Detailed information for compound 1146245

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.713 | Formula: C27H52N2O3
  • H donors: 1 H acceptors: 2 LogP: 9.76 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCC/C=C\N(C(=O)CCCCCCCCC)NC(=O)COC
  • InChi: 1S/C27H52N2O3/c1-4-6-8-10-12-13-14-15-16-18-20-22-24-29(28-26(30)25-32-3)27(31)23-21-19-17-11-9-7-5-2/h22,24H,4-21,23,25H2,1-3H3,(H,28,30)/b24-22-
  • InChiKey: HZOWHYHEDAUGGZ-GYHWCHFESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia 20S proteasome alpha subunit 2 0.0167 0.2007 0.2303
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi proteasome subunit alpha type 2 0.0167 0.2007 0.2083
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Echinococcus granulosus adhesion regulating molecule 1 0.0085 0.0908 0.0908
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Echinococcus granulosus proteasome subunit beta type 7 0.0731 0.9637 0.9637
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0157 0.1876 0.2153
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0141 0.0141
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0029 0.0147 0.0147
Leishmania major proteasome beta 5 subunit, putative 0.0663 0.871 1
Schistosoma mansoni hypothetical protein 0.0079 0.0823 0.0823
Onchocerca volvulus Notchless protein homolog 0.0164 0.1966 1
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0173 0.2097 0.2407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.005 0.005
Plasmodium vivax proteasome subunit beta type-4, putative 0.0155 0.1855 0.213
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0027 0.0126 0.0126
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0035 0.0233 0.0266
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0162 0.194 0.2227
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0155 0.1855 0.2129
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0233 0.0266
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Giardia lamblia Proteasome subunit beta type 1 0.0182 0.2212 0.2538
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0162 0.1946 0.2233
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0019 0.0016 0.0019
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0157 0.1876 0.1876
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0126 0.0144
Echinococcus multilocularis proteasome subunit beta type 6 0.0162 0.1951 0.1951
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0107 0.0121
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2925
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0155 0.1855 0.1855
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0035 0.0226 0.0226
Onchocerca volvulus 0.0034 0.0216 0.1096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0141 0.0141
Brugia malayi Probable 26S protease regulatory subunit 4 0.0018 0.0001 0.0001
Leishmania major DNA polymerase eta, putative 0.0035 0.0235 0.027
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0019 0.0014 0.0014
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0018 0.0001 0.0002
Mycobacterium ulcerans proteasome PrcB 0.0663 0.871 1
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0157 0.1876 0.1876
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.005 0.0057
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0141 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Brugia malayi proteasome subunit alpha type 3 0.0164 0.1966 0.204
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0663 0.871 1
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0438 0.0454
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0254 0.0254
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.005 0.005
Loa Loa (eye worm) trypsin family protein 0.0034 0.0216 0.0216
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0199 0.0229
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0033 0.0199 0.0207
Echinococcus granulosus glycoprotein Antigen 5 0.0034 0.0216 0.0216
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0172 0.2085 0.2393
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0019 0.0014 0.0015
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0057 0.0526 0.0526
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.0526 0.0546
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2406
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0107 0.0123
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0167 0.2007 0.2304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0141 0.0141
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0162 0.194 0.194
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.008
Plasmodium vivax proteasome subunit beta type-3, putative 0.0157 0.1876 0.2153
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0194 0.0987
Giardia lamblia 20S proteasome alpha subunit 5 0.0172 0.2085 0.2393
Onchocerca volvulus 0.0034 0.0216 0.1096
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0162 0.1951 0.224
Echinococcus granulosus subfamily T1A non peptidase ue 0.0172 0.2085 0.2085
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0167 0.2007 0.2007
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0019 0.0014 0.0074
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0018 0.0001 0.0001
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0155 0.1855 0.213
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0015 0.0018
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.0526 0.0546
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0162 0.1946 0.2234
Brugia malayi proteasome subunit beta type 2 0.0157 0.1876 0.1946
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.0526 0.0546
Leishmania major carbonic anhydrase-like protein 0.0153 0.183 0.2101
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.003 0.0159 0.0182
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0035 0.0233 0.0268
