Detailed information for compound 1141437

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 705.845 | Formula: C33H55N9O8
  • H donors: 10 H acceptors: 8 LogP: -1.91 Rotable bonds: 28
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCNC(=N)N)C)CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)N)CC(C)C
  • InChi: 1S/C33H55N9O8/c1-18(2)14-24(29(46)38-20(5)27(44)39-23(32(49)50)12-9-13-37-33(35)36)41-31(48)26(17-43)42-30(47)25(15-19(3)4)40-28(45)22(34)16-21-10-7-6-8-11-21/h6-8,10-11,18-20,22-26,43H,9,12-17,34H2,1-5H3,(H,38,46)(H,39,44)(H,40,45)(H,41,48)(H,42,47)(H,49,50)(H4,35,36,37)/t20-,22-,23-,24-,25-,26-/m0/s1
  • InChiKey: PYIDEVILQSTEEX-YNAZAZDCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens complement component 3a receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta LACTamase domain containing family member 0.0372 0.0688 0.1115
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0007 0.0007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0096 0.0246
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0017 0.0025
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0266 0.0484 0.1326
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0014 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0337 0.0632
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0017 0.0068
Giardia lamblia DINP protein human, muc B family 0.0196 0.0349 0.6403
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0372 0.0688 0.1117
Plasmodium falciparum DNA repair protein REV1, putative 0.0061 0.009 0.3734
Onchocerca volvulus 0.1861 0.3548 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0337 0.0632
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0014 0.0017
Loa Loa (eye worm) thioredoxin reductase 0.0134 0.0231 0.0373
Schistosoma mansoni hypothetical protein 0.0312 0.0572 0.1077
Trypanosoma cruzi hypothetical protein, conserved 0.0714 0.1345 0.3724
Echinococcus granulosus dna polymerase kappa 0.0196 0.0349 0.0563
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0037 0.0079
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0052
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0077 0.0071
Mycobacterium tuberculosis Possible penicillin-binding protein 0.238 0.4543 0.4543
Onchocerca volvulus 0.0372 0.0688 0.1924
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0037 0.0058
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.001
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0007 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Loa Loa (eye worm) TAR-binding protein 0.0189 0.0337 0.0546
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0046 0.0062 0.0151
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0372 0.0688 0.0687
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0037 0.0083
Toxoplasma gondii peptidase family M13 protein 0.0114 0.0192 0.1429
Brugia malayi glutathione reductase 0.0134 0.0231 0.037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0008 0.0046
Brugia malayi Glycosyl hydrolases family 31 protein 0.3218 0.6154 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0041 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0196 0.0349 0.0949
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0007 0.0007
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0714 0.1345 0.3512
Loa Loa (eye worm) hypothetical protein 0.0266 0.0484 0.0785
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.0471 0.0764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0153 0.0237
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0007 0.001
Mycobacterium tuberculosis Probable lipase LipE 0.0372 0.0688 0.0687
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0029 0.0059
Loa Loa (eye worm) hypothetical protein 0.0086 0.0139 0.0224
Toxoplasma gondii hypothetical protein 0.0028 0.0028 0.0206
Plasmodium falciparum glutathione reductase 0.0046 0.0062 0.2518
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0317 0.0813
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0266 0.0484 0.356
Mycobacterium tuberculosis Conserved protein 0.0372 0.0688 0.0687
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0196 0.0349 0.0563
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0017 0.0011
Onchocerca volvulus Fatty acid synthase homolog 0.0047 0.0063 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0372 0.0688 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0192 0.0311
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0132 0.2313
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0688 0.1895
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0028 0.0366
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0058 0.0084 0.0153
Echinococcus multilocularis expressed protein 0.0066 0.0099 0.0153
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0306 0.0561 0.0555
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0007 0.0007
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Loa Loa (eye worm) hypothetical protein 0.0083 0.0132 0.0212
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0026 0.002
Echinococcus multilocularis pyruvate kinase 0.0033 0.0037 0.0054
Brugia malayi Thioredoxin reductase 0.0134 0.0231 0.037
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0014 0.0017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0134 0.0231 0.0229
Mycobacterium tuberculosis Conserved protein 0.0372 0.0688 0.0687
Trichomonas vaginalis esterase, putative 0.0372 0.0688 0.1788
Plasmodium falciparum glutathione reductase 0.0134 0.0231 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0714 0.1345 1
Onchocerca volvulus 0.0052 0.0073 0.0185
Mycobacterium ulcerans hypothetical protein 0.0372 0.0688 0.0683
Giardia lamblia NADH oxidase lateral transfer candidate 0.0046 0.0062 0.1057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0062 0.0151
