Detailed information for compound 114290

Basic information

Technical information
  • TDR Targets ID: 114290
  • Name: N-[(2S,3S,6R)-3-hydroxy-1,7-diphenyl-6-[[2-(p yridin-2-ylsulfonylamino)benzoyl]amino]heptan -2-yl]-2-(pyridin-2-ylsulfonylamino)benzamide
  • MW: 818.96 | Formula: C43H42N6O7S2
  • H donors: 5 H acceptors: 9 LogP: 6.99 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]([C@@H](NC(=O)c1ccccc1NS(=O)(=O)c1ccccn1)Cc1ccccc1)CC[C@@H](NC(=O)c1ccccc1NS(=O)(=O)c1ccccn1)Cc1ccccc1
  • InChi: 1S/C43H42N6O7S2/c50-39(38(30-32-17-5-2-6-18-32)47-43(52)35-20-8-10-22-37(35)49-58(55,56)41-24-12-14-28-45-41)26-25-33(29-31-15-3-1-4-16-31)46-42(51)34-19-7-9-21-36(34)48-57(53,54)40-23-11-13-27-44-40/h1-24,27-28,33,38-39,48-50H,25-26,29-30H2,(H,46,51)(H,47,52)/t33-,38+,39+/m1/s1
  • InChiKey: PFZKTRAEWBCIIG-IUNOAQLMSA-N  

Network

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Synonyms

  • N-[(1S,2S,5R)-1-benzyl-2-hydroxy-6-phenyl-5-[[2-(2-pyridylsulfonylamino)benzoyl]amino]hexyl]-2-(2-pyridylsulfonylamino)benzamide
  • N-[(1S,2S,5R)-1-benzyl-2-hydroxy-5-[[oxo-[2-(2-pyridylsulfonylamino)phenyl]methyl]amino]-6-phenylhexyl]-2-(2-pyridylsulfonylamino)benzamide
  • N-[(2S,3S,6R)-3-hydroxy-1,7-diphenyl-6-[[2-(pyridin-2-ylsulfonylamino)phenyl]carbonylamino]heptan-2-yl]-2-(pyridin-2-ylsulfonylamino)benzamide
  • N-[(2S,3S,6R)-3-hydroxy-1,7-di(phenyl)-6-[[2-(pyridin-2-ylsulfonylamino)benzoyl]amino]heptan-2-yl]-2-(pyridin-2-ylsulfonylamino)benzamide
  • N-[(1S,2S,5R)-2-hydroxy-6-phenyl-1-(phenylmethyl)-5-[[2-(2-pyridylsulfonylamino)benzoyl]amino]hexyl]-2-(2-pyridylsulfonylamino)benzamide
  • N-[(1S,2S,5R)-2-hydroxy-5-[[oxo-[2-(2-pyridylsulfonylamino)phenyl]methyl]amino]-6-phenyl-1-(phenylmethyl)hexyl]-2-(2-pyridylsulfonylamino)benzamide
  • N-[(1S,2S,5R)-1-(benzyl)-2-hydroxy-6-phenyl-5-[[2-(2-pyridylsulfonylamino)benzoyl]amino]hexyl]-2-(2-pyridylsulfonylamino)benzamide
  • N-[(2S,3S,6R)-3-hydroxy-1,7-di(phenyl)-6-[[2-(pyridin-2-ylsulfonylamino)phenyl]carbonylamino]heptan-2-yl]-2-(pyridin-2-ylsulfonylamino)benzamide
  • AIDS-044547
  • AIDS044547
  • N-[(1R,4S,5S)-1-Benzyl-4-hydroxy-6-phenyl-5-({2-[(pyridin-2-ylsulfonyl)amino]benzoyl}amino)hexyl]-2-[(pyridin-2-ylsulfonyl)amino]benzamide
  • 2OH-1,5-Pen-diNH2, diBn-di(Pyrid-SO2-NHPhCO) deriv.

