Detailed information for compound 1143207

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.35 | Formula: C17H19N3O4
  • H donors: 2 H acceptors: 3 LogP: 0.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)/C=C/c1ccc(cc1)c1noc(c1)CN1CCOCC1
  • InChi: 1S/C17H19N3O4/c21-17(18-22)6-3-13-1-4-14(5-2-13)16-11-15(24-19-16)12-20-7-9-23-10-8-20/h1-6,11,22H,7-10,12H2,(H,18,21)/b6-3+
  • InChiKey: HMZAFAMGNRZJEH-ZZXKWVIFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CHromoDomain protein family member 0.0036 0.0295 0.0444
Schistosoma mansoni hypothetical protein 0.0039 0.0327 0.0307
Echinococcus granulosus Chromobox protein 3 0.0034 0.0278 0.0472
Schistosoma mansoni smad1 5 8 and 0.0042 0.0365 0.0344
Entamoeba histolytica hypothetical protein 0.0076 0.0731 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0101 0.1003 0.2803
Schistosoma mansoni hypothetical protein 0.0401 0.4247 0.4235
Toxoplasma gondii NADPH-glutathione reductase 0.0101 0.1003 0.2803
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0365 0.062
Trichomonas vaginalis Heterochromatin protein, putative 0.0034 0.0278 0.0335
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0278 0.0335
Toxoplasma gondii thioredoxin reductase 0.0292 0.3071 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0315 0.0489
Brugia malayi chromobox protein homolog 3 0.0118 0.118 0.1748
Brugia malayi hypothetical protein 0.0076 0.0731 0.107
Brugia malayi glutathione reductase 0.0292 0.3071 0.4602
Trichomonas vaginalis chromobox protein, putative 0.021 0.2178 0.8219
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.2608 0.3922
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0523 0.0756
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.1003 0.2803
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0021 0.0036
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0278 0.0472
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0278 0.0281
Echinococcus granulosus Chromo domain 0.0034 0.0278 0.0472
Loa Loa (eye worm) hypothetical protein 0.0039 0.0327 0.0492
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2608 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0309 0.0389
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0278 0.0281
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0278 0.0387
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0101 0.1003 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0101 0.1003 0.1481
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0101 0.0171
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0101 0.1003 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0523 0.0786
Echinococcus multilocularis thioredoxin glutathione reductase 0.0292 0.3071 0.5216
Echinococcus granulosus chromobox protein 1 0.021 0.2178 0.37
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0101 0.012
Echinococcus granulosus GPCR family 2 0.0018 0.0101 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2608 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0101 0.1003 0.1703
Schistosoma mansoni chromobox protein 0.021 0.2178 0.2162
Entamoeba histolytica hypothetical protein 0.0076 0.0731 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Entamoeba histolytica hypothetical protein 0.0076 0.0731 1
Schistosoma mansoni cpg binding protein 0.003 0.0228 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0027 0.0197 0.0334
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0197 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0021 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0284 0.0264
Echinococcus granulosus smad 0.0042 0.0365 0.062
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0027 0.0197 0.0334
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0111 0.0189
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2608 1
Schistosoma mansoni glutamate synthase 0.0027 0.0197 0.0176
Entamoeba histolytica hypothetical protein 0.0076 0.0731 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0101 0.1003 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0347 0.0622
Mycobacterium tuberculosis Probable oxidoreductase 0.0741 0.7932 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0418
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0309 0.0433
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0365 0.0344
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0309 0.1386
Echinococcus multilocularis chromobox protein 1 0.021 0.2178 0.37
Onchocerca volvulus 0.0035 0.0284 0.1587
Loa Loa (eye worm) programmed cell death 8 0.0027 0.0197 0.0296
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0347 0.0622
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0118 0.118 0.699
Plasmodium falciparum glutathione reductase 0.0292 0.3071 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0365 0.062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0667 0.7126 0.8958
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0036 0.0295 0.0501
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0523 0.0786
Schistosoma mansoni Smad4 0.0019 0.0111 0.009
Trichomonas vaginalis chromobox protein, putative 0.0127 0.1276 0.4478
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0021 0.0036
Brugia malayi MH2 domain containing protein 0.0042 0.0365 0.0519
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0021 0.0036
Echinococcus multilocularis Chromo domain 0.0034 0.0278 0.0472
Brugia malayi MH2 domain containing protein 0.0623 0.6648 1
Plasmodium vivax thioredoxin reductase, putative 0.0292 0.3071 1
Brugia malayi Smad1 0.0042 0.0365 0.0519
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0418
