Detailed information for compound 114479

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.471 | Formula: C23H29FO6
  • H donors: 3 H acceptors: 4 LogP: 2.85 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CCC[C@@H]([C@@H](/C=C/C=C/C=C/C=C/[C@@H](COc1ccc(cc1)F)O)O)O
  • InChi: 1S/C23H29FO6/c1-29-23(28)12-8-11-22(27)21(26)10-7-5-3-2-4-6-9-19(25)17-30-20-15-13-18(24)14-16-20/h2-7,9-10,13-16,19,21-22,25-27H,8,11-12,17H2,1H3/b4-2+,5-3+,9-6+,10-7+/t19-,21+,22-/m0/s1
  • InChiKey: OHQYQMHVQDTELC-HMMPWQRTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine oxidase 0.0119 0.0088 0.0088
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0045 0.011
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0053 0.0019 0.0019
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0018 0.0096
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0013 0.0012
Brugia malayi NAD-dependent deacetylase SIRT1 0.0108 0.0076 0.0074
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0108 0.0076 0.009
Plasmodium falciparum plasmepsin V 0.0431 0.0411 0.2842
Echinococcus granulosus dihydrofolate reductase 0.297 0.3042 0.3039
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0119 0.0088 0.0086
Loa Loa (eye worm) transcriptional regulator 0.0731 0.0722 0.0722
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.007 0.0037 0.0054
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.297 0.3042 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Toxoplasma gondii kringle domain-containing protein 0.005 0.0016 0.0086
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Schistosoma mansoni integrin beta subunit 0.1699 0.1725 0.1725
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0076 0.0076
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0021 0.0021
Onchocerca volvulus 0.0095 0.0063 0.0973
Echinococcus multilocularis carbonic anhydrase 0.0119 0.0088 0.0105
Brugia malayi Furin-like cysteine rich region family protein 0.0585 0.057 0.0568
Loa Loa (eye worm) sirtuin 4 0.0108 0.0076 0.0076
Toxoplasma gondii subtilisin SUB7 0.0426 0.0406 0.2806
Toxoplasma gondii histone deacetylase SIR2-like 0.0108 0.0076 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Onchocerca volvulus Putative cubilin 0.0045 0.0011 0.0138
Echinococcus granulosus serine:threonine protein kinase N2 0.0079 0.0046 0.0042
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0055 0.0021 0.0021
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0045 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2356 0.2407 0.3941
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0083 0.005 0.0127
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Brugia malayi celfurPC protein 0.7753 0.8 0.7999
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0018 0.0023
Echinococcus granulosus integrin alpha ps 0.0066 0.0033 0.0029
Brugia malayi EGF-like domain containing protein 0.007 0.0037 0.0034
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0117 0.0115
Echinococcus granulosus furin 0.9683 1 1
Toxoplasma gondii subtilisin SUB9 0.0426 0.0406 0.2806
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0673 0.0662 0.0662
Giardia lamblia Tenascin precursor 0.007 0.0037 0.0058
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.005 0.0127
Plasmodium falciparum subtilisin-like protease 3 0.0426 0.0406 0.2806
Echinococcus multilocularis protein kinase c epsilon type 0.0097 0.0065 0.0076
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0196 0.0168 0.0168
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0062 0.0029 0.004
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.022 0.0193 0.0193
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0147 0.0117 0.0117
Plasmodium falciparum subtilisin-like protease 2 0.0426 0.0406 0.2806
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0044 0.0009 0.0009
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0078 0.0045 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0067 0.0034 0.0057
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0052 0.0018 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2356 0.2407 0.3941
Leishmania major UDP-galactopyranose mutase 0.0119 0.0088 0.0503
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Echinococcus granulosus protein arginine N methyltransferase 7 0.0053 0.0019 0.0015
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0094 0.0062 0.0403
Schistosoma mansoni dock 0.0052 0.0018 0.0018
Echinococcus granulosus Tolloid protein 1 0.0044 0.0009 0.0005
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0426 0.0406 0.1288
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0046 0.0012 0.0012
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.297 0.3042 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0731 0.0722 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.0088 0.0086
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0119 0.0088 0.0235
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0011 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0053 0.0019 0.0019
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0196 0.0168 0.0499
Schistosoma mansoni hypothetical protein 0.0055 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.3762 0.3864 0.3864
