TDR Targets

Basic information

Technical information

TDR Targets ID: 1145888
Name: 5-methyl-1-[6-[(1-methylpyridin-1-ium-4-yl)-d i(phenyl)methoxy]hexyl]pyrimidine-2,4-dione
MW: 484.609 | Formula: C30H34N3O3+
H donors: 1 H acceptors: 2 LogP: 4.6 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: C[n+]1ccc(cc1)C(c1ccccc1)(c1ccccc1)OCCCCCCn1cc(C)c(=O)[nH]c1=O
InChi: 1S/C30H33N3O3/c1-24-23-33(29(35)31-28(24)34)19-11-3-4-12-22-36-30(25-13-7-5-8-14-25,26-15-9-6-10-16-26)27-17-20-32(2)21-18-27/h5-10,13-18,20-21,23H,3-4,11-12,19,22H2,1-2H3/p+1
InChiKey: MIKIBCYBICWOMD-UHFFFAOYSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-methyl-1-[6-[(1-methyl-4-pyridin-1-iumyl)-di(phenyl)methoxy]hexyl]pyrimidine-2,4-dione
5-methyl-1-[6-[(1-methylpyridin-1-ium-4-yl)-di(phenyl)methoxy]hexyl]pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.5433	0.5921
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Brugia malayi	MH2 domain containing protein	0.0121	0.3485	0.3942
Onchocerca volvulus		0.0223	0.7365	1
Giardia lamblia	Cathepsin L precursor	0.0041	0.0487	0.5
Onchocerca volvulus		0.0223	0.7365	1
Echinococcus granulosus	cathepsin l1	0.0149	0.4576	0.6006
Echinococcus multilocularis	cysteine protease	0.0223	0.7365	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.8841	1
Giardia lamblia	Hypothetical protein	0.0041	0.0487	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Onchocerca volvulus		0.0149	0.4576	0.6214
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Brugia malayi	Cathepsin L-like precursor	0.0223	0.7365	0.833
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Trypanosoma cruzi	cysteine peptidase, putative	0.0115	0.3275	0.2931
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0041	0.0487	0.5
Echinococcus granulosus	cathepsin L	0.0041	0.0487	0.0148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0487	0.055
Echinococcus granulosus	cysteine protease	0.0115	0.3275	0.4142
Echinococcus multilocularis	geminin	0.0164	0.5141	0.6815
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Echinococcus multilocularis	cathepsin L cysteine protease	0.0223	0.7365	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.2587	0.3156
Brugia malayi	cathepsin B-like cysteine proteinase	0.0041	0.0487	0.055
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Brugia malayi	Papain family cysteine protease containing protein	0.0223	0.7365	0.833
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.2587	0.2926
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.5433	0.5921
Echinococcus multilocularis	cathepsin b	0.0041	0.0487	0.0148
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0827	0.0358
Plasmodium vivax	vivapain-3	0.0115	0.3275	0.4054
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Onchocerca volvulus		0.0223	0.7365	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0041	0.0487	0.0487
Echinococcus multilocularis	cathepsin b	0.0041	0.0487	0.0148
Loa Loa (eye worm)	ctsf protein	0.0223	0.7365	0.833
Entamoeba histolytica	cysteine proteinase 1, putative	0.0115	0.3275	0.4447
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.3485	0.3942
Toxoplasma gondii	hypothetical protein	0.0047	0.0716	0.0333
Entamoeba histolytica	cysteine proteinase, putative	0.0115	0.3275	0.4447
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Brugia malayi	cathepsin L-like cysteine proteinase	0.0041	0.0487	0.055
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0115	0.3275	0.4142
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0041	0.0487	0.055
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0262	0.8841	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0223	0.7365	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Echinococcus multilocularis	cathepsin L	0.0115	0.3275	0.4142
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0487	0.055
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0487	0.0661
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0115	0.3275	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Echinococcus granulosus	cathepsin b	0.0041	0.0487	0.0148
Giardia lamblia	Cathepsin L precursor	0.0041	0.0487	0.5
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Echinococcus multilocularis	Niemann Pick C1 protein	0.0105	0.2907	0.3615
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0041	0.0487	0.055
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Brugia malayi	cathepsin L precursor	0.0041	0.0487	0.055
Onchocerca volvulus	Cathepsin F homolog	0.0223	0.7365	1
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Leishmania major	cysteine peptidase A (CPA)	0.0223	0.7365	0.7365
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.2587	0.3156
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0074	0.1718	0.1944
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.1718	0.1295
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.4169	0.3871
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0041	0.0487	0.055
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0041	0.0487	0.0148
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0223	0.7365	1
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.5783	0.634
Entamoeba histolytica	hypothetical protein	0.0038	0.0383	0.0521
Echinococcus multilocularis	cathepsin L	0.0041	0.0487	0.0148
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0223	0.7365	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.5783	0.634
Giardia lamblia	Cysteine protease	0.0041	0.0487	0.5
Echinococcus granulosus	cathepsin L	0.0115	0.3275	0.4142
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.3275	0.2931
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0105	0.2907	0.3947
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0115	0.3275	0.4142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Onchocerca volvulus	Cathepsin L homolog	0.0223	0.7365	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.4169	0.4169
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0041	0.0487	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Giardia lamblia	Cathepsin L precursor	0.0041	0.0487	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1718	0.1944
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.7365	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Brugia malayi	Cathepsin L-like precursor	0.0223	0.7365	0.833
