Detailed information for compound 1141434

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 481.509 | Formula: C27H26F3N3O2
  • H donors: 3 H acceptors: 2 LogP: 6.27 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1O)CNCCCNc1ccnc2c1ccc(c2)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C27H26F3N3O2/c1-35-25-5-2-4-20(26(25)34)17-31-13-3-14-32-23-12-15-33-24-16-19(8-11-22(23)24)18-6-9-21(10-7-18)27(28,29)30/h2,4-12,15-16,31,34H,3,13-14,17H2,1H3,(H,32,33)
  • InChiKey: SRTBXKHATICTAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major GTP-binding protein, putative 0.0042 0.0071 0.0637
Toxoplasma gondii thioredoxin reductase 0.0284 0.0876 0.6766
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0232 0.092
Onchocerca volvulus 0.0059 0.0128 0.0496
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0426 0.1763
Schistosoma mansoni thyroid hormone receptor 0.000765287 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0128 0.0356 0.7688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0029 0.0135
Loa Loa (eye worm) hypothetical protein 0.0102 0.0272 0.1265
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0029 0.0029
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.006 0.0249
Entamoeba histolytica hypothetical protein 0.0108 0.0292 0.1654
Echinococcus multilocularis protein patched 0.0224 0.0677 0.0673
Plasmodium vivax heat shock protein 86, putative 0.0039 0.006 0.0548
Leishmania major DNA polymerase kappa, putative 0.0038 0.0059 0.0499
Loa Loa (eye worm) hypothetical protein 0.0239 0.0727 0.338
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.0219
Loa Loa (eye worm) hypothetical protein 0.0095 0.0249 0.1156
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0128 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0111 0.0302 0.0301
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0059 0.017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.032 0.032
Onchocerca volvulus 0.0092 0.0237 0.0942
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0004 0.0003
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0222 0.2336
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0057 0.0248
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Brugia malayi protein C24B5.3 0.0032 0.0038 0.0159
Onchocerca volvulus 0.0032 0.0038 0.0129
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.006 0.0402
Echinococcus multilocularis neuropeptide receptor A26 0.0916 0.2974 0.2972
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.006 0.013 0.0504
Brugia malayi jmjC domain containing protein 0.0113 0.0308 0.1418
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0071 0.0561
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0026 0.0019 0.0071
Brugia malayi RNA, U transporter 1 0.0161 0.0468 0.2162
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0056 0.0201
Entamoeba histolytica hypothetical protein 0.0087 0.0222 0.1231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.006 0.013 0.0504
Plasmodium falciparum glutathione reductase 0.0284 0.0876 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0026 0.0019 0.0137
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0026 0.0019 0.0073
Schistosoma mansoni ran 0.0042 0.0071 0.0071
Echinococcus granulosus single minded 2 0.0036 0.0051 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.017 0.0668
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.0206 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0132 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-19 0.000765287 1 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0099 0.026 0.1042
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.006 0.0582
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0034 0.0065
Plasmodium vivax glutathione reductase, putative 0.0284 0.0876 1
Brugia malayi SET domain containing protein 0.0022 0.0006 0.0012
Echinococcus granulosus chromobox protein 1 0.0069 0.0161 0.0158
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0021 0.009
Schistosoma mansoni loxhd1 0.0059 0.0128 0.0127
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0051 0.0219
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0059 0.0562
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0071 0.0261
Echinococcus multilocularis dnaJ subfamily B 0.3032 1 1
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0021 0.0061
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0189 0.0185
Onchocerca volvulus 0.0163 0.0473 0.1907
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0029 0.012
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.006 0.0582
Toxoplasma gondii sporozoite developmental protein 0.0024 0.0013 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Echinococcus multilocularis FTZ F1 alpha 0.000765287 1 1
Echinococcus multilocularis expressed conserved protein 0.0491 0.1562 0.1559
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0099 0.026 0.2873
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0109 0.0506
Loa Loa (eye worm) insulin-degrading enzyme 0.0024 0.0013 0.0059
Toxoplasma gondii patched family protein 0.0032 0.0038 0.0225
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0044 0.0153
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Schistosoma mansoni myst-related protein 0.0027 0.0022 0.0022
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0292 0.0288
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0057 0.0543
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0037 0.0153
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0071 0.0672
Plasmodium falciparum thioredoxin reductase 0.0284 0.0876 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0025 0.0017 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.017 0.1775
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0021 0.0115
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.0222 0.1031
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0047 0.0299
Loa Loa (eye worm) hypothetical protein 0.0128 0.0356 0.1653
Schistosoma mansoni hypothetical protein 0.0026 0.0019 0.0019
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0059 0.0896
Brugia malayi hypothetical protein 0.044 0.1393 0.6468
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0132 0.0958
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0128 0.0356 0.1459
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.0019 0.0016
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0017 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0216 0.065 0.065
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0128 0.1326
Entamoeba histolytica hypothetical protein 0.0046 0.0085 0.04
Onchocerca volvulus 0.0032 0.0038 0.0129
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.0057 0.0543
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0037 0.0033
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0128 0.0124
Onchocerca volvulus 0.0111 0.0302 0.1206
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0721 0.2326 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0368 0.0368
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0121 0.1238
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0029 0.0026
Onchocerca volvulus 0.0036 0.0051 0.0181
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.0019 0.0073
Trichomonas vaginalis mercuric reductase, putative 0.0099 0.026 0.1032
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.006 0.0582
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Trypanosoma cruzi peptidase, putative 0.0024 0.0013 0.0066
Schistosoma mansoni thyroid hormone receptor 0.000765287 1 1
Loa Loa (eye worm) patched family protein 0.0032 0.0038 0.0174
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2695
Echinococcus multilocularis GPCR, family 2 0.0031 0.0037 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0132 0.0131
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.0163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0261 0.12
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0059 0.0562
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0034 0.0031
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.0206 0.094
Onchocerca volvulus Alhambra homolog 0.0035 0.0047 0.0168
Trichomonas vaginalis sucrase-isomaltase, putative 0.0072 0.017 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0029 0.012
