Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | angiotensin II receptor, type 1 | References | |
Rattus norvegicus | Type-1B angiotensin II receptor | Starlite/ChEMBL | References |
Homo sapiens | angiotensin II receptor, type 2 | Starlite/ChEMBL | References |
Oryctolagus cuniculus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | No references |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.376751 | Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in Rattus norvegicus (rat) uterine membranes | ChEMBL. | No reference |
IC50 (binding) | = 42 nM | Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes | ChEMBL. | 8340920 |
IC50 (binding) | = 42 nM | Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes | ChEMBL. | 8340920 |
IC50 (binding) | = 42 nM | Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in Rattus norvegicus (rat) uterine membranes | ChEMBL. | No reference |
IC50 (functional) | = 60 nM | In vitro antagonistic activity for angiotensin II receptor, type 1 | ChEMBL. | 8355255 |
IC50 (functional) | = 60 nM | In vitro antagonistic activity for angiotensin II receptor, type 1 | ChEMBL. | 8355255 |
IC50 (binding) | = 60 nM | Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin | ChEMBL. | No reference |
Kd (functional) | = 7.1 | Antagonism of angiotensin-II mediated contraction of rabbit aortic rings expressed as pA2 (in vitro) | ChEMBL. | 8340920 |
logIC50 (binding) | = 1.778151 | Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin | ChEMBL. | No reference |
pA2 (functional) | = 7.1 | Antagonism of angiotensin-II mediated contraction of rabbit aortic rings expressed as pA2 (in vitro) | ChEMBL. | 8340920 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.