Echinococcus multilocularis	protein dispatched 1	0.0052	0.0878	0.0708
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0041	0.0487	0.5
Brugia malayi	Niemann-Pick C1 protein precursor	0.0105	0.2907	0.3288
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Plasmodium vivax	vivapain-2	0.0223	0.7365	1
Echinococcus multilocularis	expressed conserved protein	0.0099	0.2666	0.3269
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0487	0.055
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0487	0.0661
Brugia malayi	Papain family cysteine protease containing protein	0.0041	0.0487	0.055
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4576	0.5176
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1021	0.1155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.3275	0.3338
Brugia malayi	Papain family cysteine protease containing protein	0.0041	0.0487	0.055
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0487	0.000006376
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.7365	0.723
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0041	0.0487	0.0661
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.4761	1
Entamoeba histolytica	cysteine proteinase, putative	0.0149	0.4576	0.6214
Onchocerca volvulus		0.0223	0.7365	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.2587	0.3156
Schistosoma mansoni	cathepsin F (C01 family)	0.0223	0.7365	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0041	0.0487	0.0148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.4576	0.4895
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Schistosoma mansoni	cathepsin S (C01 family)	0.0041	0.0487	0.0148
Onchocerca volvulus	Glucosylceramidase homolog	0.0172	0.5433	0.7377
Giardia lamblia	Cysteine protease	0.0041	0.0487	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0041	0.0487	0.055
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Trypanosoma cruzi	cysteine protease, putative	0.0115	0.3275	0.2931
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	1	1
Brugia malayi	hypothetical protein	0.0038	0.0383	0.0434
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0115	0.3275	0.2931
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.5433	0.5921
Loa Loa (eye worm)	hypothetical protein	0.0223	0.7365	0.833
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0637	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4576	0.5176
Onchocerca volvulus	Cathepsin L homolog	0.0041	0.0487	0.0661
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0637	0.0363
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0223	0.7365	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.8841	1
Brugia malayi	Cathepsin L-like precursor	0.0223	0.7365	0.833
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.2587	0.3156
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0487	0.000006376
Onchocerca volvulus		0.0041	0.0487	0.0661
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Echinococcus multilocularis	protein patched	0.0045	0.0637	0.0363
Echinococcus granulosus	expressed conserved protein	0.0099	0.2666	0.3269
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0041	0.0487	0.055
Schistosoma mansoni	hypothetical protein	0.0044	0.0575	0.0275
Entamoeba histolytica	cysteine proteinase 2	0.0115	0.3275	0.4447
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Echinococcus multilocularis	cysteine protease	0.0223	0.7365	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.7365	0.723
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.2587	0.3156
Trypanosoma cruzi	cruzipain precursor, putative	0.0223	0.7365	0.723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.7365	0.723
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.1718	0.1944
Entamoeba histolytica	cysteine proteinase, putative	0.0115	0.3275	0.4447
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Plasmodium vivax	unspecified product	0.0074	0.1718	0.1791
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0637	0.072
Trypanosoma cruzi	cysteine proteinase, putative	0.0115	0.3275	0.2931
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.3275	0.3704
Entamoeba histolytica	hypothetical protein	0.0038	0.0383	0.0521
Brugia malayi	fibroinase precursor	0.0041	0.0487	0.055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0149	0.4576	0.4895
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.2587	0.2926
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0487	0.0661
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0223	0.7365	0.8233
Echinococcus multilocularis	Niemann Pick C1 protein	0.015	0.4614	0.606
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.8841	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Schistosoma mansoni	hypothetical protein	0.0164	0.5141	0.6815
Brugia malayi	Cathepsin L-like precursor	0.0223	0.7365	0.833
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Schistosoma mansoni	cathepsin B (C01 family)	0.0041	0.0487	0.0148
Giardia lamblia	Cathepsin L precursor	0.0041	0.0487	0.5
Schistosoma mansoni	cathepsin C	0.0041	0.0487	0.0148
Giardia lamblia	Cathepsin L precursor	0.0041	0.0487	0.5
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0487	0.0661
Giardia lamblia	Cathepsin L-like protease	0.0041	0.0487	0.5
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Brugia malayi	Cathepsin L-like precursor	0.0149	0.4576	0.5176
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0487	0.055
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0487	0.055
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0223	0.7365	0.833
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	1	1
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Echinococcus granulosus	Niemann Pick C1 protein	0.0105	0.2907	0.3615
Mycobacterium ulcerans	hypothetical protein	0.0154	0.4761	1
Plasmodium vivax	vivapain-2	0.0223	0.7365	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.8841	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Plasmodium vivax	vivapain-1	0.0115	0.3275	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0223	0.7365	0.8233
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0149	0.4576	0.5176
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Toxoplasma gondii	cathepsin CPL	0.0223	0.7365	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.7365	0.723
