Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Brugia malayi | Carboxylesterase family protein | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Echinococcus granulosus | carboxylesterase 5A | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.5136 | 0.5136 |
Echinococcus granulosus | peroxidasin | 0.0157 | 0.7596 | 0.7596 |
Onchocerca volvulus | 0.0157 | 0.7596 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.7596 | 0.7596 |
Onchocerca volvulus | Peroxidase homolog | 0.0157 | 0.7596 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.8142 | 0.8142 |
Echinococcus multilocularis | geminin | 0.0166 | 0.8142 | 0.8142 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0033 | 0 | 0.5 |
Brugia malayi | Peroxidasin | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0196 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.7596 | 0.7596 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0196 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0157 | 0.7596 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0196 | 1 | 1 |
Onchocerca volvulus | 0.0157 | 0.7596 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.5136 | 0.5136 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.8142 | 0.8142 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.7596 | 0.7596 |
Echinococcus granulosus | acetylcholinesterase | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Schistosoma mansoni | peroxidasin | 0.0157 | 0.7596 | 0.7596 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.8142 | 0.8142 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Onchocerca volvulus | Peroxidasin homolog | 0.0157 | 0.7596 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.7596 | 0.7596 |
Onchocerca volvulus | Peroxidase homolog | 0.0157 | 0.7596 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.7596 | 0.7596 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.7596 | 0.7596 |
Onchocerca volvulus | Peroxidasin homolog | 0.0157 | 0.7596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0157 | 0.7596 | 0.7596 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.5136 | 0.5136 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Brugia malayi | Animal haem peroxidase family protein | 0.0157 | 0.7596 | 0.7596 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0157 | 0.7596 | 0.7596 |
Brugia malayi | Blistered cuticle protein 3 | 0.0157 | 0.7596 | 0.7596 |
Onchocerca volvulus | 0.0157 | 0.7596 | 1 | |
Brugia malayi | hypothetical protein | 0.0157 | 0.7596 | 0.7596 |
Echinococcus granulosus | acetylcholinesterase | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0196 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0157 | 0.7596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0157 | 0.7596 | 0.7596 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0033 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0033 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30000 nM | Inhibition of human whole RBC AChE pretreated for 30 mins by Ellman technique | ChEMBL. | 20627738 |
IC50 (binding) | > 30000 nM | Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique | ChEMBL. | 20627738 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.