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0059 0.0256
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.000765287 1 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0019 0.0137
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0368 0.171
Brugia malayi Thioredoxin reductase 0.0284 0.0876 0.4062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.0057 0.0248
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0016 0.0012
Leishmania major importin beta-1 subunit, putative 0.0046 0.0085 0.0791
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0189 0.2038
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.0237 0.0233
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0019 0.0137
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0189 0.0736
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.000765287 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0059 0.0256
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0189 0.1838
Schistosoma mansoni chromobox protein 0.0069 0.0161 0.0161
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0026 0.0019 0.0016
Giardia lamblia NADH oxidase lateral transfer candidate 0.0099 0.026 0.2602
Echinococcus granulosus heat shock protein 90 0.0039 0.006 0.0057
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0073 0.0714
Loa Loa (eye worm) hypothetical protein 0.044 0.1393 0.6474
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Leishmania major mitochondrial DNA polymerase beta 0.03 0.0929 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0099 0.026 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.000765287 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Echinococcus granulosus zinc finger protein 0.0031 0.0037 0.0033
Plasmodium falciparum glutathione reductase 0.0099 0.026 0.2873
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Schistosoma mansoni alpha-glucosidase 0.0278 0.0855 0.0855
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2695
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Schistosoma mansoni hypothetical protein 0.0082 0.0206 0.0205
Schistosoma mansoni cpg binding protein 0.0227 0.0686 0.0686
Brugia malayi Trypsin family protein 0.0102 0.0272 0.1251
Toxoplasma gondii hypothetical protein 0.0032 0.0038 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0132 0.2566
Brugia malayi heat shock protein 90 0.0039 0.006 0.0264
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0029 0.012
Giardia lamblia Grp94/Hsp90 0.0031 0.0034 0.0163
Giardia lamblia DINP protein human, muc B family 0.0038 0.0059 0.0425
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0071 0.0068
Brugia malayi hypothetical protein 0.0122 0.0337 0.155
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Entamoeba histolytica hypothetical protein 0.0108 0.0292 0.1654
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0061 0.0223
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 0.0201
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0072 0.0173 0.0787
Schistosoma mansoni jumonji/arid domain-containing protein 0.0056 0.0118 0.0118
Loa Loa (eye worm) CHromoDomain protein family member 0.0025 0.0017 0.0076
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0021 0.0156
Loa Loa (eye worm) hypothetical protein 0.0163 0.0473 0.2199
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.000765287 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.000765287 1 1
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0026 0.0019 0.0097
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0059 0.0271
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0059 0.0055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0417 0.0413
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.0076
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0122 0.0118
Mycobacterium tuberculosis Probable oxidoreductase 0.0721 0.2326 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0069 0.0163 0.0159
Leishmania major hypothetical protein, conserved 0.0026 0.0019 0.0071
Loa Loa (eye worm) hypothetical protein 0.0095 0.0249 0.1156
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.000765287 1 1
Echinococcus granulosus dna polymerase kappa 0.0038 0.0059 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0019 0.0138
Echinococcus granulosus dna polymerase eta 0.0038 0.0059 0.0055
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0099 0.026 0.0256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0232 0.092
Echinococcus multilocularis lysosomal alpha glucosidase 0.0323 0.1004 0.1001
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0292 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0222 0.0222
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.0057 0.0053
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0404 0.4271
Onchocerca volvulus 0.0037 0.0057 0.0207
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.0206 0.0202
Brugia malayi protein C24B5.3 0.0032 0.0038 0.0159
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0021 0.0059
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0026 0.0019 0.0016
Brugia malayi Probable ClpP-like protease 0.0077 0.0189 0.0863
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2743
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0132 0.0128
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0099 0.026 0.2743
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0113 0.0308 0.0305
Schistosoma mansoni hypothetical protein 0.3032 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0271
Entamoeba histolytica protein kinase, putative 0.0087 0.0222 0.1231
Brugia malayi hypothetical protein 0.0161 0.0468 0.2161
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0059 0.0212
Brugia malayi CXXC zinc finger family protein 0.0213 0.0639 0.2959
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0072 0.0173 0.0787
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0036
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0021 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0029 0.012
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.0019 0.0137
Plasmodium vivax ferrodoxin reductase, putative 0.0026 0.0019 0.0072
Plasmodium falciparum importin beta, putative 0.0057 0.0121 0.127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0284 0.0876 0.3716
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.0057 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0417 0.0413
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0105 0.0487
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0101 0.0353
Mycobacterium tuberculosis Probable dehydrogenase 0.0649 0.2086 0.8958
Onchocerca volvulus 0.0128 0.0356 0.1427
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0118 0.0547
Echinococcus granulosus Niemann Pick C1 protein 0.0522 0.1667 0.1664
Echinococcus multilocularis insulin degrading enzyme 0.0024 0.0013 0.0009
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.0019 0.0051
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0057 0.0481
Onchocerca volvulus 0.0026 0.0019 0.0054
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.0222 0.2336
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0128 0.0356 0.7688
Entamoeba histolytica hypothetical protein 0.0027 0.0022 0.0017
Trichomonas vaginalis helicase, putative 0.0048 0.0093 0.0351
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0128 0.0356 0.7688
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0128 0.0356 0.1653
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0059 0.0562
Onchocerca volvulus 0.0102 0.0272 0.1087
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0132 0.2566
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0034 0.0113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0426 0.1981
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0037 0.0057 0.0857
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0128 0.0124
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Echinococcus granulosus sterol regulatory element binding protein 0.0224 0.0677 0.0673
Brugia malayi AMP-binding enzyme family protein 0.0128 0.0356 0.164
Onchocerca volvulus 0.0032 0.0038 0.0129
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0121 0.0873
Trichomonas vaginalis set domain proteins, putative 0.076 0.2456 1
