TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 305.154 | Formula: C13H14Cl2O4
H donors: 2 H acceptors: 3 LogP: 2.92 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C[C@]1(O)CC(C)(C)Oc2c1c(Cl)c(cc2)Cl
InChi: 1S/C13H14Cl2O4/c1-12(2)6-13(18,5-9(16)17)10-8(19-12)4-3-7(14)11(10)15/h3-4,18H,5-6H2,1-2H3,(H,16,17)/t13-/m0/s1
InChiKey: DNKZZHMXQUVUBS-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldo-keto reductase family 1, member B1 (aldose reductase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma cruzi	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	see also nonallelic CaP19.2244	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma brucei	prostaglandin f synthase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	prostaglandin f2-alpha synthase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Entamoeba histolytica	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma mansoni	pol-related	Get druggable targets OG5_126583	All targets in OG5_126583
Entamoeba histolytica	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium tuberculosis	Probable oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma mansoni	aldo-keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Entamoeba histolytica	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma congolense	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma brucei gambiense	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Neospora caninum	Oxidoreductase, aldo/keto reductase family, related	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania braziliensis	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldehyde reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma japonicum	ko:K00011 aldehyde reductase [EC1.1.1.21], putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma cruzi	aldo-keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldehyde reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium ulcerans	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma mansoni	aldo-keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma congolense	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma brucei gambiense	prostaglandin f synthase. putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania mexicana	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Giardia lamblia	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	see also nonallelic CaP19.2244	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium leprae	Conserved hypothetical protein	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	aldehyde reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania braziliensis	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Schistosoma japonicum	IPR001395,Aldo/keto reductase,domain-containing	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania braziliensis	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	Get druggable targets OG5_126583	All targets in OG5_126583
Toxoplasma gondii	aldose reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	aldo-keto reductase-like protein	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Trichomonas vaginalis	aldo/keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Loa Loa (eye worm)	oxidoreductase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	prostaglandin f synthase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Trypanosoma brucei	aldo-keto reductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase family 1, member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus granulosus	aldo keto reductase family 1 member B4	Get druggable targets OG5_126583	All targets in OG5_126583
Candida albicans	similar to mammalian aldo/keto reductases	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Giardia lamblia	Aldose reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Echinococcus multilocularis	aldo keto reductase	Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Onchocerca volvulus		Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania infantum	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	Get druggable targets OG5_126583	All targets in OG5_126583
Leishmania donovani	prostaglandin f2-alpha synthase	Get druggable targets OG5_126583	All targets in OG5_126583

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Conserved protein	aldo-keto reductase family 1, member B1 (aldose reductase)	316 aa	325 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4095	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.2384	0.5692	0.5692
Entamoeba histolytica	cysteine proteinase, putative	0.2384	0.5692	1
Plasmodium vivax	unspecified product	0.1281	0.2917	0.4054
Brugia malayi	Cathepsin L-like precursor	0.2384	0.5692	0.5692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.053	0.1025	0.1025
Entamoeba histolytica	cysteine proteinase, putative	0.1281	0.2917	0.4054
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.053	0.1025	0.18
Loa Loa (eye worm)	hypothetical protein	0.4095	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.053	0.1025	0.18
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0621	0.1254	0.1254
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Trypanosoma cruzi	cysteine peptidase, putative	0.2384	0.5692	0.5201
Trypanosoma cruzi	cysteine proteinase, putative	0.1281	0.2917	0.2108
Brugia malayi	Papain family cysteine protease containing protein	0.1281	0.2917	0.2917
Onchocerca volvulus	Cathepsin L homolog	0.2384	0.5692	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2384	0.5692	0.5692
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.053	0.1025	0.18
Loa Loa (eye worm)	hypothetical protein	0.053	0.1025	0.1025
Trypanosoma cruzi	cysteine protease, putative	0.1281	0.2917	0.2108
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.058	0.1151	0.2021
Brugia malayi	Cathepsin L-like precursor	0.2384	0.5692	0.5692
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.053	0.1025	0.18
Entamoeba histolytica	cysteine proteinase 2	0.1281	0.2917	0.4054
Plasmodium vivax	vivapain-2	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.053	0.1025	0.18
