TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 447.313 | Formula: C20H22IN3O
H donors: 1 H acceptors: 2 LogP: 4.23 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCNC(=O)c1c2ccccc2nc2c1cc(I)cc2)CC
InChi: 1S/C20H22IN3O/c1-3-24(4-2)12-11-22-20(25)19-15-7-5-6-8-17(15)23-18-10-9-14(21)13-16(18)19/h5-10,13H,3-4,11-12H2,1-2H3,(H,22,25)
InChiKey: VOBRTBYHSPUOFP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.055	0.366	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0428	0.282	0.7705
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0114	0.0114
Brugia malayi	RNA recognition motif domain containing protein	0.02	0.1256	0.1432
Loa Loa (eye worm)	MH2 domain-containing protein	0.0059	0.0287	0.0327
Loa Loa (eye worm)	RNA binding protein	0.02	0.1256	0.1432
Schistosoma mansoni	bromodomain containing protein	0.0031	0.0094	0.0257
Brugia malayi	Smad1	0.0059	0.0287	0.0327
Echinococcus granulosus	mothers against decapentaplegic 2	0.0026	0.0064	0.0175
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.015	0.041
Echinococcus multilocularis	peregrin	0.0111	0.0642	0.1755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0194	0.0194
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.055	0.366	1
Echinococcus granulosus	chromobox protein 1	0.0067	0.0347	0.0947
Loa Loa (eye worm)	Smad1	0.0059	0.0287	0.0327
Toxoplasma gondii	bromodomain-containing protein	0.0017	0.000000053376	0.00000046075
Entamoeba histolytica	hypothetical protein	0.0039	0.015	0.7724
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0001	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0114	0.0114
Schistosoma mansoni	hypothetical protein	0.0123	0.0725	0.198
Toxoplasma gondii	ABC1 family protein	0.0039	0.015	0.1295
Brugia malayi	MH1 domain containing protein	0.0059	0.0287	0.0327
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0051	0.0051
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0308	0.1997	0.5457
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0114	0.0114
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0026	0.0064	0.004
Schistosoma mansoni	smad1 5 8 and	0.0059	0.0287	0.0785
Plasmodium falciparum	phd finger protein, putative	0.0094	0.0526	1
Loa Loa (eye worm)	TAR-binding protein	0.02	0.1256	0.1432
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0025	0.0053	0.0146
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.0131	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0039	0.015	0.0171
Onchocerca volvulus		0.0039	0.015	0.0126
Schistosoma mansoni	tar DNA-binding protein	0.02	0.1256	0.3432
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0034	0.0094
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0059	0.0287	0.0785
Echinococcus granulosus	jumonji domain containing protein	0.013	0.0777	0.2124
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.015	0.015
Schistosoma mansoni	Smad4	0.0026	0.0064	0.0175
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.0194	1
Schistosoma mansoni	alkaline phosphatase	0.055	0.366	1
Loa Loa (eye worm)	hypothetical protein	0.016	0.0984	0.1122
Loa Loa (eye worm)	jmjC domain-containing protein	0.0193	0.1209	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0039	0.015	0.0171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.013	0.013
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0122	0.0722	0.1974
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0186	0.1158	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0248	0.1586	1
Echinococcus multilocularis	jumonji domain containing protein	0.013	0.0777	0.2124
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0037	0.014	0.0383
Brugia malayi	MH2 domain containing protein	0.0863	0.5809	0.6622
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0149	0.0149
Echinococcus granulosus	lysine specific demethylase 5A	0.0127	0.0755	0.2062
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.003	0.0091	0.0248
Brugia malayi	beta-lactamase	0.0039	0.015	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0094	0.0107
Brugia malayi	jmjC domain containing protein	0.003	0.0091	0.0104
Schistosoma mansoni	tar DNA-binding protein	0.02	0.1256	0.3432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0069	0.0069
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0031	0.0085
Brugia malayi	jmjC domain containing protein	0.0306	0.1987	0.2265
Schistosoma mansoni	hypothetical protein	0.008	0.0436	0.1191
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0143	0.0119
Echinococcus granulosus	chromobox protein 1	0.0067	0.0347	0.0947
Schistosoma mansoni	zinc finger protein	0.014	0.0846	0.2313
Toxoplasma gondii	LsmAD domain-containing protein	0.0049	0.022	0.1895
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0186	0.1158	0.3166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0069	0.0069
Trypanosoma brucei	PAB1-binding protein , putative	0.0049	0.022	0.332
Brugia malayi	hypothetical protein	0.0032	0.01	0.0115
