Detailed information for compound 1142255

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.567 | Formula: C21H20N8S2
  • H donors: 2 H acceptors: 1 LogP: 3.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CN=C(S1)NN=Cc1ccc(cc1)c1cn2c(n1)ccc(c2)C=NNC1=NCCS1
  • InChi: 1S/C21H20N8S2/c1-4-17(5-2-15(1)11-24-27-20-22-7-9-30-20)18-14-29-13-16(3-6-19(29)26-18)12-25-28-21-23-8-10-31-21/h1-6,11-14H,7-10H2,(H,22,27)(H,23,28)
  • InChiKey: LQGIZMHPJSPKIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Peroxidasin homolog 0.0561 0.3285 1
Brugia malayi Animal haem peroxidase family protein 0.0561 0.3285 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0127 0.0358
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0037 0.1093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0206 0.0206
Echinococcus granulosus protein jagged 1 0.0124 0.0663 0.2018
Schistosoma mansoni lamin 0.0029 0.009 0.0253
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0037 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0018 0.0018
Giardia lamblia High cysteine protein 0.0124 0.0663 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0206 0.0206
Echinococcus granulosus delta-like protein 1 0.0124 0.0663 0.2018
Echinococcus multilocularis neural cadherin 0.0124 0.0663 0.0663
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0127 1
Onchocerca volvulus Peroxidase homolog 0.0561 0.3285 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0025 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0127 0.0362
Schistosoma mansoni notch 0.0124 0.0663 0.2
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.009 0.0274
Schistosoma mansoni lamin 0.0029 0.009 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0037 0.2454
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0283 0.4034
Schistosoma mansoni peroxidasin 0.0561 0.3285 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.009 0.0247
Mycobacterium tuberculosis Conserved protein 0.0035 0.0127 0.0818
Brugia malayi EGF-like domain containing protein 0.0124 0.0663 0.1995
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.005 0.005
Onchocerca volvulus Chorion peroxidase homolog 0.0561 0.3285 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0124 0.0663 0.1995
Schistosoma mansoni zinc finger protein 0.0019 0.0033 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0127 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0037 0.1093
Brugia malayi Pre-SET motif family protein 0.0426 0.2472 0.7518
Echinococcus multilocularis notch 0.0124 0.0663 0.0663
Brugia malayi notch-like transmembrane receptor 0.0124 0.0663 0.1995
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0127 0.3937
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.005 0.0132
Echinococcus granulosus neurogenic locus protein delta 0.0124 0.0663 0.2018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0206 0.0626
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Brugia malayi Calcium binding EGF domain containing protein 0.0124 0.0663 0.1995
Trichomonas vaginalis esterase, putative 0.0035 0.0127 0.0362
Onchocerca volvulus 0.0561 0.3285 1
Schistosoma mansoni laminin gamma-3 chain 0.0124 0.0663 0.2
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Brugia malayi Bromodomain containing protein 0.0074 0.0363 0.108
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Brugia malayi Blistered cuticle protein 3 0.0561 0.3285 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Toxoplasma gondii EGF family domain-containing protein 0.0124 0.0663 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Schistosoma mansoni hypothetical protein 0.035 0.2018 0.6135
Leishmania major DNA polymerase eta, putative 0.002 0.0037 0.2454
Mycobacterium ulcerans lipase LipD 0.0035 0.0127 1
Echinococcus granulosus zinc finger protein 0.0019 0.0033 0.0099
Echinococcus granulosus slit 2 protein 0.0124 0.0663 0.2018
Entamoeba histolytica hypothetical protein 0.0035 0.0127 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0025 0.1528
Onchocerca volvulus Peroxidasin homolog 0.0561 0.3285 1
Schistosoma mansoni hypothetical protein 0.0124 0.0663 0.2
Loa Loa (eye worm) animal heme peroxidase 0.0561 0.3285 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0206 0.0599
Schistosoma mansoni hypothetical protein 0.0124 0.0663 0.2
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0384 0.117
Onchocerca volvulus 0.0035 0.0127 0.0114
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.0032
Schistosoma mansoni peroxidasin 0.0561 0.3285 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0037 0.2454
Echinococcus multilocularis tumor protein p63 0.037 0.214 0.214