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0141 0.0141
Trypanosoma brucei unspecified product 0.0022 0.005 0.0056
Echinococcus granulosus carbonic anhydrase 0.0057 0.0526 0.0526
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0196 0.0196
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0027 0.0124 0.014
Echinococcus granulosus transmembrane protease serine 3 0.0034 0.0216 0.0216
Trypanosoma cruzi 20S proteasome subunit 0.0157 0.1876 0.2153
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0153 0.183 0.183
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0157 0.1876 0.2153
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0141 0.0146
Brugia malayi Proteasome A-type and B-type family protein 0.0162 0.1951 0.2025
Loa Loa (eye worm) proteasome regulatory particle 0.0033 0.0199 0.0199
Toxoplasma gondii 26s proteasome subunit p55, putative 0.003 0.0159 0.0182
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Plasmodium vivax proteasome subunit beta type-7, putative 0.0207 0.2558 0.2937
Loa Loa (eye worm) hypothetical protein 0.0303 0.3854 0.3854
Schistosoma mansoni hypothetical protein 0.0174 0.2104 0.2104
Trypanosoma brucei DNA polymerase eta, putative 0.005 0.0438 0.0501
Toxoplasma gondii proteasome subunit alpha1, putative 0.0173 0.2097 0.2407
Trichomonas vaginalis 26S proteasome subunit, putative 0.0027 0.0124 0.014
Giardia lamblia 20S proteasome alpha subunit 1 0.0173 0.2097 0.2406
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0033 0.0199 0.0227
Loa Loa (eye worm) solute carrier family 8 0.0758 1 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0182 0.2212 0.2539
Onchocerca volvulus 0.0018 0.0001 0.0007
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0133 0.1552 0.1782
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0162 0.194 0.194
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2393
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Echinococcus multilocularis proteasome subunit alpha type 6 0.0173 0.2097 0.2097
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0152 0.1809 0.2076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0141 0.0146
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0018 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0182 0.2212 0.2212
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0141 0.0141
Treponema pallidum hypothetical protein 0.0019 0.0014 0.5
Loa Loa (eye worm) proteasome subunit beta type 1 0.0182 0.2212 0.2212
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0035 0.0233 0.0268
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0207 0.2547 0.2925
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Leishmania major proteasome beta 2 subunit, putative 0.0207 0.2558 0.2937
Plasmodium vivax proteasome subunit beta type-1, putative 0.0182 0.2212 0.2539
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0164 0.1966 0.1966
Brugia malayi ecdysteroid receptor 0.0028 0.0141 0.0146
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0155 0.1855 0.1855
Schistosoma mansoni carbonic anhydrase 0.0057 0.0526 0.0526
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0141 0.0141
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0157 0.1876 0.2152
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.005 0.0056
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0157 0.0163
Loa Loa (eye worm) hypothetical protein 0.0592 0.7759 0.7759
Echinococcus granulosus death domain containing protein 0.0032 0.0194 0.0194
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0133 0.1552 0.1782
Plasmodium falciparum cation/H+ antiporter 0.0019 0.0014 0.0017
Loa Loa (eye worm) PAS-3 protein 0.0147 0.1748 0.1748
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0019 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0037 0.0254 0.029
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0167 0.2007 0.2303
Brugia malayi PCI domain containing protein 0.003 0.0159 0.0164
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0033 0.0199 0.0229
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0126 0.0144
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0057 0.0526 0.0526
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2233
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0155 0.1855 0.213
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0141 0.0146
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0172 0.2085 0.2085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Schistosoma mansoni netrin receptor unc5 0.0032 0.0194 0.0194
Echinococcus granulosus nuclear factor of activated T cells 5 0.0317 0.4041 0.4041
Schistosoma mansoni hypothetical protein 0.0053 0.0472 0.0472
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0016 0.0019
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0019 0.0016 0.0017
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0194 0.0194
Giardia lamblia Proteasome subunit beta type 2 0.0157 0.1876 0.2152
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0133 0.1552 0.1768
Giardia lamblia 20S proteasome alpha subunit 4 0.0207 0.2547 0.2924
Brugia malayi Protein kinase domain containing protein 0.0032 0.0194 0.0201
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0162 0.194 0.2227
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0085 0.0908 0.0942
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.003 0.0157 0.018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0141 0.0146
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0164 0.1966 0.2256
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0148 0.175 0.2008
Toxoplasma gondii heat shock protein hslv, putative 0.0133 0.1552 0.1782
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0194 0.0194
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0172 0.2085 0.2393
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0015 0.0015
