Detailed information for compound 1141725

Basic information

Technical information
  • TDR Targets ID: 1141725
  • Name: [dichloro-(hexoxy-hydroxyphosphoryl)methyl]ph osphonic acid
  • MW: 329.052 | Formula: C7H16Cl2O6P2
  • H donors: 3 H acceptors: 5 LogP: 0.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCOP(=O)(C(P(=O)(O)O)(Cl)Cl)O
  • InChi: 1S/C7H16Cl2O6P2/c1-2-3-4-5-6-15-17(13,14)7(8,9)16(10,11)12/h2-6H2,1H3,(H,13,14)(H2,10,11,12)
  • InChiKey: IPURVIXSXJUNHF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [dichloro-(hexoxy-hydroxy-phosphoryl)methyl]phosphonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0105 0.0102
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Leishmania major DNA topoisomerase 1A 0.003 0.0012 0.0094
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0011 0.0033
Loa Loa (eye worm) RNA binding protein 0.0062 0.0054 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0037 0.0037
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0058 0.0058
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0006 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0039 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0075 0.0075
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0072 0.0067 0.0067
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0006 0.0003
Brugia malayi Inositol-1 0.0114 0.0123 0.012
Onchocerca volvulus 0.0025 0.0005 0.0012
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.003 0.0012 0.0035
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0029 0.0011 0.0034
Trypanosoma brucei cytochrome P450, putative 0.0065 0.0058 0.057
Giardia lamblia DNA topoisomerase III 0.003 0.0012 0.002
Schistosoma mansoni inositol monophosphatase 0.0114 0.0123 0.0123
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0011 0.0008
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0003 0.0003
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.0016 0.0016
Trypanosoma cruzi hypothetical protein 0.007 0.0064 0.064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0183 0.0183
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0039 0.0039
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0054 0.0054
Schistosoma mansoni mucolipin 0.0064 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0066
Brugia malayi MH2 domain containing protein 0.0265 0.0323 0.0319
Onchocerca volvulus 0.1283 0.1667 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0387 0.0483 0.048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0007
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0104 0.0509
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0011 0.0033
Brugia malayi GRF zinc finger family protein 0.003 0.0012 0.0009
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0003 0.0003
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1283 0.1667 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0069 0.0383
Brugia malayi ecdysone receptor 0.0026 0.0006 0.0003
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0051 0.0039 0.0039
Schistosoma mansoni DNA polymerase eta 0.0039 0.0024 0.0024
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0387 0.0483 0.5015
Brugia malayi Carboxylesterase family protein 0.1283 0.1667 0.1664
Echinococcus granulosus dnaJ subfamily B 0.0435 0.0547 0.0547
Brugia malayi Intermediate filament tail domain containing protein 0.0108 0.0115 0.0112
Entamoeba histolytica DNA topoisomerase II, putative 0.0559 0.071 0.3699
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0104 0.0509
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0019 0.0066
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0029 0.0011 0.0061
Onchocerca volvulus 0.1283 0.1667 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0013 0.001
Leishmania major cytochrome p450-like protein 0.0029 0.0011 0.0079
Brugia malayi RNA binding protein 0.0062 0.0054 0.0051
Trypanosoma brucei telomerase reverse transcriptase 0.009 0.0091 0.0918
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0011 0.0033
Brugia malayi Heterochromatin protein 1 0.0078 0.0075 0.0072
Schistosoma mansoni hypothetical protein 0.0055 0.0045 0.0045
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0054 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0011 0.0033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1475 0.192 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0004 0.0004
Brugia malayi hypothetical protein 0.0029 0.0011 0.0007
Brugia malayi nuclear hormone receptor 0.0055 0.0045 0.0041
Echinococcus granulosus tar DNA binding protein 0.0062 0.0054 0.0054
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.01 0.0105 0.0102
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.0031 0.0013 0.0013
Schistosoma mansoni myosin xvIII 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0387 0.0483 0.048
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0041 0.0391
Echinococcus granulosus calpain A 0.0072 0.0067 0.0067
Giardia lamblia Fructose-bisphosphate aldolase 0.1475 0.192 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0008 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0024 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0031 0.0031
Brugia malayi ThiF family protein 0.0051 0.0039 0.0036
Echinococcus multilocularis muscleblind protein 0.0303 0.0372 0.0372
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0045 0.0045
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0326 0.0403 0.4146
Schistosoma mansoni endoplasmin 0.0029 0.0011 0.0011
Loa Loa (eye worm) calpain family protein 1 0.0048 0.0036 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0024 0.0021
Echinococcus multilocularis dna polymerase eta 0.0039 0.0024 0.0024
Trypanosoma brucei heat shock protein 90, putative 0.0029 0.0011 0.008
Echinococcus granulosus single minded 2 0.0074 0.0069 0.0069
Brugia malayi tailless protein 0.0026 0.0006 0.0003
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0051 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0045 0.0041
Brugia malayi ecdysteroid receptor 0.0055 0.0045 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0045 0.0041
Onchocerca volvulus 0.0073 0.0069 0.0394
Echinococcus multilocularis BC026374 protein (S09 family) 0.1283 0.1667 0.1667
Loa Loa (eye worm) calpain family protein 1 0.0068 0.0063 0.006
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0003 0.0003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0019 0.0097
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.7596 1 1
Echinococcus multilocularis lamin dm0 0.0108 0.0115 0.0115
Trypanosoma brucei DNA topoisomerase III, putative 0.003 0.0012 0.0094
Schistosoma mansoni biogenic amine receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.1283 0.1667 0.1664
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0069 0.0069
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0015 0.0015
Plasmodium vivax heat shock protein 86, putative 0.0029 0.0011 0.0025
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0039 0.0371
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0019 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0045 0.0045
Brugia malayi beta-lactamase family protein 0.0073 0.0069 0.0066
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0024 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Echinococcus granulosus g protein coupled receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0044 0.003 0.0027
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0003 0.0003
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1283 0.1667 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0072 0.0067 0.0067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0105 0.0105
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.0016 0.0137
Mycobacterium ulcerans two component sensor kinase MprB 0.0029 0.0011 0.0034
Schistosoma mansoni tsg101-related 0.0061 0.0053 0.0053
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.0033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0045 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0039 0.0168
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0559 0.071 0.0707
Loa Loa (eye worm) hypothetical protein 0.0077 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0106 0.0112 0.0109
Schistosoma mansoni prokaryotic DNA topoisomerase 0.003 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0045 0.0041
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0066
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0003 0.0003