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.053	0.1025	0.1025
Toxoplasma gondii	cathepsin CPL	0.2384	0.5692	1
Brugia malayi	Cathepsin L-like precursor	0.2384	0.5692	0.5692
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Loa Loa (eye worm)	hypothetical protein	0.1632	0.38	0.38
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.053	0.1025	0.18
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.053	0.1025	0.18
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.053	0.1025	0.18
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.053	0.1025	0.18
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Plasmodium vivax	vivapain-3	0.1281	0.2917	0.4054
Echinococcus multilocularis	cathepsin L	0.1281	0.2917	0.2917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.053	0.1025	0.1025
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1632	0.3801	0.3801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Loa Loa (eye worm)	hypothetical protein	0.2384	0.5692	0.5692
Echinococcus multilocularis	voltage gated potassium channel	0.018	0.0144	0.0144
Brugia malayi	Cathepsin L-like precursor	0.1632	0.38	0.38
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0621	0.1254	0.1254
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4095	1	1
Onchocerca volvulus	Cathepsin F homolog	0.2384	0.5692	1
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.053	0.1025	0.18
Trypanosoma cruzi	cysteine peptidase, putative	0.2384	0.5692	0.5201
Loa Loa (eye worm)	hypothetical protein	0.018	0.0144	0.0144
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2384	0.5692	1
Onchocerca volvulus		0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.053	0.1025	0.1025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Brugia malayi	Cathepsin L-like precursor	0.2384	0.5692	0.5692
Onchocerca volvulus		0.2384	0.5692	1
Echinococcus granulosus	cathepsin l1	0.2384	0.5692	0.5692
Loa Loa (eye worm)	hypothetical protein	0.053	0.1025	0.1025
Entamoeba histolytica	cysteine protease, putative	0.2384	0.5692	1
Echinococcus multilocularis	cathepsin b	0.4095	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4095	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.053	0.1025	0.1025
Onchocerca volvulus		0.2384	0.5692	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.053	0.1025	0.1025
Brugia malayi	cathepsin F-like cysteine proteinase	0.053	0.1025	0.1025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4095	1	1
Onchocerca volvulus		0.2384	0.5692	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2384	0.5692	0.5692
Schistosoma mansoni	cathepsin F (C01 family)	0.1632	0.38	0.38
Trypanosoma cruzi	cysteine proteinase, putative	0.1281	0.2917	0.2108
Entamoeba histolytica	cysteine proteinase, putative	0.1281	0.2917	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.053	0.1025	0.1025
Plasmodium vivax	vivapain-1	0.1281	0.2917	0.4054
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0621	0.1254	0.1254
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1281	0.2917	0.2917
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1281	0.2917	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.053	0.1025	0.18
Trypanosoma cruzi	cysteine peptidase, putative	0.2384	0.5692	0.5201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1632	0.3801	0.3183
Plasmodium vivax	unspecified product	0.0752	0.1583	0.1196
Echinococcus multilocularis	cysteine protease	0.2384	0.5692	0.5692
Schistosoma mansoni	cathepsin B (C01 family)	0.053	0.1025	0.1025
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0752	0.1583	0.1583
Trypanosoma cruzi	cruzipain precursor, putative	0.2384	0.5692	0.5201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1281	0.2917	0.5124
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1632	0.3801	0.6677
Echinococcus multilocularis	cathepsin L cysteine protease	0.2384	0.5692	0.5692
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.053	0.1025	0.18
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.018	0.0144	0.0144
Echinococcus granulosus	cathepsin L cysteine protease	0.1281	0.2917	0.2917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1632	0.38	0.6676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2384	0.5692	1
Echinococcus multilocularis	cathepsin L	0.053	0.1025	0.1025
Schistosoma mansoni	cathepsin s	0.0752	0.1583	0.1583
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2384	0.5692	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1281	0.2917	0.2917
Onchocerca volvulus		0.2384	0.5692	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Loa Loa (eye worm)	hypothetical protein	0.053	0.1025	0.1025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Schistosoma mansoni	cathepsin C	0.053	0.1025	0.1025
Giardia lamblia	Cathepsin B precursor	0.1632	0.3801	1
Entamoeba histolytica	cysteine proteinase, putative	0.1281	0.2917	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2384	0.5692	0.5692
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2384	0.5692	0.5692
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.053	0.1025	0.1025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.053	0.1025	0.1025
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Loa Loa (eye worm)	hypothetical protein	0.053	0.1025	0.1025
Echinococcus multilocularis	cathepsin b	0.4095	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2384	0.5692	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.053	0.1025	0.1025
Trypanosoma cruzi	cysteine peptidase, putative	0.2384	0.5692	0.5201
Brugia malayi	cathepsin Z-like cysteine proteinase	0.053	0.1025	0.1025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.053	0.1025	0.18
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1281	0.2917	0.2917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Loa Loa (eye worm)	hypothetical protein	0.053	0.1025	0.1025
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1281	0.2917	0.4054
Loa Loa (eye worm)	hypothetical protein	0.1632	0.38	0.38
Brugia malayi	Cathepsin L-like precursor	0.2384	0.5692	0.5692
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2384	0.5692	0.5692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Brugia malayi	Papain family cysteine protease containing protein	0.053	0.1025	0.1025
