Detailed information for compound 1143594

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.527 | Formula: C23H24N4O2S
  • H donors: 2 H acceptors: 3 LogP: 3.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)N(C2=C(C1c1ccc(cc1)C)CCCC2)c1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C23H24N4O2S/c1-15-6-8-16(9-7-15)22-19-4-2-3-5-21(19)27(23(25)20(22)14-24)17-10-12-18(13-11-17)30(26,28)29/h6-13,22H,2-5,25H2,1H3,(H2,26,28,29)
  • InChiKey: ADLHMCWOHOSXJY-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0077 0.0798 0.1207
Leishmania major hypothetical protein, conserved 0.0077 0.0798 0.2775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Leishmania major importin beta-1 subunit, putative 0.0024 0.0074 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0176 0.0176
Onchocerca volvulus 0.0077 0.0798 0.2432
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0043 0.0029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0319 0.414 0.4132
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0449 0.0829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Schistosoma mansoni hypothetical protein 0.0043 0.0325 0.0325
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0043 0.0055
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0492 0.1692
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0122 0.1416 0.1404
Loa Loa (eye worm) hypothetical protein 0.0122 0.1427 0.2877
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0043 0.0029
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0038 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0043 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0335 0.061
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0308 0.3982 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0043 0.01
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0335 0.1133
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.041 0.041
Brugia malayi jmjC domain containing protein 0.0049 0.041 0.0754
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0449 0.0886
Schistosoma mansoni rab6-interacting 0.0043 0.0325 0.0325
Brugia malayi ecdysteroid receptor 0.0022 0.0043 0.0055
Brugia malayi Pre-SET motif family protein 0.0032 0.0176 0.0309
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.062 0.2144
Echinococcus granulosus lysine specific demethylase 5A 0.0049 0.041 0.0396
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Echinococcus multilocularis peregrin 0.0043 0.033 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0043 0.0055
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0798 0.1597
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0325 0.0311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0043 0.0043
Onchocerca volvulus Alhambra homolog 0.003 0.0157 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0043 0.0055
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0043 0.0043
Schistosoma mansoni rab6-interacting 0.0043 0.0325 0.0325
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0335 0.0335
Echinococcus multilocularis zinc finger protein 0.0106 0.1199 0.1186
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0335 0.0787
Brugia malayi hypothetical protein 0.0043 0.0325 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0798 0.1597
Echinococcus multilocularis microtubule associated protein 2 0.0744 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0445 0.082
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.1427 0.1414
Brugia malayi PHD-finger family protein 0.003 0.0157 0.0271
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0151 0.0137
Echinococcus granulosus transcription factor btf3 0.0225 0.2839 0.2829
Loa Loa (eye worm) RNA binding protein 0.0066 0.0645 0.1284
Plasmodium falciparum importin beta, putative 0.003 0.0152 0.0277
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0221 0.0394
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0043 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0176 0.0176
Trichomonas vaginalis ran, putative 0.0022 0.0043 0.0069
Onchocerca volvulus 0.0247 0.3148 1
Trichomonas vaginalis conserved hypothetical protein 0.0225 0.2839 0.6941
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0043 0.0055
Echinococcus granulosus snurportin 1 0.032 0.4153 0.4144
Loa Loa (eye worm) hypothetical protein 0.0217 0.2725 0.5522
Echinococcus multilocularis RUN 0.0043 0.0325 0.0311
Echinococcus granulosus cpg binding protein 0.0044 0.0343 0.0329
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0043 0.0059
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0492 0.1142
Echinococcus granulosus geminin 0.035 0.457 0.4562
Brugia malayi hypothetical protein 0.0035 0.0225 0.0402
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0308 0.3982 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0043 0.0029
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0335 0.0321
Schistosoma mansoni loxhd1 0.0043 0.0325 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0043 0.0055
Plasmodium falciparum phd finger protein, putative 0.003 0.0157 0.029
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0043 0.0055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0449 0.0436
Echinococcus multilocularis geminin 0.035 0.457 0.4562
Treponema pallidum fructose-bisphosphate aldolase 0.0315 0.4084 1
Giardia lamblia PHD finger protein 15 0.003 0.0157 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0335 0.0787
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0191 0.2373 0.2362
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0798 0.1494
Loa Loa (eye worm) hypothetical protein 0.003 0.0152 0.028
Trypanosoma cruzi transcription factor btf3, putative 0.0225 0.2839 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0043 0.0029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0074 0.0145
Leishmania major hypothetical protein, conserved 0.0081 0.086 0.2993
Schistosoma mansoni zinc finger protein 0.0081 0.086 0.086
Schistosoma mansoni hypothetical protein 0.035 0.457 0.457
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0325 0.0311
Brugia malayi nuclear receptor NHR-88 0.0022 0.0043 0.0055
Schistosoma mansoni methyl-cpg binding protein mbd 0.0091 0.0988 0.0988
