Detailed information for compound 1141870

Basic information

Technical information
  • TDR Targets ID: 1141870
  • Name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(phenylcarb amoylamino)purin-9-yl]oxolan-2-yl]methyl phos phono hydrogen phosphate
  • MW: 546.322 | Formula: C17H20N6O11P2
  • H donors: 7 H acceptors: 11 LogP: -3.4 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(Nc1ncnc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(O)O)O)Nc1ccccc1
  • InChi: 1S/C17H20N6O11P2/c24-12-10(6-32-36(30,31)34-35(27,28)29)33-16(13(12)25)23-8-20-11-14(18-7-19-15(11)23)22-17(26)21-9-4-2-1-3-5-9/h1-5,7-8,10,12-13,16,24-25H,6H2,(H,30,31)(H2,27,28,29)(H2,18,19,21,22,26)/t10-,12-,13-,16-/m1/s1
  • InChiKey: NPEOZNAZFLOGJY-XNIJJKJLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(phenylcarbamoylamino)purin-9-yl]tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate
  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-[[oxo-(phenylamino)methyl]amino]-9-purinyl]-2-tetrahydrofuranyl]methyl phosphono hydrogen phosphate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References
Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 Starlite/ChEMBL References
Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 Starlite/ChEMBL References
Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor purinergic receptor P2Y, G-protein coupled, 1 373 aa 393 aa 17.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thioredoxin glutathione reductase 0.0321 0.2234 0.2264
Toxoplasma gondii thioredoxin reductase 0.0318 0.2208 0.5664
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0081 0.0492 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Mycobacterium tuberculosis Probable lipase LipD 0.0175 0.1178 0.1419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0051 0.0057
Plasmodium falciparum thioredoxin reductase 0.011 0.0703 0.2819
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.003 0.0125 0.0505
Onchocerca volvulus 0.0027 0.0105 0.0103
Brugia malayi TAR-binding protein 0.0519 0.3672 0.4183
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0596 0.0595
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.011 0.0703 0.08
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0051 0.005
Echinococcus granulosus tumor protein p63 0.0682 0.4854 0.4921
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0029 0.0117 0.0527
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0051 0.005
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.008 0.0089
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Schistosoma mansoni malic enzyme 0.0023 0.0072 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0194
Toxoplasma gondii NADPH-glutathione reductase 0.011 0.0703 0.1782
Plasmodium falciparum heat shock protein 90, putative 0.0052 0.0282 0.099
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0323 0.0367
Brugia malayi hypothetical protein 0.023 0.1573 0.1791
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0051 0.0051
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0196 0.0474
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.1216 0.1384
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.003 0.0125 0.0125
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0175 0.1178 0.1341
Brugia malayi N-terminal motif family protein 0.0174 0.117 0.1332
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0105 0.0118
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0299 0.0302
Echinococcus granulosus geminin 0.1228 0.881 0.8932
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0014 0.0014
Plasmodium vivax thioredoxin reductase, putative 0.0318 0.2208 0.9344
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.011 0.0703 0.3143
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.1351 0.1368
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0196
Schistosoma mansoni endoplasmin 0.0089 0.0553 0.0559
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.011 0.0703 0.1716
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0308 0.1106
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0029 0.0117 0.0191
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0191 0.0598
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Echinococcus multilocularis snurportin 1 0.0332 0.2311 0.2342
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0051 0.0057
Onchocerca volvulus 0.0014 0.0006 0.0004
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0143 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0194
Brugia malayi hypothetical protein 0.002 0.0053 0.0059
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0299 0.0302
Leishmania major importin beta-1 subunit, putative 0.0025 0.0088 0.0192
Trypanosoma brucei aldehyde dehydrogenase, putative 0.003 0.0125 0.0561
Brugia malayi beta-lactamase 0.0175 0.1178 0.1341
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0059 0.0335 0.0339
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0308 0.1106
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0029 0.0117 0.0132
Brugia malayi Doublecortin family protein 0.002 0.0053 0.0059
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.1351 0.1368
Entamoeba histolytica hypothetical protein 0.007 0.0416 0.6943
Toxoplasma gondii heat shock protein 75, putative 0.0059 0.0335 0.0833
Echinococcus granulosus betaine aldehyde dehydrogenase 0.003 0.0125 0.0125
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1573 0.1594
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0118
Schistosoma mansoni alpha glucosidase 0.004 0.0196 0.0197
Echinococcus granulosus microtubule associated protein 2 0.1373 0.9863 1
Echinococcus multilocularis endoplasmin 0.0084 0.0513 0.0519
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0006 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0149 0.0168
Leishmania major heat shock protein, putative 0.0059 0.0335 0.0831
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0137
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0072 0.0072
Loa Loa (eye worm) doublecortin family protein 0.002 0.0053 0.0059
Brugia malayi Thioredoxin reductase 0.0318 0.2208 0.2515
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Brugia malayi glutathione reductase 0.0318 0.2208 0.2515
Trypanosoma cruzi malic enzyme, putative 0.0023 0.0072 0.0268
Brugia malayi Importin beta-1 subunit 0.0031 0.0131 0.0147
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0056 0.0055
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0267 0.0279
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.003 0.0125 0.0125
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0014 0.0006 0.0004
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0029 0.0117 0.0117
Onchocerca volvulus 0.0029 0.0117 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.003 0.0125 0.021
Brugia malayi hypothetical protein 0.0028 0.0105 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0014 0.0014
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0029 0.0117 0.0117
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0029 0.0117 0.0117
Schistosoma mansoni lamin 0.0027 0.0105 0.0104
Mycobacterium tuberculosis Probable reductase 0.0724 0.5159 0.6398
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0196 0.0196
Brugia malayi glutamate synthase 0.0029 0.0117 0.0132
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0175 0.1178 0.1419
Mycobacterium ulcerans heat shock protein 90 0.0084 0.0513 0.1221
Mycobacterium ulcerans glutamate synthase subunit beta 0.0029 0.0117 0.0191
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.011 0.0703 0.2819
Toxoplasma gondii heat shock protein HSP90 0.0089 0.0553 0.1394
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0596 0.0677
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.003 0.0125 0.021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0081 0.0081
Schistosoma mansoni cellular tumor antigen P53 0.01 0.063 0.0637
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0105 0.024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0088 0.0088
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0242 0.0592
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0299 0.0302
Schistosoma mansoni aldehyde dehydrogenase 0.0549 0.389 0.3943
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.041 0.0414
Loa Loa (eye worm) hypothetical protein 0.0176 0.1185 0.1349
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.003 0.0125 0.014
