TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.478 | Formula: C26H21N5O
H donors: 1 H acceptors: 4 LogP: 3.63 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(n1)c1nn(cc1c1ccc2c(c1)cccn2)Cc1cccc(c1)C(=O)N
InChi: 1S/C26H21N5O/c1-17-5-2-9-24(29-17)25-22(19-10-11-23-20(14-19)8-4-12-28-23)16-31(30-25)15-18-6-3-7-21(13-18)26(27)32/h2-14,16H,15H2,1H3,(H2,27,32)
InChiKey: INVLKWXJDGRCQV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	activin A receptor, type IB	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	Get druggable targets OG5_129709	All targets in OG5_129709
Brugia malayi	bone morphogenetic protein type 1 receptor	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus granulosus	TGF beta receptor type 1	Get druggable targets OG5_129709	All targets in OG5_129709
Schistosoma japonicum	ko:K04674 transforming growth factor, beta receptor I, putative	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus multilocularis	TGF beta receptor type 1	Get druggable targets OG5_129709	All targets in OG5_129709
Schistosoma mansoni	protein kinase	Get druggable targets OG5_129709	All targets in OG5_129709
Echinococcus granulosus	TGF-beta receptor type-1	Get druggable targets OG5_129709	All targets in OG5_129709

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	dnaJ subfamily B	0.0452	1	1
Schistosoma mansoni	smad1 5 8 and	0.0026	0.0321	0.0321
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.024	0.0426
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.1203	0.1459
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.024	0.024
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0013	0.0028	0.0028
Echinococcus granulosus	dna polymerase kappa	0.0022	0.024	0.024
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0013	0.0028	0.0028
Brugia malayi	Pre-SET motif family protein	0.0204	0.4373	0.5301
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0886	0.0886
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0158	0.3168
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0379	0.0379
Brugia malayi	RasGEF domain containing protein	0.0013	0.0028	0.0033
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0067	0.1251	0.1251
Trypanosoma brucei	unspecified product	0.0022	0.024	0.4374
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0173
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0047	0.0811	0.0811
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.024	0.4374
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Onchocerca volvulus		0.0018	0.0143	0.0181
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0186	0.3963	0.4804
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0887	0.1724
Echinococcus granulosus	tar DNA binding protein	0.0064	0.1203	0.1203
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.1203	0.1459
Loa Loa (eye worm)	Smad1	0.0026	0.0321	0.0389
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0191	0.4077	0.4943
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0158	0.1963
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0887	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1493	0.1809
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.1488	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0018	0.0143	0.0173
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1197	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0061	0.0075
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0461	0.0559
Echinococcus granulosus	histone lysine methyltransferase setb	0.0064	0.1197	0.1197
Trypanosoma cruzi	ISWI complex protein	0.0031	0.0439	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.3963	0.3963
Toxoplasma gondii	exonuclease III APE	0.0018	0.0158	0.0111
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Brugia malayi	RasGEF domain containing protein	0.0013	0.0028	0.0033
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0419	0.2049
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0186	0.3963	0.3963
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0018	0.0143	0.0143
Onchocerca volvulus		0.003	0.0419	0.0529
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0067	0.1251	0.1251
Leishmania major	hypothetical protein, conserved	0.0031	0.0439	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0375	0.8249	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0886	0.4744
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0013	0.0028	0.0033
Onchocerca volvulus		0.0032	0.0461	0.0583
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1488	0.5
Schistosoma mansoni	hypothetical protein	0.0031	0.0439	0.0439
Toxoplasma gondii	hypothetical protein	0.0027	0.0343	0.1486
Trypanosoma cruzi	ISWI complex protein	0.0031	0.0439	1
Brugia malayi	Pre-SET motif family protein	0.003	0.0419	0.0508
Brugia malayi	DIX domain containing protein	0.0018	0.0143	0.0173
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0034	0.0519	0.0519
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0074	0.1415	0.1715
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.1488	0.1488
Echinococcus multilocularis	segment polarity protein dishevelled	0.0018	0.0143	0.0143
Brugia malayi	protein C17H12.11	0.0074	0.1408	0.1707
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0158	0.0158
Brugia malayi	PHD-finger family protein	0.0056	0.1006	0.1219
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1203	0.1203
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0886	1
Brugia malayi	MH1 domain containing protein	0.0014	0.0061	0.0075
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0186	0.3963	0.3963
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.024	0.0616
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Loa Loa (eye worm)	RNA binding protein	0.0064	0.1203	0.1459
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.1203	0.1459
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.3963	0.3963
