Detailed information for compound 1143346

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.499 | Formula: C24H30NO5+
  • H donors: 1 H acceptors: 2 LogP: 4.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(OCCCCOc2ccc3c(c2)oc(=O)c(c3C)C)cc(c1)[N+](C)(C)C
  • InChi: 1S/C24H29NO5/c1-16-17(2)24(27)30-23-15-20(8-9-22(16)23)28-10-6-7-11-29-21-13-18(25(3,4)5)12-19(26)14-21/h8-9,12-15H,6-7,10-11H2,1-5H3/p+1
  • InChiKey: BHQTWYSLIIBIGC-UHFFFAOYSA-O  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0029 0.017 0.0495
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0188 0.1501 0.5485
Loa Loa (eye worm) RNA binding protein 0.0069 0.0501 0.1715
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0628 0.1829
Loa Loa (eye worm) hypothetical protein 0.0188 0.1501 0.5208
Toxoplasma gondii hypothetical protein 0.0029 0.0166 0.0614
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0501 0.1459
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0166 0.1107
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0013 0.0037
Onchocerca volvulus 0.0059 0.0422 0.2064
Mycobacterium leprae conserved hypothetical protein 0.0188 0.1501 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0422 0.123
Loa Loa (eye worm) hypothetical protein 0.0032 0.019 0.0629
Brugia malayi beta-lactamase family protein 0.0188 0.1501 0.521
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0477 0.0477
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0079 0.0395
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.049 0.0792
Loa Loa (eye worm) hypothetical protein 0.0054 0.0378 0.1286
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0501 0.1715
Echinococcus multilocularis para nitrobenzyl esterase 0.0059 0.0422 0.123
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0013 0.0037
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0079 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0013 0.0037
Loa Loa (eye worm) hypothetical protein 0.0084 0.0628 0.2159
Schistosoma mansoni ap endonuclease 0.0018 0.0079 0.023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Mycobacterium tuberculosis Conserved protein 0.0188 0.1501 0.1501
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0013 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0693 0.2021
Loa Loa (eye worm) hypothetical protein 0.0059 0.0422 0.1441
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0079 0.023
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0013 0.0037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0188 0.1501 0.1501
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0628 0.4182
Loa Loa (eye worm) beta-lactamase 0.0188 0.1501 0.5208
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0013 0.0037
Echinococcus multilocularis carboxylesterase 5A 0.0351 0.2873 0.8375
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0013 0.0015
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0059 0.0422 0.2114
Echinococcus granulosus beta LACTamase domain containing family member 0.0188 0.1501 0.4375
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.049 0.1427
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0477 0.2797
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0188 0.1501 0.5208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0013 0.0015
Schistosoma mansoni coup transcription factor 0.0011 0.0013 0.0037
Brugia malayi Pre-SET motif family protein 0.0032 0.019 0.0632
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0351 0.2873 0.8375
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.3431 1
Loa Loa (eye worm) carboxylesterase 0.0059 0.0422 0.1441
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.1501 0.7519
Onchocerca volvulus 0.0052 0.0363 0.1766
Loa Loa (eye worm) hypothetical protein 0.0351 0.2873 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0234 0.0787
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.1745 0.6061
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0385 0.1123
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0385 0.0385
Onchocerca volvulus 0.0059 0.0422 0.2064
Brugia malayi nuclear receptor NHR-88 0.0011 0.0013 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0013 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0067 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0693 0.2021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0067 0.0196
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.019 0.0553
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.1501 0.4375
Echinococcus granulosus para nitrobenzyl esterase 0.0059 0.0422 0.123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0013 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0079 0.1257
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0628 0.3859
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0013 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0378 0.1289
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.2451 0.4575
Loa Loa (eye worm) hypothetical protein 0.0188 0.1501 0.5208
Trichomonas vaginalis esterase, putative 0.0188 0.1501 0.7519
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0059 0.0422 0.123
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.049 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0013 0.0011
Mycobacterium tuberculosis Conserved protein 0.0188 0.1501 0.1501
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0013 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0693 0.2021
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0501 0.1459
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0067 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0477 0.1389
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0628 1
Schistosoma mansoni cpg binding protein 0.0031 0.0184 0.0536
Brugia malayi TAR-binding protein 0.0069 0.0501 0.1718
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.019 0.0553
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0628 0.3859
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0477 0.0767
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0013 0.0037
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0385 0.1123
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0013 0.0015
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0422 0.0422
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0013 0.0011
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0251 0.0733
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0013 0.0037
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0089 0.0675 0.1149
Brugia malayi Carboxylesterase family protein 0.0351 0.2873 1
Echinococcus granulosus BC026374 protein S09 family 0.0059 0.0422 0.123
Mycobacterium tuberculosis Carboxylesterase LipT 0.0059 0.0422 0.0422
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0028
Echinococcus granulosus carboxylesterase 5A 0.0351 0.2873 0.8375