Echinococcus granulosus peregrin 0.0043 0.033 0.0316
Loa Loa (eye worm) hypothetical protein 0.0229 0.289 0.5858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Brugia malayi nuclear hormone receptor 0.0022 0.0043 0.0055
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0152 0.039
Schistosoma mansoni DNA polymerase eta 0.002 0.0014 0.0014
Loa Loa (eye worm) beta-lactamase 0.0077 0.0798 0.1597
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0645 0.0631
Brugia malayi CXXC zinc finger family protein 0.0032 0.0178 0.0312
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2735 0.5543
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.3182 0.6454
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0043 0.0043
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0335 0.1133
Trypanosoma brucei transcription factor BTF3, putative 0.0225 0.2839 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0645 0.1201
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0187 0.2313 0.2302
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0014 0.0014
Brugia malayi jmjC domain containing protein 0.0099 0.1109 0.2086
Plasmodium vivax importin-beta 2, putative 0.003 0.0152 0.0277
Schistosoma mansoni microtubule-associated protein tau 0.0744 1 1
Echinococcus multilocularis cpg binding protein 0.0044 0.0343 0.0329
Loa Loa (eye worm) hypothetical protein 0.0077 0.0798 0.1597
Onchocerca volvulus 0.0032 0.0178 0.0434
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0431 0.1476
Echinococcus multilocularis snurportin 1 0.032 0.4153 0.4144
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0321 0.0307
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0827 0.0827
Entamoeba histolytica hypothetical protein 0.0225 0.2839 0.6941
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0798 0.1207
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.1861 0.4656
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0321 0.0307
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0798 0.1207
Brugia malayi Doublecortin family protein 0.0043 0.0325 0.0591
Schistosoma mansoni hypothetical protein 0.0081 0.086 0.086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0449 0.0436
Brugia malayi hypothetical protein 0.0055 0.0492 0.0911
Schistosoma mansoni lipoxygenase 0.0187 0.2313 0.2313
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.4153 0.8431
Loa Loa (eye worm) hypothetical protein 0.0051 0.0445 0.0877
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0798 0.2775
Schistosoma mansoni hypothetical protein 0.035 0.457 0.457
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0335 0.0321
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0335 0.0321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0043 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0043 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0798 0.2775
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0308 0.3982 1
Trypanosoma cruzi ISWI complex protein 0.0081 0.086 0.2993
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0335 0.1133
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0043 0.0029
Mycobacterium ulcerans beta-lactamase 0.0077 0.0798 0.1976
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0091 0.0988 0.0975
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1427 0.1427
Echinococcus granulosus tar DNA binding protein 0.0066 0.0645 0.0631
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0127
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0798 0.1207
Brugia malayi follicle stimulating hormone receptor 0.025 0.3182 0.6037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0043 0.0043
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0043 0.0043
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0325 0.0311
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.1427 0.1414
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.0632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0043 0.0059
Leishmania major cathepsin L-like protease 0.0064 0.062 0.2144
Echinococcus granulosus zinc finger protein 0.0106 0.1199 0.1186
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0043 0.0055
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0024 0.0074 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0449 0.0436
Plasmodium falciparum basic transcription factor 3b, putative 0.0225 0.2839 0.71
Schistosoma mansoni transcription factor btf3 0.0225 0.2839 0.2839
Brugia malayi beta-lactamase family protein 0.0077 0.0798 0.1494
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.041 0.0806
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0325 0.0716
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0043 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0043 0.0055
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0176 0.0162
Schistosoma mansoni bromodomain containing protein 0.0338 0.4403 0.4403
Loa Loa (eye worm) hypothetical protein 0.0077 0.0798 0.1597
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0445 0.082
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0645 0.0645
Toxoplasma gondii ABC1 family protein 0.0077 0.0798 0.2702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Onchocerca volvulus 0.0043 0.0325 0.0906
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0798 0.0785
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.062 0.2144
Onchocerca volvulus 0.0077 0.0798 0.2432
Echinococcus multilocularis importin subunit beta 1 0.003 0.0152 0.0138
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0043 0.01
Schistosoma mansoni methyl-cpg binding protein mbd 0.0091 0.0988 0.0988
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0043 0.0059
Mycobacterium tuberculosis Conserved protein 0.0077 0.0798 0.1207
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0178 0.0333
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0798 0.0798
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0645 0.1284
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0335 0.1133
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0335 0.0335