Mycobacterium tuberculosis Probable lipase LipE 0.0175 0.1178 0.1419
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0132
Brugia malayi hypothetical protein 0.0147 0.0971 0.1105
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.011 0.0703 0.1716
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0051 0.005
Plasmodium falciparum endoplasmin, putative 0.0065 0.0375 0.1396
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0596 0.0596
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0724 0.5159 0.6398
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0029 0.0117 0.0472
Echinococcus multilocularis musashi 0.0027 0.0105 0.0105
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0073 0.0037
Toxoplasma gondii hypothetical protein 0.0026 0.0095 0.0214
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0059 0.0335 0.0334
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0029 0.0117 0.0472
Schistosoma mansoni glutamate synthase 0.0029 0.0117 0.0117
Brugia malayi hypothetical protein 0.0036 0.0163 0.0184
Brugia malayi aldehyde dehydrogenase 0.003 0.0125 0.014
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0081 0.0091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0071 0.0262
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0071 0.0417
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.003 0.0125 0.0101
Trypanosoma brucei heat shock protein 84, putative 0.0059 0.0335 0.1517
Chlamydia trachomatis thioredoxin reductase 0.0029 0.0117 0.0697
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0072 0.0071
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0071 0.0151
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0805 0.5745 0.7132
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0457 0.0462
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0029 0.0117 0.0092
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.041 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0323 0.2252 0.2282
Schistosoma mansoni tar DNA-binding protein 0.0519 0.3672 0.3722
Trypanosoma cruzi malic enzyme 0.0023 0.0072 0.0268
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0029 0.0117 0.0092
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0006 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0051 0.0051
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0196 0.0471
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0277 0.1915 0.2181
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.011 0.0703 1
Brugia malayi hypothetical protein 0.007 0.0416 0.0472
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0251 0.0253
Brugia malayi Hsp90 protein 0.0059 0.0335 0.038
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0308 0.0308
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0006 0.0006
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0006 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0137
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0006 0.0006
Loa Loa (eye worm) TAR-binding protein 0.0519 0.3672 0.4183
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0029 0.0117 0.0277
Schistosoma mansoni inositol monophosphatase 0.0037 0.0171 0.0171
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0051 0.005
Echinococcus granulosus intermediate filament protein 0.0027 0.0105 0.0105
Onchocerca volvulus 0.0176 0.1185 0.1184
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0029 0.0117 0.0277
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0029 0.0117 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0175 0.1178 0.5306
Loa Loa (eye worm) MBCTL1 0.0054 0.0299 0.0339
Treponema pallidum oxidoreductase 0.0029 0.0117 0.0697
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0051 0.005
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0072 0.0072
Giardia lamblia Glutamate synthase 0.0029 0.0117 0.1114
Schistosoma mansoni kinase 0.0048 0.0256 0.0258
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0006 0.0005
Leishmania major DNA polymerase eta, putative 0.0019 0.0044 0.0077
Onchocerca volvulus 0.002 0.0053 0.0052
Brugia malayi Melibiase family protein 0.007 0.041 0.0465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0323 0.2252 0.2282
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0382 0.0881
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0043
Schistosoma mansoni hypothetical protein 0.003 0.0125 0.0125
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.003 0.0125 0.2007
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0052
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0596 0.1503
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0051 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0323 0.2252 0.2282
Leishmania major aldehyde dehydrogenase, putative 0.003 0.0125 0.0286
Schistosoma mansoni loxhd1 0.002 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0805 0.5745 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.003 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0821 0.586 0.5941
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0149 0.015
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0457 0.0462
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0076 0.0457 0.0519
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.003 0.0125 0.0101
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0171 0.033
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0596 0.0596
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0053 0.0053
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0029 0.0117 0.0117
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0029 0.0117 0.027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0012
Loa Loa (eye worm) glutathione reductase 0.0318 0.2208 0.2515
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0014 0.0014
Trichomonas vaginalis heat shock protein, putative 0.0084 0.0513 0.0513
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0029 0.0117 0.0472
Echinococcus granulosus heat shock protein 0.0089 0.0553 0.0559
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0432 0.0491
Echinococcus granulosus heat shock protein 90 0.0076 0.0459 0.0464
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0549 0.389 0.3943
Schistosoma mansoni disulfide oxidoreductase 0.0029 0.0117 0.0117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0382 0.0881
Echinococcus granulosus lamin dm0 0.0027 0.0105 0.0105
Brugia malayi RNA, U transporter 1 0.0088 0.0546 0.062
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.003 0.0125 0.0125
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0196
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.003 0.0125 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0051 0.0057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0791 0.08
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0051 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0416 0.042
Trypanosoma brucei polo-like protein kinase 0.0095 0.0596 0.2697
Leishmania major hypothetical protein, conserved 0.0028 0.0105 0.0237
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0251 0.0253
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0051 0.005
Echinococcus granulosus snurportin 1 0.0332 0.2311 0.2342
Brugia malayi Inositol-1 0.0037 0.0171 0.0192
Leishmania major dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.178
Loa Loa (eye worm) hypothetical protein 0.0175 0.1178 0.1341
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0175 0.1178 0.1419
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0048
Plasmodium vivax ferrodoxin reductase, putative 0.0029 0.0117 0.0277
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0247 0.0247
Trichomonas vaginalis heat shock protein, putative 0.0076 0.0459 0.0459
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0301 0.2091 0.2118
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0171 0.0769
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0051 0.0057
Schistosoma mansoni glutamate synthase 0.0029 0.0117 0.0117
Plasmodium vivax heat shock protein 90, putative 0.0059 0.0335 0.1224
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0196
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0014 0.0128
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.003 0.0125 0.009
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0457 0.1147
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0169 0.113 0.1144