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0278 0.0281
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0278 0.0335
Brugia malayi MH2 domain containing protein 0.0042 0.0365 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0365 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0278 0.0387
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0101 0.1003 0.2803
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0741 0.7932 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0101 0.1003 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Trypanosoma cruzi trypanothione reductase, putative 0.0292 0.3071 1
Echinococcus granulosus glutamate synthase 0.0027 0.0197 0.0334
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0309 0.0463
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0074 0.0711 0.1041
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0741 0.7932 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0731 0.1241
Loa Loa (eye worm) helicase 0.0034 0.0278 0.0418
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0101 0.1003 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0101 0.1003 0.2803
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0309 0.1386
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1678 0.6146
Brugia malayi MH1 domain containing protein 0.0023 0.016 0.0209
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0101 0.1003 0.1703
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0021 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Schistosoma mansoni hypothetical protein 0.0552 0.5888 0.5879
Mycobacterium tuberculosis Probable reductase 0.0667 0.7126 0.8958
Echinococcus granulosus cpg binding protein 0.003 0.0228 0.0387
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0021 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0523 0.0756
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1678 0.6146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0021 0.0036
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0101 0.1003 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0111 0.0135
Brugia malayi Protein cec-1. 0.0034 0.0278 0.0387
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0101 0.0171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0101 0.012
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0278 0.0387
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0197 0.0265
Echinococcus multilocularis chromobox protein 1 0.021 0.2178 0.37
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0667 0.7126 0.8958
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0309 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Onchocerca volvulus 0.0092 0.0904 0.5329
Toxoplasma gondii exonuclease III APE 0.0037 0.0309 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0347 0.0622
Echinococcus granulosus thioredoxin glutathione reductase 0.0292 0.3071 0.5216
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0278 0.0335
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0418
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0027 0.0197 0.0334
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0211 0.0317
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0309 0.0389
Schistosoma mansoni Smad4 0.0019 0.0111 0.009
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0365 0.062
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0278 0.0257
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0101 0.1003 1
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0808 0.2534
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0021 0.0036
Echinococcus multilocularis Smad4 0.0042 0.0365 0.062
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0197 0.0334
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.0111 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1678 0.6146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0347 0.0622
Entamoeba histolytica hypothetical protein 0.0034 0.0278 0.1514
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0101 0.0171
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0278 0.0335
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0418
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0278 0.0281
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0111 0.0189
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0667 0.7126 0.8958
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Echinococcus granulosus geminin 0.0552 0.5888 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0309 0.0144
Loa Loa (eye worm) hypothetical protein 0.0118 0.118 0.1774
Schistosoma mansoni hypothetical protein 0.0034 0.0278 0.0257
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0101 0.1003 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0074 0.0711 0.1041
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0309 0.0389
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0347 0.0622
Leishmania major trypanothione reductase 0.0292 0.3071 1
Schistosoma mansoni hypothetical protein 0.0552 0.5888 0.5879
Onchocerca volvulus 0.0034 0.0278 0.1547
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0309 0.0524
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0197 0.0296
Trichomonas vaginalis chromobox protein, putative 0.021 0.2178 0.8219
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0278 0.0281
Brugia malayi MH1 domain containing protein 0.0023 0.016 0.0209
Echinococcus multilocularis glutamate synthase 0.0027 0.0197 0.0334
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0101 0.0171
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0309 0.2092