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0051 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0128 0.0356 0.164
Trypanosoma cruzi trypanothione reductase, putative 0.0284 0.0876 0.9434
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0101 0.0097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.000765287 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0128 0.0356 0.3747
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0304 0.0941 0.4365
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Echinococcus multilocularis microtubule associated protein 2 0.1367 0.4472 0.447
Trypanosoma brucei trypanothione reductase 0.0284 0.0876 0.9434
Loa Loa (eye worm) hypothetical protein 0.0117 0.032 0.1486
Schistosoma mansoni lipoxygenase 0.0121 0.0334 0.0334
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.005 0.0047
Echinococcus multilocularis Niemann Pick C1 protein 0.0747 0.2411 0.2409
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0029 0.012
Echinococcus granulosus peregrin 0.0037 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Schistosoma mansoni polycystin 1-related 0.0059 0.0128 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Schistosoma mansoni rab6-interacting 0.0059 0.0128 0.0127
Plasmodium falciparum ferrodoxin reductase-like protein 0.0026 0.0019 0.0097
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Brugia malayi Cytochrome P450 family protein 0.0052 0.0105 0.0472
Loa Loa (eye worm) hypothetical protein 0.004 0.0066 0.0306
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0189 0.1405
Trypanosoma brucei unspecified product 0.0038 0.0059 0.0562
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Plasmodium vivax endoplasmin, putative 0.0039 0.006 0.0548
Loa Loa (eye worm) hypothetical protein 0.0068 0.0157 0.073
Toxoplasma gondii patched family protein 0.0032 0.0038 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0169 0.0786
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0261 0.12
Plasmodium vivax patched family protein, putative 0.0032 0.0038 0.0285
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0073 0.0714
Loa Loa (eye worm) RNA binding protein 0.0131 0.0368 0.171
Loa Loa (eye worm) hypothetical protein 0.0077 0.0189 0.0878
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0227 0.0686 0.0682
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.017 0.0916
Brugia malayi TAR-binding protein 0.0131 0.0368 0.1697
Loa Loa (eye worm) patched family protein 0.0032 0.0038 0.0174
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0099 0.026 0.2743
Trypanosoma brucei peptidase, putative 0.0024 0.0013 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.000765287 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2743
Brugia malayi Heterochromatin protein 1 0.0069 0.0161 0.0735
Echinococcus granulosus Protein patched homolog 1 0.0224 0.0677 0.0673
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0019 0.0082
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0026 0.0019 0.0082
Toxoplasma gondii hypothetical protein 0.0027 0.0021 0.0094
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0037 0.0057 0.0543
Echinococcus granulosus 3'partial|nardilysin 0.0024 0.0013 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0099 0.026 0.5488
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0008 0.0014
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0057 0.0543
Echinococcus granulosus Niemann Pick C1 protein 0.0747 0.2411 0.2409
Plasmodium vivax importin-beta 2, putative 0.0057 0.0121 0.1248
Brugia malayi Protein kinase domain containing protein 0.0087 0.0222 0.1017
Onchocerca volvulus 0.003 0.0033 0.011
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0057 0.0543
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0189 0.0189
Echinococcus granulosus expressed conserved protein 0.0491 0.1562 0.1559
Brugia malayi Nuclear hormone receptor family member nhr-14 0.000765287 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0649 0.2086 0.8958
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Entamoeba histolytica hypothetical protein 0.0108 0.0292 0.1654
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0099 0.026 0.0256
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0368 0.0365
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0095 0.0249 0.0995
Echinococcus multilocularis heat shock protein 90 0.0031 0.0034 0.0031
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.0057 0.0228
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0368 0.1697
Trichomonas vaginalis apoptosis inducing factor, putative 0.0026 0.0019 0.0051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.000765287 1 1
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Schistosoma mansoni RAR-like nuclear receptor 0.000765287 1 1
Brugia malayi PHD-finger family protein 0.0025 0.0017 0.006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.0019 0.0073
Onchocerca volvulus 0.0187 0.0552 0.2229
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0029 0.0135
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0323 0.1004 0.4666
Brugia malayi steroid hormone receptor 0.000765287 1 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0034 0.0065
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Mycobacterium ulcerans hypothetical protein 0.0158 0.0457 1
Echinococcus granulosus heat shock protein 0.0039 0.006 0.0057
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.006 0.0249
Leishmania major 4-coumarate:coa ligase-like protein 0.0128 0.0356 0.3747
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0019 0.0051
Echinococcus multilocularis peregrin 0.0037 0.0055 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0189 0.7063
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0037 0.0153
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.0057 0.0163
Brugia malayi nuclear receptor NHR-88 0.0029 0.0029 0.012
Echinococcus multilocularis neutral alpha glucosidase AB 0.0072 0.017 0.0167
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0099 0.026 0.2695
Loa Loa (eye worm) hypothetical protein 0.0064 0.0146 0.0677
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0189 0.2058
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0059 0.0562
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0417 0.0413
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0037 0.0057 0.0857
Loa Loa (eye worm) programmed cell death 8 0.0026 0.0019 0.0089
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0224 0.0677 0.3145
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.0206 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0019 0.0137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0037 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.017 0.1775
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0249 0.5243
Plasmodium falciparum lipid/sterol:H+ symporter 0.0032 0.0038 0.0309
Entamoeba histolytica protein kinase, putative 0.0087 0.0222 0.1231
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Onchocerca volvulus 0.0037 0.0057 0.0207
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0071 0.0695
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0114 0.0312 0.145
Leishmania major 4-coumarate:coa ligase-like protein 0.0128 0.0356 0.3747
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0029 0.012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.000765287 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0426 0.9288
Echinococcus granulosus FTZ F1 alpha 0.000765287 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.000765287 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0029 0.012
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0019 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0099 0.026 0.5488
Entamoeba histolytica acyl-coA synthetase, putative 0.0128 0.0356 0.2043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0056 0.0118 0.0118
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0531 0.1694 0.1694
Brugia malayi Nuclear hormone receptor family member nhr-1 0.000765287 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0034 0.0626
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0029 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.032 0.032
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.032 0.0317