Brugia malayi Carboxylesterase family protein 0.1283 0.1667 0.1664
Brugia malayi cytoplasmic intermediate filament protein 0.0058 0.0049 0.0046
Echinococcus granulosus muscleblind protein 0.0303 0.0372 0.0372
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0011 0.008
Trypanosoma brucei polo-like protein kinase 0.01 0.0104 0.1053
Schistosoma mansoni glutaminase 0.0285 0.0348 0.0348
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0051 0.0235
Brugia malayi ThiF family protein 0.0033 0.0016 0.0013
Leishmania major DNA polymerase eta, putative 0.0039 0.0024 0.0218
Plasmodium vivax SET domain protein, putative 0.0032 0.0015 0.0065
Trichomonas vaginalis receptor histidine kinase, putative 0.0029 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.004 0.0025 0.0022
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0183 0.0183
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0011 0.0033
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0183 0.0179
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0011 0.008
Loa Loa (eye worm) hypothetical protein 0.005 0.0039 0.0035
Brugia malayi Carboxylesterase family protein 0.1283 0.1667 0.1664
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0003 0.0003
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0053 0.0053
Echinococcus multilocularis muscleblind protein 1 0.0303 0.0372 0.0372
Schistosoma mansoni hypothetical protein 0.01 0.0105 0.0105
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0003 0.0003
Toxoplasma gondii ABC1 family protein 0.0073 0.0069 0.0634
Loa Loa (eye worm) carboxylesterase 0.1283 0.1667 0.1664
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0041 0.0391
Schistosoma mansoni nuclear receptor 0.0026 0.0006 0.0006
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0004 0.0004
Toxoplasma gondii DNA topoisomerase 2, putative 0.0559 0.071 0.7382
Brugia malayi hypothetical protein 0.0033 0.0016 0.0013
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0019 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0103 0.0103
Trypanosoma cruzi DNA topoisomerase IA, putative 0.003 0.0012 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0104 0.0509
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0051 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Onchocerca volvulus 0.0055 0.0045 0.0249
Echinococcus multilocularis para nitrobenzyl esterase 0.1283 0.1667 0.1667
Leishmania major protein kinase, putative 0.0027 0.0008 0.0045
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0003 0.0003
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Schistosoma mansoni histamine h1 receptor 0.0023 0.0003 0.0003
Leishmania major C-8 sterol isomerase-like protein 0.0387 0.0483 0.5015
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0003 0.0003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0011 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.0169 0.0166
Mycobacterium ulcerans cell division protein FtsZ 0.0318 0.0392 0.2328
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0045 0.0045
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0378 0.0471 0.2813
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0036 0.0033
Echinococcus granulosus chromobox protein 1 0.0078 0.0075 0.0075
Mycobacterium ulcerans beta-lactamase 0.0073 0.0069 0.0383
Loa Loa (eye worm) inositol-1 0.0114 0.0123 0.012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0069 0.0069
Schistosoma mansoni endoplasmin 0.0029 0.0011 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0024 0.0021
Onchocerca volvulus 0.0074 0.0069 0.0398
Mycobacterium leprae Probable two component sensor kinase MprB 0.0029 0.0011 0.0061
Trypanosoma brucei unspecified product 0.0027 0.0008 0.005
Schistosoma mansoni chromobox protein 0.0078 0.0075 0.0075
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0627 0.0801 0.8341
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0018 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.0588 0.351
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0011 0.008
Schistosoma mansoni neuropeptide receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis spcc417.12 protein, putative 0.1283 0.1667 0.8677
Loa Loa (eye worm) cytochrome P450 0.0029 0.0011 0.0008
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0559 0.071 0.071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0045 0.0041
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0011 0.008
Entamoeba histolytica hypothetical protein 0.0078 0.0075 0.0388
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0019 0.0066
Onchocerca volvulus 0.0034 0.0018 0.0086
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0318 0.0392 0.0389
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0039 0.0371
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0039 0.0371
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0003 0.0003
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.003 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0333 0.0412 0.0409
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0045 0.0249
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0019 0.0165
Toxoplasma gondii heat shock protein 90, putative 0.0029 0.0011 0.0025
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0003 0.0003
Brugia malayi nuclear receptor NHR-67 0.0026 0.0006 0.0003
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0006 0.0006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Schistosoma mansoni gliotactin 0.1283 0.1667 0.1667
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0075 0.0072
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0024 0.0124
Plasmodium vivax endoplasmin, putative 0.0029 0.0011 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0103 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0054 0.0054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0003 0.0003
Schistosoma mansoni microtubule-associated protein tau 0.2803 0.3673 0.3673
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0024 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0104 0.054
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.0104 0.1053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0318 0.0392 0.0389
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.012 0.0131 0.3069
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0073 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0045 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.003 0.0012 0.0012
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0011 0.0033
Plasmodium falciparum DNA gyrase subunit B 0.0326 0.0403 0.4146
Leishmania major hypothetical protein, conserved 0.0073 0.0069 0.0686
Echinococcus multilocularis conserved hypothetical protein 0.0724 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.0077 0.0074 0.0071
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0318 0.0392 0.9727
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0045 0.0045
Plasmodium falciparum endoplasmin, putative 0.0029 0.0011 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0105 0.0105
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0004 0.0004
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0029 0.0011 0.0034
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0024 0.0024
Brugia malayi nuclear hormone receptor 0.0026 0.0006 0.0003
Leishmania major mitochondrial DNA topoisomerase II 0.0627 0.0801 0.8341
Brugia malayi nuclear receptor RXR 0.0026 0.0006 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0069 0.0326
Loa Loa (eye worm) intermediate filament protein 0.0108 0.0115 0.0112
Echinococcus granulosus fmrfamide receptor 0.0023 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0005 0.0002
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0114 0.0123 0.0638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0045 0.0041
Brugia malayi jmjC domain containing protein 0.0057 0.0048 0.0045
Leishmania major developmentally regulated phosphoprotein-like protein 0.0029 0.0011 0.008
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0029 0.0011 0.0034
Trypanosoma cruzi cytochrome P450, putative 0.0065 0.0058 0.057
Loa Loa (eye worm) hypothetical protein 0.1283 0.1667 0.1664
Leishmania major cytochrome p450-like protein 0.0065 0.0058 0.057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0019 0.0016
Schistosoma mansoni hypothetical protein 0.0029 0.0011 0.0011
Onchocerca volvulus 0.0108 0.0115 0.0672
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0073 0.0069 0.0069
