Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0226 | 0.0248 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0152 | 0.3 | 0.3 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0.0596 | 0.2198 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0084 | 0.1587 | 0.585 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0013 | 0.0106 | 0.039 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0078 | 0.1453 | 0.1598 |
Mycobacterium leprae | putative cytochrome p450 | 0.0084 | 0.1587 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0226 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0226 | 0.0248 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0013 | 0.0106 | 0.039 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0013 | 0.0106 | 0.0729 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0084 | 0.1587 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0084 | 0.1587 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0084 | 0.1587 | 0.585 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0084 | 0.1587 | 0.585 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0078 | 0.1453 | 0.1598 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0013 | 0.0106 | 0.0116 |
Loa Loa (eye worm) | cytochrome P450 | 0.0084 | 0.1587 | 0.1587 |
Loa Loa (eye worm) | inositol-1 | 0.0073 | 0.1362 | 0.1362 |
Leishmania major | cytochrome p450-like protein | 0.0139 | 0.2712 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0084 | 0.1587 | 0.585 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0084 | 0.1587 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0106 | 0.0729 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0084 | 0.1587 | 0.585 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0084 | 0.1587 | 0.585 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0226 | 0.0226 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0084 | 0.1587 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0002 | 0.0002 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0013 | 0.0106 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.3265 | 0.3265 |
Onchocerca volvulus | 0.0049 | 0.0853 | 1 | |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0073 | 0.1362 | 0.5022 |
Brugia malayi | hypoxia-induced factor 1 | 0.0152 | 0.3 | 0.3 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0084 | 0.1587 | 0.585 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0853 | 0.0938 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0226 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0139 | 0.2712 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0078 | 0.1453 | 0.1598 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0084 | 0.1587 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.1587 | 0.1745 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0239 | 0.4803 | 0.5283 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0078 | 0.1453 | 1 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0084 | 0.1587 | 0.585 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0446 | 0.9092 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0226 | 0.0832 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0084 | 0.1587 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0066 | 0.1203 | 0.7579 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0084 | 0.1587 | 0.585 |
Brugia malayi | Cytochrome P450 family protein | 0.0282 | 0.5677 | 0.5677 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0226 | 0.0226 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0084 | 0.1587 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0084 | 0.1587 | 0.585 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0084 | 0.1587 | 1 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0084 | 0.1587 | 0.585 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0226 | 0.0832 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0139 | 0.2712 | 0.2712 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0527 | 0.058 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0013 | 0.0106 | 0.039 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0084 | 0.1587 | 0.585 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0073 | 0.1362 | 0.9374 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0226 | 0.1553 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0013 | 0.0106 | 0.039 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0084 | 0.1587 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0226 | 0.0248 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.049 | 0.049 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0073 | 0.1362 | 0.9374 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0084 | 0.1587 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0139 | 0.2712 | 0.2712 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0084 | 0.1587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0966 | 0.0966 |
Trypanosoma brucei | cytochrome P450, putative | 0.0139 | 0.2712 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.1071 | 0.6751 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0013 | 0.0106 | 0.0729 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0084 | 0.1587 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0226 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1453 | 0.1453 |
Brugia malayi | hypothetical protein | 0.0165 | 0.3265 | 0.3265 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0226 | 0.0832 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0106 | 0.0729 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0084 | 0.1587 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0073 | 0.1362 | 0.5022 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0084 | 0.1587 | 0.585 |
Echinococcus multilocularis | 0.0084 | 0.1587 | 0.1745 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0139 | 0.2712 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0073 | 0.1362 | 0.9374 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0013 | 0.0106 | 0.0729 |
Onchocerca volvulus | 0.0036 | 0.0596 | 0.6991 | |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0049 | 0.0861 | 0.0947 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0002 | 0.0002 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0078 | 0.1453 | 0.1598 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0084 | 0.1587 | 0.585 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0073 | 0.1362 | 0.5022 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0039 | 0.0039 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0002 | 0.0002 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0239 | 0.4803 | 0.5283 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0282 | 0.5677 | 0.5677 |
Schistosoma mansoni | hypothetical protein | 0.0446 | 0.9092 | 1 |
Brugia malayi | hypothetical protein | 0.0239 | 0.4803 | 0.4803 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0084 | 0.1587 | 0.585 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.049 | 0.0539 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0226 | 0.1553 |