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0059 0.0212
Schistosoma mansoni hypothetical protein 0.0216 0.065 0.065
Echinococcus granulosus insulin degrading enzyme 0.0024 0.0013 0.0009
Schistosoma mansoni disulfide oxidoreductase 0.0026 0.0019 0.0019
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.006 0.0582
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.0943 0.5604
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.017 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-31 0.000765287 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0522 0.1667 1
Loa Loa (eye worm) histone methyltransferase 0.0069 0.0163 0.0756
Brugia malayi PAS domain containing protein 0.0048 0.0092 0.0412
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Toxoplasma gondii NADPH-glutathione reductase 0.0099 0.026 0.1955
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0189 0.3876
Echinococcus multilocularis sterol regulatory element binding protein 0.0224 0.0677 0.0673
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.0163
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0029 0.0029
Brugia malayi PHD-finger family protein 0.0035 0.0047 0.0203
Onchocerca volvulus 0.0037 0.0057 0.0207
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0056 0.012 0.0116
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0128 0.0356 0.7688
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0034 0.0235
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0099 0.026 0.0259
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0128 0.0356 0.1459
Loa Loa (eye worm) hypothetical protein 0.0054 0.0113 0.0523
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0057 0.0263
Brugia malayi jmjC domain containing protein 0.0056 0.0118 0.0532
Plasmodium falciparum zinc finger protein, putative 0.0027 0.0022 0.0129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0232 0.092
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.0057 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0606 0.1943 0.9029
Mycobacterium ulcerans hypothetical protein 0.000426345 0 0.5
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0059 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.000765287 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.0019 0.0051
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0059 0.017
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0071 0.0698
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0047 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.000765287 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0099 0.026 1
Echinococcus multilocularis neuropeptide s receptor 0.0916 0.2974 0.2972
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.000765287 1 1
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0128 0.1348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0037 0.0057 0.0374
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.017 0.0668
Entamoeba histolytica Ran family GTPase 0.0042 0.0071 0.0314
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Brugia malayi ecdysteroid receptor 0.0029 0.0029 0.012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0029 0.012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0169 0.0165
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0047 0.0299
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.0943 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0037 0.0057 0.0374
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0057 0.0543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Brugia malayi nuclear hormone receptor 0.0029 0.0029 0.012
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0368 0.0368
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0071 0.0698
Entamoeba histolytica acyl-CoA synthetase, putative 0.0128 0.0356 0.2043
Schistosoma mansoni endoplasmin 0.0039 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Plasmodium falciparum heat shock protein 90 0.0039 0.006 0.0571
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0649 0.2086 0.8958
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0101 0.0353
Toxoplasma gondii hypothetical protein 0.0048 0.0093 0.0657
Echinococcus multilocularis Protein lozenge 0.0055 0.0116 0.0112
Schistosoma mansoni glutamate synthase 0.0026 0.0019 0.0019
Schistosoma mansoni bromodomain containing protein 0.0075 0.018 0.018
Schistosoma mansoni importin beta-1 0.0057 0.0121 0.0121
Schistosoma mansoni single-minded 0.0048 0.0092 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0037 0.0033
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0011 0.0017
Brugia malayi Pre-SET motif family protein 0.0668 0.2152 1
Loa Loa (eye worm) patched family protein 0.0032 0.0038 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0057 0.0248
Schistosoma mansoni DNA polymerase eta 0.0038 0.0059 0.0058
Leishmania major NADH dehydrogenase, putative 0.0026 0.0019 0.0071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0668 0.2152 1
Leishmania major cathepsin L-like protease 0.0063 0.0142 0.1408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0417 0.0417
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.006 0.0582
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0047 0.0047
Brugia malayi photoreceptor-specific nuclear receptor 0.000765287 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Schistosoma mansoni jumonji domain containing protein 0.009 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0071 0.0314
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.102
Onchocerca volvulus Protein patched homolog 0.0032 0.0038 0.0129
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0122 0.0444
Giardia lamblia PHD finger protein 15 0.0035 0.0047 0.0302
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.0929 1
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0034 0.0343
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0037 0.0057 0.0857
Echinococcus granulosus importin subunit beta 1 0.0057 0.0121 0.0117
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0085 0.0851
Schistosoma mansoni hypothetical protein 0.0082 0.0206 0.0205
Schistosoma mansoni myst-related protein 0.0027 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.000765287 1 1
Schistosoma mansoni coup transcription factor 0.000765287 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0417 0.0417
Mycobacterium ulcerans hypothetical protein 0.0128 0.0356 0.7688
Echinococcus granulosus thioredoxin glutathione reductase 0.0287 0.0887 0.0883
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0161 0.0632
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0124 0.1268
Loa Loa (eye worm) hypothetical protein 0.0057 0.0121 0.0561
Loa Loa (eye worm) hypothetical protein 0.0095 0.0249 0.1156
Schistosoma mansoni cpg binding protein 0.0213 0.0639 0.0639
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2743
Brugia malayi hypoxia-induced factor 1 0.0149 0.0426 0.1968
Brugia malayi Niemann-Pick C1 protein precursor 0.0522 0.1667 0.7742
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0417 0.1924
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.0057 0.0481
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Schistosoma mansoni alpha glucosidase 0.0072 0.017 0.017
Toxoplasma gondii selenide, water dikinase 0.0026 0.0019 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Echinococcus granulosus snurportin 1 0.0606 0.1943 0.194
Brugia malayi hypothetical protein 0.0032 0.0038 0.0159
Loa Loa (eye worm) hypothetical protein 0.0095 0.0249 0.1156
Brugia malayi CHD4 protein 0.0025 0.0017 0.006
Loa Loa (eye worm) hypothetical protein 0.0059 0.0128 0.0592
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0029 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0121 0.1238
Echinococcus granulosus fetal alzheimer antigen falz 0.0034 0.0047 0.0043
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.0019 0.0051
Trichomonas vaginalis glutathione reductase, putative 0.0099 0.026 0.1032
Echinococcus multilocularis heat shock protein 90 0.0039 0.006 0.0057
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0114 0.0312 0.1437
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0051 0.0715
Schistosoma mansoni nuclear hormone receptor 0.000765287 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0142 0.1465