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0039 0.0168
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0011 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0069 0.0383
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0041 0.0338
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0011 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0024 0.0218
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0075 0.0359
Loa Loa (eye worm) hypoxia-induced factor 1 0.0307 0.0378 0.0375
Trypanosoma brucei DNA topoisomerase ii 0.0627 0.0801 0.8341
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0011 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0058 0.0058
Echinococcus granulosus microtubule associated protein 2 0.2803 0.3673 0.3673
Loa Loa (eye worm) ThiF family protein 0.0033 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0217 0.0259 0.0256
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0183 0.0179
Echinococcus multilocularis neuropeptide s receptor 0.0995 0.1286 0.1286
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0029 0.0011 0.0034
Loa Loa (eye worm) hypothetical protein 0.7596 1 1
Loa Loa (eye worm) hypothetical protein 0.1283 0.1667 0.1664
Loa Loa (eye worm) hypothetical protein 0.0318 0.0392 0.0389
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0048 0.0048
Schistosoma mansoni adenoreceptor 0.0023 0.0003 0.0003
Plasmodium falciparum topoisomerase I 0.0748 0.0959 1
Brugia malayi hypoxia-induced factor 1 0.0307 0.0378 0.0375
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.0016 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0054 0.0054
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0029 0.0011 0.0034
Echinococcus multilocularis carboxylesterase 5A 0.7596 1 1
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0029 0.0011 0.008
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Brugia malayi nuclear receptor NHR-88 0.0055 0.0045 0.0041
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0297 0.0365 0.1899
Trichomonas vaginalis glutaminase, putative 0.0285 0.0348 0.1785
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0045 0.0041
Echinococcus granulosus g protein coupled receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis heat shock protein 90 0.0029 0.0011 0.0011
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.0104 0.0605
Loa Loa (eye worm) transcription factor SMAD2 0.0265 0.0323 0.0319
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0006 0.0006
Trypanosoma brucei C-8 sterol isomerase, putative 0.0387 0.0483 0.5015
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0019 0.0066
Echinococcus multilocularis neuroligin 0.1283 0.1667 0.1667
Mycobacterium leprae putative cytochrome p450 0.0029 0.0011 0.006
Brugia malayi calpain family protein 1 0.0068 0.0063 0.006
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0123 0.125
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0038 0.0164
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0378 0.0471 0.2813
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Echinococcus granulosus neuropeptide receptor A26 0.0995 0.1286 0.1286
Onchocerca volvulus 0.0073 0.0069 0.0394
Schistosoma mansoni bromodomain containing protein 0.0064 0.0056 0.0056
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0006 0.0003
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0008 0.0005
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0024 0.0024
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0045 0.0045
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0006 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0052 0.0052
Brugia malayi hypothetical protein 0.1283 0.1667 0.1664
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0003 0.0003
Chlamydia trachomatis DNA gyrase subunit B 0.0258 0.0312 0.7687
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0045 0.0041
Brugia malayi Carboxylesterase family protein 0.7596 1 1
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0145 0.0164 0.173
Echinococcus granulosus lamin 0.0108 0.0115 0.0115
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0045 0.0045
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.0064 0.0303
Loa Loa (eye worm) hypothetical protein 0.0051 0.0039 0.0036
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0011 0.0033
Schistosoma mansoni prokaryotic DNA topoisomerase 0.003 0.0012 0.0012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0006 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0108 0.0115 0.0112
Entamoeba histolytica hypothetical protein 0.0078 0.0075 0.0388
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0075 0.0075
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0016 0.0137
Echinococcus granulosus geminin 0.0344 0.0426 0.0426
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.0016 0.0083
Schistosoma mansoni single-minded 0.0099 0.0104 0.0104
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Echinococcus multilocularis heat shock protein 0.0029 0.0011 0.0011
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0011 0.0079
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0069 0.0383
Loa Loa (eye worm) hypothetical protein 0.0043 0.003 0.0027
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0559 0.071 0.071
Trypanosoma cruzi DNA topoisomerase II, putative 0.0529 0.0671 0.698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0104 0.0509
Echinococcus granulosus flap endonuclease 1 0.0027 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0066
Onchocerca volvulus 0.0026 0.0006 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0053 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.2803 0.3673 0.3673
Schistosoma mansoni hypothetical protein 0.0344 0.0426 0.0426
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0024 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.003 0.0123
Loa Loa (eye worm) hypothetical protein 0.0129 0.0142 0.0139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Loa Loa (eye worm) carboxylesterase 0.1283 0.1667 0.1664
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.0104 0.0104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.003 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Brugia malayi chromobox protein homolog 3 0.0044 0.003 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0003 0.0003
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0039 0.0158
Onchocerca volvulus 0.0073 0.0069 0.0394
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.012 0.0131 0.0758
Loa Loa (eye worm) hypothetical protein 0.0227 0.0273 0.0269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.003 0.0161
Brugia malayi kinase, mitochondrial precursor 0.0029 0.0011 0.0008
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Brugia malayi hypothetical protein 0.0052 0.0041 0.0037
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0008 0.0055
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0003 0.0003
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0023 0.0003 0.0003
Leishmania major DNA topoisomerase ii 0.0529 0.0671 0.698
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0011 0.0033
Onchocerca volvulus 0.0026 0.0006 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0053 0.0053
Mycobacterium tuberculosis Conserved protein 0.0073 0.0069 0.0383
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0019 0.0111
Schistosoma mansoni alpha glucosidase 0.0035 0.0019 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0045 0.0045
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0039 0.0371
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0104 0.1053
Echinococcus multilocularis chromobox protein 1 0.0078 0.0075 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0069 0.0326
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0034 0.0187
Schistosoma mansoni amine GPCR 0.0023 0.0003 0.0003
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0078 0.0075 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0008 0.005
Brugia malayi calpain family protein 1 0.0068 0.0063 0.006
Onchocerca volvulus 0.003 0.0012 0.0054
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.012 0.0131 0.063
Brugia malayi hypothetical protein 0.0078 0.0075 0.0072
Brugia malayi hypothetical protein 0.0729 0.0935 0.0932
Echinococcus multilocularis inositol monophosphatase 1 0.0114 0.0123 0.0123
Onchocerca volvulus 0.0048 0.0036 0.0197
Schistosoma mansoni DNA topoisomerase type I 0.0748 0.0959 0.0959
Trypanosoma cruzi DNA topoisomerase III, putative 0.003 0.0012 0.0094
