Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0062 | 0.1707 | 0.3892 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0062 | 0.1707 | 0.4027 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1033 | 0.1597 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.6466 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1228 | 0.2846 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0728 | 0.2609 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1033 | 0.1597 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.1737 | 0.3971 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0062 | 0.1707 | 0.3892 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0062 | 0.1707 | 0.4059 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0728 | 0.1126 |
Echinococcus granulosus | 6 phosphofructokinase | 0.011 | 0.3792 | 0.5864 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1033 | 0.2137 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1737 | 0.2686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1737 | 0.2686 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1033 | 0.1597 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0062 | 0.1707 | 0.4027 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.1737 | 0.2686 |
Brugia malayi | 6-phosphofructokinase | 0.011 | 0.3792 | 0.9342 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0728 | 0.1581 |
Schistosoma mansoni | 6-phosphofructokinase | 0.011 | 0.3792 | 0.5864 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1228 | 0.2645 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.3792 | 1 |
Onchocerca volvulus | 0.004 | 0.0728 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0728 | 0.1344 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0728 | 0.1226 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.061 | 0.0886 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0728 | 0.1226 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.003 | 0.03 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.1737 | 0.4136 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.011 | 0.3792 | 0.9324 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0728 | 0.1344 |
Onchocerca volvulus | 0.004 | 0.0728 | 0.5 | |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.011 | 0.3792 | 0.9324 |
Brugia malayi | beta-lactamase | 0.004 | 0.0728 | 0.1581 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.003 | 0.03 | 0.0445 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0693 | 0.1493 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.3792 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.2309 | 0.5585 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.061 | 0.0886 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0116 | 0.4052 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0728 | 0.1126 |
Toxoplasma gondii | 6-phosphofructokinase | 0.003 | 0.03 | 0.0445 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0728 | 0.1126 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.003 | 0.03 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0062 | 0.1707 | 0.2639 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0869 | 0.171 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0212 | 0.0274 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0728 | 0.1226 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0801 | 0.1533 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0728 | 0.1344 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0062 | 0.1707 | 0.2639 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.011 | 0.3792 | 0.5864 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1033 | 0.1597 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.1737 | 0.3971 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0728 | 0.1226 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.1737 | 0.4136 |
Echinococcus granulosus | dna polymerase kappa | 0.0062 | 0.1707 | 0.2639 |
Brugia malayi | phosphofructokinase | 0.011 | 0.3792 | 0.9342 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.003 | 0.03 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0062 | 0.1707 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.3792 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0062 | 0.1707 | 0.3193 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0728 | 0.1344 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.6466 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1737 | 0.2686 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0728 | 0.1226 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0697 | 0.1261 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.011 | 0.3792 | 0.3304 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0728 | 0.1344 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.061 | 0.0943 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1033 | 0.2352 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1033 | 0.1597 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1033 | 0.1597 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0728 | 0.1344 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0062 | 0.1707 | 0.2639 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0885 | 0.1752 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.1635 | 0.2529 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1228 | 0.2645 |
Leishmania major | DNA polymerase eta, putative | 0.0116 | 0.4052 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.1737 | 0.3971 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0728 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2121 | 0.497 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0074 | 0.219 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.1737 | 0.4136 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.1737 | 0.2686 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0525 | 0.0815 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0728 | 0.1344 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0589 | 0.0911 |
Brugia malayi | 6-phosphofructokinase | 0.011 | 0.3792 | 0.9342 |
Echinococcus granulosus | dna polymerase eta | 0.0116 | 0.4052 | 0.6266 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0728 | 0.1581 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0728 | 0.1581 |
Entamoeba histolytica | phosphofructokinase, putative | 0.011 | 0.3792 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0116 | 0.4052 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Schistosoma mansoni | 6-phosphofructokinase | 0.011 | 0.3792 | 0.5864 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.061 | 0.0886 |
Echinococcus multilocularis | geminin | 0.0172 | 0.6466 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0062 | 0.1707 | 0.1055 |
Leishmania major | ATP-dependent phosphofructokinase | 0.011 | 0.3792 | 0.9324 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.3792 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.011 | 0.3792 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0728 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1737 | 0.2686 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0062 | 0.1707 | 0.3892 |
Echinococcus multilocularis | dna polymerase kappa | 0.0062 | 0.1707 | 0.2639 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.061 | 0.0943 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0062 | 0.1707 | 0.2639 |
Leishmania major | DNA polymerase eta, putative | 0.0074 | 0.219 | 0.5152 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.3792 | 1 |
Onchocerca volvulus | 0.004 | 0.0728 | 0.5 | |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.003 | 0.03 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.1635 | 0.2529 |
Brugia malayi | hypothetical protein | 0.0037 | 0.061 | 0.1281 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0525 | 0.0812 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.1793 | 0.2773 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.061 | 0.0943 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.011 | 0.3792 | 0.9324 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.003 | 0.03 | 0.1705 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1737 | 0.2686 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1228 | 0.2846 |
Trypanosoma brucei | unspecified product | 0.0062 | 0.1707 | 0.3892 |
Trypanosoma brucei | unspecified product | 0.0043 | 0.0869 | 0.171 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0869 | 0.171 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.011 | 0.3792 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0728 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0728 | 0.1344 |
Schistosoma mansoni | DNA polymerase eta | 0.0116 | 0.4052 | 0.6266 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4052 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.6466 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0116 | 0.4052 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Leishmania major | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0525 | 0.1067 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1033 | 0.1597 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.1707 | 0.3892 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0062 | 0.1707 | 0.3193 |
Echinococcus multilocularis | dna polymerase eta | 0.0116 | 0.4052 | 0.6266 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.061 | 0.0943 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0062 | 0.1707 | 0.1055 |
Loa Loa (eye worm) | phosphofructokinase | 0.011 | 0.3792 | 0.9324 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.061 | 0.0886 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0728 | 0.1126 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0869 | 0.171 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0062 | 0.1707 | 0.4027 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.011 | 0.3792 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0074 | 0.219 | 0.5152 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0728 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0728 | 0.1344 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.003 | 0.03 | 0.1705 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0062 | 0.1707 | 0.3892 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.011 | 0.3792 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0728 | 0.1226 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.003 | 0.03 | 0.0445 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.011 | 0.3792 | 0.9324 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0062 | 0.1707 | 0.3892 |
Trypanosoma brucei | unspecified product | 0.0043 | 0.0869 | 0.171 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0589 | 0.0911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.