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.1281	0.2917	0.2917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.053	0.1025	0.18
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Echinococcus granulosus	cathepsin L	0.053	0.1025	0.1025
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Onchocerca volvulus		0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Brugia malayi	cathepsin L-like precursor	0.1632	0.38	0.38
Brugia malayi	fibroinase precursor	0.053	0.1025	0.1025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4095	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2384	0.5692	0.5692
Loa Loa (eye worm)	ctsf protein	0.2384	0.5692	0.5692
Trichomonas vaginalis	conserved hypothetical protein	0.053	0.1025	0.18
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.053	0.1025	0.1025
Brugia malayi	Cathepsin L-like precursor	0.1632	0.38	0.38
Trichomonas vaginalis	conserved hypothetical protein	0.053	0.1025	0.18
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1632	0.3801	0.3093
Echinococcus granulosus	cathepsin L	0.1281	0.2917	0.2917
Schistosoma mansoni	hypothetical protein	0.1472	0.3398	0.3398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1281	0.2917	0.5124
Trypanosoma brucei	RNA helicase, putative	0.1472	0.3398	0.1732
Leishmania major	cysteine peptidase A (CPA)	0.2384	0.5692	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2384	0.5692	1
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0752	0.1583	0.0622
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0752	0.1583	0.1583
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0752	0.1583	0.1583
Loa Loa (eye worm)	cysteine protease	0.2384	0.5692	0.5692
Loa Loa (eye worm)	hypothetical protein	0.0539	0.1047	0.1047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Loa Loa (eye worm)	hypothetical protein	0.0752	0.1583	0.1583
Echinococcus granulosus	voltage gated potassium channel	0.018	0.0144	0.0144
Onchocerca volvulus	Cathepsin L homolog	0.2384	0.5692	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0752	0.1583	0.0622
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Echinococcus granulosus	cathepsin b	0.4095	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1281	0.2917	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0752	0.1583	0.1583
Onchocerca volvulus		0.2384	0.5692	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.2384	0.5692	0.5692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Giardia lamblia	Cathepsin B precursor	0.1632	0.3801	1
Schistosoma mansoni	voltage-gated potassium channel	0.0678	0.1397	0.1397
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.053	0.1025	0.18
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2384	0.5692	0.5692
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0621	0.1254	0.1254
Plasmodium vivax	vivapain-2	0.2384	0.5692	1
Echinococcus multilocularis	cysteine protease	0.2384	0.5692	0.5692
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.053	0.1025	0.18
Brugia malayi	Cathepsin L-like precursor	0.0752	0.1583	0.1583
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2384	0.5692	0.5692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1632	0.38	0.6676
Brugia malayi	Papain family cysteine protease containing protein	0.053	0.1025	0.1025
Echinococcus granulosus	cysteine protease	0.1281	0.2917	0.2917
Echinococcus granulosus	cathepsin l1	0.1632	0.38	0.38
Loa Loa (eye worm)	hypothetical protein	0.0752	0.1583	0.1583
Giardia lamblia	Cathepsin B precursor	0.1632	0.3801	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.053	0.1025	0.1025
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Schistosoma mansoni	cathepsin S (C01 family)	0.053	0.1025	0.1025
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Leishmania major	cathepsin L-like protease	0.2384	0.5692	1
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.0144	0.0144
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.1281	0.2917	0.4054
Loa Loa (eye worm)	fibroinase	0.2384	0.5692	0.5692
Brugia malayi	cathepsin L precursor	0.053	0.1025	0.1025
Loa Loa (eye worm)	hypothetical protein	0.1632	0.38	0.38
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1632	0.38	0.3092
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.053	0.1025	0.18
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2384	0.5692	1
Schistosoma mansoni	voltage-gated potassium channel	0.0678	0.1397	0.1397
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.053	0.1025	0.1025
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.053	0.1025	0.1025
Trypanosoma cruzi	cysteine peptidase, putative	0.1281	0.2917	0.2108
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.0144	0.0144
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1632	0.38	0.38
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.058	0.1151	0.2021
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.053	0.1025	0.1025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2384	0.5692	1
Entamoeba histolytica	cysteine proteinase, putative	0.1632	0.38	0.5946
Loa Loa (eye worm)	cathepsin B	0.1632	0.3801	0.3801
Entamoeba histolytica	cysteine protease, putative	0.1281	0.2917	0.4054
Brugia malayi	Cathepsin L-like precursor	0.2384	0.5692	0.5692
Loa Loa (eye worm)	hypothetical protein	0.053	0.1025	0.1025
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.018	0.0144	0.0144
Entamoeba histolytica	cysteine proteinase, putative	0.2384	0.5692	1
Echinococcus granulosus	cathepsin b	0.4095	1	1
Toxoplasma gondii	cathepsin B	0.1632	0.3801	0.5947
Brugia malayi	Papain family cysteine protease containing protein	0.053	0.1025	0.1025
Onchocerca volvulus		0.1632	0.38	0.5946
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.018	0.0144	0.0144

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 14.8 uM	Inhibitory activity against human placental aldose reductase	ChEMBL.	1613744
IC50 (binding)	= 14.8 uM	Inhibitory activity against human placental aldose reductase	ChEMBL.	1613744

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 114591