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Toxoplasma gondii rhoptry neck protein RON9 0.0038 0.0004 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0011 0.0007
Mycobacterium ulcerans monoamine oxidase 0.0119 0.0088 0.0235
Brugia malayi Kringle domain containing protein 0.005 0.0016 0.0014
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0457 0.0438 0.2952
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.0722 0.0722
Loa Loa (eye worm) hypothetical protein 0.0044 0.0009 0.0009
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0118 0.0087 0.0246
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0426 0.0406 0.0406
Echinococcus granulosus c4b binding protein beta chain 0.0038 0.0004 0.0000082614
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Echinococcus multilocularis nmda type glutamate receptor 0.0112 0.008 0.0095
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0018 0.0023
Schistosoma mansoni hypothetical protein 0.0146 0.0116 0.0116
Onchocerca volvulus 0.0038 0.0004 0.0027
Onchocerca volvulus 0.0146 0.0116 0.1823
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.0406 0.066
Echinococcus granulosus carbonic anhydrase 0.0119 0.0088 0.0084
Trypanosoma brucei subtilisin peptidase 0.0426 0.0406 0.2729
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0052 0.0018 0.0023
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0078 0.0045 0.0111
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Trypanosoma cruzi subtilisin peptidase 0.0426 0.0406 0.2744
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0684 0.0673 0.0837
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Plasmodium falciparum protoporphyrinogen oxidase 0.0119 0.0088 0.0585
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0126 0.0095 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.008 0.0078
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0076 0.0076
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.02 0.02
Toxoplasma gondii subtilisin SUB4 0.0426 0.0406 0.2806
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0731 0.0722 0.4956
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.297 0.3042 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0731 0.0722 0.0718
Echinococcus multilocularis 0.0119 0.0088 0.0105
Giardia lamblia Hypothetical protein 0.0731 0.0722 0.1939
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.0722 0.0722
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0108 0.0076 0.042
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.0088 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5921 0.6101 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0108 0.0076 0.0401
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0426 0.0406 0.0404
Echinococcus multilocularis MAM 0.0095 0.0063 0.0074
Loa Loa (eye worm) Carm1-pending protein 0.0053 0.0019 0.0019
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0053 0.0019 0.0049
Toxoplasma gondii rhoptry neck protein RON1 0.0038 0.0004 0.0001
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0083 0.005 0.0111
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0108 0.0076 0.0072
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0053 0.0019 0.002
Echinococcus multilocularis integrin alpha 3 0.0113 0.0082 0.0097
Leishmania major subtilisin-like serine peptidase 0.0426 0.0406 0.2744
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.193 0.1965 0.3216
Toxoplasma gondii subtilisin SUB6 0.0426 0.0406 0.2806
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1421 0.1437 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0426 0.0406 0.1301
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.007 0.0037 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5921 0.6101 1
Plasmodium vivax subtilisin-like serine protease, putative 0.0426 0.0406 0.2806
Onchocerca volvulus 0.0038 0.0004 0.0027
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0053 0.0019 0.0106
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0052 0.0018 0.0017
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0053 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0053 0.0019 0.0106
Giardia lamblia Neurogenic locus Notch protein precursor 0.007 0.0037 0.0058
Loa Loa (eye worm) hypothetical protein 0.0119 0.0088 0.0088
Echinococcus multilocularis 0.7753 0.8 1
Leishmania major silent information regulator 2, putative 0.0731 0.0722 0.4966
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0078 0.0045 0.0094
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0078 0.0045 0.011
Plasmodium vivax cysteine repeat modular protein 1, putative 0.005 0.0016 0.0086
Echinococcus granulosus protein kinase c epsilon type 0.0097 0.0065 0.0061
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0094 0.0062 0.0062
Schistosoma mansoni c4b-binding protein beta chain 0.0038 0.0004 0.0004
Loa Loa (eye worm) WD40 repeat protein 0.0146 0.0116 0.0116
Echinococcus granulosus integrin alpha 3 0.0113 0.0082 0.0078
Loa Loa (eye worm) integrin beta-2 0.2902 0.2972 0.2972
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0008 0.0006
Plasmodium falciparum apical sushi protein 0.0038 0.0004 0.0001
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0053 0.0019 0.002
Brugia malayi amine oxidase, flavin-containing family protein 0.0169 0.0139 0.0137
Brugia malayi neuroendocrine convertase 1 precursor 0.6119 0.6306 0.6305
