Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.212 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0762 | 0.2286 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.212 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0762 | 0.2286 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.212 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0991 | 0.3584 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0991 | 0.3584 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0762 | 0.2286 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0762 | 0.2286 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0991 | 0.3584 | 0.3584 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.212 | 1 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.212 | 1 | 1 |
Onchocerca volvulus | 0.212 | 1 | 1 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.212 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0991 | 0.3584 | 0.3584 |
Loa Loa (eye worm) | norepinephrine transporter | 0.212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.212 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0762 | 0.2286 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.212 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0991 | 0.3584 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0991 | 0.3584 | 0.3584 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0991 | 0.3584 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0991 | 0.3584 | 0.3584 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.212 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0762 | 0.2286 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0991 | 0.3584 | 0.3584 |
Brugia malayi | Dihydrofolate reductase | 0.0991 | 0.3584 | 0.3584 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 ug ml-1 | Cytotoxicity against A/WSN/33 strain (an H1N1 subtype) influenza virus in the plaque reduction assay | ChEMBL. | 10465540 |
EC50 (functional) | = 8 ug ml-1 | Inhibitory activity against A/WSN/33 strain (an H1N1 subtype) influenza virus was measured by cell protection assay in MDBK cells | ChEMBL. | 10465540 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.