Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC MAPK | 0.228 | 0.4488 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.228 | 0.4488 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.228 | 0.4488 | 0.5 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.4847 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.228 | 0.4488 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.228 | 0.4488 | 0.4488 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.228 | 0.4488 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.228 | 0.4488 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.228 | 0.4488 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.228 | 0.4488 | 0.4488 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.228 | 0.4488 | 0.4488 |
Trichomonas vaginalis | CMGC family protein kinase | 0.228 | 0.4488 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4847 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.228 | 0.4488 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.228 | 0.4488 | 0.5 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.2748 | 0.5493 | 0.5521 |
Brugia malayi | Raf kinase | 0.4678 | 0.9637 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.228 | 0.4488 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.228 | 0.4488 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.228 | 0.4488 | 0.4488 |
Brugia malayi | MAP kinase sur-1 | 0.228 | 0.4488 | 0.4657 |
Loa Loa (eye worm) | raf kinase | 0.4824 | 0.9949 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.228 | 0.4488 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.228 | 0.4488 | 0.4488 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.228 | 0.4488 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.228 | 0.4488 | 0.4511 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.05 uM | Concentration required for maximal in vitro inhibition of aggregation of human platelet rich plasma (hPRP) | ChEMBL. | 11514170 |
IC50 (functional) | = 0.05 uM | Concentration required for maximal in vitro inhibition of aggregation of human platelet rich plasma (hPRP) | ChEMBL. | 11514170 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11514170 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.