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0035
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0052 0.0999
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0243 0.108 0.1498
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0288 0.6301
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0169 0.3625
Brugia malayi MH1 domain containing protein 0.001 0.0009 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.001 0.0007 0.0004
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0026 0.0426
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0008 0.0013
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0288 0.0412
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.001 0.0007 0.0026
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0007 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.003
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0026 0.0452
Giardia lamblia Myb 1-like protein 0.006 0.0239 0.088
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.003
Plasmodium vivax glutathione reductase, putative 0.0107 0.0452 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0047 0.0067
Echinococcus multilocularis tar DNA binding protein 0.0069 0.028 0.1063
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0007 0.0028
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.001 0.0007 0.0051
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0582 0.2636 1
Echinococcus granulosus smad 0.0018 0.0047 0.0177
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0224
Echinococcus multilocularis geminin 0.0382 0.1718 0.6519
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0071 0.0288 0.0412
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0009
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.006 0.0239 0.0835
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.001 0.0007 0.0004
Schistosoma mansoni smad 0.0018 0.0047 0.0067
Trypanosoma brucei trypanothione reductase 0.0107 0.0452 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0271 0.1205 0.1672
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0071 0.0288 0.1092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0011
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0239 0.8255
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0143
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0243 0.108 0.1498
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0071 0.0288 0.1092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0041 0.0157
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi MH2 domain containing protein 0.0018 0.0047 0.0202
Loa Loa (eye worm) Smad1 0.0018 0.0047 0.0177
Echinococcus granulosus geminin 0.0382 0.1718 0.6519
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0047 0.0067
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0007 0.0028
Trypanosoma brucei unspecified product 0.0045 0.0169 0.3625
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0132 0.2803
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0011
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0288 0.0412
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0169 0.5753
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0616 0.2792 0.2787
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0288 0.0412
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0132 0.2803
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.028 0.1063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0169 0.0225
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0011
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0169 0.7023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.003
Schistosoma mansoni Smad4 0.0018 0.0047 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0069 0.028 0.0401
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0035
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0243 0.108 0.1498
Echinococcus granulosus glutamate synthase 0.001 0.0007 0.0028
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0867
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0288 0.6301
Loa Loa (eye worm) hypothetical protein 0.0071 0.0288 0.1092
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.003
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0288 0.1245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0212 0.0806
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Echinococcus multilocularis smad 0.0018 0.0047 0.0177
Giardia lamblia DNA damage repair protein 0.0014 0.0026 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0169 0.3625
Echinococcus granulosus bloom syndrome protein 0.002 0.0052 0.0197
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2186 1 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0007 0.0028
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Onchocerca volvulus 0.001 0.0008 0.0867
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0288 0.6301
Schistosoma mansoni cpg binding protein 0.003 0.0099 0.0143
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0288 0.1245
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0212 0.0806
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0047 0.0177
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.6977 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0035
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0007 0.0028
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0071 0.0288 0.0412
Echinococcus granulosus dna polymerase kappa 0.0045 0.0169 0.064
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Plasmodium vivax phosphodiesterase gamma, putative 0.0071 0.0288 0.6311
Entamoeba histolytica hypothetical protein 0.0039 0.0143 0.5904
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0105 0.2186
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.003
Leishmania major hypothetical protein, conserved 0.0071 0.0288 0.6301
Brugia malayi MH1 domain containing protein 0.0018 0.0047 0.0202
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0069 0.028 0.0401
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.0007 0.0032
Brugia malayi glutathione reductase 0.0107 0.0452 0.1958
Trichomonas vaginalis C-MYB, putative 0.006 0.0238 0.8209
Plasmodium falciparum phosphodiesterase gamma, putative 0.0071 0.0288 0.6301
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0026 0.0426
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0212 0.0919
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0169 0.0225
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0071 0.0288 0.6301
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0041 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0052 0.0197
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0071 0.0288 0.1092
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0169 0.0242
Schistosoma mansoni tar DNA-binding protein 0.0069 0.028 0.0401
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.0452 0.1716
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0867
Loa Loa (eye worm) hypothetical protein 0.0071 0.0288 0.1092
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0071 0.0288 0.6301
Schistosoma mansoni hypothetical protein 0.0402 0.181 0.2595
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0239 0.8255
Entamoeba histolytica thioredoxin reductase, putative 0.001 0.0007 0.0051
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.003