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0018 0.0096
Trypanosoma cruzi UDP-galactopyranose mutase 0.0119 0.0088 0.0503
Onchocerca volvulus 0.0141 0.011 0.1733
Chlamydia trachomatis protoporphyrinogen oxidase 0.0119 0.0088 0.0135
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0229 0.0202 0.0248
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0021 0.0021
Toxoplasma gondii subtilisin SUB10 0.0426 0.0406 0.2806
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0004 0.0002
Giardia lamblia Tenascin-like 0.007 0.0037 0.0058
Mycobacterium ulcerans thymidylate synthase 0.0196 0.0168 0.0499
Schistosoma mansoni hypothetical protein 0.0052 0.0018 0.0018
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0147 0.0117 0.0706
Onchocerca volvulus 0.0095 0.0063 0.0973
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0426 0.0406 0.1288
Brugia malayi hypothetical protein 0.0095 0.0063 0.006
Mycobacterium ulcerans polyketide synthase Pks13 0.0118 0.0087 0.0231
Schistosoma mansoni protein kinase 0.0126 0.0095 0.0095
Toxoplasma gondii subtilisin SUB11 0.0426 0.0406 0.2806
Schistosoma mansoni hypothetical protein 0.0119 0.0088 0.0088
Schistosoma mansoni dihydrofolate reductase 0.297 0.3042 0.3042
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0062 0.0029 0.004
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0016 0.0019
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0108 0.0076 0.0503
Trichomonas vaginalis hypothetical protein 0.193 0.1965 0.3216
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0046 0.0012 0.0008
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0018 0.0096
Loa Loa (eye worm) hypothetical protein 0.9683 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0094 0.0062 0.0095
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0004 0.0004
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.005 0.0111
Toxoplasma gondii aspartyl protease ASP5 0.0393 0.0372 0.2564
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.0722 0.0722
Echinococcus multilocularis integrin alpha ps 0.0066 0.0033 0.0036
Brugia malayi Protein kinase domain containing protein 0.0095 0.0063 0.006
Echinococcus granulosus membrane bound transcription factor site 1 0.0426 0.0406 0.0402
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2356 0.2407 0.3941
Brugia malayi hypothetical protein 0.0445 0.0425 0.0423
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0108 0.0076 0.0854
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0426 0.0406 0.1288
Schistosoma mansoni hypothetical protein 0.0055 0.0021 0.0021
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0119 0.0088 0.0585
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Echinococcus multilocularis protein will die slowly 0.0146 0.0116 0.014
Echinococcus granulosus integrin beta 2 0.2144 0.2186 0.2183
Echinococcus multilocularis protoporphyrinogen oxidase 0.0119 0.0088 0.0105
Echinococcus multilocularis thymidylate synthase 0.0196 0.0168 0.0205
Schistosoma mansoni SWI/SNF complex-related 0.005 0.0016 0.0016
Echinococcus multilocularis chromatin regulatory protein sir2 0.0731 0.0722 0.0898
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0426 0.0406 0.0404
Loa Loa (eye worm) hypothetical protein 0.007 0.0037 0.0037
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0684 0.0673 0.0669
Giardia lamblia High cysteine membrane protein Group 2 0.3564 0.3658 1
Echinococcus multilocularis neuroendocrine convertase 2 0.6119 0.6306 0.7882
Onchocerca volvulus 0.0038 0.0004 0.0027
Echinococcus granulosus lysine specific histone demethylase 1A 0.0587 0.0573 0.0569
Loa Loa (eye worm) hypothetical protein 0.0426 0.0406 0.0406
Schistosoma mansoni carbonic anhydrase 0.0119 0.0088 0.0088
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0196 0.0168 0.0514
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0004 0.0004
Echinococcus multilocularis adam 0.013 0.0099 0.0119
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1421 0.1437 1
Echinococcus multilocularis integrin beta 2 0.2144 0.2186 0.2729
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0731 0.0722 0.0898
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Toxoplasma gondii bicoid-interacting protein BIN3 0.0053 0.0019 0.0106
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0426 0.0406 0.1288
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0137 0.0106 0.0106
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0426 0.0406 0.1301
Giardia lamblia Tenascin-37 0.007 0.0037 0.0058
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0076 0.0076
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0108 0.0076 0.0072
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0108 0.0076 0.0401
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0119 0.0088 0.0585
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0013 0.0012
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.011 0.0079 0.0076
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0475 0.0457 0.0457
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0018 0.0096
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0426 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0119 0.0088 0.0088
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.193 0.1965 0.3216