Mycobacterium leprae Probable lipase LipE 0.0188 0.1501 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0013 0.0037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0013 0.0037
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0079 0.0395
Brugia malayi CXXC zinc finger family protein 0.0029 0.017 0.0564
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0628 0.5
Leishmania major hypothetical protein, conserved 0.0188 0.1501 0.2743
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0166 0.0614
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0188 0.1501 0.521
Brugia malayi beta-lactamase family protein 0.0188 0.1501 0.521
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0013 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0013 0.0037
Mycobacterium ulcerans beta-lactamase 0.0188 0.1501 0.5485
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0188 0.1501 0.1501
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0013 0.0037
Schistosoma mansoni hypothetical protein 0.0052 0.0363 0.1058
Loa Loa (eye worm) carboxylesterase 0.0351 0.2873 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.049 0.168
Mycobacterium tuberculosis Conserved hypothetical protein 0.0335 0.2736 0.2736
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0013 0.0037
Brugia malayi RNA binding protein 0.0069 0.0501 0.1718
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0628 0.2294
Plasmodium vivax SET domain protein, putative 0.0032 0.019 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0013 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0013 0.0015
Echinococcus multilocularis neuroligin 0.0059 0.0422 0.123
Schistosoma mansoni hypothetical protein 0.0017 0.0067 0.0196
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0166 0.1591
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.017 0.056
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0301 0.2451 0.4575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0013 0.0011
Onchocerca volvulus 0.0188 0.1501 0.7503
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0079 0.0288
Echinococcus multilocularis acetylcholinesterase 0.0351 0.2873 0.8375
Loa Loa (eye worm) hypothetical protein 0.0188 0.1501 0.5208
Mycobacterium tuberculosis Probable hydrolase 0.0188 0.1501 0.1501
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0422 0.123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0477 0.1742
Schistosoma mansoni hypothetical protein 0.0037 0.0234 0.0682
Loa Loa (eye worm) hypothetical protein 0.0037 0.0234 0.0784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0693 0.2021
Plasmodium vivax hypothetical protein, conserved 0.0188 0.1501 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0184 0.0536
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0635 0.5264 1
Brugia malayi Carboxylesterase family protein 0.0351 0.2873 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0079 0.0243
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0013 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0079 0.023
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0013 0.0037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0067 0.0205
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0251 0.0733
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0501 0.1459
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0635 0.5264 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0477 0.1389
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0013 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0067 0.0196
Brugia malayi Probable ClpP-like protease 0.0084 0.0628 0.2161
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0013 0.0015
Brugia malayi Carboxylesterase family protein 0.0059 0.0422 0.1444
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.049 0.0792
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0013 0.0037
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0079 0.0246
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.019 0.0778
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0013 0.0037
Echinococcus multilocularis acetylcholinesterase 0.0351 0.2873 0.8375
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0378 0.1289
Echinococcus granulosus tar DNA binding protein 0.0069 0.0501 0.1459
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0628 1
Onchocerca volvulus 0.0247 0.1996 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.049 0.1427
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0013 0.0037
Onchocerca volvulus 0.0188 0.1501 0.7503
Mycobacterium tuberculosis Conserved protein 0.0188 0.1501 0.1501
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.049 0.0792
Echinococcus granulosus neuroligin 0.0059 0.0422 0.123
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0013 0.0037
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0628 0.2294
Echinococcus granulosus GPCR family 2 0.0017 0.0067 0.0196
Mycobacterium ulcerans hypothetical protein 0.0188 0.1501 0.5485
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0422 0.123
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0501 0.1459
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0422 0.0422
Brugia malayi hypothetical protein 0.0256 0.2077 0.7222
Schistosoma mansoni hypothetical protein 0.0017 0.0067 0.0196
Echinococcus multilocularis BC026374 protein (S09 family) 0.0059 0.0422 0.123
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0013 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0175 0.0509
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0013 0.0015
Brugia malayi beta-lactamase 0.0188 0.1501 0.521
Schistosoma mansoni acetylcholinesterase 0.0059 0.0422 0.123
Onchocerca volvulus 0.0059 0.0422 0.2064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0028
Schistosoma mansoni gliotactin 0.0059 0.0422 0.123
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0635 0.5264 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.049 0.1677
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.0675 0.1149
Brugia malayi Carboxylesterase family protein 0.0059 0.0422 0.1444
Loa Loa (eye worm) hypothetical protein 0.0059 0.0422 0.1441
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Brugia malayi Carboxylesterase family protein 0.0059 0.0422 0.1444
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.04 0.2257
Loa Loa (eye worm) hypothetical protein 0.0256 0.2077 0.7221
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0013 0.0037
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.049 0.0792
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0501 0.1459
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.049 0.1427
Brugia malayi nuclear hormone receptor 0.0011 0.0013 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0188 0.1501 0.2743
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0013 0.0037
Mycobacterium tuberculosis Probable lipase LipD 0.0188 0.1501 0.1501