Brugia malayi RNA binding protein 0.0189 0.0337 0.0543
Echinococcus multilocularis muscleblind protein 0.0154 0.0268 0.0421
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.011
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0132 0.0126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0372 0.0688 0.0687
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0153 0.0244
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0023 0.0033
Toxoplasma gondii NADPH-glutathione reductase 0.0046 0.0062 0.0464
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0007 0.0007
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0046 0.0062 0.4482
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0372 0.0688 0.0687
Schistosoma mansoni neprilysin 0.003 0.003 0.0052
Brugia malayi Importin beta-1 subunit 0.0029 0.0029 0.0043
Trypanosoma cruzi DNA polymerase eta, putative 0.0216 0.0389 0.106
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0099 0.024
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0029 0.0217
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3304 0.6319 1
Trypanosoma brucei unspecified product 0.0196 0.0349 0.0949
Onchocerca volvulus 0.0023 0.0017 0.0028
Loa Loa (eye worm) RNA binding protein 0.0189 0.0337 0.0546
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0046 0.0062 0.2518
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0011 0.0009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0306 0.0561 0.0559
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0114 0.0192 0.0191
Echinococcus multilocularis beta LACTamase domain containing family member 0.0372 0.0688 0.1086
Mycobacterium ulcerans beta-lactamase 0.0372 0.0688 0.0683
Mycobacterium tuberculosis Probable lipase LipD 0.0372 0.0688 0.0687
Onchocerca volvulus 0.0372 0.0688 0.1924
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0007 0.0008
Brugia malayi hypothetical protein 0.0035 0.0041 0.0062
Leishmania major pyruvate kinase 0.0033 0.0037 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.1217
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0007 0.0007
Plasmodium falciparum importin beta, putative 0.0029 0.0029 0.1047
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1887 0.3597 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0265 0.0483 0.1322
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.003 0.003 0.0052
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0265 0.0483 0.1322
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0372 0.0688 0.1115
Schistosoma mansoni hypothetical protein 0.2451 0.468 0.884
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0037 0.0055
Schistosoma mansoni hypothetical protein 0.2451 0.468 0.884
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Echinococcus granulosus lysosomal alpha glucosidase 0.3218 0.6154 1
Brugia malayi beta-lactamase family protein 0.0372 0.0688 0.1115
Trypanosoma brucei DNA polymerase IV, putative 0.0196 0.0349 0.0949
Trichomonas vaginalis alpha-glucosidase, putative 0.0714 0.1345 0.3512
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0132 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0153 0.0283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Schistosoma mansoni eyes absent homolog 0.0089 0.0145 0.0268
Mycobacterium tuberculosis Transcriptional regulatory protein (probably AraC-family) 0.0148 0.0257 0.0256
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0066 0.0099 0.0157
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0148 0.0257 0.0256
Mycobacterium ulcerans hypothetical protein 0.0023 0.0017 0.0011
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.5221 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0323 0.0594 0.1633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Trichomonas vaginalis ran, putative 0.0022 0.0014 0.0016
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0132 0.0978
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0148 0.0257 0.0256
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0572 0.0929
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0007 0.0007
Echinococcus granulosus dna polymerase eta 0.0351 0.0648 0.1048
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0893 0.1688 0.4681
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0037 0.0075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0041 0.006
Loa Loa (eye worm) hypothetical protein 0.0089 0.0145 0.0234
Schistosoma mansoni dep domain containing protein 0.0018 0.0007 0.0008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0008 0.0009
Mycobacterium ulcerans AraC/XylS family transcriptional regulator 0.0148 0.0257 0.0251
Trypanosoma cruzi DNA damage repair protein, putative 0.0061 0.009 0.0227
Schistosoma mansoni DNA polymerase eta 0.0351 0.0648 0.1219
Schistosoma mansoni ran 0.0022 0.0014 0.0022
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0037 0.0272
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0542 0.3991
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0077 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Toxoplasma gondii ABC1 family protein 0.0372 0.0688 0.512
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0317 0.0813
Plasmodium falciparum thioredoxin reductase 0.0134 0.0231 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0196 0.0349 0.0895
Onchocerca volvulus 0.0031 0.0033 0.0071
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0052
Leishmania major trypanothione reductase 0.0134 0.0231 0.062
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0046 0.0062 0.083
Mycobacterium ulcerans hypothetical protein 0.0994 0.1882 0.1877
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.034 0.0626 0.0625
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0005
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0017 0.0069
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0037 0.0075