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0099 0.026 0.2873
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.000765287 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Brugia malayi Patched related family protein 12 0.0032 0.0038 0.0159
Schistosoma mansoni rab6-interacting 0.0059 0.0128 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0021 0.0059
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Echinococcus granulosus nardilysin 0.0024 0.0013 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0264 0.0264
Trypanosoma brucei unspecified product 0.0026 0.0019 0.0138
Leishmania major cathepsin L-like protease 0.0063 0.0142 0.1408
Loa Loa (eye worm) heat shock protein 90 0.0039 0.006 0.028
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.0206 0.0202
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0097
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0071 0.0485
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.0057 0.0163
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.0943 0.5604
Trypanosoma cruzi peptidase, putative 0.0024 0.0013 0.0066
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.0019 0.0137
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0026 0.0019 0.0089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0457 0.1898
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0037 0.0057 0.0163
Brugia malayi N-terminal motif family protein 0.0179 0.0526 0.243
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0037 0.0057 0.0857
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0122 0.0122
Plasmodium falciparum phd finger protein, putative 0.0035 0.0047 0.0419
Echinococcus granulosus nuclear receptor 2DBD gamma 0.000765287 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0034 0.0163
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0029 0.0026
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.0057 0.0163
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0128 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.000765287 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0929 1
Schistosoma mansoni chromobox protein 0.0069 0.0161 0.0161
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0021 0.0007
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Leishmania major hypothetical protein, conserved 0.0026 0.0019 0.0071
Echinococcus multilocularis nardilysin 0.0024 0.0013 0.0009
Loa Loa (eye worm) patched family protein 0.0032 0.0038 0.0174
Schistosoma mansoni steroid hormone receptor ad4bp 0.000765287 1 1
Toxoplasma gondii propionate-CoA ligase 0.0037 0.0057 0.0374
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0649 0.2086 0.8958
Brugia malayi Nuclear hormone receptor family member nhr-41 0.000765287 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0142 0.1465
Brugia malayi chromobox protein homolog 3 0.0039 0.0061 0.0266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0045 0.0045
Echinococcus multilocularis zinc finger protein 0.0031 0.0037 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Onchocerca volvulus 0.0032 0.0038 0.0129
Loa Loa (eye worm) endoplasmin 0.0039 0.006 0.028
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0071 0.0261
Mycobacterium ulcerans acetyl-CoA synthetase 0.0037 0.0057 0.0857
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0057 0.0248
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.006 0.013 0.0504
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.0057 0.0163
Echinococcus multilocularis ecdysone induced protein 78C 0.000765287 1 1
Onchocerca volvulus 0.0032 0.0038 0.0129
Echinococcus granulosus lysosomal alpha glucosidase 0.0323 0.1004 0.1001
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0157 0.0715
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0929 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.0163
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.017 0.0668
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0721 0.2326 1
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0034 0.03
Brugia malayi insulin-degrading enzyme 0.0024 0.0013 0.0043
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0128 0.0124
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0142 0.1465
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0071 0.0263
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.000765287 1 1
Echinococcus granulosus chromobox protein 1 0.0069 0.0161 0.0158
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0122 0.2338
Schistosoma mansoni cpg binding protein 0.0227 0.0686 0.0686
Brugia malayi hypothetical protein 0.0108 0.0292 0.1342
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0029 0.0135
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0101 0.0097
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0026 0.0019 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Echinococcus multilocularis Niemann Pick C1 protein 0.0522 0.1667 0.1664
Loa Loa (eye worm) hypothetical protein 0.007 0.0164 0.0764
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.017 0.0668
Schistosoma mansoni hypothetical protein 0.0082 0.0206 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0029 0.012
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0127 0.0354 0.1632
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0029 0.0029
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.006 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Leishmania major DNA polymerase eta, putative 0.0038 0.0059 0.0499
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.0206 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.000765287 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.000765287 1 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.0526 0.2121
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0368 0.0368
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0114 0.0312 0.0309
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0073 0.0714
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0029 0.0026
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0121 0.0117
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.026 0.2743
Schistosoma mansoni hypothetical protein 0.0068 0.0157 0.0157
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0073 0.0714
Schistosoma mansoni lipoxygenase 0.0227 0.0686 0.0685
Echinococcus granulosus glutamate synthase 0.0026 0.0019 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.017 0.0668
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0037 0.0057 0.0857
Echinococcus granulosus lysine specific demethylase 5A 0.0056 0.0118 0.0114
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.0019 0.0137
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0721 0.2326 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0021 0.0156
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0029 0.0026
Schistosoma mansoni heat shock protein 0.0039 0.006 0.006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0287 0.0887 0.0883
Schistosoma mansoni retinoid-x-receptor (RXR) 0.000765287 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0029 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0026 0.0019 0.0072
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0019 0.0082
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.017 0.0668
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Onchocerca volvulus 0.076 0.2456 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0059 0.0055
Trypanosoma brucei NADH dehydrogenase 0.0026 0.0019 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0029 0.0135
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0099 0.026 0.2855
Trichomonas vaginalis ran, putative 0.0042 0.0071 0.0263
Toxoplasma gondii heat shock protein HSP90 0.0039 0.006 0.0402
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0072 0.017 0.0791
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.0163
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0189 0.0185
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0019 0.0051
Echinococcus multilocularis protein dispatched 1 0.0256 0.0782 0.0779
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.0057 0.0263
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0019 0.0051
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0047 0.0219