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.016	0.3377	0.3377
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0158	0.2058
Brugia malayi	hypothetical protein	0.0074	0.1408	0.1707
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0012	0.0014	0.0014
Echinococcus multilocularis	segment polarity protein dishevelled	0.0018	0.0143	0.0143
Entamoeba histolytica	hypothetical protein	0.0036	0.0559	0.8
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0692	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0028	0.0033
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1203	0.1203
Toxoplasma gondii	histone lysine methyltransferase SET1	0.007	0.1324	0.8781
Echinococcus multilocularis	GPCR, family 2	0.0067	0.1251	0.1251
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0018	0.0143	0.0173
Echinococcus multilocularis	ras GTP exchange factor	0.0013	0.0028	0.0028
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0343	0.139
Echinococcus granulosus	ras GTP exchange factor	0.0013	0.0028	0.0028
Brugia malayi	Calcitonin receptor-like protein seb-1	0.021	0.4513	0.5471
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0026	0.0321	0.0321
Schistosoma mansoni	bromodomain containing protein	0.0133	0.2757	0.2757
Loa Loa (eye worm)	MH2 domain-containing protein	0.0026	0.0321	0.0389
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0047	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.036	0.7912	0.9592
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.024	0.2915
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1488	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0559	0.0559
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.024	0.024
Echinococcus granulosus	TGF-beta receptor type-1	0.0191	0.4084	0.4084
Loa Loa (eye worm)	fli-1 protein	0.0223	0.4792	0.581
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0186	0.3963	0.3963
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1488	1
Brugia malayi	MH2 domain containing protein	0.0026	0.0321	0.0389
Schistosoma mansoni	hypothetical protein	0.0036	0.0559	0.0559
Schistosoma mansoni	gabp alpha	0.0073	0.1405	0.1405
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0067	0.1251	0.1516
Echinococcus multilocularis	son of sevenless 1	0.0013	0.0028	0.0028
Schistosoma mansoni	cpg binding protein	0.0037	0.059	0.059
Schistosoma mansoni	DNA polymerase eta	0.0022	0.024	0.024
Echinococcus multilocularis	smad	0.0026	0.0321	0.0321
Echinococcus granulosus	fetal alzheimer antigen falz	0.0047	0.0811	0.0811
Echinococcus granulosus	dna polymerase eta	0.0022	0.024	0.024
Brugia malayi	Muscleblind-like protein	0.0154	0.3227	0.3912
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.024	0.1126
Loa Loa (eye worm)	acetyltransferase	0.016	0.3377	0.4094
Schistosoma mansoni	hypothetical protein	0.0067	0.1251	0.1251
Brugia malayi	regulator of G-protein signaling egl-10	0.0018	0.0143	0.0173
Giardia lamblia	DINP protein human, muc B family	0.0022	0.024	0.1536
Entamoeba histolytica	hypothetical protein	0.0036	0.0559	0.8
Echinococcus multilocularis	regulator of G protein signaling 7	0.0018	0.0143	0.0143
Schistosoma mansoni	cpg binding protein	0.0032	0.0461	0.0461
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.1488	1
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0013	0.0028	0.0028
Trypanosoma brucei	ISWI complex protein	0.0031	0.0439	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.1488	0.1488
Echinococcus multilocularis	zinc finger protein	0.0045	0.0762	0.0762
Brugia malayi	hypothetical protein	0.0018	0.0143	0.0173
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0186	0.3963	0.4804
Brugia malayi	TAR-binding protein	0.0064	0.1203	0.1459
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0013	0.0028	0.0028
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0013	0.0028	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0142	0.297	0.36
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0158	0.0262
Brugia malayi	N-terminal motif family protein	0.0013	0.0028	0.0033
Brugia malayi	Ets-domain containing protein	0.0073	0.1405	0.1703
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.024	0.516
Brugia malayi	MH2 domain containing protein	0.0375	0.8249	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Echinococcus multilocularis	GA binding protein alpha chain	0.0073	0.1405	0.1405
Echinococcus multilocularis	regulator of G protein signaling 7	0.0018	0.0143	0.0143
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.1488	0.1488
Echinococcus multilocularis	muscleblind protein	0.0154	0.3227	0.3227
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0158	0.0192
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0067	0.1251	0.1516
Schistosoma mansoni	smad	0.0026	0.0321	0.0321
Brugia malayi	Bromodomain containing protein	0.0081	0.1576	0.191
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.501	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1488	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0419	0.0419
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.024	0.0291
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0074	0.1415	0.1715
Entamoeba histolytica	hypothetical protein	0.0036	0.0559	0.8
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.024	0.1126
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0126	0.2594	0.2594
Schistosoma mansoni	smad1 5 8 and	0.0026	0.0321	0.0321
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0151	0.317	0.317
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0064	0.1197	0.1197
Echinococcus granulosus	regulator of G protein signaling 7	0.0018	0.0143	0.0143
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0034	0.0519	0.0519
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0186	0.3963	0.3963
Schistosoma mansoni	dishevelled	0.0018	0.0143	0.0143
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0034	0.0519	0.0519