Schistosoma mansoni	smad1 5 8 and	0.0059	0.0287	0.0785
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0143	0.0143
Schistosoma mansoni	phosphatidylserine receptor	0.003	0.0091	0.0248
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0122	0.0722	0.1974
Mycobacterium ulcerans	beta-lactamase	0.0039	0.015	0.5
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1771	0.2019
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.015	0.015
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0254	0.1629	0.1857
Schistosoma mansoni	chromobox protein	0.0067	0.0347	0.0947
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0013	0.0249
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.015	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0187	0.0214
Schistosoma mansoni	smad1 5 8 and	0.0059	0.0287	0.0785
Trypanosoma cruzi	ISWI complex protein	0.011	0.0636	1
Loa Loa (eye worm)	bromodomain containing protein	0.0127	0.0752	0.0858
Brugia malayi	MH2 domain containing protein	0.0026	0.0064	0.0073
Loa Loa (eye worm)	PHD-finger family protein	0.0148	0.0898	0.1024
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0194	0.053
Schistosoma mansoni	Smad4	0.0059	0.0287	0.0785
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.055	0.366	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0308	0.1997	0.5457
Schistosoma mansoni	smad	0.0059	0.0287	0.0785
Echinococcus multilocularis	tumor protein p63	0.0329	0.2141	0.585
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.015	0.2206
Schistosoma mansoni	chromobox protein	0.0067	0.0347	0.0947
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0194	0.0194
Loa Loa (eye worm)	transcription factor SMAD2	0.0863	0.5809	0.6622
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0162	0.0992	0.2712
Mycobacterium ulcerans	lipase LipD	0.0039	0.015	0.5
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0044	0.0185	0.0505
Schistosoma mansoni	tar DNA-binding protein	0.02	0.1256	0.3432
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.055	0.366	1
Echinococcus multilocularis	phd:f box containing protein	0.003	0.0091	0.0248
Loa Loa (eye worm)	jmjC domain-containing protein	0.003	0.0091	0.0104
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0194	0.053
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0093	0.0807
Loa Loa (eye worm)	PHD-finger family protein	0.0094	0.0526	0.0599
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.0725	0.198
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0122	0.0722	0.1974
Loa Loa (eye worm)	jmjC domain-containing protein	0.003	0.0091	0.0104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.013	0.013
Brugia malayi	MH1 domain containing protein	0.0059	0.0287	0.0327
Echinococcus multilocularis	smad	0.0059	0.0287	0.0785
Echinococcus granulosus	mothers against decapentaplegic 6	0.0026	0.0064	0.0175
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0132	0.0792	0.2165
Brugia malayi	CHD4 protein	0.0025	0.0053	0.0061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0114	0.0114
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.008	0.0436	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1887	0.2151
Brugia malayi	Bromodomain containing protein	0.0274	0.1767	0.2015
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.015	0.015
Brugia malayi	hypothetical protein	0.0039	0.015	0.0171
Echinococcus granulosus	PHD finger protein rhinoceros	0.0094	0.0526	0.1436
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0306	0.1987	0.5429
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0092	0.0092
Brugia malayi	mothers against decapentaplegic homolog 3	0.0026	0.0064	0.0073
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.008	0.0436	0.1191
Schistosoma mansoni	hypothetical protein	0.008	0.0436	0.1191
Brugia malayi	MH1 domain containing protein	0.0033	0.0107	0.0122
Echinococcus multilocularis	GPCR, family 2	0.008	0.0436	0.1191
Schistosoma mansoni	thyroid hormone receptor	0.0132	0.0792	0.2165
Schistosoma mansoni	thyroid hormone receptor	0.0132	0.0792	0.2165
Plasmodium vivax	SET domain protein, putative	0.0186	0.1158	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0034	0.0114	0.0988
Brugia malayi	MH2 domain containing protein	0.0059	0.0287	0.0327
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0031	0.0093	0.1298
Onchocerca volvulus		0.0048	0.0214	0.019
Brugia malayi	hypothetical protein	0.0049	0.022	0.025
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0194	0.2911
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.022	0.4176
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0031	0.0031
Brugia malayi	latrophilin 2 splice variant baaae	0.0174	0.1076	0.1227
Leishmania major	hypothetical protein, conserved	0.0049	0.022	0.2361
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.008	0.0436	0.1191
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.022	0.2361
