Detailed information for compound 1141695

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.6 | Formula: C27H36N4O2
  • H donors: 1 H acceptors: 1 LogP: 4.55 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1oc(c(n1)c1ccccc1)CNCCCN1CCN(CC1)c1ccc(cc1)OC
  • InChi: 1S/C27H36N4O2/c1-3-8-26-29-27(22-9-5-4-6-10-22)25(33-26)21-28-15-7-16-30-17-19-31(20-18-30)23-11-13-24(32-2)14-12-23/h4-6,9-14,28H,3,7-8,15-21H2,1-2H3
  • InChiKey: VBSCODBERNHXCI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 0.0305 0.6195 0.8769
Onchocerca volvulus 0.0026 0.026 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0517 0.059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0158 0.0181
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0258 0.0053
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.7053 0.8061
Brugia malayi Bromodomain containing protein 0.008 0.1402 0.1602
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0517 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0583 0.0903
Brugia malayi 6-phosphofructokinase 0.0106 0.196 0.224
Schistosoma mansoni hypothetical protein 0.0038 0.0516 0.067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0516 0.0616
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.5979 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0517 0.059
Brugia malayi steroid hormone receptor 0.0022 0.0158 0.0181
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0517 0.0617
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Echinococcus granulosus histone lysine methyltransferase setb 0.0079 0.1385 0.1863
Loa Loa (eye worm) hypothetical protein 0.0181 0.3547 0.4054
Trichomonas vaginalis glutaminase, putative 0.0306 0.623 0.615
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0502 0.0596
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0502 0.0596
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.031 0.131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0998 0.1357
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0829 0.1065
Brugia malayi Pre-SET motif family protein 0.0061 0.0998 0.114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0207 0.0269
Onchocerca volvulus Alhambra homolog 0.0028 0.0306 0.015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0306 0.037
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0691 0.079
Schistosoma mansoni bromodomain containing protein 0.0067 0.1136 0.1554
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.031 0.0106
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.196 0.273
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.1054 0.1389
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0158 0.0159
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0258 0.0053
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0181 0.3547 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0691 0.0868
Toxoplasma gondii hypothetical protein 0.0048 0.0712 0.6394
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2672 0.4424
Echinococcus multilocularis thyroid hormone receptor alpha 0.0156 0.3015 0.4204
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0691 0.0868
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0962 0.1306
Brugia malayi beta-lactamase family protein 0.0038 0.0517 0.059
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0478 0.3435
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1277 0.1756
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0158 0.0103
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0306 0.1254
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0158 0.0159
Echinococcus multilocularis zinc finger protein 0.0021 0.0144 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0998 0.1357
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0517 0.0317
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.196 0.3224
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0502 0.0768
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0158 0.0103
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0207 0.0236
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.875 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0517 0.0317
Brugia malayi mbt repeat family protein 0.0047 0.0691 0.079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0517 0.059
Entamoeba histolytica hypothetical protein 0.0038 0.0516 0.0926
Plasmodium falciparum phd finger protein, putative 0.0028 0.0306 0.5455
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0502 0.0574
Loa Loa (eye worm) hypothetical protein 0.0038 0.0517 0.059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0158 0.0181
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0829 0.1065
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.3007 0.5671
Trichomonas vaginalis esterase, putative 0.0038 0.0517 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0253 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.031 0.3506
Mycobacterium ulcerans lipase LipD 0.0038 0.0517 0.0025
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.031 0.131
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.3608 0.5055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0158 0.0181
Loa Loa (eye worm) hypothetical protein 0.0038 0.0517 0.059
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0691 0.0868
Echinococcus multilocularis lamin dm0 0.0026 0.026 0.0249
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.196 0.33
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0158 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0158 0.0181
Brugia malayi RNA, U transporter 1 0.0092 0.1658 0.1895
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0962 0.0803
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0388 0.2299
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0517 0.0317
Echinococcus multilocularis musashi 0.0026 0.026 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0477 0.0545
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0517 0.0671
Schistosoma mansoni hypothetical protein 0.0028 0.0306 0.037
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0158 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0776 0.1229
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0962 0.1257