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0085 0.032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.006 0.013 0.0504
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.01 0.0264 0.199
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Brugia malayi CHE-14 protein 0.0224 0.0677 0.3134
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0222 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0114 0.0312 0.0309
Loa Loa (eye worm) hypothetical protein 0.0275 0.0844 0.3923
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0029 0.0029
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0019 0.0082
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Schistosoma mansoni SET domain protein 0.0022 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0029 0.0029
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0025 0.0017 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0021 0.0156
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.006 0.013 0.0504
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0426 0.1763
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.000765287 1 1
Echinococcus multilocularis RUN 0.0059 0.0128 0.0124
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0004 0.0003
Echinococcus multilocularis chromobox protein 1 0.0069 0.0161 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.000765287 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0029 0.012
Schistosoma mansoni patched 1 0.0224 0.0677 0.0677
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0057 0.0204
Onchocerca volvulus Bile acid receptor homolog 0.000765287 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0029 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.000765287 1 1
Brugia malayi hypothetical protein 0.0059 0.0128 0.0577
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0128 0.0356 0.1459
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0019 0.0137
Leishmania major alpha glucosidase II subunit, putative 0.0072 0.017 0.172
Echinococcus multilocularis thyroid hormone receptor alpha 0.000765287 1 1
Schistosoma mansoni alpha-glucosidase 0.0278 0.0855 0.0855
Leishmania major trypanothione reductase 0.0284 0.0876 0.943
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0029 0.0026
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0037 0.0057 0.0481
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0649 0.2086 0.8958
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0021 0.0059
Schistosoma mansoni hypothetical protein 0.0108 0.0292 0.0292
Plasmodium falciparum thioredoxin reductase 0.0099 0.026 0.2873
Brugia malayi Glycosyl hydrolases family 31 protein 0.0323 0.1004 0.4658
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Loa Loa (eye worm) hypothetical protein 0.0102 0.0272 0.1265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0029 0.0026
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.0677 0.2735
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0101 0.0353
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0227 0.0686 0.0682
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.006 0.013 0.0504
Onchocerca volvulus 0.0059 0.0128 0.0496
Entamoeba histolytica hypothetical protein 0.0108 0.0292 0.1654
Schistosoma mansoni zinc finger protein 0.0031 0.0037 0.0037
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0026 0.0019 0.0097
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Echinococcus granulosus neuropeptide s receptor 0.0916 0.2974 0.2972
Loa Loa (eye worm) hypothetical protein 0.0059 0.0128 0.0592
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0128 0.0356 0.164
Onchocerca volvulus 0.000765287 1 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0368 0.0368
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0037 0.0057 0.053
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0099 0.026 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.0222 0.2285
Loa Loa (eye worm) hypothetical protein 0.0122 0.0337 0.1563
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.004 0.0088
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0189 0.7282
Brugia malayi hypothetical protein 0.0163 0.0473 0.2187
Echinococcus multilocularis snurportin 1 0.0606 0.1943 0.194
Loa Loa (eye worm) runx1 0.0055 0.0116 0.0537
Loa Loa (eye worm) patched family protein 0.0032 0.0038 0.0174
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0599
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0099 0.026 0.2743
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Trichomonas vaginalis heat shock protein, putative 0.0039 0.006 0.0219
Loa Loa (eye worm) CXXC zinc finger family protein 0.0213 0.0639 0.2971
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0161 0.0632
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Treponema pallidum NADH oxidase 0.0099 0.026 0.2602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Plasmodium vivax SET domain protein, putative 0.01 0.0264 0.2907
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0029 0.0026
Loa Loa (eye worm) hypothetical protein 0.0099 0.0261 0.1214
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0128 0.0356 0.7688
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0034 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0179 0.0526 0.2443
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0026 0.0019 0.0137
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0142 0.1465
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0071 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0019 0.0138
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0189 0.7282
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1762 0.5783 0.5782
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0097 0.0979
Toxoplasma gondii patched family protein 0.0032 0.0038 0.0225
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0021 0.0059
Echinococcus multilocularis cpg binding protein 0.0227 0.0686 0.0683
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0059 0.0499
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0132 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0029 0.012
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Onchocerca volvulus Protein patched homolog 0.0032 0.0038 0.0129
Plasmodium falciparum acyl-CoA synthetase 0.0095 0.0249 0.2749
Loa Loa (eye worm) glutathione reductase 0.0284 0.0876 0.4072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0029 0.0026
Loa Loa (eye worm) thioredoxin reductase 0.0284 0.0876 0.4072
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0034 0.0113
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0029 0.0095
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0037 0.0057 0.0857
Brugia malayi hypothetical protein 0.0032 0.0038 0.0159
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.027
Brugia malayi hypothetical protein 0.0032 0.0038 0.0159
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0047 0.0044
Echinococcus multilocularis glutamate synthase 0.0026 0.0019 0.0016
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0059 0.0055
Brugia malayi Importin beta-1 subunit 0.0057 0.0121 0.0546
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.0057 0.0053
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0649 0.2086 0.8958
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Brugia malayi Patched related family protein 10 0.0032 0.0038 0.0159
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.000765287 1 1
Schistosoma mansoni sulfide quinone reductase 0.0026 0.0019 0.0019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0021 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0029 0.0135
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0011 0.0017
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0071 0.0698
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.0224 0.0677 0.3145
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0024 0.0013 0.0031
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0404 0.4309
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0029 0.0095
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0029 0.012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0029 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0019 0.0138
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0026 0.0019 0.0016