Echinococcus multilocularis lamin dm0 0.0029 0.009 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0037 0.0111
Echinococcus multilocularis neurogenic locus notch protein 4 0.0124 0.0663 0.0663
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0269 0.0819
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0127 0.0364
Echinococcus granulosus fibropellin Ia 0.0124 0.0663 0.2018
Trichomonas vaginalis set domain proteins, putative 0.0484 0.2825 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0384 0.117
Mycobacterium tuberculosis Conserved protein 0.0035 0.0127 0.0818
Mycobacterium ulcerans hypothetical protein 0.0035 0.0127 1
Echinococcus multilocularis zinc finger protein 0.0019 0.0033 0.0033
Onchocerca volvulus 0.0124 0.0663 0.1792
Loa Loa (eye worm) blistered cuticle protein 3 0.0561 0.3285 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0037 0.2454
Entamoeba histolytica hypothetical protein 0.0035 0.0127 1
Schistosoma mansoni septate junction protein 0.0124 0.0663 0.2
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0206 0.0605
Onchocerca volvulus 0.0035 0.0127 0.0114
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0056
Brugia malayi Animal haem peroxidase family protein 0.0561 0.3285 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0025 0.1528
Brugia malayi GCC2 and GCC3 family protein 0.0124 0.0663 0.1995
Loa Loa (eye worm) hypothetical protein 0.0042 0.017 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0283 0.084
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0127 0.0386
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0127 0.0818
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.009 0.0274
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Brugia malayi EGF-like domain containing protein 0.0124 0.0663 0.1995
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0037 0.0089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0127 0.0364
Brugia malayi Delta serrate ligand family protein 0.0124 0.0663 0.1995
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.2454
Echinococcus granulosus neurogenic locus notch protein 4 0.0124 0.0663 0.2018
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0037 0.2454
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0037 0.004
Brugia malayi PHD-finger family protein 0.0025 0.0064 0.0169
Echinococcus multilocularis fat cadherin tumor suppressor 0.0124 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) animal heme peroxidase 0.0561 0.3285 1
Loa Loa (eye worm) notch protein 0.0124 0.0663 0.2018
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.1528
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0127 0.0818
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0127 0.0818
Brugia malayi EGF-like domain containing protein 0.0124 0.0663 0.1995
Echinococcus multilocularis lamin 0.0029 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0111
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Onchocerca volvulus 0.0561 0.3285 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0037 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Entamoeba histolytica hypothetical protein 0.0035 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0386
Plasmodium vivax SET domain protein, putative 0.0061 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Brugia malayi Animal haem peroxidase family protein 0.0561 0.3285 1
Schistosoma mansoni notch 0.0124 0.0663 0.2
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0386
Onchocerca volvulus Putative cubilin 0.0124 0.0663 0.1792
Echinococcus multilocularis neurogenic locus protein delta 0.0124 0.0663 0.0663
Trypanosoma brucei unspecified product 0.002 0.0037 0.2454
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0127 0.0362
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.0265
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0127 0.0362
Loa Loa (eye worm) hypothetical protein 0.004 0.0159 0.0484
Schistosoma mansoni hypothetical protein 0.002 0.0039 0.0097
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0127 0.0365
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0025 0.1528
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Schistosoma mansoni slit 0.0124 0.0663 0.2
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0242 0.0715
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Schistosoma mansoni hypothetical protein 0.0124 0.0663 0.2
Echinococcus granulosus dna polymerase eta 0.002 0.0037 0.0111
Schistosoma mansoni hypothetical protein 0.0124 0.0663 0.2
Brugia malayi EGF-like domain containing protein 0.0124 0.0663 0.1995
Schistosoma mansoni hypothetical protein 0.0124 0.0663 0.2
