Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.014 | 0.4739 | 0.461 |
Schistosoma mansoni | lipoxygenase | 0.0178 | 0.6938 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0077 | 0.1093 | 0.0874 |
Echinococcus multilocularis | 0.0077 | 0.1093 | 0.1274 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0882 | 0.0882 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0077 | 0.1093 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.0882 | 0.0959 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0077 | 0.1093 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0077 | 0.1093 | 1 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0077 | 0.1093 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0077 | 0.1093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0882 | 0.0882 |
Trypanosoma cruzi | cytochrome P450, putative | 0.014 | 0.4739 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0077 | 0.1093 | 1 |
Brugia malayi | cytochrome P450 | 0.0077 | 0.1093 | 0.0874 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0077 | 0.1093 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0077 | 0.1093 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0077 | 0.1093 | 0.1896 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0882 | 0.0882 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0077 | 0.1093 | 0.1896 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0232 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0077 | 0.1093 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0077 | 0.1093 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0077 | 0.1093 | 0.1896 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.0882 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0077 | 0.1093 | 0.1896 |
Loa Loa (eye worm) | CYP4Cod1 | 0.014 | 0.4739 | 0.4739 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0077 | 0.1093 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0178 | 0.6938 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.014 | 0.4739 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.0882 | 0.0882 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0077 | 0.1093 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0077 | 0.1093 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0077 | 0.1093 | 0.1896 |
Leishmania major | cytochrome p450-like protein | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0077 | 0.1093 | 0.1896 |
Leishmania major | cytochrome p450-like protein | 0.014 | 0.4739 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.0882 | 0.0882 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0077 | 0.1093 | 0.1896 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.014 | 0.4739 | 0.4739 |
Schistosoma mansoni | lipoxygenase | 0.0105 | 0.2743 | 0.3737 |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.0882 | 0.0959 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0077 | 0.1093 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0077 | 0.1093 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0077 | 0.1093 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0135 | 0.4445 | 0.4309 |
Schistosoma mansoni | cytochrome P450 | 0.0077 | 0.1093 | 0.1274 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0077 | 0.1093 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1093 | 0.1274 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0073 | 0.0882 | 0.0959 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.0882 | 0.0658 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0077 | 0.1093 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0077 | 0.1093 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.014 | 0.4739 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0077 | 0.1093 | 0.1896 |
Brugia malayi | Cytochrome P450 family protein | 0.014 | 0.4739 | 0.461 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0077 | 0.1093 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0077 | 0.1093 | 0.1896 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0073 | 0.0882 | 0.0959 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0077 | 0.1093 | 0.1896 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0077 | 0.1093 | 0.1896 |
Loa Loa (eye worm) | cytochrome P450 | 0.0077 | 0.1093 | 0.1093 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0077 | 0.1093 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0077 | 0.1093 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0077 | 0.1093 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0077 | 0.1093 | 0.1274 |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.0882 | 0.0882 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0178 | 0.6938 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.014 | 0.4739 | 1 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0077 | 0.1093 | 0.1896 |
Onchocerca volvulus | 0.0073 | 0.0882 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0077 | 0.1093 | 0.1896 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.014 | 0.4739 | 0.4739 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0135 | 0.4445 | 0.4445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.