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.0104 0.0101
Brugia malayi heat shock protein 90 0.0029 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0104 0.0104
Onchocerca volvulus 0.1283 0.1667 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0029 0.0011 0.0034
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1283 0.1667 0.1667
Mycobacterium tuberculosis Cell division protein FtsZ 0.0318 0.0392 0.2328
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0003 0.0003
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0008 0.0055
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0034 0.0146
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0105 0.0102
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0075 0.0359
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0045 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0005 0.0021
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0003 0.0003
Trypanosoma brucei unspecified product 0.0039 0.0024 0.0218
Mycobacterium ulcerans hypothetical protein 0.0073 0.0069 0.0383
Leishmania major DNA topoisomerase IB, large subunit 0.0748 0.0959 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0005 0.0002
Schistosoma mansoni opsin-like receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0019 0.0066
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0045 0.0249
Schistosoma mansoni hypothetical protein 0.01 0.0105 0.0105
Brugia malayi beta-lactamase family protein 0.0073 0.0069 0.0066
Trypanosoma brucei DNA topoisomerase IA, putative 0.003 0.0012 0.0094
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.009 0.0091 0.0918
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Brugia malayi Cytochrome P450 family protein 0.0029 0.0011 0.0008
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0024 0.0218
Echinococcus multilocularis musashi 0.0108 0.0115 0.0115
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.0064 0.0303
Toxoplasma gondii heat shock protein HSP90 0.0029 0.0011 0.0025
Brugia malayi intermediate filament protein 0.0108 0.0115 0.0112
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Echinococcus granulosus dna polymerase eta 0.0039 0.0024 0.0024
Leishmania major cytochrome p450-like protein 0.0029 0.0011 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0045 0.0045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0058 0.0315
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0006 0.0019
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0011 0.0023
Brugia malayi Probable DNA topoisomerase II 0.0559 0.071 0.0707
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0006 0.0006
Treponema pallidum cell division protein FtsZ 0.0318 0.0392 0.1997
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.007 0.0064 0.0334
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1283 0.1667 0.1667
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Brugia malayi hypothetical protein 0.0026 0.0006 0.0003
Entamoeba histolytica hypothetical protein 0.0297 0.0365 0.1899
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0015 0.0015
Brugia malayi nuclear receptor NHR-88 0.0026 0.0006 0.0003
Brugia malayi Pre-SET motif family protein 0.0032 0.0015 0.0011
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0029 0.0011 0.0034
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0054 0.0051
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0326 0.0403 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1475 0.192 1
Brugia malayi hypothetical protein 0.0129 0.0142 0.0139
Loa Loa (eye worm) CYP4Cod1 0.0065 0.0058 0.0055
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0029 0.0011 0.0025
Giardia lamblia DINP protein human, muc B family 0.0039 0.0024 0.0081
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0029 0.0011 0.008
Plasmodium vivax ubiquitin activating enzyme, putative 0.0051 0.0039 0.0323
Onchocerca volvulus Huntingtin homolog 0.0129 0.0142 0.0835
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0011 0.0033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0045 0.0045
Leishmania major DNA topoisomerase III, putative 0.003 0.0012 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0103 0.0103
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0011 0.0033
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0069 0.0383
Onchocerca volvulus 0.0026 0.0006 0.0019
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0045 0.0045
Echinococcus granulosus neuropeptide s receptor 0.0995 0.1286 0.1286
Echinococcus granulosus allatostatin A receptor 0.0023 0.0003 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0005 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0045 0.0041
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0041 0.0338
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0011 0.0011
Trypanosoma cruzi DNA topoisomerase II, putative 0.0529 0.0671 0.698
Brugia malayi bHLH-PAS transcription factor 0.0074 0.0069 0.0066
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0029 0.0011 0.0034
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.003 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0003 0.0003
Plasmodium falciparum heat shock protein 90 0.0029 0.0011 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0058 0.0049 0.0046
Schistosoma mansoni inositol monophosphatase 0.0114 0.0123 0.0123
Schistosoma mansoni BC026374 protein (S09 family) 0.1283 0.1667 0.1667
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0029 0.0011 0.0034
Trichomonas vaginalis esterase, putative 0.0073 0.0069 0.0326
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0003 0.0003
Brugia malayi DNA topoisomerase I 0.0748 0.0959 0.0956
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0003 0.0003
Schistosoma mansoni kinase 0.0051 0.004 0.004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.7596 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0045 0.0041
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0003 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0039 0.0168
Toxoplasma gondii ThiF family protein 0.0033 0.0016 0.0083
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0058 0.0569
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0008 0.0045
Giardia lamblia DNA repair protein RAD52 0.1045 0.1352 0.7028
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0103 0.0099
Loa Loa (eye worm) mucolipin 1 0.0069 0.0064 0.0061
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0019 0.0016
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0529 0.0671 0.698
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0045 0.0045
Brugia malayi Flap endonuclease-1 0.0027 0.0008 0.0005
Trypanosoma brucei developmentally regulated phosphoprotein 0.0029 0.0011 0.008
Schistosoma mansoni survival motor neuron protein 0.0149 0.0169 0.0169
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0003 0.0003
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0003 0.0003
Echinococcus granulosus inositol monophosphatase 1 0.0114 0.0123 0.0123
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.0064 0.0303
Toxoplasma gondii RNA-directed DNA polymerase 0.009 0.0091 0.0868
Plasmodium vivax DNA topoisomerase 3, putative 0.003 0.0012 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0045 0.0045
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0033 0.0016 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0069 0.0066
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0045 0.0045
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0006 0.0003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0024 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0198 0.0233 0.023
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.0104 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Schistosoma mansoni alpha-glucosidase 0.0137 0.0153 0.0153
Brugia malayi Coelomocyte uptake defective protein 5 0.0069 0.0064 0.0061
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.003 0.0012 0.0009
Echinococcus multilocularis acetylcholinesterase 0.7596 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0045 0.0045
Leishmania major hypothetical protein, conserved 0.0029 0.0011 0.008
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0052 0.0041 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0011 0.0033
Treponema pallidum DNA topoisomerase I (topA) 0.003 0.0012 0.0007
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0029 0.0011 0.0023
Loa Loa (eye worm) glutaminase 2 0.0285 0.0348 0.0345
