Detailed information for compound 1145245

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 578.601 | Formula: C21H24N9O7S2+
  • H donors: 5 H acceptors: 8 LogP: 0.75 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1[C@@H](NC(=O)/C(=N\OC(C(=O)O)(C)C)/c2nsc(n2)N)[C@@H]2N1C(=C(CS2)C[n+]1ccc2n1CCN2)C(=O)O
  • InChi: 1S/C21H23N9O7S2/c1-21(2,19(35)36)37-26-11(14-25-20(22)39-27-14)15(31)24-12-16(32)30-13(18(33)34)9(8-38-17(12)30)7-28-5-3-10-23-4-6-29(10)28/h3,5,12,17H,4,6-8H2,1-2H3,(H5,22,24,25,27,31,33,34,35,36)/p+1/b26-11-/t12-,17-/m1/s1
  • InChiKey: YYQBJKKFQZUSPR-QDECCPLTSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0314 0.3966 0.4644
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0775 0.0771
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0051 0.0353 0.1962
Brugia malayi Latrophilin receptor protein 2 0.0099 0.1017 0.1166
Mycobacterium tuberculosis Probable dehydrogenase 0.0336 0.4262 0.7108
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0386 0.042
Onchocerca volvulus 0.0072 0.0645 0.3136
Leishmania major cathepsin L-like protease 0.0204 0.2447 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0147 0.1673 0.167
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0297 0.1076
Treponema pallidum NADH oxidase 0.0051 0.0353 0.4522
Trichomonas vaginalis ferritin, putative 0.0026 0.0004 0.0062
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0353 0.1334
Schistosoma mansoni Smad4 0.0044 0.0255 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0132 0.2046
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0255 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Schistosoma mansoni transcription factor LCR-F1 0.0225 0.2739 0.2736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0525
Onchocerca volvulus 0.0053 0.0386 0.1516
Echinococcus multilocularis cathepsin L 0.0028 0.003 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0386 0.1472
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0645 1
Schistosoma mansoni smad 0.0044 0.0255 0.0251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0039 0.0453
Brugia malayi Cathepsin L-like precursor 0.0053 0.0386 0.042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1305
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0039 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Trypanosoma brucei trypanothione reductase 0.0147 0.1673 0.6797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0132 0.2046
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0537 0.0599
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0645 0.107
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0386 0.0382
Leishmania major cathepsin L-like protease 0.0053 0.0386 0.1443
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0143 0.0418
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0336 0.4262 0.7108
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0051 0.0353 0.1305
Echinococcus granulosus Smad4 0.0044 0.0255 0.0251
Echinococcus multilocularis lamin dm0 0.014 0.1569 0.1566
Brugia malayi Cathepsin L-like precursor 0.0036 0.0143 0.0134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0124
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.003 0.0026
Echinococcus multilocularis microtubule associated protein 2 0.0754 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Onchocerca volvulus 0.0152 0.1743 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0053 0.0386 0.2165
Loa Loa (eye worm) hypothetical protein 0.0137 0.1534 0.1769
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0645 0.2544
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1334
Brugia malayi intermediate filament protein 0.014 0.1569 0.1818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.1743 0.2016
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0645 0.1343
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0775 0.0771
Plasmodium falciparum cysteine proteinase falcipain 3 0.0053 0.0386 0.2165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0132 0.2046
Schistosoma mansoni hypothetical protein 0.0099 0.1017 0.1014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0645 0.0717
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0297 0.1105
Brugia malayi Cathepsin L-like precursor 0.0053 0.0386 0.042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.1017 0.1014
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0775 1
Onchocerca volvulus 0.0053 0.0386 0.1516
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0353 0.4522
Onchocerca volvulus 0.014 0.1569 0.8914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0165 0.2563
Onchocerca volvulus 0.0107 0.1119 0.61
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.5995 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0255 0.0256
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0645 0.0726
Loa Loa (eye worm) hypothetical protein 0.0072 0.0645 0.0717
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0255 0.0251
Brugia malayi Cathepsin L-like precursor 0.0053 0.0386 0.042
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0297 0.0293
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0537 0.0533
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0051 0.0353 0.0582
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0051 0.0353 0.1962
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0645 0.107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1334
Brugia malayi RNA binding protein 0.0064 0.0537 0.0599
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.1017 0.1166
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.014 0.1569 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Plasmodium vivax glutathione reductase, putative 0.0147 0.1673 1
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.2447 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0165 0.2563
Loa Loa (eye worm) ctsf protein 0.0053 0.0386 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0085 0.1316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.003 0.0467
Loa Loa (eye worm) hypothetical protein 0.0053 0.0386 0.0411
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0051 0.0353 0.4522
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0373 0.4776 0.7967