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.7365	1
Giardia lamblia	Cysteine protease	0.0041	0.0487	0.5
Loa Loa (eye worm)	cysteine protease	0.0223	0.7365	0.833
Echinococcus granulosus	cathepsin b	0.0041	0.0487	0.0148
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0041	0.0487	0.0148
Brugia malayi	CHE-14 protein	0.0045	0.0637	0.072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.8841	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0041	0.0487	0.055
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0223	0.7365	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0383	0.0521
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0637	0.018
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1718	0.1944
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Giardia lamblia	Hypothetical protein	0.0041	0.0487	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0115	0.3275	0.2931
Brugia malayi	Cathepsin L-like precursor	0.0074	0.1718	0.1944
Brugia malayi	cathepsin L-like precursor	0.0149	0.4576	0.5176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.2587	0.3156
Echinococcus granulosus	geminin	0.0164	0.5141	0.6815
Entamoeba histolytica	hypothetical protein	0.0038	0.0383	0.0521
Loa Loa (eye worm)	fibroinase	0.0223	0.7365	0.833
Trypanosoma cruzi	cruzipain precursor, putative	0.0074	0.1718	0.1295
Giardia lamblia	Cathepsin L precursor	0.0041	0.0487	0.5
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0115	0.3275	0.4142
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4576	0.5176
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0487	0.000006376
Brugia malayi	cathepsin F-like cysteine proteinase	0.0074	0.1718	0.1944
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.8841	1
Onchocerca volvulus		0.0223	0.7365	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0223	0.7365	0.8233
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.3485	0.3942
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0115	0.3275	0.2931
Echinococcus granulosus	Niemann Pick C1 protein	0.015	0.4614	0.606
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0637	0.072
Schistosoma mansoni	cathepsin F (C01 family)	0.0223	0.7365	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0041	0.0487	0.0148
Giardia lamblia	Cysteine protease	0.0041	0.0487	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Schistosoma mansoni	cathepsin F (C01 family)	0.0149	0.4576	0.6006
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0262	0.8841	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0041	0.0487	0.055
Entamoeba histolytica	cysteine proteinase, putative	0.0115	0.3275	0.4447
Schistosoma mansoni	hypothetical protein	0.0044	0.0575	0.0275
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0223	0.7365	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Entamoeba histolytica	cysteine proteinase, putative	0.0115	0.3275	0.4447
Brugia malayi	Cathepsin L-like precursor	0.0223	0.7365	0.833
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.2587	0.3156
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0487	0.055
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0223	0.7365	0.833
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.5433	0.5921
Brugia malayi	Cathepsin L-like precursor	0.0149	0.4576	0.5176
Brugia malayi	Papain family cysteine protease containing protein	0.0115	0.3275	0.3704
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Echinococcus granulosus	cathepsin l1	0.0223	0.7365	1
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0637	0.0363
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0487	0.0661
Brugia malayi	Papain family cysteine protease containing protein	0.0041	0.0487	0.055
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.5433	0.5921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.7365	0.8233
Schistosoma mansoni	cathepsin s	0.0074	0.1718	0.1912
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0223	0.7365	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0041	0.0487	0.0148
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0223	0.7365	1
Schistosoma mansoni	hypothetical protein	0.0044	0.0575	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0105	0.2907	0.3288
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0487	0.055
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.5433	0.5921
Schistosoma mansoni	hypothetical protein	0.0044	0.0575	0.0275
Plasmodium vivax	unspecified product	0.0115	0.3275	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0487	0.0148
Schistosoma mansoni	patched 1	0.0045	0.0637	0.0363
Giardia lamblia	Cathepsin B precursor	0.0041	0.0487	0.5
Entamoeba histolytica	cysteine protease, putative	0.0223	0.7365	1
Brugia malayi	Cathepsin L-like precursor	0.0223	0.7365	0.833
Onchocerca volvulus		0.0223	0.7365	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.5433	0.5921
Schistosoma mansoni	hypothetical protein	0.0164	0.5141	0.6815
Giardia lamblia	Encystation-specific protease	0.0041	0.0487	0.5
Onchocerca volvulus		0.0223	0.7365	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0487	0.000006376
Onchocerca volvulus	Cathepsin L homolog	0.0223	0.7365	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0041	0.0487	0.0661
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.7365	0.723
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.3275	0.3338
Loa Loa (eye worm)	cathepsin B	0.0041	0.0487	0.055
Entamoeba histolytica	hypothetical protein	0.0041	0.0487	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1718	0.1944
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0041	0.0487	0.5
Echinococcus granulosus	cathepsin L cysteine protease	0.0115	0.3275	0.4142
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0107	0.2969	0.3703
Entamoeba histolytica	cysteine protease, putative	0.0041	0.0487	0.0661
Giardia lamblia	Cathepsin L-like protease	0.0041	0.0487	0.5
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0149	0.4576	0.4299
Entamoeba histolytica	cysteine protease, putative	0.0115	0.3275	0.4447
Leishmania major	cathepsin L-like protease	0.0223	0.7365	0.7365
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.4169	0.3871

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1185874

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1145888