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.0547 0.0547
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0058 0.0315
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0748 0.0959 1
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0045 0.0045
Echinococcus multilocularis GPCR, family 2 0.01 0.0105 0.0105
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0029 0.0011 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0104 0.0509
Brugia malayi Cytochrome P450 family protein 0.0065 0.0058 0.0055
Plasmodium falciparum DNA topoisomerase 3, putative 0.003 0.0012 0.0039
Loa Loa (eye worm) DNA topoisomerase I 0.0748 0.0959 0.0956
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0052 0.0041 0.0038
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0559 0.071 0.0707
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.012 0.0131 0.129
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0039 0.0371
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0029 0.0011 0.0011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0123 0.125
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0011 0.0033
Chlamydia trachomatis DNA gyrase subunit B 0.0326 0.0403 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0006 0.0003
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0011 0.0033
Trichomonas vaginalis sensor histidine kinase, putative 0.0029 0.0011 0.0023
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0029 0.0011 0.0023
Echinococcus multilocularis survival motor neuron protein 1 0.0729 0.0935 0.0935
Loa Loa (eye worm) TOPoisomerase family member 0.0559 0.071 0.0707
Entamoeba histolytica hypothetical protein 0.0078 0.0075 0.0388
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0012 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0105 0.0105
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0023 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0078 0.0075 0.0075
Schistosoma mansoni heat shock protein 0.0029 0.0011 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0003 0.0003
Echinococcus multilocularis geminin 0.0344 0.0426 0.0426
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Onchocerca volvulus 0.0149 0.0169 0.0995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0003 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0034 0.0146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0029 0.0011 0.0034
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0011 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0019 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Schistosoma mansoni neuropeptide receptor 0.0023 0.0003 0.0003
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.0016 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0217 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0303 0.0372 0.0369
Loa Loa (eye worm) MH2 domain-containing protein 0.0265 0.0323 0.0319
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0006 0.0006
Onchocerca volvulus 0.0092 0.0094 0.0546
Brugia malayi follicle stimulating hormone receptor 0.0508 0.0643 0.064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1283 0.1667 0.1667
Mycobacterium ulcerans putative regulatory protein 0.0074 0.0069 0.0386
Toxoplasma gondii DNA topoisomerase I, putative 0.0748 0.0959 1
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0069 0.0686
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0045 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0045 0.0045
Schistosoma mansoni aryl hydrocarbon receptor 0.0099 0.0104 0.0104
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0024 0.0024
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.003 0.0012 0.0076
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0006 0.0003
Leishmania major protein kinase, putative 0.0027 0.0008 0.0045
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0102 0.0107 0.1108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0011 0.0033
Brugia malayi TAR-binding protein 0.0062 0.0054 0.0051
Brugia malayi glutaminase DH11.1 0.0285 0.0348 0.0345
Echinococcus granulosus DNA topoisomerase 3 alpha 0.003 0.0012 0.0012
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0006 0.0006
Brugia malayi Pre-SET motif family protein 0.0219 0.0262 0.0259
Schistosoma mansoni nuclear receptor 0.0026 0.0006 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0041 0.0391
Onchocerca volvulus 0.0108 0.0115 0.0672
Entamoeba histolytica DNA topoisomerase III, putative 0.003 0.0012 0.0062
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0066
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0006 0.0034
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0019 0.0019
Onchocerca volvulus 0.0045 0.0031 0.017
Schistosoma mansoni DNA topoisomerase II 0.0559 0.071 0.071
Echinococcus granulosus neuropeptide receptor 0.0023 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0061 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0378 0.0472 0.0469
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0011 0.0079
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Plasmodium vivax DNA gyrase subunit A, putative 0.012 0.0131 0.129
Brugia malayi CXXC zinc finger family protein 0.0031 0.0013 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0005 0.0021
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0006 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Echinococcus granulosus mucolipin 3 0.0069 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0054 0.0054
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0051 0.0048
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.005 0.0038 0.0196
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0183 0.0183
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0011 0.0033
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0072 0.0067 0.0067
Loa Loa (eye worm) endoplasmin 0.0029 0.0011 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0045 0.0041
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0003 0.0003
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0066
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Schistosoma mansoni lamin 0.0108 0.0115 0.0115
Brugia malayi DNA topoisomerase III beta-1 0.003 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.0039 0.0035
Onchocerca volvulus 0.0249 0.0302 0.1793
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0011 0.0033
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0045 0.0045
Leishmania major hypothetical protein, conserved 0.0052 0.0041 0.0391
Loa Loa (eye worm) hypothetical protein 0.1283 0.1667 0.1664
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0011 0.0025
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0011 0.0033
Entamoeba histolytica heat shock protein 90, putative 0.0029 0.0011 0.0055
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0019 0.0066
Echinococcus multilocularis serotonin receptor 0.0023 0.0003 0.0003
Echinococcus granulosus sentrin specific protease 8 0.007 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0045 0.0041
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0006 0.0006
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0039 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0069 0.0686
Loa Loa (eye worm) hypothetical protein 0.0303 0.0372 0.0369
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0045 0.0045
Giardia lamblia Kinase, PLK 0.01 0.0104 0.0499
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0029 0.0011 0.0011
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0024 0.0218
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0008 0.0043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0045 0.0045
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0003 0.0003
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0011 0.0011
Trypanosoma brucei DNA topoisomerase III, putative 0.003 0.0012 0.0094
Loa Loa (eye worm) hypothetical protein 0.1283 0.1667 0.1664
Schistosoma mansoni cpg binding protein 0.0034 0.0017 0.0017
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0003 0.0003
Echinococcus granulosus carboxylesterase 5A 0.7596 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0069 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0045 0.0041
Echinococcus granulosus serotonin receptor 0.0023 0.0003 0.0003
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0008 0.005
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0029 0.0011 0.0034
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0045 0.0041