Toxoplasma gondii proteasome 26S regulatory subunit 0.0019 0.0009 0.001
Leishmania major DNA polymerase kappa, putative 0.0022 0.005 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0141 0.0141
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0157 0.1876 0.1876
Loa Loa (eye worm) hypothetical protein 0.0194 0.2375 0.2375
Mycobacterium ulcerans hypothetical protein 0.0034 0.0216 0.0191
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0001 0.0002
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.002 0.0031 0.0034
Plasmodium vivax proteasome subunit beta type-5, putative 0.0663 0.871 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0182 0.2212 0.2538
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0018 0.0001 0.0002
Echinococcus multilocularis transmembrane protease serine 3 0.0034 0.0216 0.0216
Leishmania major proteasome beta 2 subunit, putative 0.0157 0.1876 0.2153
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi Proteasome subunit alpha type 7-1 0.0207 0.2547 0.2643
Toxoplasma gondii peptidase, T1 family protein 0.0164 0.1966 0.2257
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0141 0.0141
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.0526 0.0526
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0141 0.0141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Echinococcus granulosus enteropeptidase 0.0034 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0141 0.0146
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0141 0.0141
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0027 0.0126 0.0144
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0147 0.0152
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0085 0.0908 0.0908
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0027 0.0124 0.0124
Loa Loa (eye worm) RPT-2 protein 0.0018 0.0001 0.0001
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0284 0.0326
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Plasmodium falciparum proteasome subunit beta type-4 0.0155 0.1855 0.213
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0141 0.0141
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0133 0.1552 0.1552
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2407
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0126 0.0144
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0157 0.1876 0.1876
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2234
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0019 0.0016 0.0016
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0164 0.1966 0.1966
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi proteasome subunit alpha type 6 0.0173 0.2097 0.2176
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0172 0.2085 0.2394
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0173 0.2097 0.2406
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Brugia malayi 20S proteasome alpha5 subunit 0.0172 0.2085 0.2164
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0153 0.183 0.2101
Toxoplasma gondii hypothetical protein 0.0057 0.0526 0.0604
Echinococcus granulosus carbonic anhydrase II 0.0153 0.183 0.183
Giardia lamblia Hypothetical protein 0.0033 0.0199 0.0227
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.003 0.0159 0.018
Leishmania major proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2234
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0164 0.1966 0.2257
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0133 0.1552 0.1782
Echinococcus multilocularis carbonic anhydrase 0.0057 0.0526 0.0526
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0107 0.0107
Leishmania major proteasome alpha 7 subunit, putative 0.0164 0.1966 0.2257
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0167 0.2007 0.2304
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0107
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0039 0.0284 0.0294
Plasmodium falciparum carbonic anhydrase 0.0057 0.0526 0.0604
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0019 0.0014 0.0015
Echinococcus granulosus proteasome subunit beta type 6 0.0162 0.1951 0.1951
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0019 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0141 0.0141
Schistosoma mansoni 26S proteasome subunit S9 0.0033 0.0199 0.0199
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0172 0.2085 0.2085
Brugia malayi proteasome subunit alpha type 4 0.0147 0.1748 0.1814
Leishmania major proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2925
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0018 0.0001 0.0002
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0134 0.1563 0.1793
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.003 0.0159 0.0182
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0133 0.1552 0.1782
Echinococcus granulosus carbonic anhydrase 0.0057 0.0526 0.0526
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0027 0.0126 0.0144
Toxoplasma gondii proteasome subunit 0.0162 0.1951 0.224
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0164 0.1966 0.2257
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0157 0.1876 0.1876
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Brugia malayi PCI domain containing protein 0.0027 0.0124 0.0128
Toxoplasma gondii hypothetical protein 0.0024 0.008 0.0092
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0182 0.2212 0.2539
Echinococcus multilocularis glycoprotein Antigen 5 0.0034 0.0216 0.0216
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0141 0.0146
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0207 0.2547 0.2924
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0124 0.0142
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0141 0.0141
Giardia lamblia 20S proteasome alpha subunit 7 0.0164 0.1966 0.2256
Onchocerca volvulus 0.0034 0.0216 0.1096