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0171 0.0171
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0051 0.0057
Echinococcus granulosus cpg binding protein 0.0061 0.0347 0.0351
Schistosoma mansoni rab6-interacting 0.002 0.0053 0.0052
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0149 0.015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0051 0.0057
Trypanosoma brucei malic enzyme 0.0023 0.0072 0.0325
Entamoeba histolytica hypothetical protein 0.007 0.0416 0.6943
Loa Loa (eye worm) hypothetical protein 0.01 0.063 0.0716
Brugia malayi MH2 domain containing protein 0.0116 0.0748 0.085
Schistosoma mansoni aldehyde dehydrogenase 0.003 0.0125 0.0125
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0029 0.0117 0.0191
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0191 0.0216
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.003 0.0125 0.0101
Loa Loa (eye worm) RNA binding protein 0.0519 0.3672 0.4183
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0072 0.0071
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0053 0.0053
Echinococcus granulosus RUN 0.002 0.0053 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0308 0.1344
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0029 0.0117 0.0267
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0191 0.0216
Giardia lamblia Malic enzyme 0.0023 0.0072 0.0437
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0308 0.035
Loa Loa (eye worm) beta-lactamase 0.0175 0.1178 0.1341
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0596 0.0603
Trichomonas vaginalis glutaminase, putative 0.0547 0.3876 0.3876
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0117 0.0472
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0382 0.0386
Leishmania major hypothetical protein, conserved 0.0029 0.0117 0.0267
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0251 0.0253
Loa Loa (eye worm) hypothetical protein 0.0147 0.0971 0.1105
Loa Loa (eye worm) hypothetical protein 0.0175 0.1178 0.1341
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0191 0.0598
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0044 0.0077
Leishmania major hypothetical protein, conserved 0.0029 0.0117 0.0267
Brugia malayi hypothetical protein 0.0014 0.0006 0.0005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0171 0.0171
Brugia malayi steroid hormone receptor 0.002 0.0051 0.0057
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0029 0.0117 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0519 0.3672 0.3722
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0029 0.0117 0.0117
Echinococcus multilocularis microtubule associated protein 2 0.1373 0.9863 1
Loa Loa (eye worm) hypothetical protein 0.007 0.041 0.0466
Brugia malayi hypothetical protein 0.0036 0.0163 0.0184
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0014 0.0014
Leishmania major DNA polymerase kappa, putative 0.0019 0.0044 0.0077
Onchocerca volvulus 0.002 0.0051 0.005
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0029 0.0117 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0051 0.0057
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0029 0.0117 0.1882
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0006 0.0005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.011 0.0703 0.0825
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.117 0.1169
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0839 0.0849
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0006 0.0004
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Leishmania major hypothetical protein, conserved 0.0175 0.1178 0.3005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0549 0.389 1
Onchocerca volvulus 0.0082 0.0502 0.0501
Trypanosoma cruzi trypanothione reductase, putative 0.0318 0.2208 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0457 0.175
Mycobacterium ulcerans esterase/lipase LipP 0.0175 0.1178 0.295
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0006 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0105 0.0118
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0051 0.005
Schistosoma mansoni thyroid hormone receptor 0.002 0.0051 0.005
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1573 0.1594
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0176 0.1185 0.1201
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0084 0.0513 0.0776
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0029 0.0117 0.0117
Trypanosoma cruzi heat shock protein 85, putative 0.0089 0.0553 0.2457
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0006 0.0005
Loa Loa (eye worm) endoplasmin 0.0089 0.0553 0.0628
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0056 0.0055
Trichomonas vaginalis esterase, putative 0.0175 0.1178 0.1178
Leishmania major malic enzyme, putative 0.0023 0.0072 0.0152
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.011 0.0703 0.3143
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0051 0.0051
Giardia lamblia Alcohol dehydrogenase 0.003 0.0125 0.1227
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0549 0.389 0.4811
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0029 0.0117 0.0117
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.003 0.0125 0.0101
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0596 0.0596
Entamoeba histolytica hypothetical protein 0.007 0.0416 0.6943
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0044 0.0042
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0029 0.0117 0.0077
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.003 0.0125 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0176 0.1185 0.12
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0175 0.1178 0.1193
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0251 0.0285
Schistosoma mansoni ran 0.0023 0.0071 0.007
Brugia malayi nuclear receptor NHR-88 0.002 0.0051 0.0057
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.011 0.0703 0.0712
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0029 0.0117 0.0117
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0014 0.0014
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0196 0.0196
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0149 0.015
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0242 0.0592
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.003 0.0125 0.009
Brugia malayi mbt repeat family protein 0.0048 0.0251 0.0285
Onchocerca volvulus 0.0058 0.0323 0.0322
Leishmania major acetoin dehydrogenase e3 component-like protein 0.011 0.0703 0.178
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0039 0.0191 0.0192
Schistosoma mansoni heat shock protein 0.0089 0.0553 0.0559
Trypanosoma cruzi NADH dehydrogenase, putative 0.0029 0.0117 0.0472
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0044 0.0042
Mycobacterium ulcerans monoxygenase 0.0029 0.0117 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0596 0.0596
Echinococcus multilocularis lamin 0.0027 0.0105 0.0105
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0267 0.0279
Loa Loa (eye worm) hypothetical protein 0.0149 0.0989 0.1126
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0029 0.0117 0.0117
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0014 0.0059
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0012 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0748 0.0851
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0029 0.0117 0.0697
Schistosoma mansoni survival motor neuron protein 0.0047 0.0246 0.0247
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Mycobacterium ulcerans hypothetical protein 0.0029 0.0117 0.0191
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.003 0.0125 0.0814
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.003 0.0125 0.0561
Schistosoma mansoni aldehyde dehydrogenase 0.003 0.0125 0.0125
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0006 0.0005
Trypanosoma brucei glucosidase, putative 0.004 0.0196 0.0885
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0176 0.1185 0.12
Trichomonas vaginalis penicillin-binding protein, putative 0.0175 0.1178 0.1178
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0006 0.0004
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0308 0.035
Trichomonas vaginalis malic enzyme, putative 0.0017 0.0029 0.0029
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0044 0.0044
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0502 0.0508