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0101 0.1003 0.2803
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1678 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Plasmodium falciparum thioredoxin reductase 0.0292 0.3071 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0101 0.0171
Trichomonas vaginalis hypothetical protein 0.0034 0.0278 0.0335
Mycobacterium tuberculosis Probable dehydrogenase 0.0667 0.7126 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Entamoeba histolytica hypothetical protein 0.0034 0.0278 0.1514
Onchocerca volvulus 0.0028 0.0211 0.1142
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0197 0.0334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0347 0.0622
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0021 0.0036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0667 0.7126 0.8958
Schistosoma mansoni smad 0.0042 0.0365 0.0344
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Schistosoma mansoni chromobox protein 0.0034 0.0278 0.0257
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0278 0.1514
Echinococcus granulosus chromobox protein 2 0.0034 0.0278 0.0472
Brugia malayi MH2 domain containing protein 0.0019 0.0111 0.0135
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0731 0.0711
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.2608 0.3902
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2608 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0197 0.0334
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0101 0.1003 0.1042
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0365 0.0549
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0309 0.0389
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0027 0.0197 0.0334
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0101 0.1003 0.2803
Schistosoma mansoni chromobox protein 0.0034 0.0278 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1678 0.6146
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0309 0.0463
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0101 0.1003 0.2803
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0483 0.0996
Onchocerca volvulus 0.0034 0.0278 0.1547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0021 0.0032
Trypanosoma brucei trypanothione reductase 0.0292 0.3071 1
Trichomonas vaginalis chromobox protein, putative 0.0127 0.1276 0.4478
Echinococcus multilocularis cpg binding protein 0.003 0.0228 0.0387
Schistosoma mansoni Smad4 0.0042 0.0365 0.0344
Trichomonas vaginalis mercuric reductase, putative 0.0101 0.1003 0.3342
Brugia malayi glutamate synthase 0.0027 0.0197 0.0265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0021 0.0036
Loa Loa (eye worm) transcription factor SMAD2 0.0623 0.6648 1
Schistosoma mansoni smad1 5 8 and 0.0042 0.0365 0.0344
Loa Loa (eye worm) hypothetical protein 0.0092 0.0904 0.136
Schistosoma mansoni cpg binding protein 0.003 0.0228 0.0207
Echinococcus granulosus chromobox protein 1 0.021 0.2178 0.37
Brugia malayi CXXC zinc finger family protein 0.0028 0.0211 0.0285
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0278 0.0472
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0111 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0021 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.118 0.4077
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0309 0.0389
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0101 0.0152
Plasmodium vivax glutathione reductase, putative 0.0292 0.3071 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0021 0.0036
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0101 0.1003 0.0983
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.031 0.0468
Loa Loa (eye worm) glutathione reductase 0.0292 0.3071 0.4619
Plasmodium falciparum glutathione reductase 0.0101 0.1003 0.2803
Brugia malayi MH1 domain containing protein 0.0042 0.0365 0.0519
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0309 0.0524
Schistosoma mansoni hypothetical protein 0.0018 0.0101 0.008
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0667 0.7126 0.8958
Brugia malayi Heterochromatin protein 1 0.021 0.2178 0.3255
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0027 0.0197 0.0334
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0278 0.0472
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0111 0.0189
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0027 0.0197 0.0334
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0101 0.1003 0.2803
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0327 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1678 0.6146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0418
Loa Loa (eye worm) Smad1 0.0042 0.0365 0.0549
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2608 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0309 0.0389
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0278 0.0281
Schistosoma mansoni smad 0.0019 0.0111 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0101 0.1003 0.2803
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0021 0.0032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0292 0.3071 0.3716
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0197 0.0334
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0278 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0021 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1774 0.6542
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0309 0.1386
Echinococcus multilocularis chromobox protein 2 0.0034 0.0278 0.0472
Schistosoma mansoni hypothetical protein 0.0018 0.0101 0.008