Schistosoma mansoni | cytochrome P450 | 0.0084 | 0.1587 | 0.1745 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0042 | 0.0046 |
Onchocerca volvulus | 0.0013 | 0.0106 | 0.1241 | |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0084 | 0.1587 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0226 | 0.0248 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0139 | 0.2712 | 0.2712 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0853 | 0.0853 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0226 | 0.1422 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.1218 | 0.134 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0002 | 0.0002 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0084 | 0.1587 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0078 | 0.1453 | 0.5357 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0084 | 0.1587 | 1 |
Brugia malayi | cytochrome P450 | 0.0084 | 0.1587 | 0.1587 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0084 | 0.1587 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0078 | 0.1453 | 0.1598 |
Brugia malayi | bHLH-PAS transcription factor | 0.0036 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0042 | 0.0042 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0527 | 0.058 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0066 | 0.1203 | 0.7579 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0226 | 0.1553 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0084 | 0.1587 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0527 | 0.058 |
Brugia malayi | Cytochrome P450 family protein | 0.0139 | 0.2712 | 0.2712 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0013 | 0.0106 | 0.039 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0036 | 0.0596 | 0.0656 |
Leishmania major | cytochrome p450-like protein | 0.0084 | 0.1587 | 0.585 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0084 | 0.1587 | 0.585 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0106 | 0.0729 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0084 | 0.1587 | 0.585 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0084 | 0.1587 | 0.585 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0084 | 0.1587 | 0.585 |
Schistosoma mansoni | inositol monophosphatase | 0.0073 | 0.1362 | 0.1498 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0078 | 0.1453 | 0.5357 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0073 | 0.1362 | 0.1498 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0013 | 0.0106 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0084 | 0.1587 | 0.585 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0078 | 0.1453 | 0.1598 |
Echinococcus granulosus | dnaJ subfamily B | 0.0446 | 0.9092 | 1 |
Mycobacterium leprae | Possible regulatory protein | 0.0013 | 0.0106 | 0.0667 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0078 | 0.1453 | 0.1453 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0853 | 0.0938 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0073 | 0.1362 | 0.9374 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0084 | 0.1587 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0084 | 0.1587 | 0.585 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0013 | 0.0106 | 0.0729 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0013 | 0.0106 | 0.0116 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0013 | 0.0106 | 0.0729 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0226 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0226 | 0.0832 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0073 | 0.1362 | 0.5022 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0073 | 0.1362 | 0.5022 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0078 | 0.1453 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0078 | 0.1453 | 0.1598 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0073 | 0.1362 | 0.1498 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0078 | 0.1453 | 0.5357 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0078 | 0.1453 | 0.5357 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0013 | 0.0106 | 0.0729 |
Brugia malayi | Inositol-1 | 0.0073 | 0.1362 | 0.1362 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0084 | 0.1587 | 0.585 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0013 | 0.0106 | 0.0116 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0139 | 0.2712 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0013 | 0.0106 | 0.0729 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0084 | 0.1587 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0139 | 0.2712 | 0.2712 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0084 | 0.1587 | 0.1745 |
Echinococcus granulosus | single minded 2 | 0.0036 | 0.0596 | 0.0656 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0226 | 0.1422 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0084 | 0.1587 | 0.585 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0013 | 0.0106 | 0.039 |
Brugia malayi | PAS domain containing protein | 0.0049 | 0.0861 | 0.0861 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0084 | 0.1587 | 0.585 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.1453 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.049 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0013 | 0.0106 | 0.039 |
Schistosoma mansoni | inositol monophosphatase | 0.0073 | 0.1362 | 0.1498 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0527 | 0.058 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.049 | 0.049 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0073 | 0.1362 | 0.8583 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0078 | 0.1453 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0084 | 0.1587 | 0.585 |
Brugia malayi | Cytochrome P450 family protein | 0.0084 | 0.1587 | 0.1587 |
Onchocerca volvulus | 0.0031 | 0.049 | 0.5748 | |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0084 | 0.1587 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0002 | 0.0002 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0078 | 0.1453 | 0.1598 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0078 | 0.1453 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0084 | 0.1587 | 0.585 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0106 | 0.0106 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0042 | 0.0046 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0226 | 0.1553 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0013 | 0.0106 | 0.039 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0013 | 0.0106 | 0.0106 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0013 | 0.0106 | 0.0116 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0084 | 0.1587 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0073 | 0.1362 | 1 |
Leishmania major | protein kinase, putative | 0.0013 | 0.0106 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.4803 | 0.4803 |
Schistosoma mansoni | single-minded | 0.0049 | 0.0861 | 0.0947 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.