Schistosoma mansoni hypothetical protein 0.0059 0.0128 0.0127
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0021 0.0059
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.0206 0.0955
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0056 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0129 0.036 0.167
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0057 0.0163
Echinococcus granulosus neuropeptide receptor A26 0.0916 0.2974 0.2972
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.006 0.0582
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0021 0.0059
Chlamydia trachomatis insulinase family protease III 0.0024 0.0013 0.0493
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0127 0.0354 0.1645
Schistosoma mansoni apoptosis regulator bax 0.0082 0.0206 0.0205
Brugia malayi hypothetical protein 0.0059 0.0128 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0029 0.012
Schistosoma mansoni coup transcription factor 0.0029 0.0029 0.0029
Onchocerca volvulus 0.044 0.1393 0.5661
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.01 0.0264 0.0261
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Brugia malayi glutathione reductase 0.0284 0.0876 0.4062
Schistosoma mansoni sulfide quinone reductase 0.0026 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0409 0.1291 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0034 0.0113
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0095 0.0249 0.9588
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0026 0.0019 0.0072
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0026 0.0019 0.0082
Schistosoma mansoni glutamate synthase 0.0026 0.0019 0.0019
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.0019 0.0016
Brugia malayi Doublecortin family protein 0.0059 0.0128 0.0577
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0417 0.1937
Schistosoma mansoni hypothetical protein 0.0216 0.065 0.065
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0013 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0103 0.1046
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Schistosoma mansoni heat shock protein 0.0039 0.006 0.006
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0061 0.0221
Echinococcus multilocularis dual specificity 0.0087 0.0222 0.0219
Plasmodium vivax acetyl-CoA synthetase, putative 0.0037 0.0057 0.0507
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0056 0.012 0.0116
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0099 0.026 0.2743
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.017 0.0776
Echinococcus granulosus GPCR family 2 0.0031 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0189 0.3876
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0034 0.03
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0021 0.0011
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0019 0.0137
Brugia malayi nuclear receptor NHR-88 0.000765287 1 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.0337 0.1348
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0092 0.0089
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0111 0.03 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.006 0.013 0.0504
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0021 0.0081
Brugia malayi F/Y-rich N-terminus family protein 0.0082 0.0204 0.0932
Loa Loa (eye worm) hypothetical protein 0.0031 0.0037 0.0169
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2743
Brugia malayi Nuclear hormone receptor-like 1 0.000765287 1 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0021 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0069 0.0163 0.0159
Echinococcus granulosus mixed lineage leukemia protein mll 0.0056 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.000765287 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Brugia malayi Pre-SET motif family protein 0.01 0.0264 0.1212
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0132 0.2566
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0099 0.026 0.2743
Toxoplasma gondii patched family protein 0.0032 0.0038 0.0225
Brugia malayi hypothetical protein 0.0032 0.0038 0.0159
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0099 0.026 0.2743
Schistosoma mansoni hypothetical protein 0.0035 0.0047 0.0047
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0026 0.0019 0.0016
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0099 0.026 0.5488
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.0019 0.0137
Echinococcus granulosus heat shock protein 90 0.0031 0.0034 0.0031
Brugia malayi nuclear hormone receptor 0.000765287 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Trypanosoma brucei heat shock protein, putative 0.0039 0.006 0.0582
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0029 0.0026
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.0019 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.000765287 1 1
Trypanosoma brucei unspecified product 0.0026 0.0019 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0417 0.0413
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0128 0.0124
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0222 0.2336
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0059 0.0896
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0037 0.0033
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0099 0.026 0.2695
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0029 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0059 0.0562
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0026 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0095 0.0249 0.1156
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.0057 0.0204
Schistosoma mansoni endoplasmin 0.0039 0.006 0.006
Echinococcus multilocularis dna polymerase eta 0.0038 0.0059 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.000765287 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0943 0.3821
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0169 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Treponema pallidum heat shock protein 90 0.0031 0.0034 0.0163
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0086 0.022 0.102
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0016 0.0012
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Echinococcus granulosus microtubule associated protein 2 0.1367 0.4472 0.447
Loa Loa (eye worm) hypothetical protein 0.044 0.1393 0.6474
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0059 0.0058
Brugia malayi ecdysteroid receptor 0.000765287 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0061 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0261 0.1214
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0026 0.0019 0.0051
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0072 0.017 0.1259
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Onchocerca volvulus 0.0032 0.0038 0.0129
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.017 0.0668
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Mycobacterium tuberculosis Probable reductase 0.0649 0.2086 0.8958
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0114 0.0312 0.145
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0128 0.0592
Echinococcus multilocularis endoplasmin 0.0031 0.0034 0.0031
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0272 0.0272
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0029 0.0026
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.0057 0.0057
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.0057 0.0163
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0368 0.171
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0099 0.026 0.1191
Brugia malayi RNA binding protein 0.0131 0.0368 0.1697
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0455 0.1443 0.1443
Echinococcus granulosus RUN 0.0059 0.0128 0.0124
Echinococcus granulosus endoplasmin 0.0031 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.000765287 1 1
Brugia malayi Bromodomain containing protein 0.0037 0.0055 0.0239
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0092 0.0089
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0132 0.0128
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.000765287 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0029 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0368 0.0368