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0053 0.0019 0.002
Schistosoma mansoni furin-1 (S08 family) 0.4189 0.4306 0.4306
Loa Loa (eye worm) hypothetical protein 0.007 0.0037 0.0037
Schistosoma mansoni integrin alpha-ps 0.0066 0.0033 0.0033
Schistosoma mansoni amine oxidase 0.0119 0.0088 0.0088
Echinococcus multilocularis dihydrofolate reductase 0.297 0.3042 0.38
Plasmodium vivax plasmepsin V, putative 0.0431 0.0411 0.2842
Entamoeba histolytica hypothetical protein 0.0147 0.0117 0.1431
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5921 0.6101 0.7625
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0076 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.0406 0.066
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.015 0.012 0.0118
Brugia malayi Sushi domain 0.0038 0.0004 0.0002
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0018 0.0096
Echinococcus multilocularis carbonic anhydrase 0.0119 0.0088 0.0105
Mycobacterium leprae Probable polyketide synthase Pks1 0.0083 0.005 0.0111
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0004 0.0004
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Toxoplasma gondii type I fatty acid synthase, putative 0.0083 0.005 0.0323
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.9683 1 1
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Onchocerca volvulus 0.0038 0.0004 0.0026
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0076 0.0076
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.008 0.0047 0.5
Echinococcus multilocularis integrin alpha ps 0.0066 0.0033 0.0036
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0731 0.0722 1
Loa Loa (eye worm) reprolysin 0.0046 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0119 0.0088 0.0088
Schistosoma mansoni protein kinase 0.0126 0.0095 0.0095
Echinococcus multilocularis protein arginine methyltransferase 0.0094 0.0062 0.0072
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1421 0.1437 1
Echinococcus granulosus methyltransferase protein 5 0.0053 0.0019 0.0015
Brugia malayi SWIRM domain containing protein 0.005 0.0016 0.0013
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.005 0.0016 0.0012
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0097 0.0065 0.0065
Brugia malayi pregnancy-associated plasma protein-A 0.0038 0.0004 0.0002
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0095 0.0063 0.0063
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0018 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Giardia lamblia Sirtuin type 2 0.0108 0.0076 0.0166
Loa Loa (eye worm) hypothetical protein 0.0082 0.0049 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2356 0.2407 0.3941
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.006 0.0026 0.0026
Brugia malayi hypothetical protein 0.006 0.0026 0.0024
Loa Loa (eye worm) thymidylate synthase 0.0196 0.0168 0.0168
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0011 0.0008
Toxoplasma gondii subtilisin SUB2 0.0426 0.0406 0.2806
Brugia malayi SWIRM domain containing protein 0.0637 0.0624 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.0406 0.066
Loa Loa (eye worm) hypothetical protein 0.0637 0.0624 0.0624
Echinococcus granulosus MAM 0.0095 0.0063 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0119 0.0088 0.0585
Loa Loa (eye worm) hypothetical protein 0.0119 0.0088 0.0088
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0108 0.0076 0.009
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0004 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Schistosoma mansoni hypothetical protein 0.0095 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0095 0.0063 0.0063
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0119 0.0088 0.0585
Onchocerca volvulus 0.0052 0.0018 0.0248
Schistosoma mansoni integrin alpha 0.0148 0.0117 0.0117
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0019 0.0025
Schistosoma mansoni hypothetical protein 0.005 0.0016 0.0016
Brugia malayi Putative carbonic anhydrase 5 precursor 0.022 0.0193 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0019 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2356 0.2407 0.3941
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0108 0.0076 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Schistosoma mansoni carbonic anhydrase-related 0.0119 0.0088 0.0088
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0108 0.0076 0.0212
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0119 0.0088 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Loa Loa (eye worm) hypothetical protein 0.0095 0.0063 0.0063
Mycobacterium leprae Polyketide synthase Pks13 0.0118 0.0087 0.0231
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Loa Loa (eye worm) carbonic anhydrase 3 0.022 0.0193 0.0193
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0445 0.0425 0.0425
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0018 0.0014
Brugia malayi Carm1-pending protein 0.0053 0.0019 0.0017
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.022 0.0193 0.0193
Trichomonas vaginalis hypothetical protein 0.007 0.0037 0.0054
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Echinococcus granulosus adam 0.013 0.0099 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0016 0.0019
Loa Loa (eye worm) dihydrofolate reductase 0.297 0.3042 0.3042
