Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0851 | 0.0679 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1315 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.5806 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.5806 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.5806 | 0.782 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1315 | 0.0059 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.5806 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.5806 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0851 | 0.0739 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.5806 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9254 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.5806 | 0.782 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.5806 | 0.782 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7332 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.5806 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.5806 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7332 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1315 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0851 | 0.0739 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1315 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.5806 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.5806 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0518 | 0.0242 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.7956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4024 | 0.4348 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3186 | 0.4076 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.5806 | 0.52 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3186 | 0.4076 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.5806 | 0.718 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4357 | 0.4709 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3599 | 0.2673 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.5806 | 0.782 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.5806 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0518 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1315 | 0.1421 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.5806 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3611 | 0.3902 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.5806 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.5806 | 0.6274 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.5806 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.5806 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.