Schistosoma mansoni	Smad4	0.0026	0.0321	0.0321
Schistosoma mansoni	ap endonuclease	0.0018	0.0158	0.0158
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.1381	0.1381
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.024	0.0291
Loa Loa (eye worm)	PHD-finger family protein	0.0042	0.0683	0.0828
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0887	0.5526
Plasmodium vivax	SET domain protein, putative	0.003	0.0419	0.196
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.021	0.4513	0.5471
Schistosoma mansoni	hypothetical protein	0.0067	0.1251	0.1251
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0026	0.0321	0.0321
Schistosoma mansoni	ras GTP exchange factor	0.0013	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0018	0.0143	0.0173
Brugia malayi	hypothetical protein	0.0036	0.0559	0.0678
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0692	0.4014
Schistosoma mansoni	hypothetical protein	0.0144	0.3003	0.3003
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1687	0.2045
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0018	0.0143	0.0143
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.036	0.7912	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0191	0.4077	0.4943
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0013	0.0028	0.0028
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1203	0.1203
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.016	0.3377	0.3377
Leishmania major	DNA polymerase kappa, putative	0.0022	0.024	0.2915
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1203	0.1203
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.024	0.024
Brugia malayi	latrophilin 2 splice variant baaae	0.0144	0.3003	0.364
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.1203	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0028	0.0033
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0018	0.0143	0.0181
Onchocerca volvulus		0.0013	0.0028	0.0035
Brugia malayi	Bromodomain containing protein	0.0157	0.3292	0.3991
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0419	0.0419
Entamoeba histolytica	hypothetical protein	0.0036	0.0559	0.8
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0013	0.0028	0.0028
Leishmania major	DNA polymerase eta, putative	0.0022	0.024	0.2915
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0887	0.0887
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.024	0.0426
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0886	0.0886
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1488	1
Schistosoma mansoni	smad1 5 8 and	0.0026	0.0321	0.0321
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.024	0.0616
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0013	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0042	0.0683	0.0683
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.1197	0.1197
Brugia malayi	Smad1	0.0026	0.0321	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0173
Brugia malayi	Ets-domain containing protein	0.0073	0.1405	0.1703
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1488	1
Echinococcus granulosus	Protein son of sevenless	0.0013	0.0028	0.0028
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0158	0.0262
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.024	0.516
Schistosoma mansoni	hypothetical protein	0.0067	0.1251	0.1251
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.0086	0.1702	0.1702
Brugia malayi	Latrophilin receptor protein 2	0.0067	0.1251	0.1516
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1488	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0173
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0559	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3227	0.3912
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0158	0.0158
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0461	0.0559
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.021	0.4513	0.5471
Schistosoma mansoni	z-protein (S1r protein)	0.0018	0.0143	0.0143
Echinococcus granulosus	segment polarity protein dishevelled	0.0018	0.0143	0.0143
Echinococcus multilocularis	activin receptor type	0.0086	0.1702	0.1702
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0692	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0886	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0026	0.0321	0.0321
Echinococcus multilocularis	Smad4	0.0026	0.0321	0.0321
Echinococcus granulosus	muscleblind protein	0.0154	0.3227	0.3227
Brugia malayi	Fli-1 protein	0.0223	0.4792	0.581
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0559	0.0559
Loa Loa (eye worm)	MH2 domain-containing protein	0.0375	0.8249	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.4373	0.5301
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Loa Loa (eye worm)	nuclear factor I	0.0014	0.0061	0.0075
Brugia malayi	MH1 domain containing protein	0.0026	0.0321	0.0389
Brugia malayi	MH1 domain containing protein	0.0026	0.0321	0.0389
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0186	0.3963	0.3963
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.024	0.3197
Echinococcus granulosus	segment polarity protein dishevelled	0.0018	0.0143	0.0143
Echinococcus granulosus	regulator of G protein signaling 7	0.0018	0.0143	0.0143
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0034	0.0519	0.0519
Brugia malayi	MH1 domain containing protein	0.0014	0.0061	0.0075
Loa Loa (eye worm)	bromodomain containing protein	0.0039	0.0634	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1815	0.2201
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.024	0.516
Echinococcus granulosus	GA binding protein alpha chain	0.0073	0.1405	0.1405
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.024	0.4374
Loa Loa (eye worm)	MH1 domain-containing protein	0.0026	0.0321	0.0389
Echinococcus multilocularis	TGF beta receptor type 1	0.0191	0.4084	0.4084