Onchocerca volvulus 0.007 0.0037 0.0555
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Onchocerca volvulus 0.0038 0.0004 0.0027
Brugia malayi hypothetical protein 0.0119 0.0088 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Brugia malayi hypothetical protein 0.0147 0.0117 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0065 0.0065
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0119 0.0088 0.0235
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0053 0.0019 0.002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0045 0.0094
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0019 0.0102
Mycobacterium tuberculosis Hypothetical protein 0.0093 0.0061 0.0162
Toxoplasma gondii subtilisin SUB8 0.0426 0.0406 0.2806
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Mycobacterium ulcerans Sir2-like regulatory protein 0.0108 0.0076 0.0196
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.005 0.0016 0.0016
Brugia malayi proprotein convertase 2 0.6119 0.6306 0.6305
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0045 0.011
Toxoplasma gondii SWIRM domain-containing protein 0.005 0.0016 0.0082
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0426 0.0406 0.2744
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0076 0.0043 0.0043
Toxoplasma gondii hypothetical protein 0.0119 0.0088 0.0585
Loa Loa (eye worm) hypothetical protein 0.0042 0.0008 0.0008
Brugia malayi transcriptional regulator, Sir2 family protein 0.0731 0.0722 0.072
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0108 0.0076 0.042
Echinococcus granulosus thymidylate synthase 0.0196 0.0168 0.0164
Mycobacterium ulcerans dehydrogenase 0.0119 0.0088 0.0235
Echinococcus granulosus protein arginine N methyltransferase 8 0.0094 0.0062 0.0058
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Echinococcus granulosus fibrillin 2 0.007 0.0037 0.0033
Toxoplasma gondii PA14 domain-containing protein 0.0052 0.0018 0.0096
Toxoplasma gondii subtilisin SUB12 0.0426 0.0406 0.2806
Loa Loa (eye worm) hypothetical protein 0.0116 0.0084 0.0084
Brugia malayi EGF-like domain containing protein 0.007 0.0037 0.0034
Giardia lamblia Furin precursor putative serine protease 0.193 0.1965 0.535
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Toxoplasma gondii histone lysine-specific demethylase 0.0119 0.0088 0.0585
Loa Loa (eye worm) subtilase 0.0426 0.0406 0.0406
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1358 0.1372 0.1372
Brugia malayi EGF-like domain containing protein 0.007 0.0037 0.0034
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0018 0.0014
Onchocerca volvulus 0.0076 0.0043 0.0646
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Echinococcus granulosus carbonic anhydrase 0.0119 0.0088 0.0084
Schistosoma mansoni growth factor receptor-bound protein 0.0137 0.0106 0.0106
Brugia malayi Dihydrofolate reductase 0.297 0.3042 0.304
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0126 0.0095 0.0114
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0021 0.0021
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0426 0.0406 0.1288
Onchocerca volvulus 0.0038 0.0004 0.0026
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0731 0.0722 0.4966
Giardia lamblia Tenascin-X 0.007 0.0037 0.0058
Echinococcus granulosus glutamate NMDA receptor subunit 0.0264 0.0238 0.0234
Plasmodium falciparum subtilisin-like protease 1 0.0426 0.0406 0.2806
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.022 0.0193 0.0193
Echinococcus multilocularis growth factor receptor bound protein 2 0.0137 0.0106 0.0127
Toxoplasma gondii histone deacetylase SIR2 0.0108 0.0076 0.0503
Mycobacterium ulcerans polyketide synthase 0.0078 0.0045 0.0094
Mycobacterium tuberculosis Probable thioesterase TesA 0.0067 0.0034 0.0073
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0094 0.0062 0.0072
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0078 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0133 0.0102 0.0102
Entamoeba histolytica hypothetical protein, conserved 0.0108 0.0076 0.0854
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0076 0.0043 0.0101
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0083 0.005 0.0111
Trypanosoma cruzi UDP-galactopyranose mutase 0.0119 0.0088 0.0503
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Echinococcus granulosus discoidin domain receptor 0.0052 0.0018 0.0014
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0108 0.0076 0.0072
Schistosoma mansoni carbonic anhydrase-related 0.0119 0.0088 0.0088
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0053 0.0019 0.0019
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0052 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0134 0.0103 0.0103
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.193 0.1965 0.3216
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.011 0.0079 0.0079
Giardia lamblia hypothetical protein 0.007 0.0037 0.0058
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0094 0.0062 0.0403
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0094 0.0062 0.0062
Mycobacterium tuberculosis Possible oxidoreductase 0.0119 0.0088 0.0251
Trichomonas vaginalis WD repeat domain, putative 0.0146 0.0116 0.0183
Echinococcus multilocularis carbonic anhydrase 0.0119 0.0088 0.0105