Loa Loa (eye worm) hypothetical protein 0.0038 0.0145 0.0441
Brugia malayi Animal haem peroxidase family protein 0.0561 0.3285 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0127 0.5
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0039 0.0119
Brugia malayi intermediate filament protein 0.0029 0.009 0.0247
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0025 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Echinococcus multilocularis dna polymerase kappa 0.002 0.0037 0.0037
Echinococcus multilocularis protein jagged 1 0.0124 0.0663 0.0663
Echinococcus granulosus notch 0.0124 0.0663 0.2018
Echinococcus multilocularis peroxidasin 0.0561 0.3285 0.3285
Echinococcus granulosus neurogenic locus notch protein 0.0124 0.0663 0.2018
Echinococcus granulosus geminin 0.035 0.2018 0.6143
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0127 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0272 0.0828
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.005 0.0153
Brugia malayi Cadherin domain containing protein 0.0124 0.0663 0.1995
Echinococcus multilocularis neurogenic locus notch protein 0.0124 0.0663 0.0663
Brugia malayi EGF-like domain containing protein 0.0124 0.0663 0.1995
Brugia malayi hypothetical protein 0.0561 0.3285 1
Schistosoma mansoni notch 0.0124 0.0663 0.2
Brugia malayi EGF-like domain containing protein 0.0124 0.0663 0.1995
Echinococcus granulosus lamin 0.0029 0.009 0.0274
Echinococcus granulosus intermediate filament protein 0.0029 0.009 0.0274
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Schistosoma mansoni notch 0.0124 0.0663 0.2
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Loa Loa (eye worm) hypothetical protein 0.0054 0.0242 0.0735
Brugia malayi Peroxidasin 0.0561 0.3285 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1262 1
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Loa Loa (eye worm) Notch2 0.0124 0.0663 0.2018
Schistosoma mansoni cell polarity protein 0.0124 0.0663 0.2
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0127 0.0818
Schistosoma mansoni hypothetical protein 0.0035 0.0127 0.0365
Schistosoma mansoni intermediate filament proteins 0.0029 0.009 0.0253
Onchocerca volvulus 0.0054 0.0242 0.0474
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.2472 0.7525
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.013 0.0396
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0127 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0127 0.0386
Echinococcus multilocularis neurogenic locus protein delta 0.0124 0.0663 0.0663
Onchocerca volvulus 0.0124 0.0663 0.1792
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0018 0.0054
Onchocerca volvulus 0.0124 0.0663 0.1792
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Onchocerca volvulus 0.0561 0.3285 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0025 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0025 0.5
Schistosoma mansoni hypothetical protein 0.035 0.2018 0.6135
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Onchocerca volvulus 0.0484 0.2825 0.856
Echinococcus granulosus neural cadherin 0.0124 0.0663 0.2018
Echinococcus multilocularis protein jagged 1 0.0124 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Giardia lamblia DINP protein human, muc B family 0.002 0.0037 0.0174
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0274
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0037 0.0089
Brugia malayi Cadherin domain containing protein 0.0124 0.0663 0.1995
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Echinococcus multilocularis dna polymerase eta 0.002 0.0037 0.0037
Onchocerca volvulus Dual oxidase homolog 0.0561 0.3285 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0037 0.0083
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Entamoeba histolytica hypothetical protein 0.0035 0.0127 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0293 0.0873
Brugia malayi beta-lactamase family protein 0.0035 0.0127 0.0358
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.013 0.013
Echinococcus multilocularis geminin 0.035 0.2018 0.2018
Mycobacterium ulcerans beta-lactamase 0.0035 0.0127 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0272 0.0272
Schistosoma mansoni notch 0.0124 0.0663 0.2
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0037 0.1091
Loa Loa (eye worm) animal heme peroxidase 0.0561 0.3285 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0127 0.1588
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0384 0.115
Schistosoma mansoni hypothetical protein 0.0124 0.0663 0.2
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0025 0.0077