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.1295	0.8772	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0067	0.0067
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0122	0.0722	0.1974
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0214	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0143	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0308	0.1997	0.2277
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0194	0.0221
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.003	0.0091	0.0784
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0131	0.1896
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.015	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0049	0.022	0.1895
Schistosoma mansoni	hypothetical protein	0.0286	0.1846	0.5043
Brugia malayi	PHD-finger family protein	0.0094	0.0526	0.0599
Loa Loa (eye worm)	jmjC domain-containing protein	0.003	0.0091	0.0104
Plasmodium falciparum	ataxin-2 like protein, putative	0.0049	0.022	0.4176
Giardia lamblia	PHD finger protein 15	0.0094	0.0526	1
Entamoeba histolytica	hypothetical protein	0.0039	0.015	0.7724
Brugia malayi	Pre-SET motif family protein	0.0186	0.1158	0.1321
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.003	0.0287
Loa Loa (eye worm)	hypothetical protein	0.003	0.0091	0.0104
Echinococcus granulosus	fetal alzheimer antigen falz	0.0162	0.0992	0.2712
Schistosoma mansoni	hypothetical protein	0.008	0.0436	0.1191
Brugia malayi	jmjC domain containing protein	0.003	0.0091	0.0104
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0428	0.282	0.7705
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0194	0.0221
Schistosoma mansoni	hypothetical protein	0.0094	0.0526	0.1436
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0094	0.0526	0.1436
Echinococcus granulosus	GPCR family 2	0.008	0.0436	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1981	0.2258
Loa Loa (eye worm)	MH2 domain-containing protein	0.0026	0.0064	0.0073
Brugia malayi	AF-10 protein	0.0031	0.0093	0.0107
Loa Loa (eye worm)	beta-lactamase	0.0039	0.015	0.0171
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.015	0.041
Loa Loa (eye worm)	heterochromatin protein 1	0.0067	0.0347	0.0395
Schistosoma mansoni	hypothetical protein	0.0039	0.015	0.0409
Loa Loa (eye worm)	hypothetical protein	0.003	0.0087	0.0099
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0194	0.2911
Brugia malayi	jmjC domain containing protein	0.003	0.0091	0.0104
Leishmania major	hypothetical protein, conserved	0.011	0.0636	1
Brugia malayi	Latrophilin receptor protein 2	0.008	0.0436	0.0497
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0031	0.0093	0.1778
Schistosoma mansoni	bromodomain containing protein	0.0453	0.2996	0.8186
Echinococcus granulosus	lysine specific demethylase 6a	0.003	0.0091	0.0248
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.015	0.015
Brugia malayi	PHD-finger family protein	0.0044	0.0187	0.0214
Toxoplasma gondii	PHD-finger domain-containing protein	0.0094	0.0526	0.4538
Entamoeba histolytica	hypothetical protein	0.0039	0.015	0.7724
Trichomonas vaginalis	set domain proteins, putative	0.1474	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.015	0.041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0067	0.0067
Brugia malayi	SET domain containing protein	0.0018	0.0006	0.0007
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0031	0.0035
Brugia malayi	SET domain containing protein	0.0021	0.0024	0.0028
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.015	0.0409
Brugia malayi	jmjC domain containing protein	0.0127	0.0755	0.086
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0197	0.1234	0.3373
Brugia malayi	Pre-SET motif family protein	0.1295	0.8772	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.015	0.0171
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0179	0.1112	0.3037
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.02	0.1256	0.1432
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0163	0.0139
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0347	0.0347
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.0194	1
Brugia malayi	jmjC domain containing protein	0.003	0.0091	0.0104
Echinococcus granulosus	zinc finger protein	0.014	0.0846	0.2313
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0051	0.0051
Leishmania major	hypothetical protein, conserved	0.0039	0.015	0.1086
Brugia malayi	Bromodomain containing protein	0.0537	0.3572	0.4072
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0031	0.0031
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.015	0.1086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0051	0.0051
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0308	0.1997	0.5457
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0073
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.015	0.1295
Echinococcus multilocularis	lysine specific demethylase 6a	0.003	0.0091	0.0248