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0162 0.194 0.2226
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0035 0.0226 0.0259
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Toxoplasma gondii proteasome subunit alpha type, putative 0.0162 0.1946 0.2234
Trypanosoma brucei proteasome beta 7 subunit 0.0155 0.1855 0.2129
Brugia malayi Death domain containing protein 0.0032 0.0194 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0015
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0731 0.9637 0.9637
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0216 0.0216
Giardia lamblia 26S protease regulatory subunit 6A 0.0019 0.0016 0.0017
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0019 0.0016 0.0019
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0172 0.2085 0.2085
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0207 0.2558 0.2937
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0162 0.194 0.2226
Echinococcus multilocularis sodium calcium exchanger 0.0758 1 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0182 0.2212 0.2539
Echinococcus granulosus dna polymerase eta 0.005 0.0438 0.0438
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2407
Schistosoma mansoni hypothetical protein 0.0032 0.0194 0.0194
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.0526 0.0546
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0207 0.2547 0.2924
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0056
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0153 0.183 0.183
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0019 0.0014 0.0015
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0019 0.0014 0.0014
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0172 0.2085 0.2085
Schistosoma mansoni hypothetical protein 0.0174 0.2104 0.2104
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0141 0.0141
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0033 0.0199 0.0229
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0141 0.0146
Echinococcus granulosus carbonic anhydrase 0.0057 0.0526 0.0526
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0194 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0158 0.1887 0.1887
Schistosoma mansoni coup transcription factor 0.0028 0.0141 0.0141
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0085 0.0908 0.0908
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0663 0.871 1
Leishmania major proteasome alpha 2 subunit, putative 0.0167 0.2007 0.2304
Brugia malayi proteasome subunit alpha type 1 0.0162 0.194 0.2013
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0162 0.1951 0.224
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0167 0.2007 0.2303
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0162 0.1946 0.2233
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0153 0.183 0.2101
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0054 0.0487 0.2478
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Echinococcus granulosus proteasome prosome macropain 0.0663 0.871 0.871
Echinococcus multilocularis adhesion regulating molecule 1 0.0085 0.0908 0.0908
Echinococcus multilocularis dna polymerase kappa 0.0022 0.005 0.005
Echinococcus granulosus dna polymerase kappa 0.0022 0.005 0.005
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0162 0.1951 0.1951
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0107 0.0123
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0182 0.2212 0.2539
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0207 0.2558 0.2936
Toxoplasma gondii proteasome regulatory subunit 0.0027 0.0126 0.0144
Brugia malayi Ubiquitin interaction motif family protein 0.0019 0.0015 0.0016
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0167 0.2007 0.2304
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0027 0.0124 0.0124
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0027 0.0126 0.0126
Brugia malayi nuclear hormone receptor 0.0028 0.0141 0.0146
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.005 0.005
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0016 0.0016
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0027 0.0126 0.013
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0182 0.2212 0.2212
Toxoplasma gondii manganese resistance 1 protein, putative 0.0019 0.0014 0.0017
Brugia malayi Proteasome A-type and B-type family protein 0.0663 0.871 0.9038
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0141 0.0141
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0044 0.0356 0.0409
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0026 0.0107 0.0107
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0194 0.2375 0.2464
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0162 0.1946 0.2234
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.003 0.0159 0.0159
Leishmania major proteasome beta 7 subunit, putative 0.0155 0.1855 0.213
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0039 0.0284 0.0284
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0155 0.1855 0.1855
Giardia lamblia 26S proteasome regulatory subunit, putative 0.002 0.0031 0.0034
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0034 0.0216 0.0224
Brugia malayi Proteasome A-type and B-type family protein 0.0155 0.1855 0.1925
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0039 0.0284 0.0324
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0141 0.0141
Leishmania major proteasome beta 3 subunit, putative 0.0157 0.1876 0.2153
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.003 0.0157 0.018
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0079 0.0823 0.0823
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0173 0.2097 0.2407
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0018 0.0001 0.0001
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0019 0.0015 0.0015