Mycobacterium tuberculosis Probable reductase 0.0243 0.108 0.1498
Echinococcus multilocularis GPCR, family 2 0.0017 0.0041 0.0157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0288 1
Plasmodium falciparum glutathione reductase 0.0107 0.0452 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0132 0.2803
Leishmania major DNA polymerase eta, putative 0.0075 0.0305 0.6686
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0071 0.0288 0.1092
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0047 0.0177
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0288 0.1092
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0002 0.0008
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 0.6301
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0169 0.3625
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.0157
Loa Loa (eye worm) hypothetical protein 0.0582 0.2636 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0288 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0052 0.0197
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2186 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0035
Schistosoma mansoni glutamate synthase 0.001 0.0007 0.0011
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0008 0.0039
Brugia malayi polk-prov protein 0.0014 0.0026 0.0114
Mycobacterium ulcerans hypothetical protein 0.0014 0.0026 0.0019
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.001 0.0007 0.0011
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0007 0.0028
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0007 0.0028
Leishmania major cAMP-specific phosphodiesterase, putative 0.0071 0.0288 0.6301
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0169 0.5753
Brugia malayi TAR-binding protein 0.0069 0.028 0.1212
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0008 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0169 0.0161
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0071 0.0288 0.1245
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0238 0.8209
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0132 0.2803
Schistosoma mansoni hypothetical protein 0.0382 0.1718 0.2463
Giardia lamblia hypothetical protein 0.0071 0.0288 0.1067
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.003
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0071 0.0288 0.6301
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0132 0.0501
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0157
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8209
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0132 0.2803
Schistosoma mansoni DNA helicase recq1 0.002 0.0052 0.0074
Brugia malayi hypothetical protein 0.0039 0.0143 0.0618
Loa Loa (eye worm) RNA binding protein 0.0069 0.028 0.1063
Loa Loa (eye worm) glutathione reductase 0.0107 0.0452 0.1716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.003
Echinococcus multilocularis bloom syndrome protein 0.002 0.0052 0.0197
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0169 0.073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0169 0.064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0008 0.0013
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0026 0.0426
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 0.6311
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0071 0.0288 0.1245
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.157 0.717 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0132 0.2803
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0288 0.6301
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0132 0.2803
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0132 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0616 0.2792 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0071 0.0288 0.1092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0071 0.0288 0.0412
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0582 0.2636 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0132 0.0475
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0132 0.2803
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0164
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0243 0.108 0.1498
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0052 0.1586
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0071 0.0288 0.1092
Brugia malayi MH1 domain containing protein 0.001 0.0009 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0009
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0071 0.0288 0.6301
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0132 0.2803
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0052 0.0999
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0071 0.0288 0.1092
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0163 0.0561
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.0452 0.1716
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0511 0.2311 0.8765
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Leishmania major DNA polymerase eta, putative 0.0044 0.0163 0.3487
Echinococcus granulosus Smad4 0.0018 0.0047 0.0177
Entamoeba histolytica recQ family helicase, putative 0.002 0.0052 0.1973
Schistosoma mansoni sulfide quinone reductase 0.001 0.0007 0.0011
Plasmodium vivax ferrodoxin reductase, putative 0.001 0.0007 0.0026
Leishmania major DNA damage repair protein, putative 0.0014 0.0026 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0288 0.6301
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.003
Trypanosoma brucei unspecified product 0.0031 0.0105 0.2186
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8209
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0238 0.034
Plasmodium falciparum phosphodiesterase delta, putative 0.0071 0.0288 0.6301
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Trichomonas vaginalis MYB3r3, putative 0.006 0.0238 0.8209
Loa Loa (eye worm) transcription factor SMAD2 0.0269 0.12 0.455
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0009
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0007 0.0028
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.028 0.1212
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.001 0.0007 0.0026
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0071 0.0288 0.1092
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0087 0.0377
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Schistosoma mansoni glutamate synthase 0.001 0.0007 0.0011
Giardia lamblia Hypothetical protein 0.0071 0.0288 0.1067
Echinococcus multilocularis cpg binding protein 0.003 0.0099 0.0377
Schistosoma mansoni glutamate synthase 0.001 0.0007 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.0157
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0007 0.0011
Schistosoma mansoni hypothetical protein 0.0039 0.0143 0.0205
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0052 0.0999
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Giardia lamblia DINP protein human, muc B family 0.0045 0.0169 0.0614
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0132 0.0452
Plasmodium falciparum thioredoxin reductase 0.0037 0.0132 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0132 0.0189
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0288 0.6301
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0071 0.0288 0.6301
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0288 0.6301
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0143 0.0542