Echinococcus granulosus neutral alpha glucosidase AB 0.0714 0.1345 0.2181
Mycobacterium ulcerans DNA polymerase IV 0.0196 0.0349 0.0343
Leishmania major mitochondrial DNA polymerase beta 0.1887 0.3597 1
Echinococcus multilocularis snurportin 1 0.0312 0.0572 0.0902
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0023 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.0196 0.0349 0.0563
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.0688 0.1895
Loa Loa (eye worm) hypothetical protein 0.0086 0.0139 0.0224
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0046 0.0062 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0017 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.009 0.0227
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0046 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0027
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0023 0.0017
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0062 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.03 0.0767
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0023 0.0021
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0062 0.4391
Mycobacterium ulcerans thioesterase 0.0022 0.0014 0.0009
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0135 0.0218
Brugia malayi Glycosyl hydrolases family 31 protein 0.0714 0.1345 0.2181
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0067 0.0105
Mycobacterium leprae Probable lipase LipE 0.0372 0.0688 0.0683
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0014 0.0013
Schistosoma mansoni pyruvate kinase 0.0017 0.0006 0.0006
Loa Loa (eye worm) glutaminase 0.1999 0.3813 0.6196
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0084 0.0153
Leishmania major DNA polymerase kappa, putative 0.0061 0.009 0.0227
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0005 0.004
Mycobacterium tuberculosis Conserved protein 0.0372 0.0688 0.0687
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0037 0.0079
Schistosoma mansoni neprilysin-2 (M13 family) 0.0058 0.0084 0.0153
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0022 0.0106
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0011 0.0085
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0046 0.0062 0.0097
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0023 0.0021
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0047 0.0046
Schistosoma mansoni hypothetical protein 0.0035 0.0041 0.0072
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.5221 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0372 0.0688 0.0687
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0052
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0306 0.0561 0.0559
Mycobacterium ulcerans polyketide synthase 0.0027 0.0026 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0153 0.0283
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0026 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0372 0.0688 0.1788
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0058
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0006 0.0042
Brugia malayi beta-lactamase family protein 0.0372 0.0688 0.1115
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0196 0.0349 0.0347
Mycobacterium tuberculosis Probable reductase 0.0306 0.0561 0.0559
Schistosoma mansoni dishevelled 0.0018 0.0007 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0337 0.0632
Loa Loa (eye worm) hypothetical protein 0.0361 0.0667 0.1083
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0017 0.0011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0019
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.0337 0.0543
Mycobacterium tuberculosis Probable oxidoreductase 0.034 0.0626 0.0625
Brugia malayi Peptidase family M13 containing protein 0.0114 0.0192 0.0308
Entamoeba histolytica hypothetical protein 0.0035 0.0041 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0372 0.0688 0.1788
Brugia malayi DIX domain containing protein 0.0018 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0037 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0039 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0153 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Echinococcus granulosus endothelin converting enzyme 1 0.0114 0.0192 0.0308
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0372 0.0688 0.1117
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0084 0.0153
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0062 0.4391
Treponema pallidum NADH oxidase 0.0046 0.0062 0.1016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0017 0.0011
Schistosoma mansoni alpha-glucosidase 0.277 0.5293 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0017 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0046 0.0062 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0714 0.1345 0.3724
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0007 0.0007
Schistosoma mansoni glutaminase 0.1999 0.3813 0.7202
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.1217
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0026 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0351 0.0648 0.1048
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0011 0.0009
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0046 0.0062 0.0151
Trypanosoma brucei glycosyl hydrolase-like protein 0.0266 0.0484 0.1326
Mycobacterium ulcerans transcriptional regulatory protein 0.0148 0.0257 0.0251
Toxoplasma gondii exonuclease III APE 0.0018 0.0008 0.0061
Loa Loa (eye worm) hypothetical protein 0.0372 0.0688 0.1117
Mycobacterium ulcerans glutaminase 0.1999 0.3813 0.381
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0019 0.0027
Echinococcus multilocularis geminin 0.2451 0.468 0.7405
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Trypanosoma brucei DNA damage repair protein, putative 0.0061 0.009 0.0227