Trypanosoma cruzi cruzipain precursor, putative 0.0204 0.2447 1
Brugia malayi hypothetical protein 0.0028 0.0038 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1305
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0336 0.4262 0.7108
Mycobacterium ulcerans hypothetical protein 0.0072 0.0645 0.8317
Toxoplasma gondii NADPH-glutathione reductase 0.0051 0.0353 0.1923
Schistosoma mansoni hypothetical protein 0.0099 0.1017 0.1014
Brugia malayi hypothetical protein 0.0152 0.1743 0.2023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0165 0.2563
Loa Loa (eye worm) hypothetical protein 0.0072 0.0645 0.0717
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0051 0.0353 0.0349
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0386 0.0382
Plasmodium vivax thioredoxin reductase, putative 0.0147 0.1673 1
Loa Loa (eye worm) transcription factor SMAD2 0.0645 0.8498 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0336 0.4262 0.7108
Mycobacterium tuberculosis Probable oxidoreductase 0.0373 0.4776 0.7967
Brugia malayi beta-lactamase 0.0072 0.0645 0.0726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Brugia malayi Cathepsin L-like precursor 0.0053 0.0386 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0353 0.1334
Brugia malayi Smad1 0.0044 0.0255 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0034 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0386 0.5982
Leishmania major trypanothione reductase 0.0147 0.1673 0.6786
Entamoeba histolytica cysteine protease, putative 0.0053 0.0386 0.1313
Onchocerca volvulus 0.0072 0.0645 0.3136
Mycobacterium tuberculosis Conserved protein 0.0072 0.0645 0.107
Plasmodium vivax vivapain-2 0.0053 0.0386 0.2165
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0255 0.0251
Toxoplasma gondii ABC1 family protein 0.0072 0.0645 0.3712
Onchocerca volvulus 0.0053 0.0386 0.1516
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0386 0.1313
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0167 0.0161
Brugia malayi TAR-binding protein 0.0064 0.0537 0.0599
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0537 0.0533
Entamoeba histolytica hypothetical protein 0.0225 0.2739 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0388 0.0641
Brugia malayi hypothetical protein 0.0225 0.2739 0.32
Onchocerca volvulus 0.0053 0.0386 0.1516
Loa Loa (eye worm) hypothetical protein 0.0099 0.1017 0.1157
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0297 0.0306
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0166 0.0561
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0255 0.0251
Mycobacterium ulcerans beta-lactamase 0.0072 0.0645 0.8317
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0051 0.0353 0.1305
Leishmania major cathepsin L-like protease 0.0053 0.0386 0.1443
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0167 0.0161
Onchocerca volvulus 0.014 0.1569 0.8914
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0038 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0186 0.2205 0.8997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0775 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0001 0.0008
Brugia malayi MH2 domain containing protein 0.0044 0.0255 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0071 0.11
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0775 0.4532
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0775 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0051 0.0353 0.1334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Echinococcus granulosus smad 0.0044 0.0255 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0165 0.2563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0386 0.5982
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0297 0.0293
Loa Loa (eye worm) beta-lactamase 0.0072 0.0645 0.0717
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0537 0.059
Leishmania major cathepsin L-like protease 0.0204 0.2447 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.0386 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0297 0.4609
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0297 0.0293
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0166 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0132 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0388 0.0384
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0775 0.4505
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0645 0.0641
Leishmania major hypothetical protein, conserved 0.0072 0.0645 0.2519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0132 0.2046
Mycobacterium ulcerans lipase LipD 0.0072 0.0645 0.8317
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.0386 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Brugia malayi Thioredoxin reductase 0.0147 0.1673 0.194
Schistosoma mansoni smad1 5 8 and 0.0044 0.0255 0.0251
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0353 0.1334
Plasmodium falciparum glutathione reductase 0.0147 0.1673 1
Schistosoma mansoni lamin 0.014 0.1569 0.1566
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.1017 0.1014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Plasmodium falciparum glutathione reductase 0.0051 0.0353 0.1962
Giardia lamblia NADH oxidase lateral transfer candidate 0.0051 0.0353 1
Brugia malayi MH1 domain containing protein 0.0044 0.0255 0.0265
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0166 0.053
Echinococcus granulosus lamin dm0 0.014 0.1569 0.1566
Schistosoma mansoni smad1 5 8 and 0.0044 0.0255 0.0251
Leishmania major cysteine peptidase A (CPA) 0.0053 0.0386 0.1443
Echinococcus granulosus cathepsin L 0.0028 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0072 0.0645 0.0717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.003 0.0467
Loa Loa (eye worm) glutathione reductase 0.0147 0.1673 0.1933
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Loa Loa (eye worm) RNA binding protein 0.0064 0.0537 0.059
Brugia malayi Intermediate filament tail domain containing protein 0.014 0.1569 0.1818
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0373 0.4776 0.7967
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0255 0.0251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0645 0.0641
Plasmodium vivax vivapain-2 0.0053 0.0386 0.2165