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0077 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0043 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0798 0.1207
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0245 0.0231
Brugia malayi Importin beta-1 subunit 0.003 0.0152 0.0262
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0074 0.0209
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0798 0.0785
Schistosoma mansoni eyes absent homolog 0.0093 0.1022 0.1022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0043 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0077 0.0062
Loa Loa (eye worm) hypothetical protein 0.0052 0.0456 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0043 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0645 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0225 0.2839 0.6941
Trypanosoma cruzi ISWI complex protein 0.0081 0.086 0.2993
Schistosoma mansoni hypothetical protein 0.032 0.4153 0.4153
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0043 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0798 0.1926
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0043 0.0028
Brugia malayi Bromodomain containing protein 0.0204 0.2546 0.4825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0449 0.0449
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1109 0.1096
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0492 0.1608
Schistosoma mansoni ran 0.0022 0.0043 0.0043
Leishmania major cathepsin L-like protease 0.0064 0.062 0.2144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Leishmania major hypothetical protein, conserved 0.0055 0.0492 0.1692
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0122 0.1416 0.1416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0449 0.0436
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0449 0.0449
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0043 0.0055
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0798 0.1976
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0445 0.0877
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0319 0.414 0.4132
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0043 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0798 0.1926
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0043 0.0029
Schistosoma mansoni hypothetical protein 0.0025 0.0077 0.0077
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0043 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0043 0.0055
Loa Loa (eye worm) hypothetical protein 0.0157 0.1898 0.3837
Trichomonas vaginalis set domain proteins, putative 0.0247 0.3148 0.7699
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0043 0.0043
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0157 0.0143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0687 0.0687
Leishmania major basic transcription factor 3a, putative 0.0225 0.2839 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0335 0.0787
Loa Loa (eye worm) hypothetical protein 0.0077 0.0798 0.1597
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0308 0.3982 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1109 0.1096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0043 0.0059
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0043 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0492 0.1142
Loa Loa (eye worm) hypothetical protein 0.0376 0.4923 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0315 0.4084 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0043 0.0055
Brugia malayi RNA binding protein 0.0066 0.0645 0.1201
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0043 0.0029
Schistosoma mansoni polycystin 1-related 0.0043 0.0325 0.0325
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0038 0.0024
Brugia malayi TAR-binding protein 0.0066 0.0645 0.1201
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0492 0.1142
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0798 0.0798
Onchocerca volvulus 0.0077 0.0798 0.2432
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.0204 0.2551 0.5168
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0645 0.1284
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0544 0.1873
Schistosoma mansoni zinc finger protein 0.0106 0.1199 0.1199
Toxoplasma gondii NAC domain-containing protein 0.0225 0.2839 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0798 0.1597
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0449 0.0449
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0043 0.0043
Trypanosoma cruzi transcription factor btf3, putative 0.0225 0.2839 1
Brugia malayi RNA, U transporter 1 0.0085 0.0914 0.1715
Brugia malayi Bromodomain containing protein 0.0043 0.033 0.0602
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0043 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1427 0.1427
Plasmodium vivax SET domain protein, putative 0.0032 0.0176 0.034
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0043 0.0043
Onchocerca volvulus 0.0032 0.0176 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0645 0.0645
Schistosoma mansoni importin beta-1 0.003 0.0152 0.0152
Leishmania major GTP-binding protein, putative 0.0022 0.0043 0.01
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0074 0.0145
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Entamoeba histolytica Ran family GTPase 0.0022 0.0043 0.0069
Onchocerca volvulus 0.0043 0.0325 0.0906
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.4084 1
Brugia malayi beta-lactamase family protein 0.0077 0.0798 0.1494
Schistosoma mansoni hypothetical protein 0.003 0.0157 0.0157
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.062 0.2144
Loa Loa (eye worm) hypothetical protein 0.0093 0.1022 0.2054
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0492 0.1692
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0325 0.0311
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0602 0.1198
Brugia malayi beta-NAC-like protein 0.0225 0.2839 0.5384
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0798 0.2775
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0043 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Schistosoma mansoni coup transcription factor 0.0022 0.0043 0.0043
Brugia malayi beta-lactamase 0.0077 0.0798 0.1494