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0003 0.0003
Brugia malayi cytochrome P450 0.0029 0.0011 0.0008
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0003 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0058 0.0517
Echinococcus multilocularis lamin 0.0108 0.0115 0.0115
Schistosoma mansoni acetylcholinesterase 0.1283 0.1667 0.1667
Brugia malayi hypothetical protein 0.0333 0.0412 0.0409
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0024 0.0092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0069 0.0069
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0024 0.0021
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0054 0.0051
Mycobacterium ulcerans glutaminase 0.0285 0.0348 0.2063
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0326 0.0403 0.2392
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0045 0.0041
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0011 0.0033
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0069 0.0383
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0006 0.0003
Mycobacterium ulcerans DNA gyrase subunit B 0.0326 0.0403 0.2392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis hypothetical protein 0.0036 0.0019 0.0067
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0011 0.0023
Chlamydia trachomatis DNA gyrase subunit A 0.012 0.0131 0.3045
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0029 0.0011 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0058 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Brugia malayi Cell division protein ftsZ 0.0153 0.0174 0.0171
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0045 0.0045
Mycobacterium leprae Probable lipase LipE 0.0073 0.0069 0.0692
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0003 0.0003
Schistosoma mansoni amine GPCR 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.1283 0.1667 0.1664
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0051 0.0039 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.0165
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0039 0.0039
Schistosoma mansoni zinc finger protein 0.0026 0.0006 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0104 0.0509
Schistosoma mansoni hypothetical protein 0.01 0.0105 0.0105
Echinococcus multilocularis cpg binding protein 0.0034 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0045 0.0041
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0039 0.0317
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0029 0.0011 0.0034
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0003 0.0003
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0046 0.0033 0.0033
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1283 0.1667 0.1667
Echinococcus granulosus acetylcholinesterase 0.7596 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0045 0.0249
Leishmania major telomerase reverse transcriptase, putative 0.009 0.0091 0.0918
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0006 0.0019
Chlamydia trachomatis DNA gyrase subunit A 0.012 0.0131 0.3045
Brugia malayi nuclear receptor RXR 0.0029 0.0011 0.0007
Mycobacterium tuberculosis Conserved protein 0.0073 0.0069 0.0383
Loa Loa (eye worm) hypothetical protein 0.0378 0.0472 0.0469
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0065 0.0058 0.0316
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0011 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0011 0.0033
Trypanosoma brucei protein kinase, putative 0.005 0.0039 0.0371
Brugia malayi Endoplasmin precursor 0.0029 0.0011 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0008 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0011 0.0011
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0029 0.0011 0.0061
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0114 0.0123 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0103 0.0099
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0123 0.0608
Loa Loa (eye worm) DNA topoisomerase III 0.003 0.0012 0.0009
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.003 0.0012 0.0012
Trichomonas vaginalis inositol monophosphatase, putative 0.0114 0.0123 0.0608
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0039 0.0168
Echinococcus multilocularis mucolipin 3 0.0069 0.0064 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.0104 0.0104
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0013 0.0035
Schistosoma mansoni intermediate filament proteins 0.0108 0.0115 0.0115
Toxoplasma gondii DNA topoisomerase family protein 0.003 0.0012 0.0039
Mycobacterium leprae Probable two-component sensor kinase 0.0029 0.0011 0.0061
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.009 0.0091 0.0918
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0029 0.0011 0.0034
Echinococcus multilocularis sentrin specific protease 8 0.007 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0045 0.0041
Schistosoma mansoni alpha-glucosidase 0.0137 0.0153 0.0153
Brugia malayi latrophilin 2 splice variant baaae 0.0217 0.0259 0.0256
Echinococcus multilocularis 0.0029 0.0011 0.0011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0011 0.0079
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0006 0.0034
Schistosoma mansoni biogenic amine receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0003 0.0003
Mycobacterium ulcerans carboxylesterase, LipT 0.1283 0.1667 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0123 0.125
Echinococcus granulosus orexin receptor type 2 0.0023 0.0003 0.0003
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0011 0.008
Giardia lamblia Pms1-like protein 0.0029 0.0011 0.0012
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0051 0.0039 0.0039
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Schistosoma mansoni hypothetical protein 0.006 0.0051 0.0051
Loa Loa (eye worm) beta-lactamase 0.0073 0.0069 0.0066
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0029 0.0011 0.0011
Schistosoma mansoni neuropeptide receptor 0.0023 0.0003 0.0003
Brugia malayi Bromodomain containing protein 0.0037 0.0022 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0053 0.005
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0103 0.0103
Brugia malayi DNA topoisomerase III 0.003 0.0012 0.0009
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0039 0.0371
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0052 0.0041 0.0037
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0002
Plasmodium vivax DNA topoisomerase II, putative 0.0559 0.071 0.7382
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0378 0.0471 0.2813
Loa Loa (eye worm) hypothetical protein 0.0068 0.0063 0.006
Loa Loa (eye worm) DR-78 0.0026 0.0006 0.0003
Mycobacterium leprae Possible regulatory protein 0.0026 0.0006 0.0013
Brugia malayi PHD-finger family protein 0.0026 0.0007 0.0004
Brugia malayi Bromodomain containing protein 0.0075 0.0072 0.0068
Echinococcus multilocularis somatostatin receptor 0.0023 0.0003 0.0003
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0029 0.0011 0.0034
Brugia malayi hypothetical protein 0.0029 0.0011 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0069 0.0383
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0123 0.0608
Loa Loa (eye worm) hypothetical protein 0.0068 0.0063 0.006
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.009 0.0091 0.0528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0227 0.0273 0.0269
Mycobacterium tuberculosis Conserved protein 0.0029 0.0011 0.0034
Loa Loa (eye worm) acetylcholinesterase 1 0.7596 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0045 0.0041
Leishmania major DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0318 0.0392 0.0389
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0051 0.0051
Schistosoma mansoni chromobox protein 0.0078 0.0075 0.0075
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0006 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0011 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0104 0.0509
Echinococcus granulosus BC026374 protein S09 family 0.1283 0.1667 0.1667
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0029 0.0011 0.008
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0006 0.0006
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0748 0.0959 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0114 0.0123 0.1202
Echinococcus granulosus neuroligin 0.1283 0.1667 0.1667
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Trichomonas vaginalis receptor histidine kinase, putative 0.0029 0.0011 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0003 0.0003