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0095 0.0182
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0072 0.0072
Trypanosoma cruzi heat shock protein 85, putative 0.0076 0.0459 0.2031
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0662 0.067
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.0662 0.067
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0029 0.0117 0.0191
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0073 0.0077
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Brugia malayi CXXC zinc finger family protein 0.0058 0.0323 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0196 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.3143
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.011 0.0703 0.2819
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0051 0.0051
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0023 0.0072 0.0081
Schistosoma mansoni DNA polymerase eta 0.0019 0.0044 0.0042
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.011 0.0703 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0338 0.236 0.6054
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0051 0.0057
Mycobacterium tuberculosis Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarbo 0.0023 0.0072 0.0036
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.003 0.0125 0.0505
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.007 0.0416 0.042
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0051 0.0051
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0006 0.0005
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0171 0.0715
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0051 0.0051
Onchocerca volvulus 0.002 0.0053 0.0052
Brugia malayi hypothetical protein 0.0018 0.0034 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0051 0.0051
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0308 0.4015
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0012 0.0011
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0006 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0051 0.0057
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0056 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0051 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0175 0.1178 0.1178
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0006 0.0006
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1216 0.1232
Toxoplasma gondii exonuclease III APE 0.0056 0.0308 0.0764
Entamoeba histolytica heat shock protein 90, putative 0.0089 0.0553 0.9266
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0006 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0744 0.1887
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0051 0.0051
Echinococcus multilocularis geminin 0.1228 0.881 0.8932
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0149 0.015
Plasmodium falciparum ferrodoxin reductase-like protein 0.0029 0.0117 0.0277
Echinococcus multilocularis beta LACTamase domain containing family member 0.0175 0.1178 0.1193
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0242 0.0818
Echinococcus multilocularis heat shock protein 90 0.0089 0.0553 0.0559
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0044 0.0048
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0072 0.0072
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Brugia malayi RNA recognition motif domain containing protein 0.0519 0.3672 0.4183
Schistosoma mansoni ran 0.0023 0.0071 0.007
Loa Loa (eye worm) NADP-malic enzyme 0.0017 0.0029 0.0032
Plasmodium falciparum thioredoxin reductase 0.0318 0.2208 0.9344
Brugia malayi RNA binding protein 0.0519 0.3672 0.4183
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0073 0.0329
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.011 0.0703 0.0712
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0051 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0051 0.0057
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0457 0.0462
Echinococcus multilocularis tar DNA binding protein 0.0519 0.3672 0.3722
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.003 0.0125 0.0125
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.003 0.0125 0.0286
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0029 0.0117 0.0132
Echinococcus granulosus GPCR family 2 0.0034 0.0149 0.015
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0014 0.0014
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.003 0.0125 0.0125
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0029 0.0117 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0196
Brugia malayi Aldehyde dehydrogenase protein 4 0.003 0.0125 0.014
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.003 0.0125 0.014
Loa Loa (eye worm) glutaminase 0.0547 0.3876 0.4416
Schistosoma mansoni hypothetical protein 0.1228 0.881 0.8932
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0131 0.0589
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0006 0.0005
Plasmodium falciparum glutathione reductase 0.011 0.0703 0.2819
Trichomonas vaginalis ran, putative 0.0023 0.0071 0.0071
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0382 0.0386
Leishmania major GTP-binding protein, putative 0.0023 0.0071 0.0148
Loa Loa (eye worm) hypothetical protein 0.0027 0.0101 0.0113
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0071 0.0319
Brugia malayi Probable ClpP-like protease 0.0076 0.0457 0.0519
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0006 0.0005
Mycobacterium ulcerans lipase LipD 0.0175 0.1178 0.295
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0029 0.0117 0.0277
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0029 0.0117 0.0697
Giardia lamblia NADH oxidase lateral transfer candidate 0.011 0.0703 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0149 0.0168
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0051 0.005
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0072 0.0072
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0308 0.0311
Mycobacterium tuberculosis Probable dehydrogenase 0.0724 0.5159 0.6398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.3143
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0131 0.0305
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0457 0.6089
Toxoplasma gondii melibiase subfamily protein 0.0104 0.0662 0.1676
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0105 0.0418
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0105 0.0226
Onchocerca volvulus 0.0105 0.0663 0.0662
Schistosoma mansoni aldehyde dehydrogenase 0.003 0.0125 0.0125
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0308 0.1394
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0006 0.0004
Trichomonas vaginalis apoptosis inducing factor, putative 0.0029 0.0117 0.0117
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0175 0.1178 0.1193
Loa Loa (eye worm) hypothetical protein 0.0054 0.0299 0.0339
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0006 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0012 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0051 0.0057
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.003 0.0125 0.0505
Schistosoma mansoni lamin 0.0027 0.0105 0.0104
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0072 0.0072
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0056 0.0055
Mycobacterium ulcerans malate dehydrogenase 0.0023 0.0072 0.0075
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0662 0.067
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.003 0.0125 0.021
Toxoplasma gondii heat shock protein 90, putative 0.0089 0.0553 0.1394
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0081 0.0081
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.003 0.0125 0.0289
Trichomonas vaginalis endoplasmin, putative 0.0065 0.0375 0.0375
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.011 0.0703 0.2819
Plasmodium falciparum importin beta, putative 0.0031 0.0131 0.0335
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0748 0.0851
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0149 0.0168
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.003 0.0125 0.021
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0072 0.0072
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0051 0.0057
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.003 0.0125 0.0101
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0194