Entamoeba histolytica transcription factor BTF3, putative 0.0225 0.2839 0.6941
Brugia malayi Pre-SET motif family protein 0.0217 0.2735 0.5185
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0176 0.0478
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0043 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0225 0.2839 0.6941
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0043 0.0029
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.062 0.2144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4084 1
Trichomonas vaginalis esterase, putative 0.0077 0.0798 0.1926
Onchocerca volvulus 0.0157 0.1898 0.5974
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0491 0.6511 1
Echinococcus granulosus RUN 0.0043 0.0325 0.0311
Schistosoma mansoni hypothetical protein 0.0035 0.0221 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Schistosoma mansoni cpg binding protein 0.0044 0.0343 0.0343
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0325 0.0311
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0157 0.029
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0492 0.1692
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0152 0.0486
Leishmania major cathepsin L-like protease 0.0064 0.062 0.2144
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0335 0.0321
Plasmodium vivax basic transcription factor 3b, putative 0.0225 0.2839 0.71
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0325 0.0311
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0335 0.0321
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0043 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0325 0.0632
Brugia malayi Bromodomain containing protein 0.04 0.5262 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0043 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Brugia malayi PHD-finger family protein 0.0022 0.004 0.0049
Loa Loa (eye worm) PHD-finger family protein 0.011 0.1251 0.2519
Schistosoma mansoni cpg binding protein 0.0044 0.0343 0.0343
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.0077 0.0798 0.1597
Brugia malayi steroid hormone receptor 0.0022 0.0043 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Echinococcus granulosus importin subunit beta 1 0.003 0.0152 0.0138
Mycobacterium ulcerans lipase LipD 0.0077 0.0798 0.1976
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0325 0.0632
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0043 0.0054
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0157 0.0408
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0335 0.0787
Brugia malayi hypothetical protein 0.0093 0.1022 0.1921
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0325 0.0716
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0152 0.0486
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0157 0.0408
Schistosoma mansoni cpg binding protein 0.0032 0.0178 0.0178
Brugia malayi PHD-finger family protein 0.0134 0.159 0.3002
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0157 0.0157
Schistosoma mansoni ran 0.0022 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0043 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0798 0.1919
Schistosoma mansoni hypothetical protein 0.011 0.1251 0.1251
Brugia malayi hypothetical protein 0.0157 0.1898 0.3589
Plasmodium vivax hypothetical protein, conserved 0.003 0.0157 0.029
Trypanosoma brucei ISWI complex protein 0.0081 0.086 0.2993
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0091 0.0988 0.0975
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0157 0.0143
Echinococcus multilocularis transcription factor btf3 0.0225 0.2839 0.2829
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0798 0.1926
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0798 0.1207
Brugia malayi hypothetical protein 0.0043 0.0325 0.0591
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0798 0.1926
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0043 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Schistosoma mansoni lipoxygenase 0.011 0.1258 0.1258
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0798 0.1926
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0043 0.0029
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0165 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0645 0.0645
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0308 0.3982 0.6107
Loa Loa (eye worm) hypothetical protein 0.0093 0.1022 0.2054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.076 0.2567
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0187 0.2313 0.2302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0421
Mycobacterium ulcerans hypothetical protein 0.0077 0.0798 0.1976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144
Loa Loa (eye worm) bromodomain containing protein 0.0094 0.1033 0.2076
Loa Loa (eye worm) ICD-1 protein 0.0225 0.2839 0.5755
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0798 0.1207
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0335 0.0321
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0335 0.0652
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0191 0.2373 0.2362
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0074 0.0145
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0798 0.1976
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.1861 0.2843
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0645 0.0645
Echinococcus granulosus fetal alzheimer antigen falz 0.0122 0.1416 0.1404
Schistosoma mansoni bromodomain containing protein 0.0025 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0335 0.0787
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0059
Mycobacterium tuberculosis Conserved protein 0.0077 0.0798 0.1207
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0043 0.0029
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.4084 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.1861 0.3339
Loa Loa (eye worm) hypothetical protein 0.0055 0.0492 0.0974
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0798 0.1207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.062 0.2144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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