Schistosoma mansoni thyroid hormone receptor 0.0156 0.3015 0.4237
Onchocerca volvulus 0.0047 0.0691 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0158 0.0181
Leishmania major importin beta-1 subunit, putative 0.0026 0.0258 0.0356
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.5979 1
Brugia malayi jmjC domain containing protein 0.0036 0.0477 0.0545
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0211 0.0179
Trichomonas vaginalis set domain proteins, putative 0.0483 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0829 0.1065
Echinococcus granulosus importin subunit beta 1 0.0032 0.0388 0.0433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0158 0.0181
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0087 0.0057
Loa Loa (eye worm) hypothetical protein 0.0305 0.6195 0.7081
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0207 0.0269
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0388 0.0433
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0962 0.0803
Echinococcus granulosus intermediate filament protein 0.0026 0.026 0.0249
Entamoeba histolytica hypothetical protein 0.0038 0.0516 0.0926
Loa Loa (eye worm) hypothetical protein 0.0047 0.0691 0.079
Brugia malayi PHD-finger family protein 0.0027 0.0265 0.0303
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0583 0.0903
Loa Loa (eye worm) intermediate filament protein 0.0026 0.026 0.0298
Loa Loa (eye worm) hypothetical protein 0.0032 0.0388 0.0444
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0158 0.0103
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0502 0.0574
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.196 0.179
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0502 0.0596
Mycobacterium ulcerans beta-lactamase 0.0038 0.0517 0.0025
Giardia lamblia PHD finger protein 15 0.0028 0.0306 0.3357
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.031 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.196 0.179
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.5979 1
Echinococcus granulosus snurportin 1 0.0345 0.7053 1
Brugia malayi nuclear hormone receptor 0.0022 0.0158 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0158 0.0181
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0517 0.0317
Leishmania major hypothetical protein, conserved 0.0038 0.0517 0.0792
Loa Loa (eye worm) hypothetical protein 0.0063 0.1032 0.1179
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.031 0.131
Onchocerca volvulus 0.0038 0.0517 0.0364
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0477 0.056
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0962 0.955
Brugia malayi Muscleblind-like protein 0.0305 0.6195 0.7081
Entamoeba histolytica hypothetical protein 0.0038 0.0516 0.0926
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0583 0.0903
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.196 0.5249
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0158 0.0103
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0158 0.0159
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.031 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0829 0.0947
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.196 0.224
Toxoplasma gondii ABC1 family protein 0.0038 0.0517 0.3919
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0158 0.0103
Loa Loa (eye worm) hypothetical protein 0.0038 0.0517 0.059
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.031 0.131
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.3608 0.5055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0158 0.0181
Brugia malayi phosphofructokinase 0.0106 0.196 0.224
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Entamoeba histolytica hypothetical protein 0.0038 0.0516 0.0926
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.1385 0.191
Loa Loa (eye worm) glutaminase 2 0.0306 0.623 0.712
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.1054 0.1389
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0158 0.0103
Plasmodium vivax importin-beta 2, putative 0.0032 0.0388 0.2299
Schistosoma mansoni zinc finger protein 0.0021 0.0144 0.0139
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0517 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Schistosoma mansoni hypothetical protein 0.0345 0.7053 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0478 0.0727
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.1032 0.1179
Trypanosoma brucei unspecified product 0.0026 0.0253 0.0348
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.031 0.5
Echinococcus granulosus dna polymerase eta 0.0063 0.1032 0.1357
Onchocerca volvulus 0.0061 0.0998 0.0853
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.031 0.031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0158 0.0181
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.2409 0.2753
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.196 0.2689
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.031 0.131
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0158 0.0103
Leishmania major GTP-binding protein, putative 0.0024 0.0207 0.0269
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0691 0.092
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0181 0.3547 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0306 0.0349
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0207 0.0236
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.196 0.273
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0517 0.0025
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0306 0.1254
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0158 0.0181
Echinococcus granulosus peregrin 0.0031 0.036 0.0392
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0211 0.0179
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.196 0.3224
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0517 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0158 0.0181
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0543 0.0655
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0079 0.1385 0.191
Onchocerca volvulus 0.0038 0.0517 0.0364
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0211 0.0235