Schistosoma mansoni multiubiquitin binding protein S5a 0.0019 0.0015 0.0015
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.005 0.0056
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0039 0.0284 0.0326
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0155 0.1855 0.2129
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0164 0.1966 0.1966
Brugia malayi Proteasome subunit alpha type 1 0.0147 0.1742 0.1807
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0157 0.1876 0.1876
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.003 0.0159 0.0159
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0182 0.2212 0.2212
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.005 0.0056
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0157 0.0157
Brugia malayi 26S proteasome subunit P45 family protein 0.0018 0.0001 0.0001
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.003 0.0157 0.0179
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0141 0.0141
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0663 0.871 1
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0157 0.1876 0.2153
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0019 0.0016 0.0016
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0018 0.0001 0.0002
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0033 0.0199 0.0227
Loa Loa (eye worm) proteasome subunit beta type 2 0.0157 0.1876 0.1876
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0133 0.1552 0.1782
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0317 0.4041 0.4041
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0019 0.0016 0.0019
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0182 0.2212 0.2538
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0663 0.871 0.871
Echinococcus multilocularis proteasome (prosome, macropain) 0.0663 0.871 0.871
Plasmodium vivax proteasome subunit beta type-2, putative 0.0157 0.1876 0.2153
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0141 0.0141
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.1876 0.2152
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.0526 0.0526
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0027 0.0126 0.0143
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0018 0.0001 0.0001
Leishmania major proteasome alpha 1 subunit, putative 0.0173 0.2097 0.2407
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.003 0.0157 0.018
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0141 0.0146
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0027 0.0126 0.0144
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0019 0.0014 0.0014
Toxoplasma gondii PCI domain-containing protein 0.0035 0.0233 0.0268
Echinococcus multilocularis Ankyrin 0.0033 0.0196 0.0196
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0438 0.0503
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Echinococcus granulosus proteasome subunit alpha type 6 0.0173 0.2097 0.2097
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0126 0.0143
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.003 0.0159 0.0182
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0141 0.0141
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0039 0.0284 0.0324
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0035 0.0233 0.0268
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0016 0.0016
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0141 0.0141
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0019 0.0016 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0141 0.0717
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0157 0.0179
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0157 0.018
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0207 0.2558 0.2936
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0079 0.0823 0.0823
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0162 0.1951 0.224
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2925
Brugia malayi hypothetical protein 0.0037 0.0254 0.0264
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0159 0.018
Brugia malayi Proteasome A-type and B-type family protein 0.0731 0.9637 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0173 0.2097 0.2406
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0663 0.871 1
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0027 0.0126 0.0143
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0663 0.871 0.871
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0226 0.0259
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0035 0.0226 0.0258
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0019 0.0015 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0141 0.0141
Loa Loa (eye worm) PCI domain-containing protein 0.0027 0.0124 0.0124
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0182 0.2212 0.2539
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0027 0.0126 0.013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0141 0.0717
Echinococcus multilocularis dna polymerase eta 0.005 0.0438 0.0438
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0019 0.0014 0.0014
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0162 0.1951 0.2239
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0107 0.0123
Echinococcus multilocularis carbonic anhydrase 0.0057 0.0526 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0141 0.0146
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0027 0.0126 0.0144
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0663 0.871 1
Brugia malayi proteasome subunit beta type 3 0.0157 0.1876 0.1946
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0164 0.1966 0.2256
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0027 0.0124 0.0142
Onchocerca volvulus 0.0034 0.0216 0.1096
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.003 0.0157 0.0179
