Detailed information for compound 1146143

Basic information

Technical information
  • TDR Targets ID: 1146143
  • Name: N-[(3-methoxy-4-tetradecoxyphenyl)methyl]-3-[ (5-methyl-1,3-thiazol-3-ium-3-yl)methyl]benza mide
  • MW: 565.829 | Formula: C34H49N2O3S+
  • H donors: 1 H acceptors: 1 LogP: 10.46 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCOc1ccc(cc1OC)CNC(=O)c1cccc(c1)C[n+]1csc(c1)C
  • InChi: 1S/C34H48N2O3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-21-39-32-20-19-29(23-33(32)38-3)24-35-34(37)31-18-16-17-30(22-31)26-36-25-28(2)40-27-36/h16-20,22-23,25,27H,4-15,21,24,26H2,1-3H3/p+1
  • InChiKey: NJIQHHFEESASQI-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • N-[(3-methoxy-4-tetradecoxy-phenyl)methyl]-3-[(5-methylthiazol-3-ium-3-yl)methyl]benzamide
  • N-[(3-methoxy-4-tetradecoxyphenyl)methyl]-3-[(5-methyl-3-thiazol-3-iumyl)methyl]benzamide
  • N-(3-methoxy-4-myristyloxy-benzyl)-3-[(5-methylthiazol-3-ium-3-yl)methyl]benzamide
  • N-[(3-methoxy-4-tetradecoxy-phenyl)methyl]-3-[(5-methyl-1,3-thiazol-3-ium-3-yl)methyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0071 0.1267
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0073 0.0576 0.3481
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.8162 0.8157
Schistosoma mansoni hypothetical protein 0.005 0.0303 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0317 0.3278
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.0879
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0161 0.3745
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0048 0.0287
Plasmodium vivax acyl-CoA synthetase, putative 0.0073 0.0576 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0871 0.5121
Onchocerca volvulus 0.0098 0.0871 0.8689
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.1338 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0048 0.0432
Echinococcus granulosus biogenic amine 5HT receptor 0.0407 0.4559 0.4545
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.1338 0.8085
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0026 0.0024
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0349 0.5709
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0871 0.5121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.1174 0.7095
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1143 0.3049
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0193 0.0432
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0317 0.0791
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0048 0.0287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0528 0.3194
Brugia malayi Thioredoxin reductase 0.0054 0.0349 0.0878
Onchocerca volvulus 0.0029 0.0048 0.0226
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0375 0.0971
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0098 0.0871 0.5121
Echinococcus multilocularis musashi 0.0056 0.0375 0.0351
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.1338 0.8085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0098 0.0871 0.5261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0067 0.1138
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0317 0.0814
Mycobacterium ulcerans hypothetical protein 0.0098 0.0871 0.5121
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0048 0.0027
Loa Loa (eye worm) TAR-binding protein 0.0336 0.3713 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0067 0.1138
Plasmodium falciparum acyl-CoA synthetase 0.0073 0.0576 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0816 0.9435 0.9434
Onchocerca volvulus 0.0108 0.0998 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0048 0.0287
Echinococcus multilocularis tar DNA binding protein 0.0336 0.3713 0.3697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0103 0.2387
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.034 0.087
Schistosoma mansoni tar DNA-binding protein 0.0336 0.3713 0.4532
Plasmodium falciparum glutathione reductase 0.0054 0.0349 0.5709
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Echinococcus granulosus intermediate filament protein 0.0056 0.0375 0.0351
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.015 0.1492 0.3993
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0871 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0048 0.006
Schistosoma mansoni tar DNA-binding protein 0.0336 0.3713 0.4532
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0048 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Schistosoma mansoni hypothetical protein 0.005 0.0303 0.0341
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0048 0.0432
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.012 0.0116
Schistosoma mansoni intermediate filament proteins 0.0056 0.0375 0.043
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0317 0.0803
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.0084
Onchocerca volvulus 0.0029 0.0048 0.0226
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0997 0.2634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0036 0.0018
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0349 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0528 0.3194
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Entamoeba histolytica acyl-coA synthetase, putative 0.0098 0.0871 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0098 0.0871 0.5121
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0026 0.0024
Echinococcus multilocularis lamin dm0 0.0056 0.0375 0.0351
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.1174 0.7095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.0084
Echinococcus granulosus lamin 0.0056 0.0375 0.0351
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0048 0.0287
Echinococcus granulosus biogenic amine 5HT receptor 0.015 0.1492 0.1471
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0349 0.0325
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0048 0.0287
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0303 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0192 0.556
Loa Loa (eye worm) hypothetical protein 0.015 0.1492 0.3993
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0029 0.0003
Echinococcus multilocularis GPCR, family 2 0.005 0.0303 0.0278
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0026 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.1594 0.4255
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.012 0.0095
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.0879
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0048 0.0084
Echinococcus granulosus lamin dm0 0.0056 0.0375 0.0351
Brugia malayi hypothetical protein 0.0035 0.012 0.0256
Leishmania major mitochondrial DNA polymerase beta 0.031 0.3406 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0098 0.0871 0.2311
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0048 0.006
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.1174 0.873
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0317 0.0803
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0336 0.3713 0.4532
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0226 0.0531
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1457 0.4196
Schistosoma mansoni hypothetical protein 0.005 0.0303 0.0341
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0098 0.0871 0.2311
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0375 0.0949
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1143 0.3049
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0048 0.006
Echinococcus granulosus tumor protein p63 0.0741 0.8537 0.8533
Echinococcus granulosus tar DNA binding protein 0.0336 0.3713 0.3697
Brugia malayi Latrophilin receptor protein 2 0.005 0.0303 0.0753
Loa Loa (eye worm) RNA binding protein 0.0336 0.3713 1
Schistosoma mansoni hypothetical protein 0.0035 0.012 0.0116
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1457 0.4196
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0064 0.0105
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0317 0.0803
Trypanosoma brucei trypanothione reductase 0.0054 0.0349 0.0898
Loa Loa (eye worm) hypothetical protein 0.0108 0.0998 0.2656
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0026 0.0024
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0026 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.1174 0.7095
Leishmania major trypanothione reductase 0.0054 0.0349 0.0898
Mycobacterium ulcerans hypothetical protein 0.0163 0.1655 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0073 0.0576 0.1514
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0026 0.0024
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1457 0.4196