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.1032 0.166
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0962 0.1041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0517 0.0671
Brugia malayi Importin beta-1 subunit 0.0032 0.0388 0.0444
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0134 0.2556 0.3545
Brugia malayi Bromodomain containing protein 0.0041 0.0569 0.065
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0388 0.0576
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0158 0.0181
Plasmodium vivax SET domain protein, putative 0.0061 0.0998 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.026 0.0298
Mycobacterium ulcerans hypothetical protein 0.0155 0.3007 0.4374
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0515 0.0615
Echinococcus granulosus lamin dm0 0.0026 0.026 0.0249
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0087 0.0057
Leishmania major DNA polymerase eta, putative 0.0063 0.1032 0.166
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0158 0.0159
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0388 0.0576
Brugia malayi beta-lactamase family protein 0.0038 0.0517 0.059
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.196 0.179
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0516 0.067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.4919 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0951 0.1087
Leishmania major DNA polymerase eta, putative 0.0037 0.0478 0.0727
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0207 0.0172
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0158 0.0181
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0158 0.0159
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0502 0.0768
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0502 0.0302
Schistosoma mansoni thyroid hormone receptor 0.0156 0.3015 0.4237
Brugia malayi Bromodomain containing protein 0.0031 0.036 0.0411
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0158 0.0103
Loa Loa (eye worm) beta-lactamase 0.0038 0.0517 0.059
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.031 0.0106
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.031 0.5697
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.031 0.5697
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.196 0.5249
Mycobacterium ulcerans hypothetical protein 0.0038 0.0517 0.0025
Brugia malayi mbt repeat family protein 0.0047 0.0691 0.079
Echinococcus granulosus muscleblind protein 0.0305 0.6195 0.8769
Echinococcus multilocularis snurportin 1 0.0345 0.7053 1
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0517 0.0792
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0517 0.0617
Brugia malayi MH2 domain containing protein 0.0127 0.2409 0.2753
Loa Loa (eye worm) glutaminase 0.0306 0.623 0.712
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0502 0.0768
Schistosoma mansoni intermediate filament proteins 0.0026 0.026 0.0305
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0158 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0158 0.0181
Mycobacterium tuberculosis Conserved protein 0.0038 0.0517 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0962 0.0803
Loa Loa (eye worm) phosphofructokinase 0.0106 0.196 0.224
Schistosoma mansoni coup transcription factor 0.0022 0.0158 0.0159
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0517 0.0033
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0433 0.0498
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0258 0.0356
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1685 0.2294
Echinococcus granulosus zinc finger protein 0.0021 0.0144 0.0082
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0134 0.2556 0.3545
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0306 0.0349
Loa Loa (eye worm) hypothetical protein 0.0305 0.6195 0.7081
Trypanosoma brucei unspecified product 0.0038 0.0502 0.0768
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0306 0.1254
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0253 0.0348
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0158 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0158 0.0103
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.026 0.0298
Brugia malayi jmjC domain containing protein 0.0093 0.1685 0.1926
Schistosoma mansoni DNA polymerase eta 0.0063 0.1032 0.1406
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.095 0.1239
Brugia malayi hypothetical protein 0.0038 0.0516 0.059
Loa Loa (eye worm) hypothetical protein 0.0026 0.026 0.0298
Loa Loa (eye worm) hypothetical protein 0.0043 0.0624 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0158 0.0181
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0477 0.0614
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0691 0.0542
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0502 0.065
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.196 1
Echinococcus granulosus lamin 0.0026 0.026 0.0249
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0158 0.0103
Brugia malayi beta-lactamase 0.0038 0.0517 0.059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0158 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Loa Loa (eye worm) hypothetical protein 0.0053 0.0829 0.0947
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0502 0.0885
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.031 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0253 0.0348
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0517 0.0033
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0207 0.0172
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0515 0.0615
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0517 0.0025
Schistosoma mansoni hypothetical protein 0.0134 0.2556 0.3582
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0691 0.092
Entamoeba histolytica hypothetical protein 0.0026 0.0258 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0517 0.0792
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0158 0.0181
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0158 0.0159
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2672 0.4424
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.196 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0517 0.0033
