Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0131 | 0.3757 | 0.41 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0038 | 0.0052 | 0.0056 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.053 | 0.053 |
Loa Loa (eye worm) | glutamate receptor | 0.0234 | 0.7849 | 0.7849 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.006 | 0.0927 | 0.0927 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5127 | 0.5594 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.2646 | 0.2887 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.053 | 0.0578 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0266 | 0.9125 | 0.9956 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 0.9165 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.9165 | 0.9165 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.9165 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.9165 | 0.9165 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.3757 | 0.3757 |
Brugia malayi | RNA binding protein | 0.0131 | 0.3757 | 0.41 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5127 | 0.5594 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0038 | 0.0052 | 0.0052 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0166 | 0.5127 | 0.5127 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3757 | 0.41 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.2646 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0927 | 0.0927 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.3757 | 0.3757 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.2646 | 0.2646 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.3757 | 0.3757 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0196 | 0.6338 | 0.6915 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0234 | 0.7849 | 0.8564 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0196 | 0.6338 | 0.6338 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0038 | 0.0052 | 0.0052 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.006 | 0.0927 | 0.1011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3757 | 0.41 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1347 | 0.147 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.3757 | 0.3757 |
Schistosoma mansoni | glutaminase | 0.0267 | 0.9165 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0235 | 0.7864 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1347 | 0.147 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.053 | 0.0578 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.9165 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.053 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.006 | 0.0927 | 0.0927 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.053 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2646 | 0.2646 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0212 | 0.6974 | 0.7609 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0114 | 0.3078 | 0.3358 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.3757 | 0.41 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.053 | 0.053 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1347 | 0.1347 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.053 | 0.053 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3757 | 0.41 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3757 | 0.41 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.053 | 0.053 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0114 | 0.3078 | 0.3358 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0052 | 0.0056 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.053 | 0.053 |
Echinococcus multilocularis | geminin | 0.0166 | 0.5127 | 0.5127 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0038 | 0.0052 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3757 | 0.41 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0038 | 0.0052 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0092 | 0.2203 | 0.2203 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.3757 | 0.3757 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0196 | 0.6338 | 0.6338 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.