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0871 0.6378
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0871 0.2292
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0048 0.006
Echinococcus multilocularis tumor protein p63 0.0741 0.8537 0.8533
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0048 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0576 0.3288
Loa Loa (eye worm) hypothetical protein 0.0073 0.0576 0.1514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Schistosoma mansoni biogenic amine (5HT) receptor 0.015 0.1492 0.1803
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0048 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0317 1
Echinococcus multilocularis serotonin receptor 0.015 0.1492 0.1471
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0116 0.2856
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0026 0.0024
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0317 0.0803
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0528 0.3194
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0871 0.2292
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0317 0.0803
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0098 0.0871 0.5121
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0193 0.0432
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.0998 0.1195
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0226 0.0531
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Toxoplasma gondii hypothetical protein 0.005 0.0302 0.8445
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0528 0.3194
Brugia malayi RNA binding protein 0.0336 0.3713 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.444
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0317 0.0359
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0317 0.3278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0073 0.0576 0.1514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0303 0.0278
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0048 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0336 0.3713 0.4532
Echinococcus granulosus microtubule associated protein 2 0.0709 0.8162 0.8157
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Brugia malayi MH2 domain containing protein 0.0121 0.1143 0.3032
Mycobacterium tuberculosis Probable reductase 0.0123 0.1174 0.7095
Giardia lamblia GTOR 0.0051 0.0317 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0303 0.0278
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0064 0.0129
Loa Loa (eye worm) hypothetical protein 0.005 0.0303 0.0775
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0871 0.245
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0026 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.444
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0871 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0407 0.4559 0.5572
Loa Loa (eye worm) hypothetical protein 0.0108 0.0997 0.2652
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0048 0.0287
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.3406 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0303 0.0278
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Schistosoma mansoni lamin 0.0056 0.0375 0.043
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.1338 0.8085
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0048 0.0287
Onchocerca volvulus 0.0029 0.0048 0.0226
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.1174 0.7095
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0226 0.0531
Echinococcus multilocularis lamin 0.0056 0.0375 0.0351
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0098 0.0871 0.5121
Loa Loa (eye worm) hypothetical protein 0.0098 0.0871 0.2311
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0349 0.09
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0192 0.556
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0029 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.444
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.3406 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0048 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0158 0.1594 0.4269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0192 0.556
Schistosoma mansoni lamin 0.0056 0.0375 0.043
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0317 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Onchocerca volvulus 0.0056 0.0375 0.3598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.444
Toxoplasma gondii thioredoxin reductase 0.0054 0.0349 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0336 0.3713 0.4532
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0036 0.0018
Brugia malayi intermediate filament protein 0.0056 0.0375 0.0949
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0863 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0071 0.1267
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.012 0.0095
Brugia malayi RNA recognition motif domain containing protein 0.0336 0.3713 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0363 0.0938
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0375 0.0971
Plasmodium falciparum thioredoxin reductase 0.0054 0.0349 0.5709
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.1594 0.4255
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0036 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0048 0.006
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0073 0.0576 0.1514
Loa Loa (eye worm) hypothetical protein 0.0056 0.0375 0.0971
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0073 0.0576 0.5
Echinococcus granulosus GPCR family 2 0.005 0.0303 0.0278
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0317 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Schistosoma mansoni hypothetical protein 0.005 0.0303 0.0341
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.0879
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0871 0.2292
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.3406 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0407 0.4559 0.4545
Brugia malayi TAR-binding protein 0.0336 0.3713 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0303 0.0775
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0048 0.0287
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0098 0.0871 0.5261
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.8162 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0048 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0317 0.0803
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.0879
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.1174 0.7095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0071 0.1267
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0336 0.3713 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.444
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0303 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0192 0.556
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0193 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0161 0.444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0192 0.556
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0871 0.6378
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0226 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0228 0.6827
Echinococcus granulosus tm gpcr rhodopsin 0.0816 0.9435 0.9434
Brugia malayi glutathione reductase 0.0054 0.0349 0.0878
Loa Loa (eye worm) hypothetical protein 0.0073 0.0576 0.1514
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0871 0.245
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0026 0.0024
Echinococcus multilocularis serotonin receptor 0.015 0.1492 0.1471
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.1594 0.4269
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0349 0.0898
Onchocerca volvulus 0.0056 0.0375 0.3598
Onchocerca volvulus 0.0029 0.0048 0.0226
Loa Loa (eye worm) oxidoreductase 0.0029 0.0048 0.0084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.1655 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0349 0.2111
Plasmodium vivax glutathione reductase, putative 0.0054 0.0349 0.5709
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Loa Loa (eye worm) glutathione reductase 0.0054 0.0349 0.09
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0024
Schistosoma mansoni hypothetical protein 0.0108 0.0997 0.1194
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0871 0.5121
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0871 0.245

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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