Mycobacterium ulcerans	hypothetical protein	0.0039	0.015	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.0026	0.0064	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0143	0.0143
Echinococcus granulosus	smad	0.0059	0.0287	0.0785
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0114	0.0114
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0347	0.0347
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0044	0.0185	0.0505
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.055	0.366	1
Onchocerca volvulus	Alhambra homolog	0.0094	0.0526	0.0502
Echinococcus granulosus	jumonji domain containing 1A	0.003	0.0091	0.0248
Echinococcus granulosus	tumor protein p63	0.0329	0.2141	0.585
Trypanosoma brucei	ISWI complex protein	0.011	0.0636	1
Echinococcus granulosus	phd:f box containing protein	0.003	0.0091	0.0248
Plasmodium vivax	JmjC domain containing protein	0.003	0.0091	0.0784
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0257	0.1651	0.4511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1076	0.1227
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.015	0.015
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.015	0.0171
Schistosoma mansoni	hypothetical protein	0.0148	0.0898	0.2455
Echinococcus multilocularis	lysine specific demethylase 5A	0.0113	0.0661	0.1806
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0031	0.0035
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0031	0.0085
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.015	0.5
Brugia malayi	PHD-finger family protein	0.0178	0.1109	0.1264
Schistosoma mansoni	jumonji domain containing protein	0.0243	0.1554	0.4247
Schistosoma mansoni	tar DNA-binding protein	0.02	0.1256	0.3432
Schistosoma mansoni	alkaline phosphatase	0.055	0.366	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.013	0.013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0114	0.0114
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0163	0.0163
Schistosoma mansoni	jumonji domain containing protein	0.003	0.0091	0.0248
Echinococcus granulosus	intestinal type alkaline phosphatase	0.055	0.366	1
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0025	0.0053	0.0146
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.0725	0.198
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0067	0.0067
Loa Loa (eye worm)	MH1 domain-containing protein	0.0059	0.0287	0.0327
Echinococcus granulosus	Smad4	0.0059	0.0287	0.0785
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0031	0.0093	0.0807
Giardia lamblia	GTOR	0.0045	0.0194	0.369
Brugia malayi	Heterochromatin protein 1	0.0067	0.0347	0.0395
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0194	0.0194
Schistosoma mansoni	phd/f-box containing protein	0.003	0.0091	0.0248
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0031	0.0093	0.1298
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0347	0.0947
Brugia malayi	Bromodomain containing protein	0.0111	0.0642	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0039	0.015	0.0171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0085	0.0085
Loa Loa (eye worm)	latrophilin receptor protein 2	0.008	0.0436	0.0497
Schistosoma mansoni	hypothetical protein	0.011	0.0636	0.1738
Onchocerca volvulus		0.0039	0.015	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0107	0.0122
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0034	0.0094
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0127	0.0755	0.2062
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0526	0.0599
Entamoeba histolytica	hypothetical protein	0.0039	0.015	0.7724
Loa Loa (eye worm)	hypothetical protein	0.008	0.0436	0.0497
Echinococcus multilocularis	zinc finger protein	0.014	0.0846	0.2313
Schistosoma mansoni	hypothetical protein	0.0031	0.0093	0.0255
Brugia malayi	TAR-binding protein	0.02	0.1256	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0049	0.022	0.025
Echinococcus multilocularis	tar DNA binding protein	0.02	0.1256	0.3432
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0067	0.0067
Trypanosoma cruzi	ISWI complex protein	0.011	0.0636	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.015	0.0171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0051	0.0051
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0194	0.1892
Echinococcus granulosus	histone lysine methyltransferase setb	0.0308	0.1997	0.5457
Loa Loa (eye worm)	jmjC domain-containing protein	0.0127	0.0755	0.086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0051	0.0051
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.015	0.0409
Echinococcus granulosus	tar DNA binding protein	0.02	0.1256	0.3432
Trichomonas vaginalis	esterase, putative	0.0039	0.015	0.015
Plasmodium vivax	SET domain containing protein	0.0024	0.0047	0.0405
Echinococcus multilocularis	Smad4	0.0059	0.0287	0.0785
Echinococcus multilocularis	jumonji domain containing 1A	0.003	0.0091	0.0248