Entamoeba histolytica hypothetical protein 0.0225 0.2739 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0203 0.3147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0165 0.2563
Loa Loa (eye worm) Smad1 0.0044 0.0255 0.0256
Brugia malayi Cathepsin L-like precursor 0.0053 0.0386 0.042
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0775 0.4532
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0645 0.107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0124
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0386 0.1516
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0143 0.0139
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0537 0.059
Mycobacterium tuberculosis Probable reductase 0.0336 0.4262 0.7108
Schistosoma mansoni hypothetical protein 0.0099 0.1017 0.1014
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0645 0.107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0038 0.0584
Mycobacterium tuberculosis Conserved protein 0.0072 0.0645 0.107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Echinococcus granulosus cysteine protease 0.0028 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0107 0.1119 0.1278
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0051 0.0353 0.4522
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.0386 0.0411
Trypanosoma cruzi major cysteine proteinase, putative 0.016 0.1849 0.7525
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0314 0.3966 0.4644
Loa Loa (eye worm) MH2 domain-containing protein 0.0645 0.8498 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0038 0.0033
Echinococcus multilocularis Smad4 0.0044 0.0255 0.0251
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0053 0.0386 0.2165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0645 0.8317
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0645 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0353 0.1334
Leishmania major cathepsin L-like protease 0.0204 0.2447 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0645 0.0717
Onchocerca volvulus 0.0053 0.0386 0.1516
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0143 0.0134
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0051 0.0353 0.1962
Schistosoma mansoni hypothetical protein 0.0099 0.1017 0.1014
Schistosoma mansoni hypothetical protein 0.0215 0.2601 0.2598
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0039 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0001 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0645 1
Schistosoma mansoni smad1 5 8 and 0.0044 0.0255 0.0251
Schistosoma mansoni lamin 0.014 0.1569 0.1566
Echinococcus granulosus GPCR family 2 0.0099 0.1017 0.1014
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0386 0.0382
Echinococcus granulosus cathepsin l1 0.0053 0.0386 0.0382
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0067 0.0577 0.0574
Loa Loa (eye worm) hypothetical protein 0.0072 0.0645 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0132 0.2046
Echinococcus granulosus lamin 0.014 0.1569 0.1566
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0132 0.0574
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1334
Brugia malayi beta-lactamase family protein 0.0072 0.0645 0.0726
Echinococcus multilocularis cysteine protease 0.0053 0.0386 0.0382
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0297 0.1076
Loa Loa (eye worm) thioredoxin reductase 0.0147 0.1673 0.1933
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0645 1
Brugia malayi cathepsin L-like precursor 0.0036 0.0143 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0297 0.4609
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.003 0.0026
Brugia malayi cytoplasmic intermediate filament protein 0.0075 0.0679 0.0767
Entamoeba histolytica hypothetical protein 0.0225 0.2739 1
Trichomonas vaginalis glutathione reductase, putative 0.0051 0.0353 0.5466
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0038 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.2447 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0297 0.0315
Onchocerca volvulus Cathepsin F homolog 0.0053 0.0386 0.1516
Brugia malayi Cathepsin L-like precursor 0.0053 0.0386 0.042
Loa Loa (eye worm) hypothetical protein 0.014 0.1569 0.181
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.1017 0.1014
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0386 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0143 0.2222
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0147 0.1673 0.2786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0001 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Echinococcus granulosus tumor protein p63 0.073 0.9675 0.9675
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0386 0.0382
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0051 0.0353 0.1962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0132 0.2046
Schistosoma mansoni intermediate filament proteins 0.014 0.1569 0.1566
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0537 0.0533
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0645 0.107
Loa Loa (eye worm) hypothetical protein 0.0065 0.0542 0.0596
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0353 0.4522
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0038 0.0048
Loa Loa (eye worm) hypothetical protein 0.0065 0.0542 0.0596
Toxoplasma gondii hypothetical protein 0.0028 0.0039 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.1017 0.1157
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0067 0.0577 0.0574
Plasmodium falciparum thioredoxin reductase 0.0147 0.1673 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0645 0.107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0143 0.2222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0297 0.4609
Mycobacterium leprae Probable lipase LipE 0.0072 0.0645 0.1343
Echinococcus multilocularis tumor protein p63 0.073 0.9675 0.9675
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0645 0.107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.2447 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0075 0.0679 0.0758
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.2601 0.3036
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0775 0.4505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0386 0.1516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0001 0.0008