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0041 0.0072
Plasmodium falciparum pyruvate kinase 0.0033 0.0037 0.1374
Schistosoma mansoni dishevelled 0.0018 0.0007 0.0008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0266 0.0484 0.125
Trypanosoma brucei unspecified product 0.0135 0.0232 0.0624
Plasmodium vivax glutathione reductase, putative 0.0134 0.0231 0.3295
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0027
Trypanosoma brucei chrX additional, unordered contigs 0.0061 0.009 0.0227
Echinococcus multilocularis pyruvate kinase 0.0026 0.0023 0.0032
Echinococcus granulosus muscleblind protein 0.0154 0.0268 0.0432
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0066 0.0099 0.016
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0061 0.009 0.0667
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0135 0.0218
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0372 0.0688 0.1788
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0251 0.0249
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0017 0.0011
Echinococcus granulosus snurportin 1 0.0312 0.0572 0.0926
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0096 0.0246
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0046 0.0062 0.083
Loa Loa (eye worm) hypothetical protein 0.0084 0.0135 0.0218
Schistosoma mansoni DNA polymerase IV / kappa 0.0061 0.009 0.0164
Loa Loa (eye worm) zinc metallopeptidase 4 0.0028 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.0061 0.009 0.0144
Trypanosoma brucei glucosidase, putative 0.0714 0.1345 0.3724
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.03 0.0767
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0014 0.0107
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0196 0.0349 0.0565
Trichomonas vaginalis maltase-glucoamylase, putative 0.0714 0.1345 0.3512
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0132 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0028 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0008 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0033 0.0048
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0026 0.0025
Entamoeba histolytica deoxycytidyl transferase, putative 0.0196 0.0349 0.2549
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.034 0.0626 0.0621
Trichomonas vaginalis alpha-glucosidase, putative 0.0266 0.0484 0.125
Mycobacterium tuberculosis Transcriptional regulatory protein (probably AraC/XylS-family) 0.0148 0.0257 0.0256
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0067 0.0104
Loa Loa (eye worm) hypothetical protein 0.0033 0.0037 0.0059
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0337 0.0632
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0006 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0372 0.0688 0.0683
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0017 0.0025
Toxoplasma gondii peptidylprolyl isomerase 0.0064 0.0096 0.0716
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0026 0.0025
Loa Loa (eye worm) beta-lactamase 0.0372 0.0688 0.1117
Trypanosoma brucei hypothetical protein, conserved 0.0372 0.0688 0.1895
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0028 0.0026 0.0045
Loa Loa (eye worm) hypothetical protein 0.0086 0.0139 0.0224
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0061 0.009 0.0667
Schistosoma mansoni hypothetical protein 0.0033 0.0037 0.0065
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0251 0.0245
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0046 0.0062 0.2518
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0029 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0372 0.0688 0.1296
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0062 0.0151
Schistosoma mansoni alpha-glucosidase 0.277 0.5293 1
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0022 0.0034
Mycobacterium ulcerans polyketide synthase 0.0026 0.0023 0.0017
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.0471 0.0762
Mycobacterium ulcerans zinc metalloprotease 0.0114 0.0192 0.0186
Trypanosoma cruzi DNA damage repair protein, putative 0.0061 0.009 0.0227
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0714 0.1345 1
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.009 0.0227
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0013 0.0007
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0014 0.0019
Mycobacterium ulcerans hypothetical protein 0.0061 0.009 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0266 0.0484 0.125
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0077 0.0121
Mycobacterium ulcerans Ada regulatory protein AlkA 0.0148 0.0257 0.0251
Trypanosoma brucei DNA polymerase IV, putative 0.0196 0.0349 0.0949
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0008
Brugia malayi hypothetical protein 0.0018 0.0007 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0014 0.0017
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.1217
Entamoeba histolytica hypothetical protein 0.0024 0.0019 0.0078
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0026 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0017 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0372 0.0688 0.1117
Echinococcus granulosus importin subunit beta 1 0.0029 0.0029 0.0043
Chlamydia trachomatis pyruvate kinase 0.0033 0.0037 0.2431
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0028 0.0206
Trichomonas vaginalis glutaminase, putative 0.1999 0.3813 1
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0052
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.0021 0.002
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0046 0.0062 0.0056
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0064 0.0096 0.0246
Trichomonas vaginalis alpha-glucosidase, putative 0.0714 0.1345 0.3512
Trichomonas vaginalis alpha-glucosidase, putative 0.0266 0.0484 0.125