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0045 0.0045
Schistosoma mansoni amine GPCR 0.0023 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0011 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0011 0.0033
Brugia malayi hypothetical protein 0.0026 0.0006 0.0003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0006 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0065 0.0058 0.057
Trypanosoma brucei heat shock protein 90, putative 0.0029 0.0011 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Schistosoma mansoni pyruvate dehydrogenase 0.0029 0.0011 0.0011
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0011 0.0033
Schistosoma mansoni hypothetical protein 0.0344 0.0426 0.0426
Plasmodium falciparum DNA topoisomerase 2 0.0559 0.071 0.7382
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0005 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0013 0.0035
Giardia lamblia DNA topoisomerase III 0.003 0.0012 0.002
Mycobacterium ulcerans DNA topoisomerase I 0.003 0.0012 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0006 0.0006
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0003 0.0003
Echinococcus granulosus cpg binding protein 0.0034 0.0017 0.0017
Entamoeba histolytica DNA topoisomerase III, putative 0.003 0.0012 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0011 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0045 0.0041
Trypanosoma brucei glucosidase, putative 0.0035 0.0019 0.0165
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.007 0.0064 0.0064
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0037 0.0037
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0721 0.0924 0.5528
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0011 0.0033
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0029 0.0011 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0045 0.0041
Echinococcus granulosus acetylcholinesterase 0.7596 1 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0072 0.0067 0.0067
Trypanosoma brucei unspecified product 0.0027 0.0008 0.005
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0011 0.0033
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.0011 0.006
Mycobacterium ulcerans two component regulator - sensor kinase 0.0029 0.0011 0.0034
Schistosoma mansoni DNA topoisomerase type I 0.0748 0.0959 0.0959
Plasmodium vivax topoisomerase I, putative 0.0748 0.0959 1
Echinococcus granulosus GPCR family 2 0.01 0.0105 0.0105
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0011 0.0079
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0045 0.0045
Schistosoma mansoni heat shock protein 0.0029 0.0011 0.0011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0066
Trichomonas vaginalis DNA topoisomerase II, putative 0.0559 0.071 0.3679
Brugia malayi MAP kinase sur-1 0.005 0.0039 0.0035
Plasmodium vivax telomerase reverse transcriptase, putative 0.0556 0.0707 0.7346
Trypanosoma cruzi DNA topoisomerase IA, putative 0.003 0.0012 0.0094
Loa Loa (eye worm) glutaminase 0.0285 0.0348 0.0345
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.01 0.0105 0.0105
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0114 0.0123 0.2856
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0029 0.0011 0.0023
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0069 0.0383
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0104 0.1053
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0529 0.0671 0.698
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0075 0.0075
Trypanosoma cruzi DNA topoisomerase III, putative 0.003 0.0012 0.0094
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0262 0.0259
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0003 0.0003
Brugia malayi PAS domain containing protein 0.0099 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.0108 0.0115 0.0112
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0024 0.0113
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Schistosoma mansoni lamin 0.0108 0.0115 0.0115
Echinococcus multilocularis rho GTPase activating protein 20 0.003 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0058 0.0055
Trypanosoma brucei Heat shock protein 83, putative 0.0029 0.0011 0.008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0052 0.0052
Brugia malayi Carboxylesterase family protein 0.1283 0.1667 0.1664
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0029 0.001 0.0073
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0008 0.0055
Plasmodium falciparum DNA gyrase subunit A 0.012 0.0131 0.129
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0729 0.0935 0.0932
Mycobacterium ulcerans putative regultory protein 0.0029 0.0011 0.0034
Schistosoma mansoni mucolipin 0.0069 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0045 0.0041
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0627 0.0801 0.8341
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0326 0.0403 0.2053
Echinococcus granulosus somatostatin receptor 0.0023 0.0003 0.0003
Brugia malayi Muscleblind-like protein 0.0303 0.0372 0.0369
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0011 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Loa Loa (eye worm) carboxylesterase 0.7596 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0058 0.0055
Echinococcus granulosus neuropeptide receptor 0.0023 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0006 0.0006
Echinococcus multilocularis sex peptide receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis neuropeptide receptor A26 0.0995 0.1286 0.1286
Schistosoma mansoni DNA topoisomerase type I 0.0748 0.0959 0.0959
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis transfer RNA-Lys 0.0074 0.0069 0.0069
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0008 0.0045
Mycobacterium leprae cell division protein FtsZ 0.0318 0.0392 0.4211
Toxoplasma gondii hypothetical protein 0.0051 0.0039 0.0323
Mycobacterium ulcerans DNA gyrase subunit A 0.012 0.0131 0.0758
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0011 0.0033
Echinococcus granulosus para nitrobenzyl esterase 0.1283 0.1667 0.1667
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0029 0.0011 0.0034
Brugia malayi Latrophilin receptor protein 2 0.01 0.0105 0.0102
Onchocerca volvulus Huntingtin homolog 0.0129 0.0142 0.0835
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0029 0.0011 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0029 0.0011 0.0023
Echinococcus granulosus dna polymerase kappa 0.0039 0.0024 0.0024
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0005 0.0026
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0003 0.0003
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0003 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0058 0.0315
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0003 0.0003
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0029 0.0011 0.0034
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0435 0.0547 0.0547
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0037 0.0037
Trichomonas vaginalis Sentrin-specific protease, putative 0.007 0.0064 0.0303
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0059 0.0059
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0003 0.0003
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0029 0.0011 0.0034
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.0165
Schistosoma mansoni cytochrome P450 0.0029 0.0011 0.0011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0721 0.0924 0.5528
Echinococcus granulosus g protein coupled receptor 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0066
Echinococcus granulosus DNA topoisomerase 1 0.0748 0.0959 0.0959
Schistosoma mansoni hypothetical protein 0.0149 0.0169 0.0169
Brugia malayi steroid hormone receptor 0.0055 0.0045 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0103 0.0103
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0721 0.0924 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0123 0.125
Loa Loa (eye worm) hypothetical protein 0.0069 0.0064 0.0061
Trypanosoma cruzi DNA topoisomerase III, putative 0.003 0.0012 0.0094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0045 0.0045
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0011 0.0033
Mycobacterium tuberculosis Carboxylesterase LipT 0.1283 0.1667 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0005 0.0021
Echinococcus granulosus heat shock protein 90 0.0029 0.0011 0.0011