Mycobacterium tuberculosis Conserved protein 0.0175 0.1178 0.1419
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0006 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0051 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0246 0.0278
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0457 0.6089
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0029 0.0117 0.0077
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0029 0.0117 0.0077
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Entamoeba histolytica hypothetical protein 0.007 0.0416 0.6943
Mycobacterium tuberculosis Probable oxidoreductase 0.0805 0.5745 0.7132
Echinococcus granulosus expressed protein 0.0014 0.0006 0.0005
Onchocerca volvulus 0.0048 0.0251 0.025
Trichomonas vaginalis D-aminoacylase, putative 0.0175 0.1178 0.1178
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.003 0.0125 0.021
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.003 0.0125 0.021
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.011 0.0703 1
Schistosoma mansoni tar DNA-binding protein 0.0519 0.3672 0.3722
Trypanosoma cruzi heat shock protein 85, putative 0.0089 0.0553 0.2457
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.003 0.0125 0.021
Loa Loa (eye worm) aldehyde dehydrogenase 0.003 0.0125 0.014
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0006 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0175 0.1178 0.295
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0044 0.0194
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.003 0.0125 0.0125
Brugia malayi nuclear hormone receptor 0.002 0.0051 0.0057
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Treponema pallidum heat shock protein 90 0.0084 0.0513 0.698
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0191 0.0216
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0029 0.0117 0.0267
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0382 0.0434
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0318 0.2208 0.2708
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0171 0.0408
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0596 0.0678
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.003 0.0125 0.0505
Loa Loa (eye worm) hypothetical protein 0.0073 0.0432 0.0491
Trichomonas vaginalis heat shock protein, putative 0.0084 0.0513 0.0513
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0006 0.0004
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.003 0.0125 0.014
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0084 0.0513 0.698
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0308 0.0761
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0105 0.0226
Treponema pallidum NADH oxidase 0.011 0.0703 1
Entamoeba histolytica heat shock protein 90, putative 0.0089 0.0553 0.9266
Brugia malayi follicle stimulating hormone receptor 0.0277 0.1915 0.2181
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0662 0.067
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.003 0.0125 0.2007
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0029 0.0117 0.0191
Plasmodium vivax glutathione reductase, putative 0.0318 0.2208 0.9344
Entamoeba histolytica Ran family GTPase 0.0023 0.0071 0.1103
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0596 0.0603
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0051 0.005
Trypanosoma brucei Heat shock protein 83, putative 0.0089 0.0553 0.2501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0323 0.2252 0.2282
Mycobacterium ulcerans glutaminase 0.0547 0.3876 0.9964
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0095 0.0039
Echinococcus granulosus muscleblind protein 0.0149 0.0989 0.1002
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0196
Echinococcus multilocularis muscleblind protein 0.0149 0.0989 0.1002
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0196 0.0196
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0051 0.0051
Schistosoma mansoni lipoxygenase 0.0122 0.0791 0.08
Brugia malayi heat shock protein 90 0.0089 0.0553 0.0628
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0014 0.0006 0.0004
Brugia malayi beta-lactamase family protein 0.0175 0.1178 0.1341
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0029 0.0117 0.027
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.2311 0.2632
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0072 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0308 0.1344
Trichomonas vaginalis mercuric reductase, putative 0.011 0.0703 0.0703
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.003 0.0125 0.0289
Onchocerca volvulus 0.0175 0.1178 0.1177
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.1216 0.1384
Echinococcus granulosus FTZ F1 alpha 0.002 0.0051 0.0051
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0308 0.0689
Echinococcus multilocularis dnaJ subfamily B 0.0821 0.586 0.5941
Entamoeba histolytica thioredoxin reductase, putative 0.0029 0.0117 0.1882
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.011 0.0703 0.3183
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.011 0.0703 0.178
Echinococcus granulosus thioredoxin glutathione reductase 0.0321 0.2234 0.2264
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0095 0.0351
Schistosoma mansoni hypothetical protein 0.1228 0.881 0.8932
Schistosoma mansoni tar DNA-binding protein 0.0519 0.3672 0.3722
Mycobacterium tuberculosis Probable esterase LipL 0.0175 0.1178 0.1419
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0196 0.0832
Plasmodium falciparum glutathione reductase 0.0318 0.2208 0.9344
Giardia lamblia Thioredoxin reductase 0.0029 0.0117 0.1114
Onchocerca volvulus 0.0175 0.1178 0.1177
Entamoeba histolytica hypothetical protein 0.0025 0.0088 0.1389
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0051 0.0051
Brugia malayi mbt repeat family protein 0.0048 0.0251 0.0285
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1121 0.8038 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0071 0.0262
Trichomonas vaginalis set domain proteins, putative 0.1392 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.011 0.0703 0.3143
Onchocerca volvulus 0.01 0.063 0.0628
Schistosoma mansoni importin beta-1 0.0031 0.0131 0.0131
Loa Loa (eye worm) heat shock protein 75 0.0059 0.0335 0.0381
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.003 0.0125 0.0505
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0029 0.0117 0.0117
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0051 0.0051
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0014 0.0014
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0596 0.2654
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0084 0.0513 0.1289
Loa Loa (eye worm) heat shock protein 90 0.0089 0.0553 0.0628
Treponema pallidum thioredoxin reductase (trxB) 0.0029 0.0117 0.0697
Trichomonas vaginalis D-aminoacylase, putative 0.0175 0.1178 0.1178
Echinococcus granulosus glutamate synthase 0.0029 0.0117 0.0117
Schistosoma mansoni heat shock protein 0.0089 0.0553 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0051 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0053 0.0053
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0072 0.0072
Trypanosoma cruzi heat shock protein 90, putative 0.0076 0.0459 0.2031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0176 0.1185 0.12
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.003 0.0125 0.021
Mycobacterium tuberculosis Conserved protein 0.0175 0.1178 0.1419
Schistosoma mansoni endoplasmin 0.0089 0.0553 0.0559
Mycobacterium ulcerans aldehyde dehydrogenase 0.003 0.0125 0.021
Echinococcus granulosus beta LACTamase domain containing family member 0.0175 0.1178 0.1193
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0029 0.0117 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0323 0.2252 0.2282
Schistosoma mansoni cpg binding protein 0.0061 0.0347 0.035
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0267 0.0269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0137
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0143 0.0123
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0029 0.0117 0.0527
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0006 0.0005
Echinococcus multilocularis expressed protein 0.0014 0.0006 0.0005
Onchocerca volvulus 0.0047 0.0246 0.0244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0549 0.389 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0791 0.08
