Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.004 | 0.0143 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0232 | 0.1404 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0147 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1404 | 0.3541 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0039 | 0.0007 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0147 | 0.1044 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.004 | 0.0051 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.008 | 0.0301 |
Onchocerca volvulus | 0.0232 | 0.1404 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0147 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.1596 | 0.4033 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0084 | 0.0596 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0187 | 0.0167 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.004 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0039 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.1562 | 0.3947 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.0438 | 0.1068 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0048 | 0.0225 | 0.1481 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0232 | 0.1404 | 0.1462 |
Plasmodium vivax | hypothetical protein, conserved | 0.0232 | 0.1404 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0232 | 0.1404 | 0.1462 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0162 | 0.1157 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0084 | 0.0596 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0048 | 0.0225 | 0.0205 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0187 | 0.7911 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0438 | 0.0418 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.004 | 0.0273 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0232 | 0.1404 | 0.1462 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0162 | 0.1157 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.004 | 0.0273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0627 | 0.3926 | 0.3913 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0021 | 0.0147 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.004 | 0.0051 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0257 | 0.1562 | 0.3947 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0162 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1042 | 0.2614 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 0.0778 | 0.0759 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0143 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.008 | 0.0428 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0232 | 0.1404 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.026 | 0.0239 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0232 | 0.1404 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0438 | 0.0418 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.004 | 0.0143 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0048 | 0.0225 | 0.1481 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0232 | 0.1404 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.0714 | 0.0695 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0023 | 0.0063 | 0.0434 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0438 | 0.0418 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1577 | 1 | 1 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.002 | 0.0045 | 0.0308 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0232 | 0.1404 | 0.1386 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0232 | 0.1404 | 0.1462 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.004 | 0.0288 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0187 | 0.7911 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.026 | 0.0612 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.008 | 0.0301 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.008 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0039 | 0.0046 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.008 | 0.0152 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0101 | 0.0723 |
Onchocerca volvulus | 0.0054 | 0.026 | 0.1358 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0147 | 0.1044 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.004 | 0.002 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0048 | 0.0225 | 0.0205 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0021 | 0.0147 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.0438 | 0.0418 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.0438 | 0.0418 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0438 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0039 | 0.0046 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0225 | 0.1606 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.008 | 0.0301 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.0438 | 0.1068 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.026 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1404 | 0.3541 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.008 | 0.0301 |
Schistosoma mansoni | tar DNA-binding protein | 0.0627 | 0.3926 | 0.3913 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.008 | 0.0152 |
Mycobacterium ulcerans | beta-lactamase | 0.0232 | 0.1404 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0627 | 0.3926 | 0.3913 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0041 | 0.018 | 0.1285 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0016 | 0.0021 | 0.0132 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0232 | 0.1404 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0232 | 0.1404 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0147 | 0.1044 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0125 | 0.0714 | 0.0695 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0187 | 0.7911 |
Mycobacterium ulcerans | lipase LipD | 0.0232 | 0.1404 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1577 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0039 | 0.5 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0038 | 0.0163 | 0.1145 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0048 | 0.0225 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.008 | 0.0051 |
Mycobacterium leprae | conserved hypothetical protein | 0.0232 | 0.1404 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0048 | 0.0225 | 0.0524 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.0438 | 0.1068 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0162 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1404 | 0.3541 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0039 | 0.0046 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0232 | 0.1404 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0147 | 0.1044 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0438 | 0.0418 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.011 | 0.0622 | 0.0603 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.004 | 0.002 |
Toxoplasma gondii | ABC1 family protein | 0.0232 | 0.1404 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.008 | 0.0301 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.01 | 0.071 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.004 | 0.0012 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.004 | 0.0273 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.004 | 0.0009 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.008 | 0.0051 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0232 | 0.1404 | 0.1462 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0187 | 0.0426 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.004 | 0.002 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.008 | 0.0301 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0048 | 0.0225 | 0.0205 |
Echinococcus multilocularis | tar DNA binding protein | 0.0627 | 0.3926 | 0.3913 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.004 | 0.0051 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0083 | 0.0595 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.004 | 0.002 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0143 |
