Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin D | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | cathepsin D | 412 aa | 339 aa | 28.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0641 | 0.3598 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1677 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0641 | 0.3598 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1677 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1677 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0103 | 0.0273 | 0.0273 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0641 | 0.3598 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0641 | 0.3598 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0103 | 0.0273 | 0.0273 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0103 | 0.0273 | 0.0273 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0513 | 0.2805 | 0.2805 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1677 | 1 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.071 | 0.071 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.071 | 0.071 |
Schistosoma mansoni | dihydrofolate reductase | 0.1677 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1677 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1677 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1677 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0641 | 0.3598 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0641 | 0.3598 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0103 | 0.0273 | 0.0273 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0513 | 0.2805 | 0.2805 |
Echinococcus granulosus | carbonic anhydrase II | 0.0103 | 0.0273 | 0.0273 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0103 | 0.0273 | 0.0273 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1677 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.69 uM | In vitro inhibition of cathepsin D. | ChEMBL. | No reference |
IC50 (binding) | = 3.69 uM | In vitro inhibition of cathepsin D. | ChEMBL. | No reference |
Inhibition (binding) | = 4.4 % | Compound was evaluated for the inhibition of leucine amino peptidase. | ChEMBL. | No reference |
Inhibition (binding) | = 4.4 % | Compound was evaluated for the inhibition of leucine amino peptidase. | ChEMBL. | No reference |
Inhibition (functional) | = 18.4 % | Evaluated for the inhibition of fluorescence quenching before the release of 7-amido-4-methylcourmarin (AMC). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.