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0013	0.0028	0.0028
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.024	0.516
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1251	0.1516
Schistosoma mansoni	zinc finger protein	0.0031	0.0439	0.0439
Schistosoma mansoni	protein kinase	0.0086	0.1696	0.1696
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0126	0.2594	0.2594
Loa Loa (eye worm)	DIX domain-containing protein	0.0018	0.0143	0.0173
Brugia malayi	Protein kinase domain containing protein	0.0074	0.1415	0.1715
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1163	0.141
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.024	0.024
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1203	0.1203
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0073	0.1405	0.1703
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0018	0.0143	0.0143
Schistosoma mansoni	hypothetical protein	0.0067	0.1251	0.1251
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Brugia malayi	RNA binding protein	0.0064	0.1203	0.1459
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0067	0.1251	0.1251
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.024	0.516
Brugia malayi	N-terminal motif family protein	0.0013	0.0028	0.0033
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0887	0.5476
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0018	0.0143	0.0173
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0419	0.0419
Echinococcus granulosus	son of sevenless 1	0.0013	0.0028	0.0028
Schistosoma mansoni	ap endonuclease	0.0018	0.0158	0.0158
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0343	0.139
Schistosoma mansoni	zinc finger protein	0.0045	0.0762	0.0762
Echinococcus multilocularis	Protein son of sevenless	0.0013	0.0028	0.0028
Echinococcus granulosus	cpg binding protein	0.0037	0.059	0.059
Schistosoma mansoni	cpg binding protein	0.0037	0.059	0.059
Brugia malayi	N-terminal motif family protein	0.036	0.7912	0.9592
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.1293	0.1293
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0013	0.0028	0.0035
Echinococcus granulosus	Smad4	0.0026	0.0321	0.0321
Schistosoma mansoni	dep domain containing protein	0.0018	0.0143	0.0143
Schistosoma mansoni	dishevelled	0.0018	0.0143	0.0143
Echinococcus multilocularis	muscleblind protein 1	0.0154	0.3227	0.3227
Onchocerca volvulus		0.0232	0.501	0.6332
Echinococcus multilocularis	dna polymerase eta	0.0022	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3227	0.3912
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.1488	1
Brugia malayi	Probable ClpP-like protease	0.0077	0.1488	0.1804
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0067	0.1251	0.1251
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.024	0.4374
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0013	0.0028	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1488	0.1804
Brugia malayi	acetyltransferase, GNAT family protein	0.016	0.3377	0.4094
Brugia malayi	F/Y-rich N-terminus family protein	0.0015	0.0072	0.0088
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0158	0.3168
Echinococcus granulosus	GPCR family 2	0.0067	0.1251	0.1251
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0158	0.0192
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.1197	0.1197
Echinococcus granulosus	TGF beta receptor type 1	0.0191	0.4084	0.4084
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0887	0.5526
Schistosoma mansoni	ets-related	0.0223	0.4792	0.4792
Brugia malayi	MH2 domain containing protein	0.0026	0.0321	0.0389
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Brugia malayi	RasGEF domain containing protein	0.0013	0.0028	0.0033
Echinococcus multilocularis	cpg binding protein	0.0037	0.059	0.059
Schistosoma mansoni	regulator of G protein signaling	0.0018	0.0143	0.0143
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.024	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0064	0.0077
Echinococcus granulosus	smad	0.0026	0.0321	0.0321
Schistosoma mansoni	protein kinase	0.0191	0.4084	0.4084
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.024	0.4374
Loa Loa (eye worm)	hypothetical protein	0.021	0.4513	0.5471
Loa Loa (eye worm)	hypothetical protein	0.0022	0.024	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1408	0.1707
Schistosoma mansoni	bromodomain containing protein	0.0014	0.0064	0.0064
Echinococcus granulosus	zinc finger protein	0.0045	0.0762	0.0762
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0026	0.0321	0.0321
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0343	0.139
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.1488	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3003	0.364
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.024	0.4374
Schistosoma mansoni	hypothetical protein	0.0452	1	1
Echinococcus granulosus	activin receptor type	0.0086	0.1702	0.1702
Echinococcus granulosus	mothers against decapentaplegic 5	0.0026	0.0321	0.0321
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.1381	0.1381

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.131 uM	Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells	ChEMBL.	20472445
Inhibition (binding)	= 9 %	Inhibition of human ALK5 activity in human HaCaT cells assessed as inhibition of TGF-beta-induced p3TP-luciferase reporter activity at 0.1 uM relative to control	ChEMBL.	20472445
Inhibition (binding)	= 18 %	Inhibition of human ALK5 activity in human HaCaT cells assessed as inhibition of TGF-beta-induced SBE-luciferase reporter activity at 0.1 uM relative to control	ChEMBL.	20472445
Inhibition (binding)	= 22 %	Inhibition of human ALK5 activity in human HaCaT cells assessed as inhibition of TGF-beta-induced ARE-luciferase reporter activity at 0.1 uM relative to control	ChEMBL.	20472445

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1164022

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1141977