Loa Loa (eye worm) | TAR-binding protein | 0.0627 | 0.3926 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0232 | 0.1404 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0187 | 0.7911 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0124 | 0.0884 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0232 | 0.1404 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0083 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0438 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.008 | 0.0152 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.008 | 0.2133 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0232 | 0.1404 | 0.1386 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.004 | 0.002 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0232 | 0.1404 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0232 | 0.1404 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0016 | 0.0021 | 0.0132 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0125 | 0.0714 | 0.0695 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.008 | 0.2133 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1404 | 0.3541 |
Brugia malayi | beta-lactamase family protein | 0.0232 | 0.1404 | 0.3541 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0048 | 0.0225 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.1042 | 0.1023 |
Mycobacterium tuberculosis | Conserved protein | 0.0232 | 0.1404 | 0.1462 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.008 | 0.0152 |
Schistosoma mansoni | tar DNA-binding protein | 0.0627 | 0.3926 | 0.3913 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0021 | 0.0147 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0257 | 0.1562 | 0.3947 |
Brugia malayi | beta-lactamase family protein | 0.0232 | 0.1404 | 0.3541 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.004 | 0.002 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0143 |
Mycobacterium ulcerans | hypothetical protein | 0.0232 | 0.1404 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0083 | 0.0595 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.008 | 0.0428 |
Brugia malayi | RNA binding protein | 0.0627 | 0.3926 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0627 | 0.3926 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0048 | 0.0225 | 0.1481 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0187 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1404 | 0.3541 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0187 | 0.0167 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0627 | 0.3926 | 0.3913 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0147 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0622 | 0.154 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0021 | 0.0147 |
Loa Loa (eye worm) | beta-lactamase | 0.0232 | 0.1404 | 0.3541 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0232 | 0.1404 | 0.1462 |
Brugia malayi | TAR-binding protein | 0.0627 | 0.3926 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.01 | 0.071 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.1485 | 0.9413 | 1 |
Onchocerca volvulus | 0.011 | 0.0622 | 0.4095 | |
Brugia malayi | beta-lactamase | 0.0232 | 0.1404 | 0.3541 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0225 | 0.1606 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0232 | 0.1404 | 0.1462 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0232 | 0.1404 | 0.3541 |
Echinococcus granulosus | tumor protein p63 | 0.0753 | 0.4732 | 0.4721 |
Mycobacterium tuberculosis | Conserved protein | 0.0232 | 0.1404 | 0.1462 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0084 | 0.0596 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0232 | 0.1404 | 0.1386 |
Mycobacterium tuberculosis | Conserved protein | 0.0232 | 0.1404 | 0.1462 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.004 | 0.0273 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.004 | 0.002 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0232 | 0.1404 | 0.1386 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.008 | 0.2133 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0257 | 0.1562 | 0.3947 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.004 | 0.002 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0038 | 0.0163 | 0.1027 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.008 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.004 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.1404 | 0.3541 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.004 | 0.0273 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0048 | 0.0225 | 0.1593 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0101 | 0.0723 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0039 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.004 | 0.0009 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0135 | 0.0778 | 0.0759 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0162 | 0.1157 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0101 | 0.0723 |
Onchocerca volvulus | 0.0232 | 0.1404 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0225 | 0.1606 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0143 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0262 | 0.1596 | 0.1578 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0048 | 0.0225 | 0.1481 |
Giardia lamblia | GTOR | 0.0048 | 0.0225 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0232 | 0.1404 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0262 | 0.1596 | 0.1578 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.004 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0084 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.008 | 0.0152 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 0.0778 | 0.0759 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.0438 | 0.0418 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0627 | 0.3926 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.004 | 0.0288 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.008 | 0.0428 |
Onchocerca volvulus | 0.0232 | 0.1404 | 1 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0117 | 0.0836 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0438 | 0.0418 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0232 | 0.1404 | 0.3541 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0176 | 0.1042 | 0.2614 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0021 | 0.0147 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.008 | 0.0152 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0038 | 0.0163 | 0.1027 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0187 | 0.0167 |
Brugia malayi | hypothetical protein | 0.0262 | 0.1596 | 0.4033 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0048 | 0.0225 | 0.0524 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0438 | 0.0418 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0048 | 0.0225 | 0.1593 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0232 | 0.1404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0039 | 0.0046 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.004 | 0.0143 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.004 | 0.0273 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0801 | 0.5041 | 0.503 |
Echinococcus granulosus | tar DNA binding protein | 0.0627 | 0.3926 | 0.3913 |
Echinococcus multilocularis | tumor protein p63 | 0.0753 | 0.4732 | 0.4721 |
Loa Loa (eye worm) | RNA binding protein | 0.0627 | 0.3926 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 72 % | Cytotoxicity against human MCF7 cells assessed as cell viability at 15 uM after 72 hrs by Celltitre-glo assay | ChEMBL. | 25455492 |
CD (binding) | = 0.4 uM | Induction of human NQO1 activity in mouse Hepa-1c1c7 cells assessed as concentration require for 2 fold induction after 48 hrs | ChEMBL. | 20392544 |
Inhibition (binding) | Inhibition of RAR-beta (unknown origin) assessed as change in DNA methylation | ChEMBL. | 25455492 | |
Inhibition (binding) | Modulation of sirtuin 2 (unknown origin) by thermal shift assay | ChEMBL. | 25455492 | |
Inhibition (binding) | = 46 % | Inhibition of HDAC in human HeLa cell extract at 100 uM after 15 mins by fluorescence assay | ChEMBL. | 25455492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.