Mycobacterium ulcerans acyl-CoA synthetase 0.0128 0.0356 0.7688
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0122 0.0118
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.0057 0.0248
Brugia malayi PHD-finger family protein 0.0037 0.0054 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0142 0.1465
Echinococcus multilocularis lysosomal alpha glucosidase 0.0323 0.1004 0.1001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0034 0.0047 0.0047
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0029 0.0029
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0071 0.0068
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0026 0.0019 0.0051
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.0019 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0037 0.0057 0.0248
Leishmania major hypothetical protein, conserved 0.0026 0.0019 0.0071
Trichomonas vaginalis hypothetical protein 0.0026 0.0018 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.000765287 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0071 0.033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0157 0.0157
Schistosoma mansoni microtubule-associated protein tau 0.1367 0.4472 0.4472
Brugia malayi Steroid receptor seven-up type 2 0.000765287 1 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0037 0.0057 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0132 0.1298
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0037 0.0057 0.0857
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.0068
Plasmodium vivax acyl-CoA synthetase, putative 0.0095 0.0249 0.2731
Schistosoma mansoni ran 0.0042 0.0071 0.0071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0128 0.0356 0.2043
Echinococcus granulosus neutral alpha glucosidase AB 0.0072 0.017 0.0167
Loa Loa (eye worm) hypothetical protein 0.0039 0.0061 0.0282
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0026 0.0019 0.0016
Chlamydia trachomatis thioredoxin reductase 0.0026 0.0019 0.0743
Brugia malayi Myosin head containing protein 0.0032 0.0038 0.0159
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0059 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.0354 0.0354
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.026 0.2743
Echinococcus multilocularis chromobox protein 1 0.0069 0.0161 0.0158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0029 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.000765287 1 1
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.006 0.0582
Leishmania major cathepsin L-like protease 0.0063 0.0142 0.1408
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0029 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0029 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0153
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.006 0.0582
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.0943 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0085 0.032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0029 0.0026
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0417 0.0417
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0122 0.2338
Onchocerca volvulus Protein ultraspiracle homolog 0.000765287 1 1
Schistosoma mansoni hypothetical protein 0.0216 0.065 0.065
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0059 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0019 0.0137
Loa Loa (eye worm) oxidoreductase 0.0037 0.0057 0.0263
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0161 0.075
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0099 0.026 0.1955
Brugia malayi Endoplasmin precursor 0.0039 0.006 0.0264
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.032 0.0317
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0016
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0122 0.055
Echinococcus multilocularis heat shock protein 0.0039 0.006 0.0057
Schistosoma mansoni lozenge 0.0055 0.0116 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.006 0.013 0.0504
Leishmania major heat shock protein 83-1 0.0039 0.006 0.052
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.0019 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0093 0.0351
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0013 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0047 0.0395
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0292 0.0288
Brugia malayi steroid hormone receptor 0.0029 0.0029 0.012
Loa Loa (eye worm) hypothetical protein 0.0128 0.0356 0.1653
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0122 0.1189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.000765287 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.000765287 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0099 0.026 0.2855
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.0019 0.0137
Brugia malayi glutamate synthase 0.0026 0.0019 0.0073
Brugia malayi Patched family protein 0.0032 0.0038 0.0159
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0057 0.0163
Echinococcus granulosus dual specificity 0.0087 0.0222 0.0219
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0085 0.032
Onchocerca volvulus 0.0041 0.007 0.0259
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0122 0.0337 0.1563
Schistosoma mansoni glutamate synthase 0.0026 0.0019 0.0019
Brugia malayi Patched protein homolog 1 0.0032 0.0038 0.0159
Mycobacterium ulcerans acyl-CoA synthetase 0.0128 0.0356 0.7688
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0128 0.0356 0.1459
Onchocerca volvulus Huntingtin homolog 0.0122 0.0337 0.1348
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0013 0.0013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.005 0.0047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.000765287 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.0057 0.0857
Onchocerca volvulus 0.0029 0.0029 0.0095
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0021 0.0059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.017 0.0916
Plasmodium vivax thioredoxin reductase, putative 0.0284 0.0876 1
Trypanosoma brucei glucosidase, putative 0.0072 0.017 0.1775
Loa Loa (eye worm) hypothetical protein 0.0522 0.1667 0.7746
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.2173
Brugia malayi Bromodomain containing protein 0.0086 0.0219 0.1002
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0026 0.0019 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.000765287 1 1
Echinococcus multilocularis nardilysin 0.0024 0.0013 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0232 0.092
Brugia malayi Patched related family protein 4 0.0032 0.0038 0.0159
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0189 0.1405
Onchocerca volvulus 0.0213 0.0639 0.2584
Echinococcus granulosus cpg binding protein 0.0227 0.0686 0.0683
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0029 0.0026
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0089
Echinococcus granulosus tar DNA binding protein 0.0131 0.0368 0.0365
Schistosoma mansoni hypothetical protein 0.0606 0.1943 0.1943
Brugia malayi Nuclear hormone receptor family member nhr-3 0.000765287 1 1
Brugia malayi Bromodomain containing protein 0.0038 0.0058 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0029 0.0135
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0113 0.0308 0.0305
Onchocerca volvulus 0.0032 0.0038 0.0129
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0404 0.4309
Loa Loa (eye worm) hypothetical protein 0.0082 0.0206 0.0955
Loa Loa (eye worm) steroid hormone receptor 0.000765287 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0029 0.012

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.013 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasitemia after 72 hrs by spectrophotometry ChEMBL. 21910466
EC50 (ADMET) = 2.21 uM Cytotoxicity against human HepG2 cells assessed as intracellular ATP level after 72 hrs by Celltiter-Glo luminescent assay ChEMBL. 21910466
Ratio EC50 (functional) = 1.8 Ratio of EC50 for chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes to EC50 for chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes ChEMBL. 21910466

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21910466
Homo sapiens ChEMBL23 21910466

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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