Detailed information for compound 1142334

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.338 | Formula: C13H20N6O
  • H donors: 3 H acceptors: 3 LogP: -0.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nonc1CNC(c1nc[nH]c1)C1CCNCC1
  • InChi: 1S/C13H20N6O/c1-9-11(19-20-18-9)7-16-13(12-6-15-8-17-12)10-2-4-14-5-3-10/h6,8,10,13-14,16H,2-5,7H2,1H3,(H,15,17)
  • InChiKey: XGCYMPKIYIZNAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromobox protein 0.0071 1 1
Schistosoma mansoni intermediate filament proteins 0.003 0.2599 0.2397
Loa Loa (eye worm) hypothetical protein 0.004 0.4288 0.4288
Echinococcus granulosus chromobox protein 1 0.0071 1 1
Echinococcus multilocularis chromobox protein 1 0.0071 1 1
Schistosoma mansoni lamin 0.003 0.2599 0.2397
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0038 0.4055 0.4055
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0056 0.732 0.732
Trichomonas vaginalis chromobox protein, putative 0.0043 0.4841 0.3419
Echinococcus granulosus lamin 0.003 0.2599 0.2397
Echinococcus multilocularis lamin dm0 0.003 0.2599 0.2397
Echinococcus granulosus intermediate filament protein 0.003 0.2599 0.2397
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.732 0.732
Loa Loa (eye worm) hypothetical protein 0.0018 0.0266 0.0266
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.4288 0.7532
Schistosoma mansoni lamin 0.003 0.2599 0.2397
Trichomonas vaginalis chromobox protein, putative 0.0071 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.2497 0.2497
Loa Loa (eye worm) intermediate filament protein 0.003 0.2599 0.2599
Onchocerca volvulus 0.0031 0.2713 0.051
Trichomonas vaginalis conserved hypothetical protein 0.004 0.4288 0.2714
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.4055 0.4055
Trichomonas vaginalis conserved hypothetical protein 0.004 0.4288 0.2714
Echinococcus granulosus lamin dm0 0.003 0.2599 0.2397
Echinococcus multilocularis chromobox protein 1 0.0071 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.2599 0.2599
Trichomonas vaginalis chromobox protein, putative 0.0043 0.4841 0.3419
Echinococcus granulosus chromobox protein 1 0.0071 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.4841 1
Schistosoma mansoni chromobox protein 0.0071 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0266 0.0266
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.732 0.732
Trichomonas vaginalis chromobox protein, putative 0.0071 1 1
Echinococcus multilocularis lamin 0.003 0.2599 0.2397
Schistosoma mansoni hypothetical protein 0.0038 0.4055 0.3892
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0031 0.2713 0.2713
Loa Loa (eye worm) heterochromatin protein 1 0.0071 1 1
Brugia malayi chromobox protein homolog 3 0.004 0.4288 0.4288
Echinococcus multilocularis musashi 0.003 0.2599 0.2397
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.732 0.732
Brugia malayi intermediate filament protein 0.003 0.2599 0.2599
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0266 0.0266

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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