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi MH1 domain containing protein 0.0018 0.0047 0.0202
Echinococcus multilocularis Smad4 0.0018 0.0047 0.0177
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0269 0.12 0.455
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0132 0.0125
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0071 0.0288 0.1245
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 0.6301
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0035
Leishmania major hypothetical protein, conserved 0.0071 0.0288 0.6301
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 0.6311
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Entamoeba histolytica hypothetical protein 0.0039 0.0143 0.5904
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0133 0.0577
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0208 0.0725
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0616 0.2792 0.2787
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.001 0.0007 0.0051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0164
Treponema pallidum NADH oxidase 0.0037 0.0132 0.0125
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0071 0.0288 0.1092
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0224
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0071 0.0288 0.6301
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0035
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8209
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0052 0.0169
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0007 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0035
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0069 0.028 0.0401
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0143 0.0542
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0071 0.0288 0.6301
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 0.6311
Trichomonas vaginalis MYB72, putative 0.006 0.0238 0.8209
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Echinococcus multilocularis dna polymerase eta 0.0075 0.0305 0.1157
Echinococcus granulosus GPCR family 2 0.0017 0.0041 0.0157
Echinococcus granulosus cpg binding protein 0.003 0.0099 0.0377
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0026 0.0072
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0288 0.6301
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0169 0.0161
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.0349
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0071 0.0288 0.0412
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0035
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.157 0.717 1
Trichomonas vaginalis C-MYB, putative 0.006 0.0238 0.8209
Loa Loa (eye worm) TAR-binding protein 0.0069 0.028 0.1063
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0132 0.2822
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 0.6301
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0052 0.0999
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0041 0.0179
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.0132
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.0452 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.001 0.0007 0.0051
Loa Loa (eye worm) PDE1B protein 0.0071 0.0288 0.1092
Loa Loa (eye worm) hypothetical protein 0.0075 0.0305 0.1157
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0582 0.2636 1
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0026 0.0426
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0059
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0071 0.0288 0.6301
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0035
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0052 0.1586
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.0305 0.6686
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.1238 0.1774
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0288 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0132 0.0125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.003
Mycobacterium tuberculosis Probable oxidoreductase 0.0271 0.1205 0.1672
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi Smad1 0.0018 0.0047 0.0202
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0007 0.0032
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0288 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0288 0.0412
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0132 0.0125
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0047 0.0177
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Mycobacterium tuberculosis Probable dehydrogenase 0.0243 0.108 0.1498
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.0452 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0071 0.0288 0.6301
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0071 0.0288 0.0412
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8209
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0582 0.2636 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0132 0.0572
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0047 0.0177
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0026 0.0426
Echinococcus granulosus dnaJ subfamily B 0.0402 0.181 0.6867
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0052 0.0999
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0052 0.0197
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.003
Toxoplasma gondii thioredoxin reductase 0.0107 0.0452 0.1601
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0305 0.1319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0011
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0034
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0511 0.2311 0.8765
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0867
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0212 0.0919
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0011
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0011
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0071 0.0288 0.1092
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0026 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0026 0.0426
Trichomonas vaginalis MYB, putative 0.006 0.0239 0.8255
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0132 0.0174
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0169 0.064
Echinococcus granulosus dna polymerase eta 0.0075 0.0305 0.1157
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0288 0.6301
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0071 0.0288 0.0412
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0582 0.2636 0.9441
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0035
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0071 0.0288 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0511 0.2311 0.8765
Echinococcus multilocularis glutamate synthase 0.001 0.0007 0.0028
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0008 0.0001
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0582 0.2636 0.3778
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0035
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0071 0.0288 0.6301
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.0452 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0288 1
Leishmania major DNA polymerase kappa, putative 0.0014 0.0026 0.0426
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0035
