Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.2025 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.5815 | 0.4753 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.2025 | 0.2025 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.5815 | 0.4753 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.2025 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2025 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5586 | 0.9606 |
Onchocerca volvulus | 0.0027 | 0.5815 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.5815 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.5815 | 0.5815 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.5815 | 0.5815 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.2025 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.2025 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.2025 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2025 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.2025 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.5815 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.2025 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.5815 | 0.4753 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.5815 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.2025 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.5815 | 0.4753 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.2025 | 0.3482 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5815 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.2025 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.5815 | 0.4753 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.2025 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2025 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.5815 | 0.4753 |
Schistosoma mansoni | lamin | 0.0027 | 0.5815 | 0.4753 |
Echinococcus multilocularis | musashi | 0.0027 | 0.5815 | 0.4753 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.5815 | 0.4753 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.2025 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.