Echinococcus multilocularis tumor protein p63 0.0682 0.4854 0.4921
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0196 0.0222
Echinococcus multilocularis expressed protein 0.0046 0.0242 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0323 0.2252 0.2565
Trypanosoma brucei heat shock protein 90, putative 0.0089 0.0553 0.2501
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0308 0.0331
Trypanosoma brucei hypothetical protein, conserved 0.0175 0.1178 0.5334
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0029 0.0117 0.0077
Loa Loa (eye worm) inositol-1 0.0037 0.0171 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0088 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.3143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0676 0.0769
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0059 0.0335 0.0339
Echinococcus granulosus heat shock protein 90 0.0089 0.0553 0.0559
Mycobacterium ulcerans ferredoxin reductase 0.0029 0.0117 0.0191
Plasmodium vivax importin-beta 2, putative 0.0031 0.0131 0.0335
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0029 0.0117 0.1882
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0457 0.6089
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0171 0.2787
Echinococcus granulosus dna polymerase kappa 0.0019 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0059
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0416 0.042
Onchocerca volvulus 0.0014 0.0006 0.0004
Leishmania major trypanothione reductase 0.0318 0.2208 0.5663
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0071 0.0079
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.003 0.0125 0.0286
Schistosoma mansoni microtubule-associated protein tau 0.1373 0.9863 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0171 0.0171
Schistosoma mansoni aldehyde dehydrogenase 0.003 0.0125 0.0125
Entamoeba histolytica disulphide oxidoreductase, putative 0.0029 0.0117 0.1882
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0308 0.3733
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0989 0.1002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0175 0.1178 0.1341
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0299 0.0302
Trypanosoma brucei trypanothione reductase 0.0318 0.2208 1
Brugia malayi Endoplasmin precursor 0.0089 0.0553 0.0628
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0171 0.0715
Schistosoma mansoni nuclear hormone receptor 0.002 0.0051 0.005
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0308 0.0308
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0029 0.0117 0.0117
Loa Loa (eye worm) thioredoxin reductase 0.0318 0.2208 0.2515
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.003 0.0125 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0176 0.1185 0.3025
Trypanosoma brucei aldehyde dehydrogenase, putative 0.003 0.0125 0.0561
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.011 0.0703 0.0712
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.003 0.0125 0.0505
Brugia malayi hypothetical protein 0.002 0.0053 0.0059
Trichomonas vaginalis glutathione reductase, putative 0.011 0.0703 0.0703
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0051 0.0051
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0029 0.0117 0.0267
Plasmodium vivax endoplasmin, putative 0.0089 0.0553 0.2166
Onchocerca volvulus 0.0014 0.0006 0.0004
Trypanosoma cruzi heat shock protein 90, putative 0.0089 0.0553 0.2457
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.011 0.0703 0.3183
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.003 0.0125 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.3143
Schistosoma mansoni cpg binding protein 0.0058 0.0323 0.0326
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0105 0.0418
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0131 0.0589
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1223 0.8776 1
Trypanosoma cruzi malic enzyme 0.0023 0.0072 0.0268
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.003 0.0125 0.0561
Echinococcus multilocularis glutamate synthase 0.0029 0.0117 0.0117
Echinococcus multilocularis lamin dm0 0.0027 0.0105 0.0105
Schistosoma mansoni polycystin 1-related 0.002 0.0053 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0117 0.0527
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0073 0.0154
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0191 0.0461
Schistosoma mansoni ap endonuclease 0.0056 0.0308 0.0311
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0006 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0051 0.0057
Plasmodium vivax SET domain protein, putative 0.0176 0.1185 0.4909
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0006 0.0004
Mycobacterium tuberculosis Probable hydrolase 0.0175 0.1178 0.1419
Schistosoma mansoni heat shock protein 0.0059 0.0335 0.0338
Loa Loa (eye worm) glutaminase 2 0.0547 0.3876 0.4416
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.003 0.0125 0.021
Trichomonas vaginalis glutamate synthase, putative 0.0029 0.0117 0.0117
Brugia malayi Muscleblind-like protein 0.0149 0.0989 0.1125
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0044 0.0043
Echinococcus granulosus dna polymerase eta 0.0019 0.0044 0.0043
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0029 0.0117 0.1114
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0267 0.0341
Loa Loa (eye worm) hypothetical protein 0.0175 0.1178 0.1341
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0805 0.5745 0.7132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.3143
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0299 0.0302
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0072 0.0072
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0029 0.0117 0.0117
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0131 0.0131
Trypanosoma brucei heat shock protein 90, putative 0.0089 0.0553 0.2501
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0076 0.0459 0.0464
Trichomonas vaginalis glutamate synthase, putative 0.0029 0.0117 0.0117
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.003 0.0125 0.021
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0072 0.0072
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0059 0.0335 0.5583
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0596 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.003 0.0125 0.0101
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0071 0.0071
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.0662 0.067
Trypanosoma brucei NADP-dependent malic enzyme, cytosolic 0.0023 0.0072 0.0325
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0196 0.0222
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0006 0.0005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.003 0.0125 0.0101
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0056 0.0055
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0175 0.1178 0.1419
Loa Loa (eye worm) hypothetical protein 0.0082 0.0502 0.0571
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0051 0.005
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0105 0.0474
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0006 0.0005
Brugia malayi intermediate filament protein 0.0027 0.0105 0.0117
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0242 0.0818
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0676 0.0769
Schistosoma mansoni glutaminase 0.0547 0.3876 0.3929
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0071 0.0077
Leishmania major NADH dehydrogenase, putative 0.0029 0.0117 0.0267
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.011 0.0703 0.1782
Leishmania major aldehyde dehydrogenase, putative 0.003 0.0125 0.0286
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0051 0.0051
Echinococcus multilocularis GPCR, family 2 0.0034 0.0149 0.015
Loa Loa (eye worm) programmed cell death 8 0.0029 0.0117 0.0132
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0457 0.175
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0006 0.0005
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0171 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0323 0.2252 0.2282
Schistosoma mansoni hypothetical protein 0.0332 0.2311 0.2342
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0308 0.3733
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0029 0.0117 0.027
Brugia malayi Pre-SET motif family protein 0.1223 0.8776 1