Schistosoma mansoni septate junction protein 0.0066 0.0033 0.0033
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0731 0.0722 0.4966
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0119 0.0088 0.0235
Plasmodium vivax subtilisin-like protease 1 0.0426 0.0406 0.2806
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0147 0.0117 0.0706
Schistosoma mansoni tyrosine kinase 0.0585 0.057 0.057
Echinococcus multilocularis Furin 1 0.2356 0.2407 0.3005
Brugia malayi Protein kinase domain containing protein 0.0052 0.0018 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Plasmodium vivax apical sushi protein, putative 0.0038 0.0004 0.0001
Echinococcus granulosus chromatin regulatory protein sir2 0.0731 0.0722 0.0718
Schistosoma mansoni site-1 peptidase (S08 family) 0.0426 0.0406 0.0406
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0094 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.193 0.1965 0.1965
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2356 0.2407 0.3941
Mycobacterium ulcerans thioesterase TesA 0.0067 0.0034 0.0057
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.0088 0.0086
Onchocerca volvulus 0.0038 0.0004 0.0027
Plasmodium falciparum cysteine repeat modular protein 1 0.005 0.0016 0.0086
Echinococcus multilocularis membrane bound transcription factor site 1 0.0426 0.0406 0.0503
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0119 0.0088 0.0585
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0018 0.0014
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0078 0.0045 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0046 0.0012 0.0012
Brugia malayi Integrin beta pat-3 precursor 0.2902 0.2972 0.297
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Echinococcus granulosus epidermal growth factor receptor 0.0585 0.057 0.0566
Trypanosoma brucei carbonic anhydrase-like protein 0.022 0.0193 0.1223
Entamoeba histolytica PH domain containing protein kinase, putative 0.0079 0.0046 0.0435
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0083 0.005 0.0127
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0044 0.0009 0.0009
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.008 0.0047 0.0117
Echinococcus multilocularis epidermal growth factor receptor 0.0585 0.057 0.0708
Echinococcus multilocularis Tolloid protein 1 0.0044 0.0009 0.0007
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0094 0.0062 0.0095
Loa Loa (eye worm) hypothetical protein 0.0108 0.0076 0.0076
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Leishmania major arginine N-methyltransferase-like protein 0.0094 0.0062 0.032
Echinococcus granulosus nmda type glutamate receptor 0.0112 0.008 0.0076
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0094 0.0062 0.0095
Echinococcus granulosus lysine specific histone demethylase 1A 0.0119 0.0088 0.0084
Echinococcus granulosus tissue type plasminogen activator 0.005 0.0016 0.0012
Onchocerca volvulus 0.0038 0.0004 0.0027
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.022 0.0193 0.019
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.008 0.0047 0.0101
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0076 0.0854
Schistosoma mansoni growth factor receptor-bound protein 0.0137 0.0106 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.0202 0.0202
Leishmania major sir2-family protein-like protein 0.0108 0.0076 0.042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0018 0.0096
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0119 0.0088 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0061 0.0093
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Loa Loa (eye worm) hypothetical protein 0.005 0.0016 0.0016
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.008 0.0047 0.5
Echinococcus granulosus Furin 1 0.2356 0.2407 0.2404
Mycobacterium leprae Possible secreted protease 0.0426 0.0406 0.1288
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0426 0.0406 0.1301
Mycobacterium ulcerans thioesterase 0.0067 0.0034 0.0057
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0003 0.0003
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0426 0.0406 0.0402
Schistosoma mansoni carbonic anhydrase-related 0.0119 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0053 0.0019 0.0019
Onchocerca volvulus 0.0052 0.0018 0.0248
Onchocerca volvulus 0.0038 0.0004 0.0027
Brugia malayi Angiotensin-converting enzyme family protein 0.0673 0.0662 0.0659
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0108 0.0076 0.042
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Mycobacterium ulcerans oxidoreductase 0.0119 0.0088 0.0235
Echinococcus granulosus C type lectin domian containing protein 0.0038 0.0004 0.0000082614
Echinococcus granulosus fibrillin 1 0.0072 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0112 0.008 0.008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0008 0.0006
Brugia malayi Stress-activated protein kinase jnk-1 0.0229 0.0202 0.02
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.0007 0.0018
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0457 0.0438 0.2967
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0119 0.0088 0.0088
Schistosoma mansoni protein arginine n-methyltransferase 0.0053 0.0019 0.0019
Echinococcus multilocularis tissue type plasminogen activator 0.005 0.0016 0.0015