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0162 0.1946 0.2233
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0172 0.2085 0.2393
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0019 0.0009 0.001
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.003 0.0157 0.0157
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0199 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Toxoplasma gondii proteasome subunit beta type, putative 0.0663 0.871 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0152 0.1809 0.2075
Leishmania major hypothetical protein, conserved 0.0044 0.0356 0.0409
Toxoplasma gondii PCI domain-containing protein 0.0033 0.0199 0.0229
Trypanosoma brucei proteasome alpha 7 subunit 0.0164 0.1966 0.2256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0141 0.0141
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0001 0.0002
Brugia malayi Trypsin-like protease protein 5 0.0034 0.0216 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0141 0.0141
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0018 0.0001 0.0001
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0157 0.1876 0.2152
Echinococcus multilocularis proteasome subunit alpha type 2 0.0167 0.2007 0.2007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0141 0.0146
Giardia lamblia 20S proteasome alpha subunit 3 0.0162 0.1946 0.2233
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0157 0.1876 0.2153
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0033 0.0199 0.0229
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0027 0.0126 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Echinococcus multilocularis proteasome subunit beta type 7 0.0731 0.9637 0.9637
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0107 0.0121
Echinococcus granulosus proteasome subunit beta t family 0.0157 0.1876 0.1876
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0157 0.1876 0.2152
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0133 0.1552 0.178
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0207 0.2558 0.2936
Brugia malayi Sodium/calcium exchanger protein 0.0303 0.3854 0.3999
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0026 0.0113 0.013
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0153 0.183 0.183
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0173 0.2097 0.2097
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0034 0.0216 0.0216
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Onchocerca volvulus 0.0028 0.0141 0.0717
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0018 0.0001 0.0002
Loa Loa (eye worm) proteasome Regulatory Particle 0.003 0.0157 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0254 0.0254
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0019 0.0014 0.0014
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0207 0.2547 0.2925
Brugia malayi Proteasome/cyclosome repeat family protein 0.0029 0.0147 0.0152
Schistosoma mansoni hypothetical protein 0.0194 0.2375 0.2375
Schistosoma mansoni hypothetical protein 0.0037 0.0254 0.0254
Entamoeba histolytica hypothetical protein 0.0035 0.0226 0.0258
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0019 0.0015 0.0016
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Echinococcus multilocularis geminin 0.0174 0.2104 0.2104
Plasmodium vivax proteasome subunit beta type-6, putative 0.0162 0.1951 0.224
Brugia malayi 26S protease regulatory subunit 6A 0.0019 0.0016 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0141 0.0146
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0018 0.0001 0.0001
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0133 0.1552 0.1768
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0663 0.871 1
Trichomonas vaginalis proteasome regulatory subunits, putative 0.003 0.0159 0.018
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0663 0.871 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0027 0.0124 0.0124
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0027 0.0126 0.013
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0019 0.0016 0.0019
Plasmodium falciparum proteasome subunit beta type-5 0.0663 0.871 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0034 0.0216 0.0216
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0027 0.0126 0.0126
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0162 0.1946 0.1946
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0014 0.0015
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.003 0.0157 0.018
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0027 0.0126 0.0126
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0157 0.1876 0.2152
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0018 0.0001 0.0002
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0155 0.1855 0.2129
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.005 0.0041
Trypanosoma brucei proteasome beta 6 subunit 0.0182 0.2212 0.2538
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0162 0.1946 0.1946
Onchocerca volvulus 0.0034 0.0216 0.1096
Brugia malayi Trypsin family protein 0.0034 0.0216 0.0224
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0039 0.0284 0.0284
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0019 0.0016 0.0019
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0162 0.194 0.2227
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0026 0.0107 0.0121
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0162 0.1951 0.1951
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.1876 0.2152
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0034 0.0216 0.0216
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0162 0.194 0.194
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0141 0.0717
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0107 0.0111
Echinococcus granulosus Mastin 0.0034 0.0216 0.0216
