Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0325 | 0.0133 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.1617 | 0.2175 |
Trypanosoma brucei | polo-like protein kinase | 0.0101 | 0.1798 | 0.2493 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.3632 | 0.5982 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0183 | 0.3594 | 0.592 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.0716 | 0.0532 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.0405 | 0.1314 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.1798 | 0.2493 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0296 | 0.6071 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0101 | 0.1798 | 0.1798 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.1412 | 0.1814 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.1412 | 0.1814 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0716 | 0.0716 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.0194 | 0.032 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0101 | 0.1798 | 0.167 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0405 | 0.0045 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.0856 | 0.0714 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0674 | 0.0476 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0.0194 | 0.1081 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0379 | 0.0229 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.1798 | 0.2458 |
Echinococcus multilocularis | pyruvate kinase | 0.003 | 0.023 | 0.023 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0325 | 0.0325 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0296 | 0.6071 | 0.6071 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.2042 | 0.3363 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.1798 | 0.2458 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0101 | 0.1798 | 0.1798 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0194 | 0.032 |
Echinococcus granulosus | muscleblind protein | 0.0475 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0101 | 0.1798 | 0.2779 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0405 | 0.0405 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.1798 | 0.2458 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0296 | 0.6071 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0716 | 0.1179 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.3632 | 0.5982 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0379 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0716 | 0.1179 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.1608 | 0.1608 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0165 | 0.3184 | 0.3049 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.1412 | 0.1814 |
Chlamydia trachomatis | pyruvate kinase | 0.0038 | 0.0405 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0379 | 0.0229 |
Brugia malayi | Adenosylhomocysteinase | 0.0296 | 0.6071 | 0.5993 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0296 | 0.6071 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0405 | 0.0256 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0405 | 0.0405 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0296 | 0.6071 | 1 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0296 | 0.6071 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0405 | 0.0256 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0113 | 0.2042 | 0.1884 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0038 | 0.0405 | 0.0045 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0296 | 0.6071 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.039 | 0.039 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0405 | 0.0045 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0435 | 0.0476 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.0716 | 0.0571 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0435 | 0.0245 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0325 | 0.0535 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0194 | 0.032 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.1412 | 0.1814 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0183 | 0.3594 | 0.592 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0296 | 0.6071 | 0.601 |
Leishmania major | pyruvate kinase | 0.0038 | 0.0405 | 0.0045 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.0194 | 0.0042 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0296 | 0.6071 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0296 | 0.6071 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0475 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0296 | 0.6071 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0548 | 0.0548 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.1412 | 0.1814 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0435 | 0.0476 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0435 | 0.0476 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0296 | 0.6071 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0038 | 0.0405 | 0.0667 |
Echinococcus granulosus | pyruvate kinase | 0.0038 | 0.0405 | 0.0405 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0548 | 0.0902 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.1412 | 0.1814 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0716 | 0.0716 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0296 | 0.6071 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0379 | 0.0188 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.1608 | 0.1442 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0674 | 0.0476 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.0716 | 0.0532 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.0194 | 0.0194 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0296 | 0.6071 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0038 | 0.0405 | 0.0667 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.0716 | 0.0716 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0325 | 0.0535 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0038 | 0.0405 | 0.0045 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.0405 | 0.1314 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0093 | 0.1613 | 0.2132 |
Plasmodium falciparum | pyruvate kinase | 0.0038 | 0.0405 | 0.0667 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.1798 | 0.2458 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0101 | 0.1798 | 0.1635 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0165 | 0.3184 | 0.3049 |
Echinococcus granulosus | geminin | 0.0185 | 0.3632 | 0.3632 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0548 | 0.0902 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0405 | 0.0256 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0038 | 0.0405 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0194 | 0.0042 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0379 | 0.0624 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0296 | 0.6071 | 1 |
Echinococcus multilocularis | peregrin | 0.0028 | 0.0194 | 0.0194 |
Giardia lamblia | Kinase, PLK | 0.0101 | 0.1798 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0379 | 0.0624 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0183 | 0.3594 | 0.592 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0379 | 0.0624 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0165 | 0.3184 | 0.3078 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0548 | 0.0548 |
Echinococcus granulosus | pyruvate kinase | 0.0038 | 0.0405 | 0.0405 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0435 | 0.0716 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0101 | 0.1798 | 0.2961 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.1617 | 0.2139 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.0716 | 0.0716 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.1617 | 0.2175 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0435 | 0.0716 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0548 | 0.0401 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.1798 | 0.2458 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.1798 | 0.2458 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0548 | 0.0548 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.0716 | 0.0716 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0038 | 0.0405 | 0.0215 |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.0716 | 0.0716 |
Echinococcus multilocularis | geminin | 0.0185 | 0.3632 | 0.3632 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.119 | 0.196 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0038 | 0.0405 | 0.0215 |
Schistosoma mansoni | kinase | 0.0052 | 0.0704 | 0.1159 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0475 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0101 | 0.1798 | 0.2458 |
Schistosoma mansoni | pyruvate kinase | 0.0038 | 0.0405 | 0.0667 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.039 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.3184 | 0.3078 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.1617 | 0.2175 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0296 | 0.6071 | 0.6071 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0084 | 0.1412 | 0.1777 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.0194 | 0.0194 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0296 | 0.6071 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0548 | 0.036 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0435 | 0.0435 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.0405 | 0.1314 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0435 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0716 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0638 | 0.0492 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0548 | 0.0902 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0379 | 0.0624 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0438 | 0.0438 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0325 | 0.0174 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0296 | 0.6071 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0405 | 0.0256 |
Echinococcus granulosus | peregrin | 0.0028 | 0.0194 | 0.0194 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0038 | 0.0405 | 0.0045 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0194 | 0.032 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0101 | 0.1798 | 0.2493 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2042 | 0.1918 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0325 | 0.0325 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0.0194 | 0.032 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0548 | 0.0548 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0716 | 0.1179 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0101 | 0.1798 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0379 | 0.0624 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0101 | 0.1798 | 0.2493 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0194 | 0.032 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0438 | 0.0438 |
Giardia lamblia | Pyruvate kinase | 0.0038 | 0.0405 | 0.2252 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0435 | 0.0435 |
Leishmania major | pyruvate kinase | 0.0038 | 0.0405 | 0.0045 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0716 | 0.1179 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0183 | 0.3594 | 0.592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Displacement of [3H]MPPF from human cloned 5HT1A receptor expressed in HEK293 cells at 3 uM after 90 mins by liquid scintillation counting | ChEMBL. | 20570529 |
Activity (binding) | = 1 % | Displacement of [3H]mesulergine from human cloned 5HT2C receptor expressed in HEK293 cells at 3 uM after 90 mins by liquid scintillation counting | ChEMBL. | 20570529 |
Activity (binding) | = 6 % | Displacement of [3H]methylspiperone from human cloned 5HT2A receptor expressed in HEK293 cells at 3 uM after 90 mins by liquid scintillation counting | ChEMBL. | 20570529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.