Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.3031 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5051 | 0.2119 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5051 | 0.4991 |
Onchocerca volvulus | 0.013 | 0.3031 | 0.3758 | |
Onchocerca volvulus | 0.0252 | 0.7705 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.3031 | 0.6829 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 0.8565 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.6651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.8565 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5051 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0312 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.3031 | 0.6887 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.3031 | 0.3465 |
Brugia malayi | Pre-SET motif family protein | 0.0222 | 0.6537 | 0.7605 |
Echinococcus multilocularis | geminin | 0.0165 | 0.4393 | 0.5073 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 0.8565 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.372 | 0.3643 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.4357 | 0.65 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0062 | 0.0434 | 0.0317 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0252 | 0.7705 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.4393 | 0.5073 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0216 | 0.0278 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5051 | 0.2119 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0434 | 0.0398 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.5051 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0.0097 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.4393 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0216 | 0.0278 |
Brugia malayi | thymidylate synthase | 0.013 | 0.3031 | 0.3465 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.4357 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.4393 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.3031 | 0.4476 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.3031 | 0.3465 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0216 | 0.0141 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.0434 | 0.0514 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.5051 | 0.5 |
Brugia malayi | hypothetical protein | 0.0275 | 0.8565 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0222 | 0.6537 | 0.7605 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.3031 | 0.3465 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.5544 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 4.2 | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 4.2007 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 5.22 | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 5.2218 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6 uM | Inhibition of Toxoplasma gondii (tc) Dihydrofolate reductase | ChEMBL. | 7783147 |
IC50 (binding) | = 6 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6 uM | Inhibition of Toxoplasma gondii (tc) Dihydrofolate reductase | ChEMBL. | 7783147 |
IC50 (binding) | = 6 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 6 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 63 uM | Inhibition of rat liver Dihydrofolate reductase | ChEMBL. | 7783147 |
IC50 (binding) | = 63 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 63 uM | Inhibition of rat liver Dihydrofolate reductase | ChEMBL. | 7783147 |
IC50 (binding) | = 63 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 63 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 279 uM | Inhibition of Pneumocystis carinii (pc) Dihydrofolate reductase | ChEMBL. | 7783147 |
IC50 (binding) | = 279 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
IC50 (binding) | = 279 uM | Inhibition of Pneumocystis carinii (pc) Dihydrofolate reductase | ChEMBL. | 7783147 |
IC50 (binding) | = 279 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 3.5544 | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 4.2007 | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 15743188 |
Log IC50 (binding) | = 5.2218 | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 15743188 |
Selectivity ratio (binding) | = 0.23 | Ratio of IC50 against rat liver DHFR and P. carinii DHFR (IC50rl/IC50pc) | ChEMBL. | 7783147 |
Selectivity ratio (binding) | = 10.5 | Ratio of the IC50 against rat liver DHFR and T. gondii DHFR (IC50rl/IC50tg) | ChEMBL. | 7783147 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.