0064 0.0283 0.0828
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0138 0.0412
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0033 0.129
Echinococcus multilocularis GPCR, family 2 0.0066 0.0295 0.0295
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.175 0.5061
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.1077 0.3114
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0011 0.0428
Echinococcus granulosus Polycystic kidney disease protein 0.0064 0.0283 0.0283
Brugia malayi hypothetical protein 0.0064 0.0283 0.0818
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0187 0.7329
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0033 1
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0033 0.0033
Echinococcus multilocularis geminin 0.037 0.3418 0.3418
Brugia malayi Bromodomain containing protein 0.0124 0.0891 0.2577
Onchocerca volvulus 0.0049 0.0124 0.0364
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0028 0.11
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0045 0.0079 0.0079
Trypanosoma brucei ISWI complex protein 0.0062 0.0255 1
Schistosoma mansoni hypothetical protein 0.0064 0.0283 0.0828
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0295 0.0295
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0114 0.0793 0.2321
Onchocerca volvulus 0.0064 0.0283 0.097
Schistosoma mansoni tar DNA-binding protein 0.0191 0.1587 0.4641
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0033 1
Brugia malayi beta-lactamase family protein 0.004 0.0028 0.0081
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0084
Echinococcus granulosus methyl CpG binding domain protein 2 0.0069 0.0327 0.0327
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0028 0.7796
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0084
Schistosoma mansoni hypothetical protein 0.0052 0.0159 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0028 0.11
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0037 0.0005 0.0187
Brugia malayi hypothetical protein 0.0256 0.2253 0.6514
Loa Loa (eye worm) transcription factor SMAD2 0.0363 0.3348 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0091 0.0554 0.0554
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0028 0.7796
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0295 0.0854
Giardia lamblia PHD finger protein 15 0.0114 0.0793 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0327 0.0327
Brugia malayi PHD-finger family protein 0.0114 0.0793 0.2294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0005 0.0014
Entamoeba histolytica hypothetical protein 0.0039 0.0022 0.5142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0241 0.2091 0.2091
Brugia malayi beta-NAC-like protein 0.0038 0.0011 0.0032
Brugia malayi Doublecortin family protein 0.0064 0.0283 0.0818
Trichomonas vaginalis esterase, putative 0.004 0.0028 0.7796
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0011 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.175 0.5227
Brugia malayi hypothetical protein 0.0296 0.2658 0.7684
Brugia malayi PHD-finger family protein 0.0045 0.0084 0.0242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0295 0.0882
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.0283 0.0283
Echinococcus multilocularis neuropeptide receptor A26 0.1012 1 1
Schistosoma mansoni zinc finger protein 0.0079 0.0432 0.1263
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0374 0.3458 0.3458
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0191 0.1587 0.4738
Onchocerca volvulus Alhambra homolog 0.0114 0.0793 0.291
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0171 0.0499
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.0283 0.0283
Echinococcus multilocularis tar DNA binding protein 0.0191 0.1587 0.1587
Schistosoma mansoni loxhd1 0.0064 0.0283 0.0828
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0033 0.0033
Plasmodium falciparum phd finger protein, putative 0.0114 0.0793 1
Onchocerca volvulus 0.0296 0.2658 1
Loa Loa (eye worm) PHD-finger family protein 0.0114 0.0793 0.2369
Onchocerca volvulus 0.004 0.0028 3.3843e-17
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0033 1
Brugia malayi hypothetical protein 0.0055 0.0187 0.054
Brugia malayi Inositol-1 0.004 0.0033 0.0095
Leishmania major hypothetical protein, conserved 0.0055 0.0187 0.7329
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0084
Trypanosoma cruzi ISWI complex protein 0.0062 0.0255 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0145 0.1108 0.1108
Loa Loa (eye worm) hypothetical protein 0.0066 0.0295 0.0882
Echinococcus granulosus single minded 2 0.004 0.0028 0.0028
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0028 0.000000000000018399
Loa Loa (eye worm) hypothetical protein 0.0296 0.2658 0.7937
Echinococcus multilocularis neuropeptide s receptor 0.1012 1 1
Schistosoma mansoni hypothetical protein 0.037 0.3418 1
Schistosoma mansoni hypothetical protein 0.0066 0.0295 0.0864
Echinococcus granulosus zinc finger protein 0.0079 0.0432 0.0432
Schistosoma mansoni hypothetical protein 0.0066 0.0295 0.0864
Echinococcus granulosus transcription factor btf3 0.0038 0.0011 0.0011
Echinococcus granulosus PHD finger protein rhinoceros 0.0114 0.0793 0.0793
Schistosoma mansoni tar DNA-binding protein 0.0191 0.1587 0.4641
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0028 0.0028
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0037 0.0005 0.006
Loa Loa (eye worm) hypothetical protein 0.0055 0.0187 0.0557
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0295 0.0295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0138 0.0403
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0028 0.7796
Leishmania major hypothetical protein, conserved 0.004 0.0028 0.11
Echinococcus granulosus geminin 0.037 0.3418 0.3418
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0317 0.2879 0.2879
Schistosoma mansoni tar DNA-binding protein 0.0191 0.1587 0.4641
Echinococcus multilocularis zinc finger protein 0.0079 0.0432 0.0432
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0317 0.2879 0.2879
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0207 0.175 0.5227
Brugia malayi beta-lactamase 0.004 0.0028 0.0081
Loa Loa (eye worm) inositol-1 0.004 0.0033 0.0098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0022 0.0022
Brugia malayi jmjC domain containing protein 0.0374 0.3458 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0166 0.132 0.3942
Schistosoma mansoni bromodomain containing protein 0.0255 0.2239 0.655
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0028 0.0084
Trypanosoma cruzi ISWI complex protein 0.0062 0.0255 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0033 0.129
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0187 0.2353
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0037 0.0005 0.006
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0084
Echinococcus granulosus tar DNA binding protein 0.0191 0.1587 0.1587
Echinococcus multilocularis Polycystic kidney disease protein 0.0064 0.0283 0.0283
Mycobacterium ulcerans lipase LipD 0.004 0.0028 0.000000000000018399
Schistosoma mansoni hypothetical protein 0.0066 0.0295 0.0864

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 35 uM Antimicrobial activity against Leishmania infantum ChEMBL. 20185316

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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