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0109 0.0839 0.1466
Echinococcus multilocularis beta LACTamase domain containing family member 0.0188 0.1501 0.4375
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0013 0.0015
Mycobacterium ulcerans lipase LipD 0.0188 0.1501 0.5485
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0501 0.1459
Brugia malayi Pre-SET motif family protein 0.0217 0.1745 0.6063
Echinococcus granulosus cpg binding protein 0.0031 0.0184 0.0536
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0628 0.1829
Schistosoma mansoni ap endonuclease 0.0018 0.0079 0.023
Mycobacterium ulcerans carboxylesterase, LipT 0.0059 0.0422 0.1542
Loa Loa (eye worm) hypothetical protein 0.0059 0.0422 0.1441
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0013 0.0011
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0628 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0628 0.1829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0693 0.2021
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0013 0.0037
Echinococcus granulosus dnaJ subfamily B 0.0417 0.3431 1
Mycobacterium tuberculosis Probable esterase LipL 0.0188 0.1501 0.1501
Onchocerca volvulus 0.0029 0.017 0.0793
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0477 0.1742
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0385 0.2566
Loa Loa (eye worm) hypothetical protein 0.0188 0.1501 0.5208
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0363 0.1237
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0013 0.0015
Echinococcus granulosus acetylcholinesterase 0.0351 0.2873 0.8375
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0385 0.0385
Brugia malayi steroid hormone receptor 0.0011 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0422 0.1441
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0378 0.1286
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.1501 0.2743
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.2077 0.6055
Loa Loa (eye worm) hypothetical protein 0.0351 0.2873 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0422 0.1441
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0166 0.2648
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0301 0.2451 0.4575
Schistosoma mansoni survival motor neuron protein 0.0052 0.0363 0.1058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0202
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0059 0.0422 0.123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0693 0.2388
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0628 0.3859
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0089 0.0675 0.1149
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0013 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1501 0.7519
Schistosoma mansoni cpg binding protein 0.0031 0.0184 0.0536
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0477 0.1742
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.1501 0.7519
Schistosoma mansoni hypothetical protein 0.0017 0.0067 0.0196
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0013 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.1501 0.2743
Schistosoma mansoni neuroligin 3 (S09 family) 0.0059 0.0422 0.123
Brugia malayi ecdysteroid receptor 0.0011 0.0013 0.0015
Loa Loa (eye worm) carboxylesterase 0.0059 0.0422 0.1441
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0067 0.0202
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0477 0.1389
Mycobacterium tuberculosis Probable lipase LipE 0.0188 0.1501 0.1501
Schistosoma mansoni BC026374 protein (S09 family) 0.0059 0.0422 0.123
Echinococcus multilocularis GPCR, family 2 0.0017 0.0067 0.0196
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0013 0.0037
Loa Loa (eye worm) hypothetical protein 0.0188 0.1501 0.5208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0013 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0013 0.0011
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0501 0.1718
Trichomonas vaginalis set domain proteins, putative 0.0247 0.1996 1
Onchocerca volvulus 0.0032 0.019 0.0892
Leishmania major mitochondrial DNA polymerase beta 0.0635 0.5264 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0079 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0013 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0693 0.2021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0089 0.0675 0.1149
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0013 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1501 0.7519
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0188 0.1501 0.1501
Schistosoma mansoni hypothetical protein 0.0017 0.0067 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0693 0.2021
Brugia malayi Carboxylesterase family protein 0.0059 0.0422 0.1444
Onchocerca volvulus 0.0188 0.1501 0.7503
Loa Loa (eye worm) acetylcholinesterase 1 0.0351 0.2873 1
Toxoplasma gondii ABC1 family protein 0.0188 0.1501 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.019 0.0553
Loa Loa (eye worm) hypothetical protein 0.0059 0.0422 0.1441
Toxoplasma gondii hypothetical protein 0.0102 0.0785 0.4965
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0067 0.0196
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0013 0.0037
Mycobacterium ulcerans esterase/lipase LipP 0.0188 0.1501 0.5485
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0501 0.1715
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.019 0.0553
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.019 0.0553
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1501 0.7519
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.2077 0.6055
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0422 0.1441
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0693 0.2391
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0013 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.019 0.0553
Onchocerca volvulus 0.0059 0.0422 0.2064
Echinococcus granulosus acetylcholinesterase 0.0351 0.2873 0.8375
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0628 0.5
Brugia malayi hypothetical protein 0.0059 0.0422 0.1444
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0477 0.1389
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0456 0.1328
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0079 0.1257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.1501 0.4375
Onchocerca volvulus 0.0059 0.0422 0.2064
Trichomonas vaginalis spcc417.12 protein, putative 0.0059 0.0422 0.2114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.019 0.0553
Mycobacterium ulcerans hypothetical protein 0.0335 0.2736 1
Schistosoma mansoni hypothetical protein 0.0417 0.3431 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0188 0.1501 0.5208

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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