Loa Loa (eye worm) MBCTL1 0.0053 0.0829 0.0947
Brugia malayi ecdysteroid receptor 0.0022 0.0158 0.0181
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0829 0.1065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0158 0.0181
Brugia malayi Pre-SET motif family protein 0.0425 0.875 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.196 0.224
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0517 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0517 0.3919
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.1032 0.166
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0158 0.0103
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0158 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0158 0.0181
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0477 0.0614
Echinococcus multilocularis muscleblind protein 1 0.0305 0.6195 0.8769
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0158 0.0159
Schistosoma mansoni lamin 0.0026 0.026 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0158 0.0181
Loa Loa (eye worm) hypothetical protein 0.0075 0.1304 0.1491
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.196 0.179
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.196 0.2689
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0158 0.0181
Giardia lamblia DINP protein human, muc B family 0.0038 0.0502 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0583 0.0903
Echinococcus multilocularis peregrin 0.0031 0.036 0.0392
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.031 0.0106
Onchocerca volvulus 0.0038 0.0517 0.0364
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0158 0.0103
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0502 0.065
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0101 0.0115
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0502 0.0768
Onchocerca volvulus 0.0026 0.026 0.0104
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0158 0.0103
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0168 0.0192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0158 0.0181
Mycobacterium tuberculosis Conserved protein 0.0038 0.0517 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0158 0.0181
Schistosoma mansoni hypothetical protein 0.0283 0.5729 0.811
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.2672 0.4424
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1685 0.2294
Schistosoma mansoni ran 0.0024 0.0207 0.0228
Trypanosoma brucei unspecified product 0.0026 0.0253 0.0348
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0258 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.5979 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0739 0.0844
Brugia malayi intermediate filament protein 0.0026 0.026 0.0298
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0962 0.1257
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0517 0.0792
Schistosoma mansoni glutaminase 0.0306 0.623 0.8825
Loa Loa (eye worm) hypothetical protein 0.0045 0.0667 0.0763
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.031 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.031 0.0106
Brugia malayi glutaminase DH11.1 0.0306 0.623 0.712
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.196 0.5249
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0998 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1385 0.1583
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.196 0.3224
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.2409 0.2753
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0158 0.0159
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0158 0.0159
Plasmodium falciparum importin beta, putative 0.0032 0.0388 1
Echinococcus granulosus dna polymerase kappa 0.0038 0.0502 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0158 0.0181
Schistosoma mansoni lamin 0.0026 0.026 0.0305
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0517 0.059
Loa Loa (eye worm) hypothetical protein 0.0026 0.025 0.0286
Echinococcus granulosus jumonji domain containing protein 0.004 0.0543 0.0655
Loa Loa (eye worm) hypothetical protein 0.0038 0.0517 0.059
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0306 0.0315
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0998 0.1308
Mycobacterium ulcerans glutaminase 0.0306 0.623 1
Schistosoma mansoni hypothetical protein 0.0022 0.0168 0.0173
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0517 0.0033
Mycobacterium tuberculosis Conserved protein 0.0038 0.0517 0.0033
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0207 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Echinococcus multilocularis lamin 0.0026 0.026 0.0249
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0829 0.1116
Schistosoma mansoni importin beta-1 0.0032 0.0388 0.0488
Brugia malayi PHD-finger family protein 0.0028 0.0306 0.0349
Echinococcus multilocularis dna polymerase eta 0.0063 0.1032 0.1357
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0158 0.0103
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0691 0.092
Leishmania major DNA polymerase kappa, putative 0.0038 0.0502 0.0768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0962 0.1543
Brugia malayi nuclear receptor NHR-88 0.0022 0.0158 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.057 0.0652
Schistosoma mansoni ran 0.0024 0.0207 0.0228
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0962 0.1306
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0516 0.0616
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.196 0.2545
Brugia malayi 6-phosphofructokinase 0.0106 0.196 0.224
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0502 0.0302
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0691 0.0868
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0306 0.0315
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0079 0.1385 0.1863

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 42.13 % Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current at 10 uM by fluorescence based HTS FDSS6000 assay ChEMBL. 20621730

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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