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0251 0.0245
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0077 0.0076
Echinococcus multilocularis neutral alpha glucosidase AB 0.0714 0.1345 0.2125
Trichomonas vaginalis glutathione reductase, putative 0.0046 0.0062 0.0142
Trichomonas vaginalis rotamase, putative 0.0066 0.0099 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0003
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0361 0.0667 0.1864
Schistosoma mansoni endothelin-converting enzyme-related 0.0028 0.0026 0.0045
Entamoeba histolytica hypothetical protein 0.0035 0.0041 0.0244
Trypanosoma brucei unspecified product 0.0135 0.0232 0.0624
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0052
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0196 0.0349 0.0654
Trichomonas vaginalis alpha-glucosidase, putative 0.0266 0.0484 0.125
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0008
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0026 0.0045
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0062 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.1217
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0003 0.0003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0031 0.0033 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0232 0.0624
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0037 0.0035
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0037 0.0453
Leishmania major DNA polymerase eta, putative 0.0216 0.0389 0.106
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0046 0.0062 0.0094
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0893 0.1688 0.4681
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0153 0.0247
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0037 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0714 0.1345 0.3512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0008 0.0002
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0023 0.0017
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0026 0.0045
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0.0011 0.0268
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0036
Echinococcus multilocularis lysosomal alpha glucosidase 0.3218 0.6154 0.974
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0023 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0067 0.0104
Schistosoma mansoni terminal deoxycytidyl transferase 0.0196 0.0349 0.0654
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.1217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Leishmania major pyruvate kinase 0.0033 0.0037 0.0079
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0037 0.0058
Loa Loa (eye worm) hypothetical protein 0.0372 0.0688 0.1117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Loa Loa (eye worm) hypothetical protein 0.0056 0.0082 0.0131
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.0542 1
Schistosoma mansoni alpha glucosidase 0.0714 0.1345 0.2536
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0714 0.1345 0.3512
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0306 0.0561 0.0559
Loa Loa (eye worm) hypothetical protein 0.0351 0.0648 0.1051
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0268 0.0421
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0064 0.0096 0.066
Mycobacterium tuberculosis Probable hydrolase 0.0372 0.0688 0.0687
Echinococcus multilocularis endothelin converting enzyme 1 0.0114 0.0192 0.03
Trypanosoma brucei DNA damage repair protein, putative 0.0061 0.009 0.0227
Loa Loa (eye worm) hypothetical protein 0.0114 0.0192 0.0311
Giardia lamblia DNA damage repair protein 0.0061 0.009 0.1568
Loa Loa (eye worm) hypothetical protein 0.0086 0.0139 0.0224
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0893 0.1688 0.4681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0306 0.0561 0.0559
Leishmania major GTP-binding protein, putative 0.0022 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0372 0.0688 0.1788
Trypanosoma brucei DNA polymerase eta, putative 0.0351 0.0648 0.1782
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0132 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.001
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0037 0.0031
Entamoeba histolytica hypothetical protein 0.0035 0.0041 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0153 0.0237
Trichomonas vaginalis maltase-glucoamylase, putative 0.0266 0.0484 0.125
Trypanosoma cruzi trypanothione reductase, putative 0.0134 0.0231 0.062
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.03 0.0767
Loa Loa (eye worm) hypothetical protein 0.0044 0.0058 0.0093
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0046 0.0062 0.0464
Leishmania major DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Mycobacterium tuberculosis Conserved hypothetical protein 0.0994 0.1882 0.1881
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0008 0.0063
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0013 0.0007
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0014 0.0128
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0132 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0132 0.0978
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0062 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.03 0.0767
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Echinococcus multilocularis dna polymerase kappa 0.0196 0.0349 0.0548
Echinococcus multilocularis dna polymerase eta 0.0351 0.0648 0.1021
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0037 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0046
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0037 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0232 0.0624
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0077 0.0117
Brugia malayi glutaminase DH11.1 0.1999 0.3813 0.6195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.0027