Schistosoma mansoni neuropeptide receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0045 0.0045
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0006 0.0003
Echinococcus granulosus heat shock protein 0.0029 0.0011 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0069 0.0634
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0041 0.0338
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0055 0.0045 0.0837
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0102 0.0107 0.0612
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0011 0.0033
Onchocerca volvulus 0.0031 0.0013 0.0057
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0019 0.0097
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0006 0.0006
Echinococcus granulosus hypothetical protein 0.0748 0.096 0.096
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0006 0.0006
Echinococcus multilocularis chromobox protein 1 0.0078 0.0075 0.0075
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0024 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0038 0.0164
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0006 0.0003
Echinococcus multilocularis calpain family protein 1, d 0.0048 0.0036 0.0036
Echinococcus granulosus intermediate filament protein 0.0108 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0011 0.0007
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0029 0.0011 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0003 0.0003
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1045 0.1352 0.7041
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0052 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0007
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0011 0.0033
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2665 0.3491 0.3491
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0008 0.0045
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0024 0.0218
Echinococcus multilocularis acetylcholinesterase 0.7596 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0069 0.0686
Brugia malayi conserved hypotetical protein 0.0026 0.0006 0.0003
Echinococcus granulosus lamin dm0 0.0108 0.0115 0.0115
Mycobacterium ulcerans lipase LipD 0.0073 0.0069 0.0383
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.003 0.0012 0.003
Schistosoma mansoni tsg101-related 0.0061 0.0053 0.0053
Trichomonas vaginalis endoplasmin, putative 0.0029 0.0011 0.0023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0003 0.0003
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1283 0.1667 0.1667
Schistosoma mansoni coup transcription factor 0.0055 0.0045 0.0045
Brugia malayi Cell division protein ftsZ 0.0157 0.018 0.0176
Plasmodium vivax DNA gyrase subunit B, putative 0.0326 0.0403 0.4146
Giardia lamblia DNA topoisomerase II 0.053 0.0672 0.3471
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0003 0.0003
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0006 0.0034
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0069 0.0692
Brugia malayi DnaJ domain containing protein 0.006 0.0051 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0019 0.0066
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0006 0.0006
Echinococcus multilocularis DNA topoisomerase 1 0.0748 0.0959 0.0959
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0045 0.0045
Giardia lamblia Telomerase catalytic subunit 0.009 0.0091 0.0432
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0003 0.0003
Brugia malayi beta-lactamase 0.0073 0.0069 0.0066
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0069 0.0326
Schistosoma mansoni neuroligin 3 (S09 family) 0.1283 0.1667 0.1667
Schistosoma mansoni cpg binding protein 0.0034 0.0017 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0069 0.0383
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0011 0.0033
Schistosoma mansoni biogenic amine receptor 0.0023 0.0003 0.0003
Echinococcus granulosus chromobox protein 1 0.0078 0.0075 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0037 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0045 0.0041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0039 0.0371
Entamoeba histolytica heat shock protein 90, putative 0.0029 0.0011 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0302 0.1542
Trypanosoma brucei heat shock protein, putative 0.0029 0.0011 0.008
Echinococcus multilocularis serotonin receptor 0.0023 0.0003 0.0003
Trypanosoma cruzi Heat shock protein 83, putative 0.0029 0.0011 0.008
Treponema pallidum fructose-bisphosphate aldolase 0.1475 0.192 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Brugia malayi hypothetical protein 0.0073 0.0069 0.0066
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0069 0.0066
Onchocerca volvulus 0.1283 0.1667 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1283 0.1667 0.8677
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0003 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0024 0.0218
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0129 0.0142 0.0139
Echinococcus granulosus survival motor neuron protein 1 0.0729 0.0935 0.0935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0069 0.0326
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0053 0.0472
Echinococcus granulosus sex peptide receptor 0.0023 0.0003 0.0003
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.007 0.0064 0.0061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Brugia malayi Cytochrome P450 family protein 0.0065 0.0058 0.0055
Schistosoma mansoni flap endonuclease-1 0.0025 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0023 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0022 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1475 0.192 1
Schistosoma mansoni amine GPCR 0.0023 0.0003 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0011 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0003 0.0003
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0029 0.0011 0.0034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0003 0.0003
Loa Loa (eye worm) Ulp1 protease 0.007 0.0064 0.0061
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0024 0.0113
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0041
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0019 0.0019
Schistosoma mansoni tsg101-related 0.005 0.0038 0.0038
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Leishmania major heat shock protein 83-1 0.0029 0.0011 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0011 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0041 0.0338
Echinococcus multilocularis calpain A 0.0072 0.0067 0.0067
Leishmania major DNA topoisomerase III, putative 0.003 0.0012 0.0094
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0011 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0058 0.0315
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.0016 0.0137
Loa Loa (eye worm) heat shock protein 90 0.0029 0.0011 0.0008
Brugia malayi Cytochrome P450 family protein 0.0029 0.0011 0.0008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0003 0.0003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0015 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0054 0.0054
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0003 0.0003
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0008 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0011 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0069 0.0326
Onchocerca volvulus 0.1283 0.1667 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0069 0.0383
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0008 0.005
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.1283 0.1667 0.1664
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0024 0.0218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0045 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0011 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0011 0.0033
Plasmodium falciparum telomerase reverse transcriptase 0.0556 0.0707 0.7346
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0019 0.0066
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0024 0.0024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0508 0.0643 0.064
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 21.1 % In vitro inhibition of bone resorption tested in mouse calvarial resorption assay by measuring release of 45Ca from labelled bones ChEMBL. 1831506

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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