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0063 0.003 0.0059
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0108 0.0076 0.0503
Schistosoma mansoni protein kinase 0.0126 0.0095 0.0095
Onchocerca volvulus 0.0038 0.0004 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0058 0.0024 0.0041
Echinococcus granulosus protein will die slowly 0.0146 0.0116 0.0112
Echinococcus multilocularis carbonic anhydrase II 0.022 0.0193 0.0236
Onchocerca volvulus 0.005 0.0016 0.0225
Toxoplasma gondii subtilisin SUB5 0.0426 0.0406 0.2806
Loa Loa (eye worm) hypothetical protein 0.0119 0.0088 0.0088
Leishmania major arginine N-methyltransferase, type I 0.0053 0.0019 0.002
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0457 0.0438 0.2967
Brugia malayi hypothetical protein 0.0093 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0045 0.0011 0.0011
Schistosoma mansoni discoidin domain receptor 0.0052 0.0018 0.0018
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.005 0.0016 0.0015
Onchocerca volvulus 0.0196 0.0168 0.2657
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.005 0.0016 0.0016
Onchocerca volvulus 0.0426 0.0406 0.6497
Loa Loa (eye worm) hypothetical protein 0.0169 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0018 0.0017
Toxoplasma gondii subtilisin SUB1 0.0426 0.0406 0.2806
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.0406 0.066
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0229 0.0202 0.0202
Echinococcus granulosus protein arginine methyltransferase 0.0094 0.0062 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0076 0.0503
Brugia malayi protein kinase C II. 0.0097 0.0065 0.0062
Echinococcus multilocularis protein jagged 2 0.007 0.0037 0.0041
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0053 0.0019 0.002
Brugia malayi dihydrofolate reductase family protein 0.297 0.3042 0.304
Mycobacterium ulcerans polyketide synthase 0.0083 0.005 0.0111
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0264 0.0238 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0016 0.0016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0095 0.0063 0.0063
Onchocerca volvulus 0.0038 0.0004 0.0027
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0094 0.0062 0.0403
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0426 0.0406 0.066
Loa Loa (eye worm) TK/EGFR protein kinase 0.0585 0.057 0.057
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.022 0.0193 0.124
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0021 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0043 0.004
Onchocerca volvulus 0.0038 0.0004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0587 0.0573 0.0573
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0013 0.0012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0004 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Brugia malayi Sex muscle abnormal protein 5 0.0137 0.0106 0.0103
Brugia malayi thymidylate synthase 0.0196 0.0168 0.0165
Brugia malayi Will die slowly protein 0.0146 0.0116 0.0113
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0045 0.0094
Schistosoma mansoni glutamate receptor NMDA 0.0264 0.0238 0.0238
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Loa Loa (eye worm) DEAH box polypeptide 35 0.0067 0.0034 0.0034
Plasmodium vivax NAD-dependent deacetylase, putative 0.0108 0.0076 0.0503
Chlamydia trachomatis dihydrofolate reductase 0.297 0.3042 1
Plasmodium vivax subtilisin-like protease 2, putative 0.0426 0.0406 0.2806
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0731 0.0722 0.1178
Echinococcus multilocularis fibrillin 2 0.007 0.0037 0.0041
Echinococcus granulosus growth factor receptor bound protein 2 0.0137 0.0106 0.0102
Giardia lamblia High cysteine protein 0.007 0.0037 0.0058
Onchocerca volvulus Fatty acid synthase homolog 0.0146 0.0115 0.1817
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0062 0.0029 0.004
Brugia malayi Probable ATP-dependent helicase DHX35 0.0067 0.0034 0.0032
Brugia malayi Protein kinase domain containing protein 0.005 0.0016 0.0014
Echinococcus multilocularis fibrillin 1 0.0085 0.0053 0.0061
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0053 0.0019 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Echinococcus multilocularis discoidin domain receptor 0.0052 0.0018 0.0017
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0055 0.0021 0.0021
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0018 0.0017
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1421 0.1437 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0426 0.0406 0.1301
Brugia malayi GCC2 and GCC3 family protein 0.0053 0.0019 0.0017
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0078 0.0045 0.0045
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0038 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Brugia malayi Kelch motif family protein 0.0475 0.0457 0.0454
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0011 0.0011
Schistosoma mansoni site-1 peptidase (S08 family) 0.0426 0.0406 0.0406
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0118 0.0087 0.0246
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0024 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0004 0.0004
Echinococcus granulosus c-Jun N-terminal kinases 0.0229 0.0202 0.0198
