Detailed information for compound 1146860

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 274.226 | Formula: C14H10O6
  • H donors: 3 H acceptors: 4 LogP: 2.42 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(O)ccc2c1c(=O)c1c(o2)c(O)ccc1O
  • InChi: 1S/C14H10O6/c1-19-13-7(16)4-5-9-11(13)12(18)10-6(15)2-3-8(17)14(10)20-9/h2-5,15-17H,1H3
  • InChiKey: UFUVMMHQLLOVQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0285 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0285 0.0285
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0285 0.0285
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 1 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0072 1 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0285 0.0285
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0285 1
Schistosoma mansoni coup transcription factor 0.002 0.0285 0.0285
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0072 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0285 0.0285
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0285 0.0285
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Brugia malayi ecdysteroid receptor 0.002 0.0285 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0285 0.0285
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0285 0.0285
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0 0.5
Onchocerca volvulus 0.002 0.0285 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0285 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0285 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0285 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0072 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0285 0.0285
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0285 0.0285
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0285 1
Brugia malayi steroid hormone receptor 0.002 0.0285 0.0285
Brugia malayi nuclear hormone receptor 0.002 0.0285 0.0285
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0285 0.0285
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0285 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0285 0.0285
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0285 0.0285
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0285 0.0285
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0285 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0285 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0285 0.0285
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0285 0.0285
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0285 0.0285
Schistosoma mansoni transcription factor LCR-F1 0.0072 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0285 0.0285
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0285 0.0285
Schistosoma mansoni nuclear hormone receptor 0.002 0.0285 0.0285
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0 0.5
Trichomonas vaginalis ap endonuclease, putative 0.0019 0 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0285 0.0285
Schistosoma mansoni thyroid hormone receptor 0.002 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0285 0.0285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0072 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0285 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0285 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0 0.5
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0285 0.0285
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0285 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0285 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0285 0.0285
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0285 0.0285
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0285 0.0285
Toxoplasma gondii exonuclease III APE 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0285 0.0285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0285 0.0285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0072 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0285 0.0285
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0285 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0285 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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