Echinococcus granulosus neurogenic locus notch protein 0.0124 0.0663 0.2018
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0127 0.0818
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0384 0.0384
Onchocerca volvulus 0.0035 0.0127 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0127 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0127 0.0127
Leishmania major hypothetical protein, conserved 0.0035 0.0127 1
Brugia malayi EGF-like domain containing protein 0.0124 0.0663 0.1995
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0127 0.0386
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0127 1
Brugia malayi Calcium binding EGF domain containing protein 0.0124 0.0663 0.1995
Brugia malayi Muscle positioning protein 4 0.0124 0.0663 0.1995
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Echinococcus multilocularis fibropellin Ia 0.0124 0.0663 0.0663
Onchocerca volvulus 0.0124 0.0663 0.1792
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0037 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0206 0.0605
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Brugia malayi Calcium binding EGF domain containing protein 0.0124 0.0663 0.1995
Echinococcus multilocularis protein jagged 2 0.0124 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0386
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0206 0.0626
Leishmania major DNA polymerase kappa, putative 0.002 0.0037 0.2454
Echinococcus granulosus protein jagged 1 0.0124 0.0663 0.2018
Onchocerca volvulus Slit protein homolog 0.0124 0.0663 0.1792
Schistosoma mansoni hypothetical protein 0.0124 0.0663 0.2
Loa Loa (eye worm) animal heme peroxidase 0.0561 0.3285 1
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0037 0.0111
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Schistosoma mansoni notch 0.0124 0.0663 0.2
Echinococcus granulosus protein jagged 2 0.0124 0.0663 0.2018
Loa Loa (eye worm) beta-lactamase 0.0035 0.0127 0.0386
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0037 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0386
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Echinococcus granulosus tumor protein p63 0.037 0.214 0.6516
Echinococcus granulosus peroxidasin 0.0561 0.3285 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0206 0.0626
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0127 0.0818
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0124 0.0663 0.1792
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0206 0.0605
Brugia malayi Pre-SET motif family protein 0.0061 0.0283 0.0834
Onchocerca volvulus Peroxidase homolog 0.0561 0.3285 1
Echinococcus multilocularis slit 2 protein 0.0124 0.0663 0.0663
Echinococcus multilocularis musashi 0.0029 0.009 0.009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0127 0.0818
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0037 0.0037
Brugia malayi Bromodomain containing protein 0.0038 0.0144 0.0412
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0037 0.2454
Loa Loa (eye worm) hypothetical protein 0.007 0.0338 0.1028
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0025 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0127 0.0362
Onchocerca volvulus 0.0124 0.0663 0.1792
Echinococcus multilocularis neurogenic locus notch protein 0.0124 0.0663 0.0663
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0384 0.115
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0037 0.0089
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0021 0.0065
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0124 0.0663 0.2
Onchocerca volvulus 0.0061 0.0283 0.0602
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0127 0.0362
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0009 0.0028
Echinococcus granulosus lamin dm0 0.0029 0.009 0.0274
Brugia malayi beta-lactamase family protein 0.0035 0.0127 0.0358
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0127 0.0127
Schistosoma mansoni ap endonuclease 0.0018 0.0025 0.0056
Loa Loa (eye worm) hypothetical protein 0.0561 0.3285 1
Brugia malayi Animal haem peroxidase family protein 0.0561 0.3285 1
Echinococcus granulosus protein jagged 2 0.0124 0.0663 0.2018
Brugia malayi hypothetical protein 0.0035 0.0127 0.0359
Brugia malayi beta-lactamase 0.0035 0.0127 0.0358
Onchocerca volvulus Neurogenic locus notch homolog 0.0124 0.0663 0.1792
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0127 0.0818
Loa Loa (eye worm) hypothetical protein 0.0124 0.0663 0.2018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0283 0.084

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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