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0596 0.0603
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0029 0.0117 0.0117
Echinococcus granulosus tar DNA binding protein 0.0519 0.3672 0.3722
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0029 0.0117 0.0117
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0457 0.1075
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0051 0.0057
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0072 0.0071
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.003 0.0125 0.0505
Schistosoma mansoni glutamate synthase 0.0029 0.0117 0.0117
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0171 0.0171
Giardia lamblia Heat shock protein HSP 90-alpha 0.0076 0.0459 0.6301
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0117 0.0472
Leishmania major aldehyde dehydrogenase, putative 0.003 0.0125 0.0286
Schistosoma mansoni alpha-glucosidase 0.0156 0.1033 0.1046
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0171 0.1544
Loa Loa (eye worm) hypothetical protein 0.0175 0.1178 0.1341
Brugia malayi ecdysteroid receptor 0.002 0.0051 0.0057
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.003 0.0125 0.2007
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0029 0.0117 0.0472
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0029 0.0117 0.0092
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0088 0.0339
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0502 0.0508
Echinococcus multilocularis dna polymerase eta 0.0019 0.0044 0.0043
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0242 0.0244
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0196 0.3221
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0196 0.0832
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0724 0.5159 0.6398
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0149
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0375 0.0375
Brugia malayi Pre-SET motif family protein 0.0176 0.1185 0.1349
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0502 0.0508
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0596 0.0596
Mycobacterium ulcerans NADH dehydrogenase 0.0029 0.0117 0.0191
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0196 0.0197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0416 0.042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0549 0.389 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.117 0.1332
Echinococcus granulosus expressed protein 0.0046 0.0242 0.0244
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0596 0.0596
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0023 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0149 0.0989 0.1126
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0242 0.0274
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0029 0.0117 0.1882
Schistosoma mansoni rab6-interacting 0.002 0.0053 0.0052
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0029 0.0117 0.0117
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.003 0.0125 0.0123
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0014 0.0012
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.003 0.0125 0.021
Toxoplasma gondii aldehyde dehydrogenase 0.0549 0.389 1
Schistosoma mansoni cpg binding protein 0.0061 0.0347 0.035
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0029 0.0117 0.0117
Trypanosoma cruzi heat shock protein 85, putative 0.0089 0.0553 0.2457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0051 0.0057
Toxoplasma gondii selenide, water dikinase 0.0029 0.0117 0.027
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0251 0.025
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.003 0.0125 0.2007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0171 0.0405
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.003 0.0125 0.0289
Loa Loa (eye worm) hypothetical protein 0.0048 0.0251 0.0285
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0282 0.0282
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.041 0.0414
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0323 0.2252 0.2282
Onchocerca volvulus 0.0147 0.0971 0.097
Toxoplasma gondii ABC1 family protein 0.0175 0.1178 0.3007
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0549 0.389 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0051 0.0051
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0029 0.0117 0.0191
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0044 0.0636
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0457 0.0677
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0029 0.0117 0.0527
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.003 0.0125 0.0505
Mycobacterium leprae Probable lipase LipE 0.0175 0.1178 0.1948
Brugia malayi beta-lactamase family protein 0.0175 0.1178 0.1341
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0549 0.389 0.3943
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.0662 0.067
Echinococcus granulosus histone lysine methyltransferase setb 0.0176 0.1185 0.1201
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Plasmodium falciparum heat shock protein 90 0.0089 0.0553 0.2166
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0006 0.0005
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0029 0.0117 0.0132
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0251 0.0253
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.003 0.0125 0.0125
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0051 0.0057
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0299 0.0339
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0006 0.0005
Echinococcus multilocularis heat shock protein 0.0089 0.0553 0.0559
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.003 0.0125 0.014
Echinococcus multilocularis cpg binding protein 0.0061 0.0347 0.0351
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0006 0.0005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.011 0.0703 0.1716
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Echinococcus multilocularis RUN 0.002 0.0053 0.0053
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0029 0.0117 0.0191
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0105 0.0226
Schistosoma mansoni ap endonuclease 0.0056 0.0308 0.0311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0676 0.0769
Schistosoma mansoni coup transcription factor 0.002 0.0051 0.005
Trypanosoma cruzi heat shock protein, putative 0.0059 0.0335 0.1467
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0029 0.0117 0.1882
Leishmania major dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.178
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.003 0.0125 0.009
Echinococcus granulosus lamin 0.0027 0.0105 0.0105
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0724 0.5159 0.6398
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0006 0.0005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0196 0.3221
Entamoeba histolytica hypothetical protein 0.0023 0.0073 0.1138
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0251 0.0253
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0118
Trypanosoma cruzi Heat shock protein 83, putative 0.0089 0.0553 0.2457
Schistosoma mansoni sulfide quinone reductase 0.0029 0.0117 0.0117
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0029 0.0117 0.0117
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.003 0.0125 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0175 0.1178 0.4878
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.035 0.0398
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0724 0.5159 0.6398
Loa Loa (eye worm) hypothetical protein 0.003 0.0125 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Trypanosoma cruzi NADH dehydrogenase, putative 0.0029 0.0117 0.0472
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0029 0.0117 0.027
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0073 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0323 0.2252 0.2565
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0029 0.0117 0.0117
Trypanosoma cruzi malic enzyme, putative 0.0023 0.0072 0.0268
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0267 0.0269
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Schistosoma mansoni inositol monophosphatase 0.0037 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0057
Giardia lamblia Heat shock protein HSP 90-alpha 0.0089 0.0553 0.7719
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0191 0.0216