Plasmodium vivax importin-beta 2, putative 0.0029 0.0029 0.0345
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0017 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0046 0.0062 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0037 0.0056
Schistosoma mansoni pyruvate kinase 0.0033 0.0037 0.0064
Plasmodium falciparum thioredoxin reductase 0.0046 0.0062 0.2518
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0013 0.0007
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0007 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Loa Loa (eye worm) glutaminase 2 0.1999 0.3813 0.6196
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.0337 0.0546
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0153 0.0244
Echinococcus granulosus thioredoxin glutathione reductase 0.0135 0.0232 0.0372
Echinococcus multilocularis pyruvate kinase 0.0033 0.0037 0.0054
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0037 0.0083
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0216 0.0389 0.289
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0084 0.0135 0.0218
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0028 0.0978
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0089 0.0145 0.0234
Loa Loa (eye worm) hypothetical protein 0.0372 0.0688 0.1117
Brugia malayi peptidase family M13 containing protein 0.0028 0.0026 0.0038
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0132 0.5595
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0037 0.0083
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0196 0.0349 0.0548
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0037 0.0031
Schistosoma mansoni hypothetical protein 0.003 0.003 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0017 0.0024
Brugia malayi hypothetical protein 0.0089 0.0145 0.0231
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0007 0.001
Leishmania major DNA polymerase eta, putative 0.0351 0.0648 0.1782
Echinococcus granulosus geminin 0.2451 0.468 0.7603
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.0542 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0046 0.0062 0.0151
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0005
Echinococcus granulosus pyruvate kinase 0.0033 0.0037 0.0055
Leishmania major alpha glucosidase II subunit, putative 0.0714 0.1345 0.3724
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0132 0.0126
Schistosoma mansoni ran 0.0022 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0086 0.0139 0.0224
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0064 0.0096 0.0246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Loa Loa (eye worm) hypothetical protein 0.0154 0.0268 0.0435
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1887 0.3597 1
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0028 0.0026 0.0045
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0114 0.0192 0.0358
Leishmania major glycosyl hydrolase-like protein 0.0266 0.0484 0.1326
Echinococcus multilocularis thioredoxin glutathione reductase 0.0135 0.0232 0.0362
Schistosoma mansoni rotamase 0.0066 0.0099 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0337 0.0632
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0062 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0017 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0266 0.0484 0.125
Schistosoma mansoni importin beta-1 0.0029 0.0029 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Mycobacterium ulcerans transcriptional regulatory protein 0.0148 0.0257 0.0251
Loa Loa (eye worm) hypothetical protein 0.0084 0.0135 0.0218
Schistosoma mansoni pyruvate kinase 0.0033 0.0037 0.0064
Onchocerca volvulus 0.0056 0.0082 0.021
Echinococcus multilocularis tar DNA binding protein 0.0189 0.0337 0.0529
Leishmania major hypothetical protein, conserved 0.0372 0.0688 0.1895
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0014 0.0018
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0047 0.0046
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0023 0.0017
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0031 0.0033 0.0031
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0026 0.002
Brugia malayi beta-lactamase 0.0372 0.0688 0.1115
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0047 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0067 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0132 1
Brugia malayi N-terminal motif family protein 0.0361 0.0667 0.108
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0232 0.0624
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0047 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.009 0.0227
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0011 0.0009
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0372 0.0688 0.1788
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.0021 0.002
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.3218 0.6154 1
Plasmodium vivax DNA repair protein REV1, putative 0.0061 0.009 0.123
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0266 0.0484 0.1326
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0266 0.0484 0.1346
Echinococcus granulosus expressed protein 0.0066 0.0099 0.0157
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0026 0.002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0132 0.1843
Giardia lamblia Pyruvate kinase 0.0033 0.0037 0.0577
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0132 0.0243
Mycobacterium ulcerans DNA polymerase IV 0.0196 0.0349 0.0343
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0046 0.0062 0.0151
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0266 0.0484 0.125
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0372 0.0688 0.1296
Loa Loa (eye worm) hypothetical protein 0.0372 0.0688 0.1117
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.03 0.0827