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0207 0.2547 0.2547
Echinococcus granulosus proteasome subunit alpha type 2 0.0167 0.2007 0.2007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Loa Loa (eye worm) carbonic anhydrase 3 0.0153 0.183 0.183
Leishmania major proteasome beta-1 subunit, putative 0.0162 0.1951 0.224
Brugia malayi hypothetical protein 0.0034 0.0216 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Brugia malayi small heat shock protein 0.0592 0.7759 0.8051
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0027 0.0124 0.014
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.0526 0.0526
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0167 0.2007 0.2007
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0164 0.1966 0.2257
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0035 0.0226 0.0226
Loa Loa (eye worm) RPN-3 protein 0.0035 0.0233 0.0233
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0027 0.0126 0.0143
Giardia lamblia 20S proteasome alpha subunit 6 0.0162 0.194 0.2226
Entamoeba histolytica proteasome regulatory subunit, putative 0.0019 0.0015 0.0016
Leishmania major proteasome alpha 1 subunit, putative 0.0162 0.194 0.2227
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0027 0.0126 0.0143
Loa Loa (eye worm) hypothetical protein 0.005 0.0438 0.0438
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0164 0.1966 0.2257
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0035 0.0226 0.0259
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0141 0.0141
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.1876 0.2152
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0019 0.0016 0.0016
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0235 0.027
Brugia malayi nuclear receptor NHR-88 0.0028 0.0141 0.0146
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0019 0.0016 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0141 0.0141
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0133 0.1552 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0141 0.0141
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0164 0.1966 0.2256
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0216 0.0216
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0207 0.2558 0.2937
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Loa Loa (eye worm) hypothetical protein 0.0057 0.0526 0.0526
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0207 0.2558 0.2936
Echinococcus granulosus geminin 0.0174 0.2104 0.2104
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0039 0.0284 0.0326
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0153 0.183 0.1899
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0663 0.871 1
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0019 0.0016 0.0017
Schistosoma mansoni DNA polymerase eta 0.005 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0057 0.0526 0.0526
Toxoplasma gondii SAC3/GANP family protein 0.0026 0.0107 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Giardia lamblia DINP protein human, muc B family 0.0022 0.005 0.0056
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0162 0.1946 0.2234
Schistosoma mansoni na/ca exchanger 0.0019 0.0014 0.0014
Echinococcus granulosus Ankyrin 0.0033 0.0196 0.0196
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0039 0.0284 0.0324
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0026 0.0107 0.0123
Loa Loa (eye worm) hypothetical protein 0.0033 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0141 0.0146
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0216 0.0216
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0153 0.183 0.1899
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0207 0.2558 0.2937
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0018 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Giardia lamblia Proteasome subunit beta type 3 0.0157 0.1876 0.2152
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0172 0.2085 0.2394
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0018 0.0001 0.0002
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0157 0.1876 0.2153
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0194 0.0194
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0173 0.2097 0.2097
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0162 0.1951 0.2239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0141 0.0141
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0207 0.2547 0.2547
Echinococcus granulosus Proteasome subunit alpha type 7 0.0207 0.2547 0.2547
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0155 0.1855 0.213
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0254 0.0254
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0019 0.0014 0.0014
Onchocerca volvulus 0.0018 0.0001 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0141 0.0141
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0207 0.2547 0.2924
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0141 0.0141
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0194 0.0194
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.0526 0.0546
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0141 0.0146
Loa Loa (eye worm) proteasome subunit beta type 3 0.0157 0.1876 0.1876
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0162 0.1946 0.1946
Loa Loa (eye worm) PCI domain-containing protein 0.003 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0194
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0019 0.0014 0.0014
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0035 0.0226 0.0226
Schistosoma mansoni 26S protease regulatory subunit 0.0018 0.0001 0.0001
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0155 0.1855 0.1855
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0207 0.2558 0.2558
Entamoeba histolytica proteasome regulatory subunit, putative 0.0033 0.0199 0.0227
