Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0869 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0869 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0869 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0869 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0869 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0869 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0869 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0869 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0869 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0869 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | < 10 % | Displacement of [3H]-CGS- 21680 from adenosine A2A receptor of rat striatal membranes at 100 microM | ChEMBL. | 10841798 |
Displacement (binding) | < 10 % | Displacement of [3H]-CGS- 21680 from adenosine A2A receptor of rat striatal membranes at 100 microM | ChEMBL. | 10841798 |
EC50 (functional) | > 10000 nM | Stimulation of [35S]-GTP-gammaS, binding to human adenosine A1 receptor | ChEMBL. | 10841798 |
EC50 (functional) | > 10000 nM | Stimulation of [35S]-GTP-gammaS, against human adenosine A3 receptor | ChEMBL. | 10841798 |
EC50 (functional) | > 10000 nM | Stimulation of [35S]-GTP-gammaS, binding to human adenosine A1 receptor | ChEMBL. | 10841798 |
EC50 (functional) | > 10000 nM | Stimulation of [35S]-GTP-gammaS, against human adenosine A3 receptor | ChEMBL. | 10841798 |
Ki (binding) | = 1960 nM | Displacement of [125I]- AB-MECA from human adenosine A3 receptor expressed in HEK cells | ChEMBL. | 10841798 |
Ki (binding) | = 1960 nM | Displacement of [125I]- AB-MECA from human adenosine A3 receptor expressed in HEK cells | ChEMBL. | 10841798 |
Ki (binding) | = 25900 nM | Displacement of [3H]-R-PIA from rat brain membrane Adenosine A1 receptor | ChEMBL. | 10841798 |
Ki (binding) | = 25900 nM | Displacement of [3H]-R-PIA from rat brain membrane Adenosine A1 receptor | ChEMBL. | 10841798 |
Max (binding) | = 5 % | Maximum stimulation against human adenosine A1 receptor | ChEMBL. | 10841798 |
Max (binding) | = 5 % | Maximum stimulation against human adenosine A1 receptor | ChEMBL. | 10841798 |
Max (binding) | = 14 % | Maximum stimulation against human adenosine A3 receptor | ChEMBL. | 10841798 |
Max (binding) | = 14 % | Maximum stimulation against human adenosine A3 receptor | ChEMBL. | 10841798 |
Ratio (binding) | = 13 | Relative binding affinity for Adenosine A1 and A3 receptors | ChEMBL. | 10841798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.