Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0088 | 0.3455 | 0.2901 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0689 | 0.0496 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0042 | 0.0689 | 0.1589 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.6238 | 1 |
Echinococcus multilocularis | musashi | 0.0088 | 0.3455 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1871 | 0.2808 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0591 | 0.0396 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3357 | 0.322 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.2873 | 0.2726 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0042 | 0.0689 | 0.1589 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.078 | 0.2714 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0076 | 0.2696 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0591 | 0.0396 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0983 | 0.3419 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1871 | 0.2808 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0071 | 0.241 | 0.7625 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0047 | 0.0973 | 0.0209 |
Schistosoma mansoni | intermediate filament proteins | 0.0088 | 0.3455 | 0.5416 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.078 | 0.1774 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2696 | 0.2545 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.2873 | 0.2271 |
Echinococcus granulosus | lamin | 0.0088 | 0.3455 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.241 | 0.7625 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0047 | 0.0973 | 0.0786 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.078 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1871 | 0.1703 |
Brugia malayi | intermediate filament protein | 0.0088 | 0.3455 | 0.2901 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0983 | 0.3419 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.2873 | 0.8232 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0134 | 0.6238 | 0.5919 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0076 | 0.2696 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0065 | 0.2036 | 0.4534 |
Brugia malayi | hypothetical protein | 0.0049 | 0.1071 | 0.0315 |
Echinococcus multilocularis | GPCR, family 2 | 0.0062 | 0.1871 | 0.5185 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.241 | 0.7625 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.1871 | 0.5185 |
Schistosoma mansoni | lamin | 0.0088 | 0.3455 | 0.5416 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.2873 | 0.8232 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.1871 | 0.5185 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0076 | 0.2696 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0062 | 0.1871 | 0.1184 |
Loa Loa (eye worm) | intermediate filament protein | 0.0088 | 0.3455 | 0.3319 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.2873 | 0.8232 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.6238 | 0.616 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0062 | 0.1871 | 0.1703 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0196 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1871 | 0.2808 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.2696 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0076 | 0.2696 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0088 | 0.3455 | 1 |
Onchocerca volvulus | 0.0088 | 0.3455 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0088 | 0.3455 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.241 | 0.7625 |
Brugia malayi | hypothetical protein | 0.0076 | 0.2696 | 0.2079 |
Echinococcus granulosus | GPCR family 2 | 0.0062 | 0.1871 | 0.5185 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1871 | 0.2808 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0062 | 0.1871 | 0.1184 |
Echinococcus multilocularis | lamin | 0.0088 | 0.3455 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.2873 | 0.8232 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.2873 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0076 | 0.2696 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.3455 | 1 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0076 | 0.2696 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0088 | 0.3455 | 0.3319 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0076 | 0.2696 | 0.5 |
Schistosoma mansoni | lamin | 0.0088 | 0.3455 | 0.5416 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.1871 | 0.5185 |
Echinococcus granulosus | lamin dm0 | 0.0088 | 0.3455 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.2873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.1871 | 0.5185 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.078 | 0.0589 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.2873 | 0.4459 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0983 | 0.2398 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3455 | 0.3319 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.2873 | 0.4459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.