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0162 0.194 0.194
Toxoplasma gondii proteasome beta subunit 0.0157 0.1876 0.2153
Echinococcus multilocularis carbonic anhydrase 0.0057 0.0526 0.0526
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.1951 0.2239
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0172 0.2085 0.2394
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0162 0.194 0.2227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0057
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.005 0.0052
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0029 0.0147 0.0167
Echinococcus multilocularis Mastin 0.0034 0.0216 0.0216
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.003 0.0157 0.0179
Brugia malayi steroid hormone receptor 0.0028 0.0141 0.0146
Brugia malayi proteasome subunit beta type 1 0.0182 0.2212 0.2295
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0027 0.0124 0.0142
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0107 0.0121
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0035 0.0233 0.0242
Schistosoma mansoni proteasome regulatory subunit-related 0.003 0.0159 0.0159
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0134 0.1563 0.1793
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0235 0.027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.0216
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0026 0.0107 0.0107
Schistosoma mansoni sodium/calcium exchanger 0.0758 1 1
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0027 0.0124 0.0142
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.003 0.0157 0.0157
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0133 0.1552 0.178
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0216
Brugia malayi Uncoordinated protein 44 0.0032 0.0194 0.0201
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0162 0.194 0.2226
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0199 0.0199
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0157 0.1876 0.2153
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0207 0.2547 0.2924
Onchocerca volvulus 0.0034 0.0216 0.1096
Toxoplasma gondii proteasome subunit alpha type, putative 0.0074 0.0752 0.0863
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0039 0.0284 0.0326
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0162 0.1951 0.2239
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0026 0.0107 0.0111
Echinococcus multilocularis carbonic anhydrase II 0.0153 0.183 0.183
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0141 0.0141
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0194 0.0194
Echinococcus multilocularis enteropeptidase 0.0034 0.0216 0.0216
Mycobacterium ulcerans proteasome PrcA 0.0133 0.1552 0.1734
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0141 0.0146
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0018 0.0001 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0141 0.0146
Entamoeba histolytica proteasome regulatory subunit, putative 0.0027 0.0124 0.014
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0167 0.2007 0.2304
Plasmodium vivax cation/H+ antiporter, putative 0.0019 0.0014 0.0017
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0085 0.0908 0.1042
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0035 0.0233 0.0233
Leishmania major DNA polymerase eta, putative 0.005 0.0438 0.0503
Echinococcus granulosus Proteasome subunit alpha beta 0.0164 0.1966 0.1966
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0141 0.0141
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.005 0.0041
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0157 0.1876 0.1876
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.003 0.0159 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0141 0.0146
Trypanosoma brucei carbonic anhydrase-like protein 0.0153 0.183 0.2099
Schistosoma mansoni hypothetical protein 0.0057 0.0526 0.0526
Toxoplasma gondii PCI domain-containing protein 0.0027 0.0124 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0056
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0107 0.0121
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0019 0.0009 0.0008

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 0.46 uM Antiproliferative activity against human HT-29 cells after 72 hrs by resazurin dye reduction assay ChEMBL. 24113061
IC50 (functional) = 0.286 uM Cytotoxicity against human MDA-MB-231 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.464 uM Cytotoxicity against human HT-29 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.539 uM Cytotoxicity against human DU145 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.598 uM Cytotoxicity against human RKO cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.676 uM Cytotoxicity against human MKN45 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.716 uM Cytotoxicity against human CAL27 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.758 uM Cytotoxicity against human HCT116 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.782 uM Cytotoxicity against human MCF7 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.882 uM Cytotoxicity against human 22Rv1 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.898 uM Cytotoxicity against human TE671 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.933 uM Cytotoxicity against human PANC1 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 0.957 uM Cytotoxicity against human LNCAP cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 1.82 uM Cytotoxicity against human Saos2 cells by propidium iodide staining ChEMBL. 21868221
IC50 (functional) = 2.31 uM Cytotoxicity against human NCI-H460 cells by propidium iodide staining ChEMBL. 21868221

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21868221

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.