Echinococcus granulosus dnaJ subfamily B 0.0401 0.4247 0.7213
Schistosoma mansoni hypothetical protein 0.0018 0.0101 0.008
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0101 0.1003 0.2803
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0309 0.1386
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0278 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0347 0.0622
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1678 0.6146
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0295 0.0274
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0278 0.0335
Schistosoma mansoni smad1 5 8 and 0.0042 0.0365 0.0344
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0101 0.1003 0.2803
Onchocerca volvulus 0.0027 0.0197 0.1059
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0278 0.0281
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0021 0.0036
Brugia malayi MH1 domain containing protein 0.0042 0.0365 0.0519
Schistosoma mansoni hypothetical protein 0.0027 0.0197 0.0176
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1774 0.6542
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0021 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0167
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0111 0.0189
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0278 0.0257
Schistosoma mansoni hypothetical protein 0.0076 0.0731 0.0711
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0418
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0027 0.0197 0.0334
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0741 0.7932 1
Brugia malayi SET domain containing protein 0.0035 0.0284 0.0397
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0552 0.0532
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0111 0.0167
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0278 0.0335
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0278 0.1514
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0197 0.0176
Echinococcus multilocularis smad 0.0042 0.0365 0.062
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.4247 0.7213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0021 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0021 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2608 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0027 0.0197 0.0265
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0027 0.0197 0.0334
Brugia malayi hypothetical protein 0.0034 0.0278 0.0387
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0036 0.0295 0.0501
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0347 0.0622
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0101 0.1003 0.2803
Loa Loa (eye worm) MH2 domain-containing protein 0.0623 0.6648 1
Schistosoma mansoni chromobox protein 0.021 0.2178 0.2162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0021 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0021 0.0032
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0278 0.0281
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0731 0.1241
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0808 0.2534
Loa Loa (eye worm) hypothetical protein 0.0023 0.016 0.024
Entamoeba histolytica hypothetical protein 0.0034 0.0278 0.1514
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0021 0.0036
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0278 0.1514
Brugia malayi M-phase phosphoprotein, mpp8 0.0034 0.0278 0.0387
Schistosoma mansoni ap endonuclease 0.0037 0.0309 0.0288
Schistosoma mansoni glutamate synthase 0.0027 0.0197 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0021 0.0036
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0418
Schistosoma mansoni hypothetical protein 0.0018 0.0101 0.008
Loa Loa (eye worm) nuclear factor I 0.0023 0.016 0.024
Echinococcus granulosus Smad4 0.0042 0.0365 0.062
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0101 0.1003 0.2803
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0315 0.0489
Schistosoma mansoni glutamate synthase 0.0027 0.0197 0.0176
Brugia malayi Thioredoxin reductase 0.0292 0.3071 0.4602
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1678 0.6146
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0032
Trichomonas vaginalis glutathione reductase, putative 0.0101 0.1003 0.3342
Schistosoma mansoni cpg binding protein 0.0028 0.0211 0.019
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0101 0.1003 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0021 0.0032
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0365 0.062
Plasmodium falciparum thioredoxin reductase 0.0101 0.1003 0.2803
Schistosoma mansoni ap endonuclease 0.0037 0.0309 0.0288
Echinococcus multilocularis geminin 0.0552 0.5888 1
Brugia malayi CHD4 protein 0.0036 0.0295 0.0413
Schistosoma mansoni disulfide oxidoreductase 0.0027 0.0197 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0278 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0152
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0197 0.0265
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0027 0.0197 0.0296
Treponema pallidum NADH oxidase 0.0101 0.1003 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0021 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.118 0.4077
Loa Loa (eye worm) thioredoxin reductase 0.0292 0.3071 0.4619
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0021 0.0036
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0127 0.1276 0.7573
Loa Loa (eye worm) heterochromatin protein 1 0.021 0.2178 0.3276

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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