Brugia malayi	F/Y-rich N-terminus family protein	0.0051	0.0234	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.013	0.013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.013	0.013
Schistosoma mansoni	smad	0.0026	0.0064	0.0175
Brugia malayi	chromobox protein homolog 3	0.0038	0.0143	0.0163
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0306	0.1987	0.5429
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0194	0.053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0051	0.0051
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0194	0.1892
Loa Loa (eye worm)	CHromoDomain protein family member	0.0025	0.0053	0.0061
Echinococcus granulosus	JmjC domain containing protein 4	0.003	0.0091	0.0248
Onchocerca volvulus		0.0039	0.015	0.0126
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0254	0.1629	0.1857
Brugia malayi	MH2 domain containing protein	0.0059	0.0287	0.0327
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0194	0.1892
Echinococcus granulosus	alkaline phosphatase	0.055	0.366	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0863	0.5809	0.6622
Loa Loa (eye worm)	hypothetical protein	0.0507	0.3362	0.3832
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0163	0.0163
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0059	0.0287	0.0785
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.008	0.0436	0.1191
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0131	0.0732
Onchocerca volvulus		0.0197	0.1234	0.1213
Loa Loa (eye worm)	nuclear factor I	0.0033	0.0107	0.0122
Trypanosoma cruzi	PAB1-binding protein , putative	0.0049	0.022	0.2361
Brugia malayi	MH1 domain containing protein	0.0033	0.0107	0.0122
Echinococcus multilocularis	alkaline phosphatase	0.055	0.366	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0254	0.1629	0.1857
Schistosoma mansoni	protein phosphatase 2C	0.003	0.0091	0.0248
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.015	0.1086
Echinococcus granulosus	mothers against decapentaplegic 5	0.0059	0.0287	0.0785
Schistosoma mansoni	hypothetical protein	0.0174	0.1076	0.2941
Schistosoma mansoni	hypothetical protein	0.0022	0.0034	0.0094
Brugia malayi	RNA binding protein	0.02	0.1256	0.1432
Schistosoma mansoni	zinc finger protein	0.011	0.0636	0.1738
Mycobacterium leprae	Probable lipase LipE	0.0039	0.015	0.5
Echinococcus granulosus	peregrin	0.0111	0.0642	0.1755
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0093	0.0807
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0026	0.0064	0.0175
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0127	0.0755	0.2062
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.003	0.0091	0.0784
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0162	0.0992	0.2712
Onchocerca volvulus		0.003	0.0087	0.0063
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0024	0.0047	0.0405
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0026	0.0064	0.0175
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0194	0.1892
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0059	0.0287	0.0785
Plasmodium vivax	hypothetical protein, conserved	0.0094	0.0526	0.4538
Echinococcus multilocularis	JmjC domain containing protein 4	0.003	0.0091	0.0248
Brugia malayi	beta-lactamase family protein	0.0039	0.015	0.0171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0039	0.015	0.0171
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0186	0.1158	0.3166
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.015	0.041
Schistosoma mansoni	hypothetical protein	0.008	0.0436	0.1191
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0347	0.0947
Loa Loa (eye worm)	hypothetical protein	0.003	0.0091	0.0104
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.015	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0214	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1629	0.1857
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0059	0.0287	0.0785
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0114	0.0114
Plasmodium falciparum	JmjC domain-containing protein, putative	0.003	0.0091	0.1728
Schistosoma mansoni	Smad4	0.0026	0.0064	0.0175
Toxoplasma gondii	PHD-finger domain-containing protein	0.0094	0.0526	0.4538
Brugia malayi	beta-lactamase family protein	0.0039	0.015	0.0171
Schistosoma mansoni	tar DNA-binding protein	0.02	0.1256	0.3432
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0094	0.0526	0.1436
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0025	0.0053	0.0146
Schistosoma mansoni	SET domain protein	0.0021	0.0024	0.0067
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.015	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0257	0.1651	0.4511
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.008	0.0436	0.1191
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.003	0.0091	0.1256

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1186464

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1144432