Trichomonas vaginalis alpha-glucosidase, putative 0.0714 0.1345 0.3512
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0058 0.0084 0.0153
Mycobacterium tuberculosis Virulence-regulating transcriptional regulator VirS (AraC/XylS family) 0.0148 0.0257 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.03 0.0767
Loa Loa (eye worm) glutathione reductase 0.0134 0.0231 0.0373
Loa Loa (eye worm) hypothetical protein 0.0114 0.0192 0.0311
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0005
Trichomonas vaginalis sucrase-isomaltase, putative 0.0714 0.1345 0.3512
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0017 0.0024
Entamoeba histolytica Ran family GTPase 0.0022 0.0014 0.0047
Leishmania major importin beta-1 subunit, putative 0.0024 0.0019 0.0029
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0114 0.0192 0.0308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0017 0.0016
Mycobacterium leprae probable zinc metalloprotease 0.0114 0.0192 0.0186
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0007 0.0007
Mycobacterium ulcerans lipase LipD 0.0372 0.0688 0.0683
Leishmania major DNA damage repair protein, putative 0.0061 0.009 0.0227
Loa Loa (eye worm) hypothetical protein 0.0086 0.0139 0.0224
Brugia malayi hypothetical protein 0.0018 0.0007 0.0007
Echinococcus multilocularis lysosomal alpha glucosidase 0.3218 0.6154 0.974
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0714 0.1345 0.2184
Toxoplasma gondii hypothetical protein 0.0018 0.0007 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0265 0.0483 0.1322
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0196 0.0349 0.0949
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0028 0.0322
Loa Loa (eye worm) hypothetical protein 0.0084 0.0135 0.0218
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0027
Trichomonas vaginalis mercuric reductase, putative 0.0046 0.0062 0.0142
Brugia malayi TAR-binding protein 0.0189 0.0337 0.0543
Mycobacterium leprae conserved hypothetical protein 0.0372 0.0688 0.0683
Toxoplasma gondii thioredoxin reductase 0.0134 0.0231 0.1715
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0029 0.0059
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0022
Toxoplasma gondii hypothetical protein 0.0304 0.0558 0.4147
Brugia malayi polk-prov protein 0.0061 0.009 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0471 0.1217
Echinococcus granulosus pyruvate kinase 0.0033 0.0037 0.0055
Plasmodium vivax thioredoxin reductase, putative 0.0134 0.0231 0.3295
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0349 0.0949
Trichomonas vaginalis DNA polymerase eta, putative 0.0196 0.0349 0.0895
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0007 0.0007
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0714 0.1345 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1887 0.3597 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0196 0.0349 0.0347
Entamoeba histolytica hypothetical protein 0.0035 0.0041 0.0244
Trypanosoma cruzi DNA polymerase eta, putative 0.0351 0.0648 0.1782
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.009 0.0227
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0017 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0266 0.0484 0.0782
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0006 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.009 0.0227
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0019 0.0029
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0017 0.0027
Echinococcus granulosus tar DNA binding protein 0.0189 0.0337 0.0543
Mycobacterium ulcerans esterase/lipase LipP 0.0372 0.0688 0.0683
Trichomonas vaginalis alpha-glucosidase, putative 0.0714 0.1345 0.3512
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.03 0.0767
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0011 0.0009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0046 0.0062 0.0097
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.034 0.0626 0.0625
Mycobacterium tuberculosis Probable dehydrogenase 0.0306 0.0561 0.0559
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.03 0.0767
Brugia malayi RNA, U transporter 1 0.0083 0.0133 0.0211
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0265 0.0483 0.1322
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0009 0.0007
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0014 0.0009
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0014 0.0009
Trypanosoma brucei trypanothione reductase 0.0134 0.0231 0.062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.0027
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0014 0.0388
Brugia malayi Probable ClpP-like protease 0.0083 0.0132 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.009 0.0227
Brugia malayi Muscleblind-like protein 0.0154 0.0268 0.0432
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0067 0.0107
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0542 0.1402
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0039 0.0058
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0542 0.3991
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0008 0.0012
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0132 0.0209
Onchocerca volvulus 0.0372 0.0688 0.1924
Loa Loa (eye worm) hypothetical protein 0.0154 0.0268 0.0435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0153 0.0283
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0008 0.0009
Trichomonas vaginalis rotamase, putative 0.0064 0.0096 0.0232

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 6.45 Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release ChEMBL. 20527893
EC50 (functional) = 0.36 uM Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release ChEMBL. 20527893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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