Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Papain family cysteine protease containing protein | 0.0018 | 0.0534 | 0.0534 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0534 | 0.0534 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.7518 | 0.9323 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0018 | 0.0534 | 0.0574 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.3955 | 0.4754 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.0534 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.1009 | 0.1025 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0018 | 0.0534 | 0.0426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.2055 | 0.2228 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.149 | 0.1645 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3955 | 0.425 |
Echinococcus multilocularis | dna polymerase eta | 0.0042 | 0.3955 | 0.4784 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.7518 | 0.9323 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.06 | 0.0507 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.3955 | 0.3955 |
Leishmania major | cysteine peptidase A (CPA) | 0.0018 | 0.0534 | 0.028 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.149 | 0.1645 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.06 | 0.0507 |
Echinococcus granulosus | dna polymerase eta | 0.0042 | 0.3955 | 0.4784 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0.0534 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.805 | 0.9938 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0042 | 0.3955 | 0.4662 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.06 | 0.051 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0315 | 0.0147 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4442 | 0.4773 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4058 | 0.436 |
Onchocerca volvulus | 0.0028 | 0.1878 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.1878 | 0.2139 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.1878 | 0.2018 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.3955 | 0.4662 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.805 | 0.9938 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.2055 | 0.2228 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0019 | 0.06 | 0.051 |
Onchocerca volvulus | 0.0028 | 0.1878 | 1 | |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.3955 | 0.4754 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.3955 | 0.4784 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0315 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0199 | 0.0214 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0534 | 0.0426 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0534 | 0.0534 |
Echinococcus multilocularis | lamin | 0.0028 | 0.1878 | 0.2139 |
Schistosoma mansoni | lamin | 0.0028 | 0.1878 | 0.2125 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.2944 | 0.3475 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0042 | 0.3955 | 0.4662 |
Echinococcus granulosus | lamin | 0.0028 | 0.1878 | 0.2139 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.2055 | 0.2228 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0199 | 0.0199 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.2055 | 0.2228 |
Echinococcus multilocularis | musashi | 0.0028 | 0.1878 | 0.2139 |
Echinococcus granulosus | cathepsin l1 | 0.0018 | 0.0534 | 0.0426 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.4046 | 0.4046 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.805 | 0.9938 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0199 | 0.0199 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.3955 | 0.4784 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.8099 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.3955 | 0.5 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.06 | 0.051 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.0534 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0064 | 0.7229 | 0.8856 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.06 | 0.0507 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.3955 | 0.3955 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9306 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.1878 | 0.2018 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0534 | 0.0534 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0534 | 0.0426 |
Schistosoma mansoni | lamin | 0.0028 | 0.1878 | 0.2125 |
Loa Loa (eye worm) | ctsf protein | 0.0018 | 0.0534 | 0.0574 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.3662 | 0.4411 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.3955 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0534 | 0.0426 |
Giardia lamblia | DINP protein human, muc B family | 0.0042 | 0.3955 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.2055 | 0.2228 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.3955 | 0.4662 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0055 | 0.592 | 0.7179 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0534 | 0.0534 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0534 | 0.0534 |
Loa Loa (eye worm) | cysteine protease | 0.0018 | 0.0534 | 0.0574 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.3955 | 0.4784 |
Leishmania major | cathepsin L-like protease | 0.0018 | 0.0534 | 0.028 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.805 | 0.865 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.1878 | 0.1878 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.06 | 0.0507 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0.0534 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.805 | 0.805 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.06 | 0.0644 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.2944 | 0.2944 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0534 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4752 | 0.5106 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0534 | 0.0426 |
Leishmania major | cathepsin L-like protease | 0.0018 | 0.0534 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0534 | 0.0574 |
Schistosoma mansoni | DNA polymerase eta | 0.0042 | 0.3955 | 0.4754 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Leishmania major | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0042 | 0.3955 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.805 | 0.865 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.3955 | 0.425 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.1878 | 0.1878 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.007 | 0.8122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.531 | 0.5706 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0018 | 0.0534 | 0.028 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.3955 | 0.4662 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0534 | 0.0424 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.007 | 0.8122 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.1009 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1804 | 0.1938 |
Brugia malayi | TAR-binding protein | 0.007 | 0.805 | 0.805 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.1009 | 0.1032 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.805 | 0.9938 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0.0534 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.3955 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.007 | 0.8122 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.805 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0534 | 0.0426 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.3955 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.149 | 0.1635 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.531 | 0.531 |
Leishmania major | cathepsin L-like protease | 0.007 | 0.8122 | 1 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.3955 | 0.4662 |
Leishmania major | cathepsin L-like protease | 0.0018 | 0.0534 | 0.028 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.531 | 0.531 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.3955 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.805 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0534 | 0.0426 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0018 | 0.0534 | 0.0426 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0018 | 0.0534 | 0.0574 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.1878 | 0.2139 |
Leishmania major | cathepsin L-like protease | 0.0018 | 0.0534 | 0.028 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Loa Loa (eye worm) | fibroinase | 0.0018 | 0.0534 | 0.0574 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0534 | 0.0534 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.1878 | 0.2125 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0042 | 0.3955 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.118 | 0.1269 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.531 | 0.5706 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.007 | 0.8122 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.118 | 0.1242 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0199 | 0.0214 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0042 | 0.3955 | 0.4662 |
Leishmania major | cathepsin L-like protease | 0.0018 | 0.0534 | 0.028 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.3662 | 0.4411 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.007 | 0.8122 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0018 | 0.0534 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.3955 | 0.4784 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.1874 | 0.1874 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Leishmania major | DNA polymerase eta, putative | 0.0042 | 0.3955 | 0.4662 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.805 | 0.9938 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.1878 | 0.2139 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0699 | 0.0751 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0019 | 0.06 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2944 | 0.3164 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.3955 | 0.4662 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1878 | 0.2018 |
Leishmania major | cathepsin L-like protease | 0.007 | 0.8122 | 1 |
Brugia malayi | RNA binding protein | 0.007 | 0.805 | 0.805 |
Leishmania major | cathepsin L-like protease | 0.007 | 0.8122 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.805 | 0.865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.