Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin receptor | 0.1339 | 0.0083 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.2228 | 0.1838 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.2228 | 0.1838 | 0.3117 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.636 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2252 | 0.1885 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.2228 | 0.1838 | 0.3117 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.636 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.4191 | 0.5715 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.4191 | 0.5715 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.636 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.636 | 1 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.2252 | 0.1885 | 0.32 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.636 | 1 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.1339 | 0.0083 | 0.0145 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.636 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2252 | 0.1885 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2252 | 0.1885 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2252 | 0.1885 | 0.32 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.4191 | 0.5715 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.636 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.4191 | 0.5715 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.4191 | 0.5715 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 2 % | Evaluated for the inhibition of fluorescence quenching before the release of 7-amido-4-methylcourmarin (AMC). | ChEMBL. | No reference |
Inhibition (binding) | = 9 % | Compound was evaluated for the inhibition of leucine amino peptidase. | ChEMBL. | No reference |
Inhibition (binding) | = 9 % | Compound was evaluated for the inhibition of leucine amino peptidase. | ChEMBL. | No reference |
Inhibition (binding) | = 53 % | Compound was evaluated for the inhibition of cathepsin D at a concentration of 4.15 microg/mL | ChEMBL. | No reference |
Inhibition (binding) | = 53 % | Compound was evaluated for the inhibition of cathepsin D at a concentration of 4.15 microg/mL | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.