Schistosoma mansoni DNA helicase recq5 0.002 0.0052 0.0074
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.0452 0.1716
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0059
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0132 0.0125
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0271 0.1205 0.1672
Brugia malayi RNA binding protein 0.0069 0.028 0.1212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0047 0.0067
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0007 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0169 0.064
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0132 0.2822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Brugia malayi MH2 domain containing protein 0.0269 0.12 0.5191
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0132 0.2803
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0163 0.3487
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0007 0.0028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0035
Brugia malayi glutamate synthase 0.001 0.0007 0.0032
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2186 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0007 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.0426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0007 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0007 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0288 0.6301
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.006 0.0238 1
Plasmodium falciparum thioredoxin reductase 0.0107 0.0452 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0007 0.0028
Brugia malayi Thioredoxin reductase 0.0107 0.0452 0.1958
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0052 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Leishmania major DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0143 0.0205
Toxoplasma gondii selenide, water dikinase 0.001 0.0007 0.0004
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0026 0.0426
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0071 0.0288 0.6301
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0071 0.0288 0.1092
Brugia malayi MH2 domain containing protein 0.0018 0.0047 0.0202
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.003
Plasmodium falciparum glutathione reductase 0.0037 0.0132 0.2803
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.0157
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0011
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0616 0.2792 0.3888
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8209
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0105 0.2186
Onchocerca volvulus 0.0028 0.0092 1
Loa Loa (eye worm) nuclear factor I 0.001 0.0009 0.0034
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0132 0.0125
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Onchocerca volvulus 0.001 0.0007 0.0803
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0582 0.2636 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0305 0.6686
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0511 0.2311 1
Schistosoma mansoni sulfide quinone reductase 0.001 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0288 0.1092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0132 0.0501
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0026 0.0426
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.01
Entamoeba histolytica hypothetical protein 0.0039 0.0143 0.5904
Schistosoma mansoni hypothetical protein 0.0382 0.1718 0.2463
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0132 0.0452
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.181 0.6867
Trypanosoma brucei unspecified product 0.0031 0.0105 0.2186
Loa Loa (eye worm) programmed cell death 8 0.001 0.0007 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0026 0.0426
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0169 0.064
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0169 0.0242
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 0.6301
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0071 0.0288 0.1245
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0007 0.0028
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0007 0.0004
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0052 0.1586
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0288 0.6301
Schistosoma mansoni smad1 5 8 and 0.0018 0.0047 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0087 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0069 0.028 0.0401
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0011
Leishmania major trypanothione reductase 0.0107 0.0452 1
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0132 0.4449
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0132 0.4449
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0169 0.3625
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0105 0.2186
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0035
Schistosoma mansoni DNA polymerase eta 0.0075 0.0305 0.0437
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0035
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0047 0.0177
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0238 0.8209
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0047 0.0177
Entamoeba histolytica glutamate synthase beta subunit, putative 0.001 0.0007 0.0051
Entamoeba histolytica hypothetical protein 0.0039 0.0143 0.5904
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0035
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0271 0.1205 0.1672
Schistosoma mansoni hypothetical protein 0.0037 0.0133 0.0191
Trichomonas vaginalis pc-MYB2, putative 0.006 0.0238 0.8209
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0169 0.3625
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0132 0.2803
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0071 0.0288 0.1092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.003
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0052 0.0197
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0052 0.0197
Entamoeba histolytica disulphide oxidoreductase, putative 0.001 0.0007 0.0051
Entamoeba histolytica recQ family DNA helicase 0.001 0.0008 0.0075
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0026 0.0426
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0011
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0071 0.0288 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0026 0.0426
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.0288 0.1011
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0007 0.0028
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0071 0.0288 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.0398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.003
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0026 0.0038
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0243 0.108 0.1498
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0132 0.2803
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.003
Echinococcus granulosus tar DNA binding protein 0.0069 0.028 0.1063

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 3000 nM Compound was evaluated for the inhibition of HIV protease ChEMBL. No reference
IC50 (binding) > 3000 nM Compound was evaluated for the inhibition of HIV protease ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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