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0251 0.0253
Brugia malayi glutaminase DH11.1 0.0547 0.3876 0.4415
Giardia lamblia Grp94/Hsp90 0.0084 0.0513 0.7116
Trypanosoma brucei NADH dehydrogenase 0.0029 0.0117 0.0527
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0072 0.0071
Plasmodium vivax heat shock protein 86, putative 0.0089 0.0553 0.2166
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0251 0.0253
Echinococcus granulosus dnaJ subfamily B 0.0821 0.586 0.5941
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0029 0.0117 0.0527
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0006 0.0005
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Mycobacterium ulcerans hypothetical protein 0.0175 0.1178 0.295
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0596 0.0596
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.011 0.0703 0.2819
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0382 0.0386
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0196 0.0197
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0724 0.5159 0.8966
Mycobacterium ulcerans dehydrogenase 0.0029 0.0117 0.0191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0175 0.1178 0.1341
Loa Loa (eye worm) hypothetical protein 0.0031 0.0131 0.0147
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0029 0.0117 0.0132
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0072 0.0072
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0043
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0149
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0242 0.0274
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0073 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0308 0.5125
Plasmodium falciparum heat shock protein 90, putative 0.0338 0.236 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0308 0.0311
Schistosoma mansoni thyroid hormone receptor 0.002 0.0051 0.005
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0029 0.0117 0.0697
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0051 0.0057
Giardia lamblia Kinase, PLK 0.0095 0.0596 0.8375
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.003 0.0125 0.0289
Echinococcus multilocularis heat shock protein 90 0.0076 0.0459 0.0464
Schistosoma mansoni intermediate filament proteins 0.0027 0.0105 0.0104
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0382 0.0424
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.003 0.0125 0.0561
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0088 0.0088
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.003 0.0125 0.021
Echinococcus granulosus endoplasmin 0.0084 0.0513 0.0519
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0029 0.0117 0.0117
Onchocerca volvulus 0.0027 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.0175 0.1178 0.1341
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0457 0.1147
Loa Loa (eye worm) hypothetical protein 0.023 0.1573 0.1792
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0502 0.0571
Mycobacterium ulcerans beta-lactamase 0.0175 0.1178 0.295
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0176 0.0742
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0105 0.0117
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0005
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0029 0.0117 0.0092
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0053 0.0053
Trypanosoma brucei unspecified product 0.0019 0.0044 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.1216 0.1232
Schistosoma mansoni hypothetical protein 0.0073 0.0432 0.0436
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0596 0.2654
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0106 0.0676 0.0769
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0029 0.0117 0.1882
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0029 0.0117 0.0277
Trypanosoma brucei heat shock protein, putative 0.0089 0.0553 0.2501
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0029 0.0117 0.0191
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.003 0.0125 0.0505
Echinococcus granulosus importin subunit beta 1 0.0031 0.0131 0.0131
Plasmodium vivax heat shock protein, putative 0.0338 0.236 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0051 0.0057
Mycobacterium leprae conserved hypothetical protein 0.0175 0.1178 0.1948
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0051 0.0057
Onchocerca volvulus 0.0175 0.1178 0.1177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.011 0.0703 0.3143
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0191 0.0192
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.003 0.0125 0.021
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.011 0.0703 0.3183
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0053 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.011 0.0703 0.3183
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0073 0.0157
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.003 0.0125 0.0125
Schistosoma mansoni aldehyde dehydrogenase 0.0549 0.389 0.3943
Schistosoma mansoni hypothetical protein 0.0047 0.0246 0.0247
Schistosoma mansoni alpha-glucosidase 0.0156 0.1033 0.1046
Leishmania major heat shock protein 83-1 0.0089 0.0553 0.1391
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0457 0.6089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0519 0.3672 0.4183
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.003 0.0125 0.0101
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0006 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0176 0.1185 0.12
Trypanosoma cruzi hypothetical protein, conserved 0.0175 0.1178 0.5306
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0071 0.0077
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0073 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0519 0.3672 0.3722
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0051 0.005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0176 0.1185 0.1201
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0168
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0073 0.0157
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0084 0.0513 0.0587
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0029 0.0117 0.0117
Schistosoma mansoni sulfide quinone reductase 0.0029 0.0117 0.0117
Schistosoma mansoni aldehyde dehydrogenase 0.003 0.0125 0.0125
Mycobacterium tuberculosis Conserved protein 0.0175 0.1178 0.1419
Brugia malayi G-protein alpha subunit 0.0014 0.0006 0.0005
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.003 0.0125 0.0505
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.003 0.0125 0.0505
Trichomonas vaginalis D-aminoacylase, putative 0.0175 0.1178 0.1178
Treponema pallidum gamma-glutamyl phosphate reductase 0.003 0.0125 0.0814
Schistosoma mansoni lipoxygenase 0.0085 0.0524 0.053
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0382 0.0952
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0662 0.067
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0457 0.1075
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0051 0.0057
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0029 0.0117 0.0092
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0081 0.0492 0.0558
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0071 0.0079
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0044 0.0137
Trichomonas vaginalis heat shock protein, putative 0.0089 0.0553 0.0553
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.1216 0.1232
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0006 0.0004
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0029 0.0117 0.0117

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.63 uM Agonist at human recombinant P2Y1 receptor expressed in human 1321 cells by calcium mobilization assay ChEMBL. 18232657
EC50 (functional) = 9.4 uM Agonist activity at P2Y2 receptor (unknown origin) expressed in human 1321 cells by calcium mobilization assay ChEMBL. 18232657
EC50 (functional) = 9.75 uM Agonist activity at P2Y6 receptor (unknown origin) expressed in human 1321 cells by calcium mobilization assay ChEMBL. 18232657
IC50 (functional) = 10.8 uM Antagonist activity at P2Y12 receptor assessed as inhibition of ADP-induced human platelet aggregation by washed platelet assay ChEMBL. 18232657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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