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0013 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0426 0.0406 0.066
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0013 0.0012
Echinococcus granulosus glutamate receptor 2 0.0047 0.0013 0.0009
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0004 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.0088 0.0251
Brugia malayi Subtilase family protein 0.0426 0.0406 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.005 0.0111
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0147 0.0117 0.0688
Loa Loa (eye worm) hypothetical protein 0.0587 0.0573 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Schistosoma mansoni discoidin domain receptor 0.0052 0.0018 0.0018
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0108 0.0076 0.0166
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0052 0.0018 0.0017
Mycobacterium ulcerans NAD-dependent deacetylase 0.0108 0.0076 0.0196
Brugia malayi Pepsin A precursor 0.0038 0.0004 0.0002
Echinococcus granulosus neuroendocrine convertase 2 0.6119 0.6306 0.6304
Brugia malayi hypothetical protein 0.0038 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0046 0.0012 0.0012
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0247 0.022 0.022
Leishmania major carbonic anhydrase-like protein 0.022 0.0193 0.124
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0731 0.0722 0.1178
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0021 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0119 0.0088 0.0585
Giardia lamblia Neurogenic locus notch-like protein 0.007 0.0037 0.0058
Echinococcus multilocularis serine:threonine protein kinase N2 0.0089 0.0056 0.0065
Toxoplasma gondii hypothetical protein 0.007 0.0037 0.0229
Giardia lamblia Transcriptional regulator, Sir2 family 0.0108 0.0076 0.0166
Loa Loa (eye worm) hypothetical protein 0.007 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0587 0.0573 0.0573
Echinococcus granulosus carbonic anhydrase II 0.022 0.0193 0.0189
Loa Loa (eye worm) TK/ALK protein kinase 0.0095 0.0063 0.0063
Giardia lamblia High cysteine protein 0.007 0.0037 0.0058
Loa Loa (eye worm) fatty acid synthase 0.008 0.0047 0.0047
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0076 0.0118
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5921 0.6101 0.6099
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1421 0.1437 1
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0013 0.0012
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0019 0.0025
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0426 0.0406 0.0503
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0021 0.0021
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1421 0.1437 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.022 0.0193 0.124
Loa Loa (eye worm) endoprotease bli-4 0.9683 1 1
Loa Loa (eye worm) proprotein convertase 2 0.2356 0.2407 0.2407
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0046 0.0012 0.001
Echinococcus granulosus carbonic anhydrase 0.0119 0.0088 0.0084
Plasmodium falciparum carbonic anhydrase 0.0119 0.0088 0.0585
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0147 0.0117 0.1431
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0119 0.0088 0.0088
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2356 0.2407 0.2407
Trichomonas vaginalis conserved hypothetical protein 0.193 0.1965 0.3216
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0119 0.0088 0.0585
Onchocerca volvulus 0.0637 0.0624 1
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0013 0.0013
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0093 0.0061 0.0314
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0112 0.008 0.0095
Onchocerca volvulus 0.015 0.012 0.1891
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0076 0.0074
Trichomonas vaginalis hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0067 0.0034 0.0034
Schistosoma mansoni btb and poz domain-containing protein 0.0052 0.0018 0.0018
Brugia malayi EGF-like domain containing protein 0.007 0.0037 0.0034
Brugia malayi Protein arginine N-methyltransferase 0.0053 0.0019 0.0017
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0052 0.0018 0.0014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0045 0.0094
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0587 0.0573 0.0711

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 1 ug hr ml-1 Area under curve of the compound was determined after intravenous administration at 3 mg/kg ChEMBL. 15056011
Cl (ADMET) = 51 ml mg-1 kg-1 Compound clearance in rats was measured after intravenous administration at 3 mg/kg ChEMBL. 15056011
Cmax (ADMET) = 0.2 Cmax of the compound was measured in rats after peroral administration at 3 mg/kg ChEMBL. 15056011
F (ADMET) = 12 % Oral bioavailability in rat ChEMBL. 15056011
T max (ADMET) = 0.5 hr Tmax of the compound was measured in rats after peroral administration at 5 mg/kg ChEMBL. 15056011
T1/2 (ADMET) = 0.3 hr Half life period of compound was determined at a dose of 3 mg/kg by intravenous administration ChEMBL. 15056011
T1/2 (ADMET) = 0.5 hr Half life period of compound was determined after peroral administration ChEMBL. 15056011

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.