Loa Loa (eye worm) intermediate filament protein 0.014 0.1569 0.181
Brugia malayi MH2 domain containing protein 0.0044 0.0255 0.0265
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0051 0.0353 0.4522
Brugia malayi MH1 domain containing protein 0.0044 0.0255 0.0265
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0051 0.0353 0.0349
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0645 0.2544
Toxoplasma gondii cathepsin CPL 0.0053 0.0386 0.2127
Toxoplasma gondii thioredoxin reductase 0.0147 0.1673 1
Echinococcus granulosus intermediate filament protein 0.014 0.1569 0.1566
Echinococcus multilocularis musashi 0.014 0.1569 0.1566
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0255 0.0256
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0225 0.2739 0.2736
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1334
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0645 0.2544
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0775 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.1017 0.1014
Brugia malayi Probable ClpP-like protease 0.0082 0.0775 0.0879
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.1119 0.1116
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0297 0.0986
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0353 0.1334
Trichomonas vaginalis esterase, putative 0.0072 0.0645 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0645 0.0641
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0386 0.1313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0314 0.3966 0.4649
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0645 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0039 0.0054
Brugia malayi beta-lactamase family protein 0.0072 0.0645 0.0726
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0388 0.0641
Echinococcus multilocularis lamin 0.014 0.1569 0.1566
Entamoeba histolytica hypothetical protein 0.0225 0.2739 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0373 0.4776 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0297 0.1105
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0336 0.4262 0.8922
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0537 0.0533
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.003 0.0026
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0297 0.0986
Trypanosoma cruzi trypanothione reductase, putative 0.0147 0.1673 0.6797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Brugia malayi MH2 domain containing protein 0.0645 0.8498 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0388 0.0384
Mycobacterium tuberculosis Conserved protein 0.0072 0.0645 0.107
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.2447 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0386 0.0382
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0051 0.0353 0.1334
Echinococcus multilocularis GPCR, family 2 0.0099 0.1017 0.1014
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0537 0.0533
Plasmodium falciparum thioredoxin reductase 0.0051 0.0353 0.1962
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0645 0.3742
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0645 0.0641
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0051 0.0353 0.0349
Loa Loa (eye worm) fibroinase 0.0053 0.0386 0.0411
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0297 0.1105
Leishmania major cathepsin L-like protease 0.0053 0.0386 0.1443
Leishmania major cathepsin L-like protease 0.0053 0.0386 0.1443
Loa Loa (eye worm) hypothetical protein 0.0082 0.0775 0.0871
Echinococcus multilocularis cysteine protease 0.0053 0.0386 0.0382
Schistosoma mansoni microtubule-associated protein tau 0.0754 1 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.0143 0.0134
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0038 0.0033
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0336 0.4262 0.7108
Leishmania major cathepsin L-like protease 0.0053 0.0386 0.1443
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0297 0.1105
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0775 0.1615
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0775 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0645 0.8317
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0225 0.2739 0.2736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0038 0.0584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0038 0.0584
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0051 0.0353 0.0381
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0388 0.0805
Brugia malayi Calcitonin receptor-like protein seb-1 0.0314 0.3966 0.4649
Onchocerca volvulus 0.0053 0.0386 0.1516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0386 0.5982
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1334
Echinococcus multilocularis smad 0.0044 0.0255 0.0251
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0775 1
Onchocerca volvulus 0.0053 0.0386 0.1516
Loa Loa (eye worm) hypothetical protein 0.0072 0.0645 0.0717
Trichomonas vaginalis mercuric reductase, putative 0.0051 0.0353 0.5466
Onchocerca volvulus 0.0072 0.0645 0.3136
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0051 0.0353 0.1923
Echinococcus granulosus thioredoxin glutathione reductase 0.0147 0.1673 0.167
Echinococcus granulosus cathepsin l1 0.0036 0.0143 0.0139
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0038 0.0048
Brugia malayi glutathione reductase 0.0147 0.1673 0.194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0353 0.1334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0386 0.5982
Loa Loa (eye worm) cysteine protease 0.0053 0.0386 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0537 0.0533
Echinococcus granulosus tar DNA binding protein 0.0064 0.0537 0.0533
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.003 0.0026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0386 0.0411
Schistosoma mansoni hypothetical protein 0.0225 0.2739 0.2736
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0775 0.0771
Loa Loa (eye worm) hypothetical protein 0.0215 0.2601 0.303
Loa Loa (eye worm) hypothetical protein 0.0067 0.0577 0.0638

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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